tetrahydroisoquinoline

MitoBloCK-6 is an effective inhibitor of Erv1 ALR with IC50 values of 900 nM and 700 nM, respectively. Additionally, MitoBloCK-6 inhibits Erv2 (IC50=1.4 μM). It induces apoptosis in hESCs by promoting the release of cytochrome c.

1,2,3,4-Tetrahydroisoquinoline-3-Methanol, with CAS No. 63006-93-9, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 1,2,3,4-Tetrahydroisoquinoline-3-Methanol provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

6-Fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride, with CAS No. 799274-08-1, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 6-Fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

(S)-N-tert-Butyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide, with CAS No. 149182-72-9, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. (S)-N-tert-Butyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

5,6,7,8-Tetrahydroisoquinoline is a nitrogen-containing heterocyclic compound that can be used in biochemical experiments and drug synthesis research.

1-Methyl-1,2,3,4-tetrahydroisoquinoline is an inhibitor of phenylethanolamine N-methyltransferase and can be used in biochemical experiments and drug synthesis.

1-benzyl-1,2,3,4-tetrahydroisoquinoline, sulfuric acid, with CAS No. 1423034-30-3, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 1-benzyl-1,2,3,4-tetrahydroisoquinoline, sulfuric acid provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

2-(tert-Butoxycarbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid is a useful organic compound for research related to life sciences. The catalog number is T66594 and the CAS number is 851784-82-2.

(S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline is a useful organic compound for research related to life sciences. The catalog number is T66649 and the CAS number is 118864-75-8.

6,7-Dimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T67325 and the CAS number is 2048273-58-9.

Solifenacin succinate (YM905) is a quinuclidine and tetrahydroisoquinoline derivative and selective M3 MUSCARINIC ANTAGONIST. It is used as a UROLOGIC AGENT in the treatment of URINARY INCONTINENCE.

Antidepressant agent 5 is a 7-substituted tetrahydroisoquinoline derivative with antidepressant activity.Antidepressant agent 5 acts similarly to magnoflorine in the study of depression and can be used for the prevention and treatment of depressive disorders.

Ecteinascidin 770 inhibits SARS-CoV-2 and Mycobacterium tuberculosis by inhibiting cancer cell viability through RDRP1 (RNA-dependent RNA polymerase 1).

Ecteinascidins are a family of tetrahydroisoquinoline alkaloids known for their antitumor and antimicrobial activities. [Ecteinascidin-Analog-1] is a valuable intermediate for the synthesis of Ecteinascidin analogues.

Gastrofensin AN 5 free base, a 4-phenyl-tetrahydroisoquinoline derivative, is an antiulcer agent.

Trabectedin (Ecteinascidin 743) has potent antitumor activity and the potential for soft tissue sarcoma and ovarian cancer research. Trabectedin inhibits cell growth of MX-1, MCF7 and MCF7 DXR cells with IC50 values of 0.1 nM, 1.5 nM and 3.7 nM, respectively.

Trethinium is a tetrahydroisoquinoline derivative that possesses antihypertensive properties.

Estrogen receptor modulator11 (Compound 27) is a tetrahydroisoquinoline derivative. It exhibits affinity for the estrogen receptor (ER), with IC50 values of 285 nM for ERα and 421 nM for ERβ. Estrogen receptor modulator11 does not demonstrate antagonist activity in MCF-7 cell assays.

GS 389 is a novel tetrahydroisoquinoline analog with vasorelaxant properties. GS-389 significantly inhibited cGMP phosphodiesterase from the rabbit brain and increased cGMP levels in the rat aorta.

KRAS inhibitor-10 (WO2021005165 A1, compound 11) is a potent and selective inhibitor of RAS proteins, with a specific focus on KRAS proteins. This orally active anti-cancer agent demonstrates strong efficacy in cancer research, specifically in pancreatic cancer, breast cancer, multiple myeloma, leukemia, and lung cancer. KRAS inhibitor-10 is classified as a tetrahydroisoquinoline compound. Its inhibitory properties provide valuable insights and potential therapeutic applications in the field of oncology [1].

Odatroltide is a nanoscale P-selectin inhibitor that serves as a nano-delivery system for 6,7-dihydroxyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid and KPAK to specifically target the thrombus.

Debrisoquin hydriodide (1,2,3,4-tetrahydroisoquinoline-2-carboximidamide hydroiodide) has antioxidant, anti-inflammatory and neuroprotective properties. It has also been found to modulate the activity of certain neurotransmitters, including dopamine and serotonin, making it a promising candidate for the treatment of neurological disorders such as Parkinson's disease and depression.

Sonidegib metabolite M25 is a smoothened (SMO) antagonist.

Nrf2 Activator-6, a tetrahydroisoquinoline compound, functions as an Nrf2 activator, demonstrating potency with an IC50 value of 5 nM in inhibiting the Kelch domain-Nrf2 interaction.