s. faecalis

Dermaseptin acetate, a peptide isolated from frog skin, exhibits potent antimicrobial activity against bacteria, fungi, and protozoa at micromolar concentration[1].

Siamycin I is a tricyclic peptide originally isolated from Streptomyces and has antiviral and antibacterial activities. It is active against laboratory strains and clinical isolates of HIV-1 (ED50s = 0.05-0.45 and 0.89-5.7 μM, respectively), as well as the CBL-20 strain of HIV-2 (ED50 = 0.45 μM), in vitro. Siamycin I inhibits HIV-induced fusion of C8166 T cells with HIV-1-infected CEM-SS cells with an ED50 value of 0.08 μM. It is also active against B. subtilis, M. luteus, and S. aureus (MICs = 1.6-6.3 μg/ml). Siamycin I inhibits autophosphorylation of the E. faecalis quorum sensing kinase FsrC induced by gelatinase biosynthesis-activating pheromone (GBAP).

Distinctin, an antimicrobial peptide derived from frog skin, exhibits antibacterial activity against a range of pathogens including E. faecalis, P. aeruginosa, S. aureus, and E. coli, with minimum inhibitory concentration (MIC) values of 14.5, 28.0, 28.0, and 14.5 μM, respectively [1].

GP-2B, an antimicrobial peptide, exhibits antibacterial activity against Gram-positive strains, with a minimum inhibitory concentration (MIC) ranging from 8 to 128 μg/mL for S. aureus and Enterococcus faecalis [1].

Tilapia piscidin 3, an antimicrobial peptide, exhibits antibacterial properties effective against both gram-positive and gram-negative bacteria. It has demonstrated minimum inhibitory concentrations (MICs) of 2.44 µg/mL for V. vulnificus 204 and V. alginolyticus, 9.78 µg/mL for S. agalactiae 819, 19.55 µg/mL for E. faecalis BCRC 10066, and 0.61 µg/mL for S. agalactiae BCRC 10787. Additionally, it presents hemolytic activity on fish red blood cells [1].