Search Result

Search Results for " ulcers "

Targets

Compounds

Natural Products

Recombinant Proteins

Libraries

Cat No.	Product Name	Synonyms	Targets
T4981	Anisotropine Methylbromide		Prostaglandin Receptor , AChR
	Anisotropine Methylbromide is an anticholinergic agent and has been used for relief of gastrointestinal spasm and for the suppression of gastric acid secretion.		Prostaglandin Receptor , AChR
T1575	Nizatidine	Axid,Acinon,Zanizal	AChE , Histamine Receptor
	Nizatidine (Acinon) is a competitive and reversible histamine H2-receptor antagonist with antacid activity.		AChE , Histamine Receptor
T14975	CJ-42794	CJ-042794	Others
	CJ-42794 (CJ-042794) is a selective antagonist of prostaglandin E receptor subtype 4 (EP4). It inhibits [3H]-PGE2 binding to the human EP4 receptor (a mean pKi: 8.5). CJ-42794 is a binding affinity that was at least 200-...		Others
T1756L	Ilaprazole	IY81149,IY 81149,IY-81149	Proton pump , TOPK
	Ilaprazole (IY-81149) is a proton pump inhibitor used in the treatment of dyspepsia gastroesophageal reflux disease (GORD/GERD) and duodenal ulcer. Studies also showed that Ilaprazole significantly prevented the developm...		Proton pump , TOPK
T1756	Ilaprazole sodium	IY-81149 sodium	Proton pump , TOPK
	Ilaprazole sodium (IY-81149 sodium) , a substituted benzimidazole prodrug, is a selective and irreversible proton pump inhibitor. A weak base, Ilaprazole accumulates in the acidic environment of the secretory canaliculus...		Proton pump , TOPK
T14546	Bermoprofen	AD-1590,AJ-1590	Others
	Bermoprofen (AD-1590) is an orally active non-steroidal anti-inflammatory compound with anti-inflammatory and analgesic activity used in the study of gastric ulcers.		Others
T33584	Namirotene	CBS 211A,Cbs 211 A	Others
	Namirotene (CBS 211A) is a protein biosynthesis inhibitor, a synthetic retinoic acid analog that is used in the study of corneal diseases, corneal ulcers and dry eye syndrome.		Others
T25737	Linetastine	TMK 688,TMK-688,TMK688	Lipoxygenase , LTR , Histamine Receptor
	Linetastine (TMK-688) is a 5-lipoxygenase inhibitor (5-LOX) that inhibits leukotriene production and antagonizes the effects of histamine.Linetastine is used in studies of asthma, atherosclerosis, and peptic ulcers.		Lipoxygenase , LTR , Histamine Receptor
T68100	Mifentidine	DA 4577	Histamine Receptor
	Mifentidine (DA 4577) is an orally available H2 receptor antagonist for the study of gastric emptying and experimental gastric and duodenal ulcers.		Histamine Receptor
T28136	NC-1300-B	NC1300B,NC 1300 B	ATPase
	NC-1300-B inhibits H(+)-K(+)-ATPase and is used in the study of gastric ulcers.		ATPase
T22267	Cetalkonium chloride	Benzylcetyldimethylammonium chloride hydrate	Antibacterial
	Cetalkonium chloride(Benzylcetyldimethylammonium chloride hydrate) is an ammonium preservative with anti-inflammatory activity that can be used in the study of aphthous ulcers.		Antibacterial
T68122	Oxmetidine	SKF 92994,Oxmetidina,Oxmetidinum	Histamine Receptor
	Oxmetidine (SKF 92994) is a novel H2 receptor antagonist that is cytotoxic. Oxmetidine inhibits transmembrane calcium flux in cardiac and vascular tissues and is used in the treatment of active duodenal ulcers.		Histamine Receptor
T1639	Amlexanox	CHX3673,Amoxanox,AA673	IL Receptor , FGFR , Others , IκB/IKK
	Amlexanox (AA673) is an anti-aphthous ulcer drug. Amlexanox inhibits the synthesis and release of inflammatory mediators, including leukotrienes and histamine, from mast cells, neutrophils, and mononuclear cells. Amlexan...		IL Receptor , FGFR , Others , IκB/IKK
T15687	Thioflosulide	L-745337	COX
	Thioflosulide (L-745337) is a selective and potent COX2 inhibitor (IC50: 2.3 nM) with anti-inflammatory activity for the study of gastric ulcers.		COX
T23667	AGN-201904	AGN201904,AGN 201904	ATPase
	AGN-201904 is a proton pump inhibitor, an omeprazole prodrug, which delays aging and may be used for the prevention and treatment of peptic ulcers.		ATPase
T7099	Gefarnate		Others
	Gefarnate is a synthetic compound used for the treatment of gastric ulcers,and also used in the treatment of dry eye syndrome.		Others
T33846	Oxyphenonium bromide	Spasmophen,Oxifenon,Oxyfenon,Atrenyl,Oxyphenon	Others
