scap

SREBP SCAP-IN-2 (compound 13) acts as a selective inhibitor of SREBP SCAP [1].

SREBP SCAP-IN-1 (compound 10b) serves as a selective inhibitor of SREBP SCAP [1].

Breviscapin (Scutellarin) is the total flavonoid components (the content of scutellarin > or =85%) extracted from the dried whole plant of Erigeron breviscapus.

Euscaphin B is a useful organic compound for research related to life sciences and the catalog number is T123857.

Euscapholide is a useful organic compound for research related to life sciences and the catalog number is T125313.

Fascaplysin is a cyclin D kinase 4 cyclin D1 inhibitor (IC50 = 0.35 μM). Fascaplysin induces caspase mediated crosstalk between autophagy and apoptosis through the inhibition of PI3K AKT mTOR signaling cascade in human leukemia HL-60 cells.

Euscaphic acid has anti-diabetic, and anti-inflammatory activities, it inhibits LPS-induced inflammatory responses by interference with the clustering of TRAF6 with IRAK1 and TAK1, resulting in blocking the activation of IKK and MAPKs signal transduction

1beta-Hydroxyeuscaphic acid demonstrates notable hepatoprotective activity, effectively minimizing the leakage of intracellular enzymes, attenuating protein oxidation, and reducing apoptosis rates.

2,3-O-Isopropylidenyl euscaphic acid exhibits a potent hepatoprotective effect, with an EC50 value of 88.36±3.25 μM in Hep G2 cells.

Lycorine (Narcissine) inhibits protein synthesis and may inhibit ascorbic acid biosynthesis, although studies on the latter are controversial and inconclusive.

Fatostatin hydrobromide (Fatostatin A HBr) ia an inhibitor of sterol regulatory element binding protein (SREBP). It impairs the activation of SREBP-1 and SREBP-2.

Fatostatin is a specific inhibitor of SREBP activation, it impairs the activation of SREBP-1 and SREBP-2. Fatostatin binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs.