β-galactosidase

β-Galactosidase (GAL) is a glycoside hydrolase that hydrolyzes the β-glycosidic bond formed between galactose and its organic part, and naturally catalyzes the hydrolysis of the galactosidic bond in oligosaccharides and disaccharides for the degradation of lactose and the production of low-lactose and lactose-free lactose products that are beneficial to lactose intolerant patients.

β-galactosidase mRNA (N1-Methylpseudo-UTP) encodes the bacterial lactose Z gene product, β-galactosidase. This enzyme catalyzes the conversion of β-galactosides into monosaccharides and serves as a universal marker for assessing transfection efficiency. The inclusion of N1-Methylpseudo-UTP reduces the immunogenicity of the generated mRNA.

β-Galactosidase Mutein, E. coli, is a hydrolase enzyme that facilitates the conversion of β-galactosides into monosaccharides. The substrates for various β-galactosidases include ganglioside GM1, lactosylceramide, lactose, and an array of glycoproteins.

α-Galactosidase, Cellvibrio mixtus (EC 3.2.1.22), is a glycoside hydrolase enzyme capable of hydrolyzing terminal α-galactosyl residues in glycolipids and glycoproteins. It exists in two recombinant forms known as α-galactosidase (INN) and β-galactosidase (INN).

α-Galactosidase, Thermus brockianus (EC 3.2.1.22), is a glycoside hydrolase enzyme that hydrolyzes terminal α-galactosyl groups from glycosides and glycoproteins. There are two recombinant forms of α-Galactosidase, known as α-galactosidase (INN) and β-galactosidase (INN).

α-Galactosidase, positionally specific, Escherichia coli (EC 3.2.1.22), is a glycoside hydrolase enzyme that catalyzes the hydrolysis of α-galactosyl residues from the termini of glycolipids and glycoproteins. It exists in two recombinant forms known as α-galactosidase (INN) and β-galactosidase (INN).

α-Galactosidase, Clostridium cellulolyticum (EC 3.2.1.22), is a glycoside hydrolase enzyme that hydrolyzes α-galactosyl groups at the terminal position of glycolipids and glycoproteins. This enzyme exists in two recombinant forms: α-Galactosidase (INN) and β-Galactosidase (INN).

exo-α-1,2-Galactosidase, Bacteroides thetaiotaomicron, is a glycoside hydrolase.

Exo-α-Galactosidase, Bacteroides thetaiotaomicron (EC.3.2.1.22), is a glycoside hydrolase enzyme.

Exo-α-Galactosidase Isoenzyme from Bacteroides thetaiotaomicron (EC.3.2.1.22) is a glycoside hydrolase enzyme.

Beta-galactosidase A (BgaA) is a hydrolase enzyme capable of breaking down lactose.

D-Ribonolactone is a sugar lactone and an inhibitor of β-galactosidase in Escherichia coli (Ki: 26 mM).

Tryptophan, N-indol-3-ylacetyl- (Indole-3-acetyl-L-tryptophan) is involved in regulatory mechanisms for the control of auxin activity during physiological and pathophysiological responses. It may also be used in the synthesis of β-D-galactosidase and β-D-glucosidase inhibitors.

Migalastat hydrochloride (GR181413A) is an orally available, potent and competitive inhibitor of alpha-galactosidase A. It promotes the transport of alpha-galactosidase A to the lysosome and can be used in the study of Fabry disease.

4-Nitrophenyl α-D-galactopyranoside (PNP-alpha-D-Gal) is an artificial substrate of 4-nitrophenyl (pNP) glycopyranoside used for detecting α-galactosidase activity. The amount of released pNP increases significantly when PNP-alpha-D-Gal is used as a substrate.

α-Galactosidase is an endogenous glycosidase that can break down oligosaccharides and glycolipids containing α-galactoside bonds and can be used in the study of Fabry disease.

Alpha-Galactosidase A is a lysosomal exoglycosidase that hydrolyzes the terminal α-galactose residues of glycoconjugates.

α-N-acetylgalactosidase (EC 3.2.1.4) is a highly specific exoglycosidase capable of effectively hydrolyzing α-N-acetylgalactosamine (GalNAc) linked to serine or threonine residues in glycoproteins (Tn antigen). This enzyme demonstrates activity towards terminal GalNAc in α 1-3 linkages and operates optimally within a pH range of 6.0-7.6, without requiring cofactors or specialized buffer systems.

SSK1 is a compound that selectively kills senescent cells and is a precursor for β-galactosidase, which can reduce the inflammatory response of the body. SSK1 can activate the phosphorylation of p38 MAPK and MKK3/MKK6 in senescent cells, and promote mitochondrial DNA damage in senescent cells.

ONPG (2-Nitrophenyl β-D-galactopyranoside) is a colorimetric and spectrophotometric substrate used to detect β-galactosidase activity.

Maltotriose is an inducer of E. coli maltose regulator, the second most abundant sugar in brewing. It induces beta-galactosidase synthesis.

Cetyldimethylethylammonium Bromide can be used to induce extracellular secretion of beta-galactosidase.

resorufin galactopyranoside is a fluorescent substrate for β-galactosidase.After cleavage by β-galactosidase, the fluorescent portion of resorufin is released and its fluorescence can be used to quantify β-galactosidase activity. It has an excitation light of 570 and an emission light of 580 nm.

N-Octyl-α-4-epivalienamine is an orally active molecular chaperone capable of crossing the blood-brain barrier. It induces high expression of defective β-galactosidase activity. This compound improves symptoms and increases survival rates in mouse models of GM1 gangliosidosis. N-Octyl-α-4-epivalienamine is applicable for research in neurogenetic diseases.