	Oxyphenonium bromide (Oxyfenon) shows anticholinergic activity and can be used for research on the treatment of gastric and duodenal ulcers and for the relief of visceral spasms.		Others
T8679	Epidermal Growth Factor		EGFR
	Epidermal Growth Factor binds to epidermal growth factor receptor (EGFR) and stimulates cell growth and proliferation. It is approved for the treatment of diabetic foot ulcers.		EGFR
T19826	Rabeprazole	LY307640	Potassium Channel , STAT
	Rabeprazole (LY307640) is an H+/K+-ATPase inhibitor that inhibits cell proliferation in gastric epithelial cells by targeting STAT3-mediated glycolysis and can be used in the study of gastric ulcers.		Potassium Channel , STAT
T13145	Thiazolidinone-Derivatives-1		Others
	Thiazolidinone-Derivatives-1 inhibits the secretion of gastric acid and can be used in research on the treatment of gastric and duodenal ulcers.		Others
T3610	Ranitidine	HSDB 3925,Ranitidin	P450 , Antibacterial , Histamine Receptor
	Ranitidine (HSDB 3925) is a non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors). It is used to treat gastrointestinal ulcers.		P450 , Antibacterial , Histamine Receptor
T3442	UK-371804	UK371804	PAI-1 , Serine Protease
	UK-371804 is an effective and specific uPA inhibitor. It was selected as a candidate for further preClinicalal evaluation for the treatment of chronic dermal ulcers.		PAI-1 , Serine Protease
T0246L	Betahistine mesylate	Extovyl,Melopat,Meginalisk	Histamine Receptor
	Betahistine mesylate (Extovyl) is a histamine analog and H1 receptor agonist that serves as a vasodilator. It is used in MENIERE DISEASE and in vascular headaches but may exacerbate bronchial asthma and peptic ulcers.		Histamine Receptor
T1338	Sucralfate	Sucrose octasulfate–aluminum complex	FGFR , Others , Antibacterial , Prostaglandin Receptor
	Sucralfate (Sucrose octasulfate–aluminum complex) is a cytoprotective agent, an oral gastrointestinal medication primarily indicated for the treatment of active duodenal ulcers.		FGFR , Others , Antibacterial , Prostaglandin Receptor
T0992	Carbenoxolone disodium	Biogastrone,Duogastrone,Bioral	Gap Junction Protein
	Carbenoxolone disodium (Duogastrone) salt is an agent derived from licorice root. It is used for the treatment of digestive tract ulcers, especially in the stomach. Antidiuretic side effects are frequent, but otherwise, ...		Gap Junction Protein
T5051	Isopropamide Iodide		AChR
	Isopropamide iodide is a long-acting anticholinergic drug. It is used in the treatment of peptic ulcers and other gastrointestinal disorders. It also acts as a muscarinic receptor antagonist which can be applied to the t...		AChR
T0674	Lansoprazole	A-65006,AG-1749	Proton pump , Phospholipase , Antibacterial
	Lansoprazole (A-65006) is a 2, 2, 2-trifluoroethoxypyridyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is fo...		Proton pump , Phospholipase , Antibacterial
T1052	Proglumide		cholecystokinin
	Proglumide (Binoside) is a cholecystokinin antagonist, which blocks both the CCKA and CCKB subtypes. Proglumide is a drug that exerts an inhibitory effect on gastric secretion and reduces gastrointestinal motility. It is...		cholecystokinin
T1651	Rabeprazole sodium	Dexrabeprazole Sodium,LY307640 sodium,Habeprazole Sodium,Rebeprazole sodium,Aciphex Sodium	Apoptosis , Proton pump
	Rabeprazole sodium (Habeprazole Sodium) is a 4-(3-methoxypropoxy)-3-methylpyridinyl derivative of timoprazole that is used in the therapy of stomach ulcers and Zollinger-Ellison syndrome. The drug inhibits H(+)-K(+)-exch...		Apoptosis , Proton pump
T4195	Betahistine	PT 9 base,Vasomotal,Serc base	Histamine Receptor
	Betahistine (Vasomotal) is a histamine analog and H1 receptor agonist that serves as a vasodilator. It is used in MENIERE DISEASE and in vascular headaches but may exacerbate bronchial asthma and peptic ulcers. Betahisti...		Histamine Receptor
T10221	Abeprazan hydrochloride	DWP14012 hydrochloride,Fexuprazan hydrochloride	Proton pump
	Abeprazan hydrochloride (Fexuprazan hydrochloride) is an effective reversible potassium-competitive acid blocker with oral activity, inhibiting H+, K+ -atPase by competitive binding to potassium ions without acid activat...		Proton pump
T77599	Methyl retinoate	Retinoic acid, methyl ester	Others
