Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty
Filter
Applied FilterClear all
TargetMol | Tags By Target
  • DNA/RNA Synthesis
    (3)
  • CDK
    (1)
  • E1/E2/E3 Enzyme
    (1)
  • IAP
    (1)
  • Mdm2
    (1)
  • PROTACs
    (1)
  • TLR
    (1)
  • c-Myc
    (1)
  • Others
    (18)
Filter
Search Result
Results for "

protein-rna interaction

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    15
    TargetMol | Inhibitors_Agonists
  • Compound Libraries
    1
    TargetMol | Compound_Libraries
  • Peptide Products
    2
    TargetMol | Peptide_Products
  • PROTAC Products
    1
    TargetMol | PROTAC
  • Recombinant Protein
    16
    TargetMol | Recombinant_Protein
Quarfloxin
CX-3543
T16703865311-47-3
Quarfloxin (CX-3543) is a fluoroquinolone derivative with antineoplastic activity with IC50 values in the nanomolar range in neuroblastoma cells. Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA template.
  • $122
In Stock
Size
QTY
Anticancer agent 73
T60420124811-87-6
Anticancer agent 73 is an anticancer agent which potently targets transactivation response(TAR) RNA-binding protein 2 (TRBP) and disrupts the TRBP-Dicer interaction. Anticancer agent 73 suppresses the growth and metastasis of HCC in vitro and in vivo by modulating expression profiles of miRNAome and proteome in HCC cells.
  • $30
In Stock
Size
QTY
TargetMol | Inhibitor Sale
PT-129
T205713
PT-129 is a RPOTAC degrader that targets the G3BP1 2NTF2 domain (protein-RNA interaction site), facilitating the breakdown of intracellular stress granules. It prevents the formation of stress granules in stressed cells and deconstructs existing ones, thereby disrupting ATF4 transmission and inhibiting cancer cell proliferation. Stress granules (SGs) are membraneless cytoplasmic compartments formed under stress, which aid in the transfer of ATF4 from fibroblasts to tumor cells, promoting fibroblast-related tumor growth. G3BP1 2 serve as central proteins in the SG network, and inhibiting them may reduce the stress resilience of cancer cells within the tumor microenvironment. PT-129 consists of a target protein ligand (red part) G3BP1 2-Targeting ligand-1, an E3 ligase ligand (blue part) Thalidomide 4-fluoride, and a PROTAC linker (black part) Amino-PEG3-C2-acid; the E3 ligase ligand and linker form the complex Thalidomide-NH-PEG3-propionic acid.
  • Inquiry Price
Size
QTY
TLR3-IN-1
CU CPT 4a
T226981279713-77-7
TLR3-IN-1 (CU CPT 4a) is a selective TLR3 inhibitor (IC50: 3.44 μM in RAW 264.7 cells). It can inhibit TLR3 dsRNA complex-mediated downstream signaling pathways and inhibit the production of TNF-α and IL-1β in whole cells.
  • $48
In Stock
Size
QTY
TargetMol | Inhibitor Sale
MX69
T36531005264-47-0
MX69 is the MDM2 XIAP inhibitor, blocking the MDM2 protein-XIAP RNA interaction, leading to MDM2 degradation.
  • $31
In Stock
Size
QTY
CR-1-31-B
T387531352914-52-3
CR-1-31-B, a synthetic rocaglate, acts as a highly potent inhibitor of eIF4A. By disrupting the interaction between eIF4A and RNA, it effectively obstructs the initiation phase of protein synthesis. Specifically, CR-1-31-B interferes with the association between Plasmodium falciparum eIF4A (PfeIF4A) and RNA. Additionally, CR-1-31-B induces apoptosis in neuroblastoma and gallbladder cancer cells [4].
  • $698
8-10 weeks
Size
QTY
cdk-in-9
T62235
CDK-IN-9 (compound 24) is a potent inhibitor of CDK and acts on CDK2 E (IC50: 4 nM). It functions as a molecular gel that induces interaction between CDK12 and DDB1, and can dephosphorylate retinoblastoma protein and RNA polymerase II, thereby inducing apoptosis.
