CSF-1R

Colony stimulating factor 1 receptor (CSF1R), also known as macrophage colony-stimulating factor receptor (M-CSFR), and CD115 (Cluster of Differentiation 115), is a cell-surface protein encoded, in humans, by the CSF1R gene (known also as c-FMS). It is a receptor for a cytokine called colony stimulating factor 1.The encoded protein is a single pass type I membrane protein and acts as the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most, if not all, of the biological effects of this cytokine. Ligand binding activates CSF1R through a process of oligomerization and trans-phosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases.

Cat. No.	Product name	CAS No.	Purity
T11390	GENZ-882706	2070864-35-4	98%
T11390	GENZ-882706 is a potent colony stimulating factor-1 receptor (CSF-1R) Inhibitor.
T10647	C-Fms-IN-8	1255303-58-2	98%
T10647	c-Fms-IN-8 is a colony-stimulating factor-1 receptor (CSF-1R, c-FMS) Type II inhibitor (IC50: 9.1 nM). It is compound 4a in the reference.
T2624	OSI-930	728033-96-3	98%
T2624	OSI-930, an orally active inhibitor of c-Kit and the vascular endothelial growth factor receptor-2 (VEGFR-2), targets cancer cell proliferation and blood vessel ...
T1667	Tandutinib	387867-13-2	98%
T1667	Tandutinib (MLN518, CT53518), an effective FLT3 antagonist (IC50: 0.22 μM), can also inhibit c-Kit and PDGFR, 15-20 fold higher potency for FLT3 versus CSF-1R an...
TQ0015	PRN1371	1802929-43-6	98%
TQ0015	PRN1371 is a specific and potent FGFR1-4 and CSF1R inhibitor (IC50s: 0.6/1.3/4.1/19.3/8.1 nM for FGFR1/2/3/4 and CSF1R).
T7100	PLX5622	1303420-67-8	98%
T7100	PLX-5622 is a highly selective brain penetrant and oral active CSF1R inhibitor.
T4376	Nampt-IN-1	1698878-14-6	98%
T4376	Nampt-IN-1 (LSN3154567) is a potent and selective NAMPT inhibitor. Nampt-IN-1 inhibits purified NAMPT with an IC50 of 3.1 nM.
T4315	Ki20227	623142-96-1	98%
T4315	Ki-20227 is a specific c-Fms tyrosine kinase(CSF1R) inhibitor (IC50: 2 nM). It also has certain inhibitory against VEGFR2(IC50: 12 nM) and c-Kit/PDGFRβ(IC50: 451...
T2115	Pexidartinib	1029044-16-3	98%
T2115	Pexidartinib is a capsule formulation containing a small-molecule receptor tyrosine kinase (RTK) inhibitor of KIT, CSF1R and FLT3 with potential antineoplastic a...
T14380	AZD7507	1041852-85-0	98%
T14380	AZD7507 is a CSF-1R inhibitor. It has antitumor activity.
T10652	Vimseltinib	1628606-05-2	98%
T10652	DCC-3014 is a c-FMS (CSF-IR) and c-Kit dual inhibitor (IC50s: <0.01 μM and 0.1-1 μM) extracted from the patent WO2014145025A2 (Example 10).
T6119	Sotuletinib	953769-46-5	98%
T6119	BLZ945 is an orally active, effective and specific CSF-1R inhibitor (IC50: 1 nM), >1000-fold selective against its closest receptor tyrosine kinase homologs.
T15199	Edicotinib	1142363-52-7	98%
T15199	Edicotinib is a brain penetrant and orally active inhibitor of the colony-stimulating factor-1 receptor (IC50: 3.2 nM). It shows less inhibitory effects on KIT a...
T2514	Linifanib	796967-16-3	98%
T2514	Linifanib (ABT-869) is a novel, potent ATP-competitive VEGFR/PDGFR inhibitor for KDR (IC50: 4 nM), CSF-1R (IC50: 3 nM), Flt-1/3 (IC50: 3/4 nM) and PDGFRβ (IC50: ...
T64066	CSF1R-IN-3	2760584-90-3	98%
T64066	CSF1R-IN-3 is an orally effective CSF-1R inhibitor with an IC50 value of 2.1 nM. CSF1R-IN-3 has anti-proliferative activity against colorectal cancer cells. CSF1...
T35333	ARRY-382	1313407-95-2	98%
T35333	ARRY-382 is a highly selective oral inhibitor of CSF-1R with an IC50 of 9 nM.