sam

AG-270 is an allosteric and orally active inhibitor of MAT2A.

FIDAS-3, a stilbene derivative and potent Wnt inhibitor with an IC50 of 4.9 μM for methionine S-adenosyltransferase 2A (MAT2A), exhibits anticancer activities by effectively competing with S-adenosylmethionine (SAM) for MAT2A binding.

FIDAS-5 is an orally active methionine adenosyltransferase 2A (MAT2A) inhibitor with an IC50 of 2.1 μM. It can effectively compete with S-adenosylmethionine for MAT2A binding and has anticancer effects.

4-Methyl-2-oxopentanoic acid is an abnormal metabolite, a neurotoxin and a metabolic toxin.

SAM-315 (WAY-255315) is a potent antagonist of 5-Hydroxytryptamine-6 (5-HT6), with Ki and IC50 values of 1.1 nM and 4.6 nM, respectively. SAM-315 notably enhances the release of acetylcholine and glutamate in the hippocampus of the brain.

Dp3-Sam chloride (Delphinidin-3-sambubioside chloride) is an anthocyanin from Hibiscus acetosella (Cranberry Hibiscus) with anti-inflammatory, antioxidant, and anticancer activities.Dp3-Sam chloride inhibits LPS-induced inflammation, and inhibits LPS-induced inflammation. Dp3-Sam chloride inhibits LPS-induced inflammatory factor release, down-regulates the NF-κB pathway, and inhibits MEK1/2-ERK1/2 signaling.Dp3-Sam chloride induces apoptosis in human leukemia cells through the mitochondrial pathway mediated by reactive oxygen species.

Niclosamide (Niclocide)(BAY2353) is used to treat most tapeworm infections by inhibiting DNA replication.

Adhesamine, a dumbbell-shaped molecule, plays a crucial role in activating the MAPK/FAK pathway, thus promoting mammalian cell adhesion and growth. Additionally, it accelerates the differentiation and enhances the survival of mice hippocampal neurons in primary culture.

Sesamodil (SD 3211) is a novel calcium antagonist that can be used to study hypertension.

Iso-Samidorphan is a biochemical reagent that can be used in biological experiments.

Samidorphan HCl is an orally active and highly potent modulator of the opioid system that binds to μ‐opioid, κ‐opioid, and delta-opioid receptors. Samidorphan HCl is a novel μ-opioid receptor antagonist, a partial agonist for k-opioid and delta-opioid receptors. Samidorphan HCl can be used to prevent and treat schizophrenia.

(Iso)-Samixogrel shows activity against Carbonic anhydrase and Cyclooxygenase 2.

Amakusamine is an indole alkaloid from the sponge of Psammocinia sp. It inhibits RANKL-induced isolation of multinucleated osteoclasts and inhibits RANKL-induced multinucleated osteoclasts.

Zonisamide (AD 810), a sulfonamide anticonvulsant, is approved for use as an adjunctive treatment in adults with partial-onset seizures. It may inhibit a carbonic anhydrase although this is not one of the main mechanisms of action. Zonisamide may act by blocking repetitive firing of voltage-gated sodium channels results in a reduction of T-type calcium channel currents, or by binding allosterically to GABA receptors. This latter action may lower the uptake of the inhibitory neurotransmitter GABA while increasing the uptake of the excitatory neurotransmitter glutamate.

Glucosamine (Chitosamine) is a natural product. Glucosamine is used as a dietary supplement. Glucosamine has pharmacological effects on cartilage and chondrocytes in osteoarthritis when used externally. Glucosamine regulates sugar metabolism. Glucosamine reduces the activity of glucoskinase in pancreatic islet homogenate.

Niclosamide olamine (Niclosamide Ethanolamine salt) is an Repellent, Insect Attractant and Chemosterilant.

N-Acetyl-D-mannosamine (ManNAc) is a potential drug for treating hereditary inclusion body myopathy.

Glucosamine sulfate (D-Glucosaminesulfate) was extracted from synthetic product;Store the product in sealed, cool and dry condition.

Desaminotyrosine (3-(4-Hydroxyphenyl)propionic acid) is a microbially associated metabolite. Desaminotyrosine protects from influenza through augmentation of type I interferon signaling.

Sesamin is a selective delta 5 desaturase inhibitor in the biosynthesis of polyunsaturated fatty acids and is a lignan abundantly present in sesame oil. It has potent neuroprotective effects against cerebral ischemia.

Glucosamine hydrochloride (Chitosamine hydrochloride) is commonly used as a treatment for osteoarthritis, although its acceptance as a medical therapy varies.

N-butyl-N-(4-hydroxybutyl) nitrosamine (N-Nitrosobutylbutanolamine) (BBN, OH-BBN) is a model compound that can induce high-level invasive tumors in the bladder.

D(+)-Galactosamine hydrochloride is a well-established experimental toxin that induces liver injury primarily by generating free radicals and depleting UTP nucleotides, and it can be used to establish lipopolysaccharide/D-Galactosamine-induced hepatitis or acute liver injury models.

N-Acetyl-D-Glucosamine (NAG) is a monosaccharide derivative of glucose. It is released by the action of O-GlcNAcase, in mammalian systems from proteins that have been post-translationally modified with O-GlcNAc.