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Search Result

Search Results for " undergoing "

Targets

DYRK

21

Compounds

2

Natural Products

10

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T14364 AZ-Dyrk1B-33 3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine DYRK
AZ-Dyrk1B-33 (3-(2-Methyl-4-pyrimidinyl)-1-(phenylmethyl)-1H-pyrrolo[2,3-c]pyridine) is a potent and selective Dyrk1B kinase inhibitor with an IC50 of 7 nM.
T0230 Prasugrel LY640315,CS-747,PCR 4099 P2Y Receptor
Prasugrel (CS-747) is a piperazine derivative and PLATELET AGGREGATION INHIBITOR that is used to prevent THROMBOSIS in patients with ACUTE CORONARY SYNDROME; UNSTABLE ANGINA and MYOCARDIAL INFARCTION, as well as in those...
TP1236 Etelcalcetide hydrochloride AMG 416 hydrochloride,KAI-4169 hydrochloride CaSR
Etelcalcetide hydrochloride (AMG 416 hydrochloride) is a synthetic peptide that acts as an allosteric modulator of the calcium-sensing receptor (CaSR), effectively lowering parathyroid hormone (PTH) levels in patients wi...
T3614 Inosine pranobex Groprinosin,Isoprinosine,Immunovir,Delimmun IL Receptor , HIV Protease
Inosine pranobex (Delimmun) has a number of immunomodulatory effects, including inducing T-lymphocyte differentiation, augmenting macrophage and NK cell functions, and stimulating IL-2 production. Through these effects a...
T21537L TMC647055 Choline Hydroxide Salt TMC647055 Choline Hydroxide Salt (1204416-97-6 free base) HCV Protease
TMC647055 Choline Hydroxide Salt is a novel and potent non-nucleoside inhibitor of the HCV NS5B polymerase which potentially for the treatment of HCV infection. It has nanomolar cellular potency (EC(50) of 82 nM) with mi...
T68312 Etanterol
Etanterol is a phenethanolamine derivative and a β2 adrenoceptor agonist that was undergoing phase II trials in Italy as a bronchodilator with Valeas.
T69961 CJ-15161 (free base)
CJ-15161 (free base), an opioid κ-receptor agonist, is undergoing development with Pfizer as an analgesic agent.
T71154 SX-576
SX-576 is undergoing further investigation as a potential therapy for pulmonary inflammation. It is also a potent non-competitive boronic acid-containing CXCR1/2 antagonists.
T6287L Tariquidar dimesylate D 06008,XR9576,D06008,XR 9576,Tariquidar dimesilate,XR-9576
Tariquidar is a P-glycoprotein inhibitor undergoing research as an adjuvant against multidrug resistance in cancer. Tariquidar non-competitively binds to the p-glycoprotein transporter, thereby inhibiting transmembrane t...
T69960 CJ-15161 hydrochloride
CJ-15161 hydrochloride is the salt form of CJ-15161 (free base), an opioid κ-receptor agonist, is undergoing development with Pfizer as an analgesic agent.
TP1235 Etelcalcetide AMG 416,KAI-4169
Etelcalcetide (AMG 416) is a synthetic peptide as an activator of the calcium sensing receptor (CaSR). Etelcalcetide is a calcimimetic drug for the treatment of secondary hyperparathyroidism in patients undergoing hemodi...
T12610 (R)-3-Hydroxy Midostaurin (R)-CGP52421 Others
(R)-3-Hydroxy Midostaurin is a potent inhibitor of kinases,is a major metabolite of midostaurin undergoing by the hepatic CYP3A4 enzyme,has the potential for acute myeloid leukemia (AML).
T37437 C17 Ceramide (d18:1/17:0)
C17 Ceramide is a synthetic ceramide that contains a non-natural C17:0 fatty acid acylated to sphingosine. It has been used as a marker of arylsulfatase A and sphingolipid activator B activity in patients undergoing enzy...
T69557 ABI-231 HCl
ABI-231 is a potent, orally bioavailable tubulin inhibitor that interacts with the colchicine binding site and is currently undergoing clinical trials for prostate cancer. ABI-231, has an average IC50 = 5.2 nM against pa...
T68639 Ciprostene (free base)
Ciprostene (free base) is a synthetic, chemically stable analog of prostacyclin (PGI2). In animal models, administration of ciprostene resulted in dose-dependent hypotension, tachycardia, and inhibition of ex vivo ADP-in...
T82006 JM3A
JM3A, a highly specific peptoid reagent, selectively targets cell surface vimentin (CSV) on early lung cancer cells undergoing tumor transformation. By conjugating with fluorophores [1], JM3A detects and stains CSV, enab...
T82654 Cy3-PEG3-TCO4
Cy3-PEG3-TCO4, a dye derivative with three polyethylene glycol (PEG) units linked to Cyanine 3 (Cy3), possesses a trans-cyclooctene (TCO) group capable of undergoing the inverse electron demand Diels-Alder reaction (iEDD...
T71549 RKS-262
RKS262 is a specific cyclin/CDK inhibitor. RKS262 was identified by structural optimization of Nifurtimox which is currently undergoing phase II clinical trials to treat high-risk neuroblastoma. In a NCI(60) cell-line as...
T83872 Oleoyl-L-carnitine chloride L-Carnitine oleoyl ester,L-Octadecanoylcarnitine,C18:1 Carnitine,CAR 18:1
Oleoyl-L-carnitine, a long-chain acylcarnitine, acts as a selective inhibitor of glycine transporter 2 (GlyT2; IC50 = 340 nM) while demonstrating significantly lesser affinity for GlyT1 (IC50 = >10,000 nM). Elevated plas...
T83798 8-bromo NAD+ sodium 8-bromo Nicotinamide adenine dinucleotide,N(8-bromo-A)D+
8-Bromo NAD+ serves as a prodrug for the cyclic ADP-ribose (cADPR) inhibitor, 8-bromo cADPR, undergoing conversion to its active form by the enzyme CD38. At a concentration of 1 mM, it effectively inhibits the rise in in...
T72213 Efonidipine hydrochloride NZ-105 hydrochloride
Efonidipine HCl (NZ-105) serves as both a T-type and L-type calcium channel blocker. This compound, distinct from other calcium channel blockers, notably increases N(6), 2'-O-dibutyryladenosine 3',5'-cyclic monophosphate...
Cat No. Product Name Synonyms Targets
T39312 2-Hexylthiophene Others
2-Hexylthiophene, a weakly basic heteroaromatic compound, can enhance the molar absorption coefficient of ruthenium sensitizers by undergoing modification.
T82799 C-2′-Decoumaroylaloeresin G
Compound 1059182-21-6 features a cyclic structure characterized by a nitrogen atom occupying an apex (corner) within the heterocycle. Its molecular scaffold integrates aromatic properties due to the presence of a conjuga...

