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Search Results for " myocardial "

Targets

139

Compounds

26

Natural Products

44

Recombinant Proteins

2

Libraries

Cat No. Product Name Synonyms Targets
T13865 Resorcinolnaphthalein RAAS
Resorcinolnaphthalein is a specific enhancer of angiotensin-converting enzyme 2 (ACE2) (EC50 value of 19.5 μM).
T2320 Indacaterol Adrenergic Receptor
Indacaterol (Onbrez; Arcapta) is a β2-Adrenergic Agonist. The mechanism of action of indacaterol is as an Adrenergic beta2-Agonist.
TP1563 Gap19 Gap Junction Protein
Gap19 is a peptide that corresponds to a sequence on the cytoplasmic loop (CL) of Cx43.
T15108 DG-041 Prostaglandin Receptor
DG-041 is an antagonist of high-affinity EP3 receptor (IC50s: 4.6 nM and 8.1 nM in the binding and FLIPR assay, respectively). DG-041 inhibits PGE2 facilitation of platelet aggregation and has the blood-brain barrier per...
T1265 Amrinone Inamrinone,Inocor,Wincoram TNF , PDE
Amrinone (Inocor) is a positive inotropic cardiotonic (cardiotonic agent) with vasodilator properties, phosphodiesterase 3 inhibitory activity.
T23312 SB 204741 5-HT Receptor
SB 204741 is a 5-HT2B receptor antagonist.
T9765 TJ-M2010-5 MyD88
TJ-M2010-5 is a MyD88 inhibitor that binds to the TIR domain to interfere with its homodimerization and suppress MyD88 signaling. TJ-M2010-5 can be used in myocardial ischemia/reperfusion injury studies.
T2671 Regadenoson CVT-3146,Lexiscan Adenosine Receptor
Regadenoson (CVT-3146) is an adenosine derivative and selective A2A adenosine receptor agonist with coronary vasodilating activity. Upon administration, regadenoson selectively binds to and activates the A2A adenosine re...
T23521 VULM 1457 Acyltransferase
VULM 1457 is a potent ACAT inhibitor. VULM 1457 has remarkable hypolipidaemic activity and improves the overall myocardial ischaemia-reperfusion injury outcomes. VULM1457 significantly reduces production and secretion of...
T15418 GS-6201 CVT-6883 Adenosine Receptor
GS-6201 (CVT-6883) is a selective antagonist of adenosine A2B receptor. GS-6201 shows high affinity and selectivity for the human adenosine A2B receptors with a Ki of 22 nM.
T1239 Indacaterol maleate QAB149 Adrenergic Receptor
Indacaterol maleate (QAB149) is an ultra-long-acting β-adrenoceptor agonist.
T1479 Isosorbide dinitrate Isordil,Nitrosorbide,Sorbide nitrate,Sorbidnitrate Others , NO Synthase
Isosorbide dinitrate (Isordil) is a vasodilator used in the treatment of angina pectoris.
T5329 Trandolapril Angiotensin-converting Enzyme (ACE)
Trandolapril is an orally administered angiotensin converting enzyme (ACE) inhibitor that is hydrolysed to the active diacid trandolaprilat.
T28178 NLRP3-IN-9 INF-4E,INF 4E,INF4E NOD
NLRP3-IN-9 (INF-4E) is an inhibitor of NLRP3 ATPase and caspase-1. NLRP3-IN-9 acts by irreversibly trapping thiol nucleophiles, which prevents both ATP- and nigericin-triggered pyroptosis of human THP-1 cells in a time- ...
T7714 Temocapil Tyrosinase
Temocapril is an inhibitor of tyrosine kinase.
T3461 Losartan Carboxylic Acid EXP-3174,E-3174 RAAS
Losartan Carboxylic Acid (E-3174) a potent AT1 antagonist (Kis: 0.57 nM, rat; 0.67 nM, human), producing a depressor response and vasodilatation. Losartan Carboxylic Acid , a metabolite of losartan, is more potent than l...
T1046 Mexiletine hydrochloride KOE-1173 (hydrochloride),Mexiletine HCl,KO1173 AhR , Sodium Channel
Mexiletine hydrochloride (KOE-1173 hydrochloride) is a voltage-gated sodium channel blocker and a Class IB antiarrhythmic drug. Mexiletine hydrochloride exerts antiarrhythmic effects by inhibiting sodium current in myoca...
T9516 Binodenoson WRC 0470,MRE-0470,2-(cyclohexylmethylidenehydrazino)adenos Adenosine Receptor
