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Melanin-concentrating Hormone Receptor (MCHR)

Two Melanin-concentrating hormone receptors (MCHR) have recently been characterized: MCH-R1 and MCH-R2. These two receptors share approximately 38% homology. MCH-R1 is expressed in all mammals.MCH-R2 is only found in some primates and carnivores including dogs, ferrets and humans.

FilterSignaling PathwaysGPCR/G ProteinMelanin-concentrating Hormone Receptor (MCHR)
  • Neuropeptide EI, rat acetate
    TP1578L
    Neuropeptide EI, rat acetate Displays functional MCH-antagonist and MSH-agonist activity in different behavioral paradigms.
    • $65
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  • TC-MCH 7c
    T13101864756-35-4
    TC-MCH 7c is an oral, selectable and blood-brain barrier penetrating MCH1R antagonist with IC50 performance of 5.6 nM against hMCH1R, and TC-MCH 7c is a phenylpyridone derivative with MCH1R Ki of 3.4 nM against human. In mice, MCH1R Ki was 3.0 nM.
    • $95
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  • Melanin Concentrating Hormone, salmon acetate
    TP1104L
    Melanin Concentrating Hormone, salmon acetate (MCH (salmon)) is a 19 amino acid cyclic peptide, is largely expressed in the hypothalamus.
    • $205
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  • PG 931 acetate
    TP1953L
    PG 931 acetate is a potent agonist of melanocortin 4 (MC4) receptors.
    • $416
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  • [Ala17]-MCH acetate
    TP1997L
    [Ala17]-MCH acetate is a selective ligand for MCHR1 with a Ki of 0.16 nM and Kd of 0.37 nM(Eu3+ chelate-labeled). [Ala17]-MCH acetate shows selectivity over MCHR2 with Ki of 34 nM.
    • $197
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  • MCH(human, mouse, rat)
    TP1996128315-56-0
    MCH(human, mouse, rat) is a potent endogenous agonist at melanin-concentration hormone (MCH) receptors (IC50 values are 0.3 and 1.5 nM and EC50 values are 3.9 and 0.1 nM at MCH1 and MCH2 receptors respectively). Increases food intake in vivo.
    • $228
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  • SNAP 94847
    T5406487051-12-7
    SNAP 94847 (SNAP-94847) is a selective and competitive MCH1 receptor (MCH1-R) antagonist (Ki: 2.2 nM). It has anxiolytic and antidepressant activity and reduces food intake in mice.
    • $45
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  • SNAP 94847 hydrochloride
    T80041781934-47-1
    SNAP 94847 hydrochloride is a melanin-concentrating hormonereceptor1 (MCHR1) antagonist(Ki= 2.2 nM)
    • $41
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  • MCHR1 antagonist 2
    T11966863115-70-2
    MCHR1 antagonist 2 is an antagonist of melanin-concentratin hormone receptor 1(MCH1-R, IC50 = 65 nM) and also inhibits hERG.
    • $45
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  • ATC 0175 hydrochloride
    T22591510733-97-8
    ATC 0175 hydrochloride is an orally active melanocyte concentrating hormone 1 receptor antagonist that is potent and selective. ATC 0175 hydrochloride has affinity for MCH1R, MCH2R, MCH1, 5-HT2B receptors and 5-HT1A receptors with IC50s of 13.5 nM, >10,000 nM, 13 nM, 9.66 nM and 16.9 nM, respectively. ATC 0175 hydrochloride exhibits antidepressant and anxiolytic effects in animal models. aTC 0175 can be used to study depression and/or anxiety disorders.
    • $72
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