	Methyl retinoate (Retinoic acid, methyl ester) induces aseptic inflammation at the site of administration in in vivo experiments, which causes an increase in the number of leukocytes in the blood and a decrease in the le...		Others
T26090	Rioprostil	TR 4698,TR4698,Rioprostilum,TR-4698
	Rioprostil is a methyl prostaglandin E1 analog that decreases gastric acid secretion and enhances the gastric mucus-bicarbonate barrier. It is effective in the treatment of gastric ulcers and gives significant protection...
T20937	Dodecenylsuccinic anhydride	Rikacid DDSA,Dodecenylsuccinic acid anhydride,DDSA	Others
	Dodecenylsuccinic anhydride (DDSA) can be grafted with collagen hydrogels as a hydrophobic wound dressing to incorporate simvastatin, which has potential application in the treatment of ulcers and prevention of wound inf...		Others
T27640	Itriglumide	CR-2945,CR2945,CR 2945
	Itriglumide, a CCK2 receptor antagonist, is used potentially for the treatment of peptic ulcers, dyspepsia, and gastroesophageal reflux disease (GERD).
T16152	Betamethasone 17-benzoate		Kinesin
	Betamethasone 17-benzoate is a representative steroid. It also can be used in the treatment of recurrent aphothous ulcers (RAU).		Kinesin
T61228	Pirenzepine
	Pirenzepine (LS 519 free base) is a selective antagonist of the M1 muscarinic acetylcholine receptor (mAChR). It effectively inhibits gastric acid secretion and reduces muscle spasm, making it a valuable compound for inv...
T2138L	Oxyphencyclimine	Oxiphencycliminum,Antulcus,Zamanil,Manir,Caridan,Naridan
	Oxyphencyclimine is a muscarinic receptor antagonist (MRA) anticholinergic drug used to treat peptic ulcers.
T12914	Siltenzepine		Others
	Siltenzepine is an agent of anti-acid agent,and used in the treatment of peptic ulcers.		Others
T32224	Isopropamide	Priazimide,Dipramide,Piaccamide,Chloroisopropamide,Dipramid
	Isopropamide (R5) is a long-acting anticholinergic drug. It is used to treat peptic ulcers and other gastrointestinal disorders involving excess gastric acid (gastrointestinal acidosis) and hyperactivity.
T37470	Bismuth subcarbonate
	Bismuth subcarbonate, also known as bismuth carbonate oxide, is a versatile semiconductor compound based on bismuth, commonly utilized for its antibacterial properties, as well as in various applications such as sensors,...
T70135	Nepaprazole sodium dihydrate
	Nepaprazole sodium dihydrate is a proton pump inhibitor potentially for treatment of gastric ulcers.
T24254	KB-5492 anhydrous	KB-5492,KB5492,KB 5492
	KB 5492 is an agent of anti-ulcer. It preventing cysteamine-induced duodenal ulcers by stimulating duodenal HCO3- secretion.
T25805	Metoquizine	Ly-42406,Ly 42406,Ly42406,Lilly 42406
	Metoquizine is an anticholinergic compound. It is a muscarinic acetylcholine receptor antagonist that has been used to treat ulcers.
T61491	(R)-ND-336
	(R)-ND-336 is a highly potent and selective MMP-9 inhibitor, displaying a K i value of 19 nM. It also exhibits inhibitory activity against MMP-2 (K i = 127 nM) and MMP-14 (K i =119 nM). With its significant potential, (R...
T69805	AU-006
	AU-006 is an anti-ulcer drug which is effective in the treatment of gastric ulcers by inhibiting gastric acid secretion.
T12047	Misoprostol acid		Others
	Misoprostol acid is an active metabolite of Misoprostol,can be used for non-steroidal anti-inflammatory drug-induced (NSAID) gastric ulcers.		Others
T79656	Urease-IN-8
	Urease-IN-8 (Compound 5e) functions as a competitive inhibitor of urease, with an IC50 value of 3.51 μM and a Ki of 3.11 μM. It is applicable for research pertaining to peptic and gastric ulcers [1].
T13488	2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide	2-_E-2-decenoylamino_ethyl_2-_cyclohexylethyl__sulfide	Prostaglandin Receptor
	2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide is a compound known to inhibit stress-induced ulcers, effectively maintaining the levels of phospholipase A2 and prostaglandin E2 in rats subjected to water immersio...		Prostaglandin Receptor
T68206	Arbortristoside A
	Arbortristoside A is an anti-inflammatory and antinociceptive. This activity may be due to the inhibiting effect of prostaglandin, histamine and serotonin. Arbortristoside A has also been shown to act on ulcerations and ...