Natural Products

2-Hexylthiophene
T39312
Synonym:
Target: Others
C-2′-Decoumaroylaloeresin G
T82799
Synonym:
Target:

Recombinant Proteins

Species：
Human (6)
Mouse (3)
Bovine (1)
Expression System：
E. coli (5)
HEK293 Cells (3)
Baculovirus Insect Cells (1)
P. pastoris (Yeast) (1)
Tag：
C-6xHis (1)
C-hFc (1)
GST (1)
His, GST (1)
N-10xHis, C-Myc (1)
N-6xHis (1)
N-6xHis-KSI (1)
N-6xHis-SUMO (1)
N-GST (1)
Tag Free (1)
Cat No. Product Name Species Expression System
TMPH-00275 ITIH2 Protein, Bovine, Recombinant (His & KSI) Bovine E. coli
May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyal...
TMPH-02730 ITIH2 Protein, Mouse, Recombinant (His & Myc) Mouse E. coli
May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyal...
TMPK-00976 AMHRII Protein, Human, Recombinant Human HEK293 Cells
The aim of the current study was to explore whether anti-Müllerian hormone receptor II (AMHRII) genetic variants influence the hormonal profile and the ovarian response to standard gonadotropin stimulation of women under...
TMPK-00977 AMHRII Protein, Human, Recombinant (hFc) Human HEK293 Cells
The aim of the current study was to explore whether anti-Müllerian hormone receptor II (AMHRII) genetic variants influence the hormonal profile and the ovarian response to standard gonadotropin stimulation of women under...
TMPJ-01051 Pleiotrophin/PTN Protein, Mouse, Recombinant (His) Mouse HEK293 Cells
Pleiotrophin (PTN) is a secreted, strongly heparinbinding, developmentally regulated cytokine. PTN is a highly conserved protein，Human, mouse, rat, canine, porcine, equine and bovine PTN share 98% aa sequence identity or...
TMPY-04458 TRIB2 Protein, Human, Recombinant (His & GST) Human Baculovirus Insect Cells
Tribbles homolog 2, also known as TRB-2, and Trib2, is a member of the protein kinase superfamily and Tribbles subfamily (Trib1, Trib2, Trib3). The identification of tribbles as regulators of signal processing systems an...
TMPY-02495 P19 INK4d Protein, Human, Recombinant (GST) Human E. coli
Cyclin-dependent kinase inhibitor 2D(also known as CDKN2D or p19ink4d), a member of the INK4 family of cyclin-dependent kinase (CDK) inhibitors, negatively regulates the cyclin D-CDK4/6 complexes, which promote G1/S tran...
TMPH-02317 YTHDF1 Protein, Human, Recombinant (His) Human P. pastoris (Yeast)
Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, and regulates their stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stabi...
TMPH-02631 PRKN Protein, Mouse, Recombinant (GST) Mouse E. coli
Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Substrates include SYT11 and VDAC1. Other substrates are BCL2, CCNE1, GPR37, ...
TMPH-01263 PRKN Protein, Human, Recombinant (His & SUMO) Human E. coli
Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Substrates include SYT11 and VDAC1. Other substrates are BCL2, CCNE1, GPR37, ...
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