  • $1,520
10-14 weeks
Size
QTY
Azaphilone-9
AZA-9
T729201448460-87-4
Azaphilone-9 (AZA-9) functions as an inhibitor of the HuR-ARE RNA interaction, with an inhibition constant (IC50) of 1.2 μM, by targeting the RNA-binding protein Hu antigen R (HuR). As HuR-RNA interactions play a critical role in stabilizing oncogenic mRNAs within tumors, Azaphilone-9 exhibits potential in inhibiting cancer cell growth and progression.
  • $2,870
10-14 weeks
Size
QTY
PINT-87aa
T76193
PINT-87aa, an 87-amino acid (aa) peptide encoded by the circular form of the long intergenic non-protein-coding RNA p53-induced transcript (LINC-PINT), directly interacts with the polymerase associated factor complex (PAF1c) to inhibit the transcriptional elongation of multiple oncogenes, effectively suppressing glioblastoma cell proliferation both in vitro and in vivo [1].
  • Inquiry Price
Size
QTY
MYC-RIBOTAC
T78055
MYC-RIBOTAC, a ribonuclease-targeting chimera (RIBOTAC) specific to the MYC internal ribosome entry site (IRES), comprises an MYC mRNA-binding element tethered to a small molecule that recruits and activates RNase L1. This interaction promotes the degradation of MYC mRNA, subsequently reducing MYC protein levels and inducing apoptosis, thereby presenting potential applications in anticancer research [1].
  • Inquiry Price
Size
QTY
TMV-IN-6
T79270
TMV-IN-6 (Compound 4g) is a novel antiviral and fungicidal agent that obstructs tobacco mosaic virus (TMV) assembly by binding to the TMV coat protein (CP) and disrupting the interaction between TMV CP and RNA [1].
  • Inquiry Price
Size
QTY
LIN28-IN-1
T81932
LIN28-IN-1 (compound 5) is a selective inhibitor targeting the RNA-binding protein LIN28, binding specifically to its cold shock domain (CSD). This compound interrupts the LIN28-let-7 miRNA interaction with an IC50 of 5.4 μM, mitigating LIN28's adverse effects on epigenetic gene control. LIN28-IN-1 also exhibits significant anti-proliferative activity against LIN28-expressing JAR cancer cells, with an IC50 value of 6.4 μM [1].
  • Inquiry Price
Size
QTY
CDK9-Cyclin T1 PPI-IN-1
T82758
CDK9-Cyclin T1 PPI-IN-1 (Compound B19) is a selective inhibitor of the CDK9-Cyclin T1 protein-protein interaction (PPI), suppressing cell proliferation in TNBC MDA-MB-231 cells with an IC50 of 0.044 μM and inducing apoptosis. This compound diminishes CDK9 transcriptional activity and downregulates phosphorylation of RNA Pol II CTD ser2. In vivo, CDK9-Cyclin T1 PPI-IN-1 effectively impedes tumor growth in a TNBC 4T1 mouse model [1].
  • Inquiry Price
Size
QTY
Tat-CIRP TFA
Tat-Cold-inducible RNA Binding Protein
T83729
Tat-CIRP, a peptide inhibitor, impedes the protein-protein interaction between myeloid differentiation 2 (MD-2), also known as lymphocyte antigen 96 (LY96), and cold-inducible RNA binding protein (CIRP) by binding to MD-2. This disrupts the MD-2 and CIRP interaction as confirmed in co-immunoprecipitation assays. Notably, in vivo studies reveal that Tat-CIRP, at dosages of 10 and 20 mg/kg, significantly reduces infarct volume in both a mouse model of middle cerebral artery occlusion (MCAO) and a rhesus monkey model of thrombosis-induced stroke. Additionally, it improves motor function, evidenced by decreased time to manipulate and withdraw food with the affected arm in the primate model.
  • TBD
Backorder
Size
QTY
Fli-1-IN-1
T864333027140-81-1
Fli-1-IN-1 (compound 21) serves as a FLI1 inhibitor by binding directly to the EWS-FLI1 protein, disrupting its interaction with RNA helicase A. This inhibition holds potential anticancer properties [1].
  • $1,820
10-14 weeks
Size
QTY