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Search Results for " necroptotic "

Targets

3

Compounds

4

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T11520 GW806742X MLK , VEGFR
GW806742X is an inhibitor of Mixed Lineage Kinase Domain-Like protein (MLKL) which binds the MLKL pseudokinase domain (Kd: 9.3 μM) with anti-necroptosis activity. GW806742X has activity against VEGFR2.
T73382 SZM-1209 RIP kinase
SZM-1209 is a potent and specific RIPK1 inhibitor with oral activity, displaying a dissociation constant (Kd) of 85 nM. It demonstrates substantial anti-necroptotic efficacy with an EC50 of 22.4 ± 8.1 nM and possesses th...
T60316 AV123
AV123 (compound 12) is a non-cytotoxic RIPK1 inhibitor with IC 50 of 12.12 μM. AV123 blocks the TNF-α-induced necroptotic with EC 50 of 1.7 μM, but not the apoptotic cell death. AV123 can be used in the study of necrotic...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPK-00749 PGLYRP1 Protein, Mouse, Recombinant (hFc) Mouse HEK293
Innate immunity protein Tag7 (PGRP-S, PGLYRP1) can interact with the TNFα receptor, TNFR1, and block the transduction of apoptotic signals through this receptor. A complex formed between the Tag7 protein and the major he...
TMPK-00745 PGLYRP1 Protein, Human, Recombinant (hFc) Human HEK293
Innate immunity protein Tag7 (PGRP-S, PGLYRP1) can interact with the TNFα receptor, TNFR1, and block the transduction of apoptotic signals through this receptor. A complex formed between the Tag7 protein and the major he...
TMPH-01694 MLKL Protein, Human, Recombinant (E. coli, His) Human E. coli
Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Does not have protein kinase activity. Activated following phosphorylation by RIPK3, leading to homotrimerization, localizat...
TMPH-01695 MLKL Protein, Human, Recombinant (His) Human Yeast
Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Does not have protein kinase activity. Activated following phosphorylation by RIPK3, leading to homotrimerization, localizat...
TargetMol