FLAP

FLAP (Arachidonate 5-lipoxygenase-activating protein) is an integral membrane protein, it facilitates the transfer of the substrate arachidonic acid (AA) to 5-lipoxygenase (5-LO) to produce leukotrienes (LTs), and is shown to be indispensable for cellular LT biosynthesis. FLAP transfers arachidonic acid to 5-LOX protein, thereby enabling this enzyme to efficiently produce oxidized lipid products (mainly eicosanoids) that are important in cell growth, differentiation and death particularly apoptosis.

Cat. No.	Product name	CAS No.	Purity
TQ0098	Quiflapon sodium	147030-01-1	98%
Quiflapon sodium (MK591) is a selective inhibitor of 5-Lipoxygenase-activating protein (FLAP).
T16087	Quiflapon	136668-42-3	98.88%
Quiflapon causes cell apoptosis. Quiflapon is a selective and specific 5-lipoxygenase-activating protein (FLAP) inhibitor (IC50: 1.6 nM in a FLAP binding assay) ...
T9023	Atuliflapon	2041075-86-7	99.13%
AZD5718 is a novel 5-Lipoxygenase Activating Protein(FLAP) inhibitor for Treatment of Coronary Artery Disease.
T10314	AM103	1147872-22-7	99.21%
AM103 is an effective and selective inhibitor of FLAP (IC50 = 4.2 nM).
T8844	Diflapolin	724453-98-9	99.23%
Diflapolin is a highly active dual 5-lipoxygenase-activating protein (FLAP)/soluble epoxide hydrolase (sEH) inhibitor with marked anti-inflammatory efficacy and ...
T6893	MK-886	118414-82-7	99.78%
MK-886 is an inhibitor of leukotriene biosynthesis, inhibiting 5-lipoxygenase-activating protein (FLAP). It is also a moderately potent PPARα antagonist.

Cat. No.

Product name

CAS No.

Purity

Chemical Structure

TQ0098

Quiflapon sodium

147030-01-1

98%

Quiflapon sodium (MK591) is a selective inhibitor of 5-Lipoxygenase-activating protein (FLAP).

T16087

Quiflapon

136668-42-3

98.88%

Quiflapon causes cell apoptosis. Quiflapon is a selective and specific 5-lipoxygenase-activating protein (FLAP) inhibitor (IC50: 1.6 nM in a FLAP binding assay) ...

T9023

Atuliflapon

2041075-86-7

99.13%

AZD5718 is a novel 5-Lipoxygenase Activating Protein(FLAP) inhibitor for Treatment of Coronary Artery Disease.

T10314

AM103

1147872-22-7

99.21%

AM103 is an effective and selective inhibitor of FLAP (IC50 = 4.2 nM).

T8844

Diflapolin

724453-98-9

99.23%

Diflapolin is a highly active dual 5-lipoxygenase-activating protein (FLAP)/soluble epoxide hydrolase (sEH) inhibitor with marked anti-inflammatory efficacy and ...

T6893

MK-886

118414-82-7

99.78%

MK-886 is an inhibitor of leukotriene biosynthesis, inhibiting 5-lipoxygenase-activating protein (FLAP). It is also a moderately potent PPARα antagonist.