Compounds

Anisotropine Methylbromide

T4981

Synonym:

Target: Prostaglandin Receptor, AChR

Nizatidine

T1575

Synonym: Axid,Acinon,Zanizal

Target: AChE, Histamine Receptor

Synonym: IY81149,IY 81149,IY-81149

Target: Proton pump, TOPK

Ilaprazole sodium

T1756

Synonym: IY-81149 sodium

Target: Proton pump, TOPK

Bermoprofen

T14546

Synonym: AD-1590,AJ-1590

Target: Others

Namirotene

T33584

Synonym: CBS 211A,Cbs 211 A

Target: Others

Linetastine

T25737

Synonym: TMK 688,TMK-688,TMK688

Target: Lipoxygenase, LTR, Histamine Receptor

Mifentidine

T68100

Synonym: DA 4577

Target: Histamine Receptor

NC-1300-B

T28136

Synonym: NC1300B,NC 1300 B

Target: ATPase

Cetalkonium chloride

T22267

Synonym: Benzylcetyldimethylammonium chloride hydrate

Target: Antibacterial

Oxmetidine

T68122

Synonym: SKF 92994,Oxmetidina,Oxmetidinum

Target: Histamine Receptor

Amlexanox

T1639

Synonym: CHX3673,Amoxanox,AA673

Target: IL Receptor, FGFR, Others, IκB/IKK

Synonym: AGN201904,AGN 201904

Synonym: Spasmophen,Oxifenon,Oxyfenon,Atrenyl,Oxyphenon

Target: Others

Epidermal Growth Factor

Target: Potassium Channel, STAT

Thiazolidinone-Derivatives-1

Synonym: HSDB 3925,Ranitidin

Target: P450, Antibacterial, Histamine Receptor

UK-371804

T3442

Synonym: UK371804

Target: PAI-1, Serine Protease

Betahistine mesylate

T0246L

Synonym: Extovyl,Melopat,Meginalisk

Target: Histamine Receptor

Sucralfate

T1338

Synonym: Sucrose octasulfate–aluminum complex

Target: FGFR, Others, Antibacterial, Prostaglandin Receptor

Carbenoxolone disodium

T0992

Synonym: Biogastrone,Duogastrone,Bioral

Target: Gap Junction Protein

Synonym: A-65006,AG-1749

Target: Proton pump, Phospholipase, Antibacterial

Proglumide

T1052

Synonym:

Target: cholecystokinin

Rabeprazole sodium

T1651

Synonym: Dexrabeprazole Sodium,LY307640 sodium,Habeprazole Sodium,Rebeprazole sodium,Aciphex Sodium

Target: Apoptosis, Proton pump

Betahistine

T4195

Synonym: PT 9 base,Vasomotal,Serc base

Target: Histamine Receptor

Abeprazan hydrochloride

T10221

Synonym: DWP14012 hydrochloride,Fexuprazan hydrochloride

Target: Proton pump

Methyl retinoate

T77599

Synonym: Retinoic acid, methyl ester

Target: Others

Rioprostil

T26090

Synonym: TR 4698,TR4698,Rioprostilum,TR-4698

Target:

Dodecenylsuccinic anhydride

T20937

Synonym: Rikacid DDSA,Dodecenylsuccinic acid anhydride,DDSA

Target: Others

Itriglumide

T27640

Synonym: CR-2945,CR2945,CR 2945

Target:

Betamethasone 17-benzoate

Synonym: Oxiphencycliminum,Antulcus,Zamanil,Manir,Caridan,Naridan

Synonym: Priazimide,Dipramide,Piaccamide,Chloroisopropamide,Dipramid

Nepaprazole sodium dihydrate

Synonym: KB-5492,KB5492,KB 5492

Target:

Metoquizine

T25805

Synonym: Ly-42406,Ly 42406,Ly42406,Lilly 42406

2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide

T13488

Synonym: 2-_E-2-decenoylamino_ethyl_2-_cyclohexylethyl__sulfide

Target: Prostaglandin Receptor

Cat No.	Product Name	Synonyms	Targets
T0070	Pentoxifylline	Oxpentifylline,PTX,BL-191	HIV Protease , PDE , Adenosine Receptor , Autophagy
	Pentoxifylline (PTX) modulates immunologic activity by stimulating cytokine production. Pentoxifylline is a methylxanthine derivative that inhibits phosphodiesterase and affects blood rheology. It also inhibits platelet ...		HIV Protease , PDE , Adenosine Receptor , Autophagy
T7908	DL-Methionine Methylsulfonium Chloride		Others
	DL-Methionine Methylsulfonium Chloride is a natural product, used in the treatment of peptic ulcers, colitis, and gastritis.		Others
TN2078	Pinocembrin chalcone	2',4',6'-Trihydroxychalcone,Pinocembrinchalcone	Calcium Channel , Tyrosinase , Antibacterial , Antifection
	Pinocembrin chalcone is an inhibitor of tyrosinase with antimutagenic effects. Pinocembrin chalcone can be used in studies about the prevention of gastric ulcers.		Calcium Channel , Tyrosinase , Antibacterial , Antifection
TN4465	Luvangetin		COX , Prostaglandin Receptor , Antifection
	Luvangetin may have anti-inflammatory activity, it can inhibit NO and PGE2 production in LPS-stimulated BV2 cells. Luvangetin shows significant protection against pylorus-ligated and aspirin-induced gastric ulcers in rat...		COX , Prostaglandin Receptor , Antifection
T83258	7(18)-Dehydroschisandro A
	7(18)-Dehydroschisandro A (Compound 2), a lignan isolated from Schizandra chinensis Baill, exhibits inhibitory effects on stress-induced gastric ulcers [1].
T83257	7(8)-Dehydroschisandrol A
	7(8)-Dehydroschisandrol A (Compound 4a), a lignan extracted from Schizandra chinensis Baill, exhibits a mild inhibitory activity against stress-induced gastric ulcers [1].
TN4659	Nimbin		COX
	Nimbin is an anti-pyretic, can be used to treat arthritis, hypoglycaemia, peptic ulcers, anti-secretory activity, and it can also be used as an antibiotic. Nimbin requires to elicit a 50% inhibition of this steroid hydro...		COX
T75507	1-Methyl-2-(8E)-8-tridecenyl-4(1H)-quinolinone
	1-Methyl-2-(8E)-8-tridecenyl-4(1H)-quinolinone exhibits strong antibacterial properties, demonstrating an MIC 50 of 22 µM and an MIC 90 of 50 µM against Helicobacter pylori Strain 51. This compound shows promise for rese...

Natural Products

Pentoxifylline

T0070

Synonym: Oxpentifylline,PTX,BL-191

Target: HIV Protease, PDE, Adenosine Receptor, Autophagy

DL-Methionine Methylsulfonium Chloride

Synonym: 2',4',6'-Trihydroxychalcone,Pinocembrinchalcone

Target: Calcium Channel, Tyrosinase, Antibacterial, Antifection

Luvangetin

TN4465

Synonym:

Target: COX, Prostaglandin Receptor, Antifection

7(18)-Dehydroschisandro A

T83258

Synonym:

Target:

7(8)-Dehydroschisandrol A

1-Methyl-2-(8E)-8-tridecenyl-4(1H)-quinolinone

T75507

Synonym:

Target:

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPY-02689	MMP-3 Protein, Human, Recombinant	Human	E. coli
	Matrix metallopeptidase 3 (abbreviated as MMP3) is also known as stromelysin 1 and progelatinase. MMP3 is a member of the matrix metalloproteinase (MMP) family whose members are involved in the breakdown of extracellular...
TMPY-00886	MMP-1 Protein, Human, Recombinant (His)	Human	HEK293
	MMP1, also known as MMP-1, contains 4 hemopexin-like domains and is a member of the matrix metalloproteinase (MMP) family. Matrix metalloproteases, also called matrixins, are zinc-dependent endopeptidases that are the ma...

MMP-3 Protein, Human, Recombinant

TMPY-02689

Species: Human

Expression System: E. coli

MMP-1 Protein, Human, Recombinant (His)

TMPY-00886

Species: Human

Expression System: HEK293

Cat No.	Product Name
L4800	Angiogenesis related Compound Library	1370 compounds
	A unique collection of 1370 proangiogenic and antiangiogenic compounds for new targets identification, research in mechanisms of angiogenesis, and high throughput screening (HTS) and high content screening (HCS);
L4700	Immunology/Inflammation Compound Library	3483 compounds
	A unique collection of 3483 anti-inflammation compounds effective for high throughput screening and high content screening.

Libraries

Angiogenesis related Compound Library

L4800

Compounds: 1370

Immunology/Inflammation Compound Library

L4700

Compounds: 3483