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Search Results for " vimentin "

Targets

6

Compounds

1

Natural Products

9

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T13410 ZLDI-8 Apoptosis , Phosphatase , Gamma-secretase , Immunology/Inflammation related
ZLDI-8 is an inhibitor of Notch activating/cleaving enzyme ADAM-17 and inhibits the cleavage of Notch protein.
T9657 FiVe1 Others
FiVe1 is a vimentin binding small molecule that promotes the disintegration and phosphorylation of vimentin in the metaphase, leading to mitotic disasters, polynuclearization, and loss of cancer cell dryness. FiVe1 selec...
T61746 Anticancer agent 82
Anticancer agent 82 is a FiVe1 derivative, an orally active and selective anticancer agent. FiVe1 binds type III intermediate filament protein vimentin ( VIM ), to induce hyperphosphorylation of Ser56, resulting selectiv...
T82006 JM3A
JM3A, a highly specific peptoid reagent, selectively targets cell surface vimentin (CSV) on early lung cancer cells undergoing tumor transformation. By conjugating with fluorophores [1], JM3A detects and stains CSV, enab...
T22036 Arylquin 1
Arylquin 1, a prostate-apoptosis-response-4 (Par-4) secretagogue, specifically targets vimentin to facilitate Par-4 secretion. Additionally, it promotes non-apoptotic cell death in cancer cells by inducing lysosomal memb...
T81400 Pritumumab
Pritumumab, a natural human IgG1kappa monoclonal antibody (mAb), was first isolated from the regional draining lymph node of a cervical carcinoma patient. It specifically recognizes cell-surface-expressed vimentin on mal...
Cat No. Product Name Synonyms Targets
T75491 3-(2-Hydroxyethyl) thio withaferin A
3-(2-Hydroxyethyl) thio withaferin A, a derivative of Withaferin A, is a steroidal lactone that inhibits NF-kB activation and targets vimentin, showcasing potent anti-inflammatory and anticancer properties. It also acts ...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-04329 Vimentin Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
Vimentin is a type III intermediate filament (IF) protein found in various non-epithelial cells, especially mesenchymal cells. A vimentin monomer, has a central α-helical domain and carboxyl (tail) domains. Two monomers ...
TMPH-02971 Vimentin Protein, Mouse, Recombinant (His & Myc) Mouse HEK293
Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or termin...
TMPH-02970 Vimentin Protein, Mouse, Recombinant (E. coli, His & Myc) Mouse E. coli
Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or termin...
TMPH-01752 Nestin/NES Protein, Human, Recombinant (His) Human Yeast
Required for brain and eye development. Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cell...
TMPK-01299 CEACAM5 Protein, Cynomolgus, Recombinant (aa 35-685, His) Cynomolgus HEK293
Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) was identified as a metastatic driver. CEACAM5 overproduction enriched for an epithelial gene expression pattern and facilitated tumor outgrowth at meta...
TMPJ-00846 GFAP Protein, Human, Recombinant (His) Human E. coli
Glial Fibrillary Acidic Protein (GFAP) is an intermediate filament (IF) protein which belongs to the intermediate filament family. GFAP is expressed in numerous cell types of the central nervous system (CNS), ependymal c...
TMPY-02910 Nicastrin Protein, Mouse, Recombinant (His) Mouse HEK293
Nicastrin (NCST, or NCT), a single-pass membrane glycoprotein that harbors a large extracellular domain, is an essential component of the gamma-secretase complex. Several lines of evidence indicate that the members of th...
TMPY-01297 Nicastrin Protein, Human, Recombinant (His) Human HEK293
Nicastrin (NCST, or NCT), a single-pass membrane glycoprotein that harbors a large extracellular domain, is an essential component of the gamma-secretase complex. Several lines of evidence indicate that the members of th...
TMPY-03074 Nicastrin Protein, Mouse, Recombinant (hFc) Mouse HEK293
Nicastrin (NCST, or NCT), a single-pass membrane glycoprotein that harbors a large extracellular domain, is an essential component of the gamma-secretase complex. Several lines of evidence indicate that the members of th...
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