Binodenoson (WRC 0470) is a potent and selective A2A adenosine receptor agonist (KD=270 nM). Binodenoson is being developed as a short-acting coronary vasodilator as an adjunct to radiotracers for use in myocardial stres...
T1101 Minocycline hydrochloride Minocycline HCl HIF/HIF Prolyl-Hydroxylase , Antibacterial , Antibiotic
Minocycline hydrochloride (Minocycline HCl) is a tetracycline antibiotic with excellent absorption and tissue penetration that is used for several bacterial infections as well as treatment of acne. Minocycline hydrochlor...
T2047 AG-1478 AG1478,NSC 693255,Tyrphostin AG-1478 EGFR , HCV Protease , Influenza Virus , HER , PDGFR
AG-1478 (NSC-693255) (Tyrphostin AG-1478) is a selective EGFR inhibitor.
T3230 NLRP3-IN-2 5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide,NLRP3 Inflammasome Inhibitor I NOD-like Receptor (NLR) , NOD
NLRP3-IN-2 (5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide), an intermediate capable of synthesizing glibenclamide, exerts an inhibitory effect on the formation of NLRP3 inflammatory vesicles in cardiomyocytes, limiting i...
T6698 Temocapril hydrochloride CS-622 HCl,Acecol,Temocapril HCl,CS-622 RAAS
Temocapril hydrochloride (CS-622 HCl), the hydrochloride of Temocapril, is a long-acting ACE inhibitor used for the therapy of hypertension.
T34648 Sinitrodil ITF296,ITF-296,ITF 296 Guanylate cyclase
Sinitrodil (ITF-296) is a guanylate cyclase stimulant that may be used in the treatment of myocardial ischemia and angina pectoris.
T27827 Libenzapril CGS 16617,Abutapril Angiotensin-converting Enzyme (ACE)
Libenzapril (CGS 16617) is a potent angiotensin-converting enzyme inhibitor used to study myocardial injury.
T11039 Didesethyl chloroquine Bisdesethylchloroquine Drug Metabolite
Didesethyl chloroquine (Bisdesethylchloroquine) is an effective myocardial inhibitor. Didesethyl chloroquine (Bisdesethylchloroquine) is the main metabolite of the antimalarial drug chloroquine.
T68130 Pobilukast SKF 104353 Z2,SKF 104353 Leukotriene Receptor
Pobilukast (SKF 104353) is a selective cysteinyl leukotriene receptor antagonist that blocks phosphatidylinositol metabolism and leukotriene D-induced thromboxane synthesis, and can be used to study limiting myocardial d...
T11239 Ethacizine hydrochloride NIK-244,Ethacizin,NIK-244 hydrochloride Sodium Channel
Ethacizine hydrochloride (NIK-244) has antiarrhythmic activity, and its effects are related to cardiac activity and can be used to study arrhythmias and myocardial infarction.
T31640 Enrasentan SB-217242,SB 217242,SB217242 Endothelin Receptor
Enrasentan (sb-217242) is a mixed antagonist of ET(A) and ET(B) receptors that reduces blood pressure, prevents cardiac hypertrophy, and protects myocardial function.
T68022L Sulotroban potassium BM 13177 potassium,Sulotroban potassium(72131-33-0 Free base) PPAR
Sulotroban potassium is a small molecule thromboxane A2 receptor (TXA2R) antagonist that can be used to study myocardial infarction and thrombosis.
T68088 Iodofiltic acid
Iodofiltic acid can be used in the adjuvant treatment of acute coronary syndromes (Zeus ACS) and can be imaged to detect myocardial ischemia.
T67972L Amp579 TFA Amp579 TFA(213453-89-5 Free base) Adenosine Receptor
Amp579 TFA is a novel adenosine A1/A2a receptor agonist that induces acute and delayed preconditioning against myocardial shock in vivo.
T23356 Linsidomine hydrochloride SIN-1 chloride Others
Linsidomine hydrochloride (SIN-1 chloride) is considered as a metabolite of moxidomine, with vasodilation, inhibition of platelet aggregation, and antiangina activity. In myocardial ischemia-reperfusion models, Linsidomi...
T28077 MMPP VEGFR , STAT
MMPP is a novel VEGFR2 inhibitor with anti-inflammatory and potential anticancer activity, inhibits STAT3, inhibits angiogenesis via VEGFR2/AKT/ERK/NF-kappaB pathway, and can be used to alleviate myocardial injury.
