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MAPK TOPK

TOPK

T-LAK cell-originated protein kinase (TOPK) is a MAPKK-like kinase which plays a role in cell cycle regulation and mitotic progression. As a consequence, TOPK expression is minimal in differentiated cells, although its overexpression is a pathophysiological feature of many tumours. Hence, TOPK has garnered interest as a cancer-specific biomarker and biochemical target with the potential to enhance cancer therapy whilst causing minimal harm to normal tissues.
Cat No. product name
T1756L Ilaprazole Ilaprazole is a proton pump inhibitor used in the treatment of dyspepsia gastroesophageal reflux disease (GORD/GERD) and duodenal ulcer. Studies also showed tha...
T4134 OTS514 hydrochloride(1338540-63-8(free base)) OTS514 is a highly effective TOPK(T-LAK cell-originated protein kinase) inhibitor (IC50: 2.6 nM).
T4135 OTS964 OTS964 is a potent and selective TOPK inhibitor with potential anticancer activity.
Ilaprazole
T1756LCAS 172152-36-2
Ilaprazole is a proton pump inhibitor used in the treatment of dyspepsia gastroesophageal reflux disease (GORD/GERD) and duodenal ulcer. Studies also showed tha...
OTS514 hydrochloride(1338540-63-8(free base))
T4134CAS 2319647-76-0
OTS514 is a highly effective TOPK(T-LAK cell-originated protein kinase) inhibitor (IC50: 2.6 nM).
OTS964
T4135CAS 1338545-07-5
OTS964 is a potent and selective TOPK inhibitor with potential anticancer activity.