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TOPK

T-LAK cell-originated protein kinase (TOPK) is a MAPKK-like kinase which plays a role in cell cycle regulation and mitotic progression. As a consequence, TOPK expression is minimal in differentiated cells, although its overexpression is a pathophysiological feature of many tumours. Hence, TOPK has garnered interest as a cancer-specific biomarker and biochemical target with the potential to enhance cancer therapy whilst causing minimal harm to normal tissues.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T4134L OTS514 1338540-63-8
OTS514
OTS514 (OTS514 Hydrochloride) is a potent TOPK inhibitor. OTS514 exhibits a growth-suppressive effect on small cell lung cancer. OTS514 effectively suppressed th...
T0199 Cephradine 38821-53-3 mixture
Cephradine
Cephradine (Anspor) is a beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity.
T4134 OTS514 hydrochloride 2319647-76-0 99.41%
OTS514 hydrochloride
OTS514 hydrochloride is a highly effective TOPK(T-LAK cell-originated protein kinase) inhibitor (IC50: 2.6 nM).
T1756L Ilaprazole 172152-36-2 99.08%
Ilaprazole
Ilaprazole (IY-81149) is a proton pump inhibitor used in the treatment of dyspepsia gastroesophageal reflux disease (GORD/GERD) and duodenal ulcer. Studies also ...
T1756 Ilaprazole sodium 172152-50-0 99.06%
Ilaprazole sodium
Ilaprazole sodium (IY-81149 sodium) , a substituted benzimidazole prodrug, is a selective and irreversible proton pump inhibitor. A weak base, Ilaprazole accumul...
T15481 HI-TOPK-032 487020-03-1 98.69%
HI-TOPK-032
HI-TOPK-032 is an effective and specific inhibitor of TOPK.
T4135 OTS964 hydrochloride 1338545-07-5 98.02%
OTS964 hydrochloride
OTS964 hydrochloride (OTS964) is a potent and selective TOPK inhibitor with potential anticancer activity.
OTS514
T4134L
OTS514 (OTS514 Hydrochloride) is a potent TOPK inhibitor. OTS514 exhibits a growth-suppressive effect on small cell lung cancer. OTS514 effectively suppressed th...
Cephradine
T0199
Cephradine (Anspor) is a beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity.
OTS514 hydrochloride
T4134
OTS514 hydrochloride is a highly effective TOPK(T-LAK cell-originated protein kinase) inhibitor (IC50: 2.6 nM).
Ilaprazole
T1756L
Ilaprazole (IY-81149) is a proton pump inhibitor used in the treatment of dyspepsia gastroesophageal reflux disease (GORD/GERD) and duodenal ulcer. Studies also ...
Ilaprazole sodium
T1756
Ilaprazole sodium (IY-81149 sodium) , a substituted benzimidazole prodrug, is a selective and irreversible proton pump inhibitor. A weak base, Ilaprazole accumul...
HI-TOPK-032
T15481
HI-TOPK-032 is an effective and specific inhibitor of TOPK.
OTS964 hydrochloride
T4135
OTS964 hydrochloride (OTS964) is a potent and selective TOPK inhibitor with potential anticancer activity.
TargetMol