craf — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T63448	BRAF V600E/CRAF-IN-1
	BRAF V600E/CRAF-IN-1 is a potent inhibitor of BRAFV600E/CRAF. BRAF V600E/CRAF-IN-1 acts in the G0/G1 phase of HCT-116 colon cancer cells to arrest the cell cycle and cause apoptosis. BRAF V600E/CRAF-IN-1 shows potential ...
T63882	BRAF V600E/CRAF-IN-2
	BRAF V600E/CRAF-IN-2 is a potent inhibitor of BRAFV600E/CRAF with IC50 values of 0.888 and 0.229 μM, respectively.BRAF V600E/CRAF-IN-2 induces cell cycle arrest at G0/G1 phase and apoptosis in HCT-116 colon cancer cells....
T6971	Ro 5126766	CH5126766,Avutometinib,VS-6766,RO5126766	Raf , MEK
	RO5126766 (CH5126766) is a dual RAF/MEK inhibitor with IC50 of 8.2 nM, 19 nM, 56 nM, and 160 nM for BRAF V600E, BRAF, CRAF, and MEK1, respectively. Phase 1.		Raf , MEK
T5172	AZ304		c-Fms , Raf , p38 MAPK , Autophagy
	AZ304 is an ATP-competitive dual BRAF kinase inhibitor, potently inhibits BRAF (WT), BRAF (V600E), and wild type CRAF (IC50s: 79/38/68 nM).		c-Fms , Raf , p38 MAPK , Autophagy
TQ0048	BI-882370		Raf
	BI-882370 is a specific RAF kinase inhibitor. BI-882370 inhibits the oncogenic BRAFV600E-mutant, the WT BRAF and CRAF kinases (IC50s: 0.4, 0.8 and 0.6 nM). BI-882370 also inhibits SRC family kinases.		Raf
T9638	CCT241161		Raf
	CCT241161 is an orally active pan-RAF inhibitor, with IC50 values of 3, 6, 10, 15, and 30 nM for LCK, CRAF, SRC, V600E-BRAF, and BRAF, respectively. It displays significant activity against BRAF and NRAS mutant melanomas...		Raf
T1886	TAK-632		Raf , FGFR , PDGFR , Aurora Kinase
	TAK-632 is a potent pan-Raf inhibitor.		Raf , FGFR , PDGFR , Aurora Kinase
T4133	CCT196969		Raf , Src
	CCT196969 is a novel orally available, pan-RAF inhibitor with anti-SRC activity. It also inhibits SRC, LCK, and the p38 MAPKs.		Raf , Src
T3711	RAF709		Raf
	RAF709 is a novel Raf kinase inhibitor with IC50s of 0.5 and 1.8 nM for c-Raf and b-Raf, respectively.		Raf
T63365	RAF-IN-1
	RAF-IN-1 is a potent inhibitor of b/cRAF, acting on cRAF (IC50: 3.8 nM), bRAFwt (IC50: 36 nM), bRAFV600E (IC50: 29.4 nM) and inhibiting A375 and H358 cell lines carrying the bRAFV600E mutation with a GI50 of 3.4 and 2.9 ...
T21602	PF-04880594
	PF-04880594 is a potent and selective RAF inhibitor which inhibits both wild-type and mutant BRAF and CRAF. PF-04880594 exhibits antitumor activity [1].
T79092	TH-Z827		Ras
	TH-Z827 is a mutant-selective inhibitor targeting KRAS(G12D) with an IC50 of 2.4 μM, demonstrating specificity by not binding to KRAS(WT) or KRAS(G12C). Additionally, it disrupts the KRAS(G12D)-CRAF interaction with an I...		Ras
T63494	Antitumor agent-60
	Antitumor agent-60 is a potent antitumor agent that targets the RAS-RAF signaling pathway and binds to CRAF (Kd: 721.3 nM). antitumor agent-60 increases p53 and ROS levels in cancer cells, resulting in oval and irregular...
T68267	RO5068760
	RO5068760 , a substituted hydantoin, is a potent, highly selective, non-adenosine triphosphate (ATP)-competitive MEK1/2 inhibitors. RO5068760 shows significant efficacy in a broad spectrum of tumors with aberrant mitogen...
T63542	SHR902275
	SHR902275 is a selective, potent, orally active RAF inhibitor capable of targeting RAS mutant cancers. SHR902275 acts on cRAF (IC50: 1.6 nM), bRAFwt (IC50: 10 nM), bRAFV600E (IC50: 5.7 nM). SHR902275 has cell growth inhi...
T36641	RAS inhibitor Abd-7
	RAS inhibitor Abd-7 is a powerful compound (Kd=51 nM) that binds to RAS and inhibits the protein-protein interaction (PPI) between RAS and its effectors. By interacting with RAS within cells, RAS inhibitor Abd-7 hinders ...
T28510	REDX05358	REDX 05358,REDX-05358
	REDX05358 is a highly selective and potent pan RAF inhibitor with a potential therapeutic for BRAF and RAS mutant tumors. REDX05358 has improved therapeutic potential and predicted safety profile. REDX05358 demonstrates ...

Compounds

BRAF V600E/CRAF-IN-1

T63448

Synonym:

Target:

BRAF V600E/CRAF-IN-2

Synonym: CH5126766,Avutometinib,VS-6766,RO5126766

Target: c-Fms, Raf, p38 MAPK, Autophagy

Target: Raf, FGFR, PDGFR, Aurora Kinase

Synonym: REDX 05358,REDX-05358

Target:

Cat No.	Product Name	Species	Expression System
TMPY-05095	RAF1 Protein, Human, Recombinant (His & GST)	Human	Baculovirus Insect Cells
	RAF1 gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds direct...

Cat No.

Product Name

Species

Expression System

TMPY-05095

RAF1 Protein, Human, Recombinant (His & GST)

Human

Baculovirus Insect Cells

RAF1 gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds direct...

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Compounds

Recombinant Proteins

Compounds

Recombinant Proteins