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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T11520 | GW806742X | MLK , VEGFR | |
GW806742X is an inhibitor of Mixed Lineage Kinase Domain-Like protein (MLKL) which binds the MLKL pseudokinase domain (Kd: 9.3 μM) with anti-necroptosis activity. GW806742X has activity against VEGFR2. | |||
T73382 | SZM-1209 | RIP kinase | |
SZM-1209 is a potent and specific RIPK1 inhibitor with oral activity, displaying a dissociation constant (Kd) of 85 nM. It demonstrates substantial anti-necroptotic efficacy with an EC50 of 22.4 ± 8.1 nM and possesses th... | |||
T60316 | AV123 | ||
AV123 (compound 12) is a non-cytotoxic RIPK1 inhibitor with IC 50 of 12.12 μM. AV123 blocks the TNF-α-induced necroptotic with EC 50 of 1.7 μM, but not the apoptotic cell death. AV123 can be used in the study of necrotic... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPK-00749 | PGLYRP1 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
Innate immunity protein Tag7 (PGRP-S, PGLYRP1) can interact with the TNFα receptor, TNFR1, and block the transduction of apoptotic signals through this receptor. A complex formed between the Tag7 protein and the major he... | |||
TMPK-00745 | PGLYRP1 Protein, Human, Recombinant (hFc) | Human | HEK293 |
Innate immunity protein Tag7 (PGRP-S, PGLYRP1) can interact with the TNFα receptor, TNFR1, and block the transduction of apoptotic signals through this receptor. A complex formed between the Tag7 protein and the major he... | |||
TMPH-01694 | MLKL Protein, Human, Recombinant (E. coli, His) | Human | E. coli |
Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Does not have protein kinase activity. Activated following phosphorylation by RIPK3, leading to homotrimerization, localizat... | |||
TMPH-01695 | MLKL Protein, Human, Recombinant (His) | Human | Yeast |
Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Does not have protein kinase activity. Activated following phosphorylation by RIPK3, leading to homotrimerization, localizat... |