T67941 PDE5-IN-9
PDE5-IN-9 inhibits Phosphodiesterase PDE1c and is used to treat hypertension, heart failure, myocardial infarction, kidney failure, asthma, bronchitis, and dementia.
T8687 Diaminohydroxypropanetetraacetic acid Others
Diaminohydroxypropanetetraacetic acid has been investigated for the treatment of Vascular Disease, Coronary Disease, Myocardial Ischemia, Coronary Restenosis, and Coronary Artery Disease, among others
T1146 Nifedipine BAY-a-1040,Procardia XL,Procardia,Adalat CaMK , Potassium Channel , Calcium Channel , Autophagy
Nifedipine (Procardia) is a dihydropyridine calcium channel blocking agent. Nifedipine inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation ...
T24115 GSK854 GSK-854,GSK 854 Apoptosis
GSK854 is a highly selective and potent inhibitor of troponin I interacting kinase (TNNI3K) that inhibits myocardial infarction-injured cellular pyroptosis and apoptosis in mice, which may limit oxidative stress, injury,...
T3597 Cutamesine dihydrochloride AGY94806 dihydrochloride,SA4503 (dihydrochloride),SA4503 dihydrochloride Sigma receptor
Cutamesine dihydrochloride (SA4503 dihydrochloride) is a selective σ1 receptor agonist (IC50: 17.4 nM). It shows selectivity for σ1 over σ2 receptors, and inhibits angiotensin II-induced cardiomyocyte hypertrophy in vitr...
T12078 ML334 LH601A Nrf2
ML334 (LH601A) is a transmembrane and potent NRF2 activator that inhibits Keap1-NRF2 protein interactions to ameliorate myocardial infarction-induced cardiac fibrosis by inhibiting cardiac fibroblast activation and proli...
T6633 Ranolazine CVT 303,Ranexa,RS 43285-003 Calcium Channel , Sodium Channel
Ranolazine (RS 43285-003) is a calcium uptake inhibitor via the sodium/calcium channel, used to treat chronic angina. It affects the sodium-dependent calcium channels during myocardial ischemia in rabbits by altering the...
T0988 Trimetazidine dihydrochloride Yoshimilon,Kyurinett,Vastarel F Autophagy , Fatty Acid Synthase
Trimetazidine dihydrochloride (Vastarel F) can improve myocardial glucose utilization by inhibiting fatty acid metabolism. Trimetazidine is the first cytoprotective anti-ischemic agent, also used as a vasodilator in isch...
T9180 LUF6096 CF-602 Adenosine Receptor
LUF6096 (CF-602) is a potent allosteric enhancer of the adenosine A3 receptor, exhibiting the capability to enhance agonist binding allosterically while demonstrating low orthosteric affinity across adenosine receptors. ...
TP2279L Obestatin (rat) acetate GHSR
Obestatin (rat) acetate is an endogenous ligand of G-protein coupled receptor 39 (GPR39). Obestatin (rat) acetate has anti-inflammatory, anti-myocardial infarction and antioxidant properties. Obestatin (rat) acetate supp...
T20563 PD-166793 PD-166793-0000,PD 166793,PD166793 MMP
PD-166793 is an orally active, potent and selective MMP inhibitor with inhibitory effects on MMP-2, MMP-3 and MMP-13.PD-166793 ameliorates myocardial ischemia and reperfusion injury in a rat model of heart failure.PD-166...
T37379 Protectin D1 Neuroprotectin D1,NPD1 Akt , PI3K
Protectin D1 (Neuroprotectin D1) is a neuroprotectin produced by neuronal cells and is a potential cardioprotective agent.Protectin D1 attenuates myocardial ischemia/reperfusion injury and inhibits imiquimod-induced psor...
T0230 Prasugrel LY640315,CS-747,PCR 4099 P2Y Receptor
Prasugrel (CS-747) is a piperazine derivative and PLATELET AGGREGATION INHIBITOR that is used to prevent THROMBOSIS in patients with ACUTE CORONARY SYNDROME; UNSTABLE ANGINA and MYOCARDIAL INFARCTION, as well as in those...
T39115 ABR-238901 TLR
ABR-238901 is an oral, active S100A8/A9 blocker that inhibits the interaction of S100A8/A9 with its receptors RAGE(receptor for advanced glycation end products) and TLR4 (toll-like receptor 4). ABR-238901 has potential a...
T3465L Vesnarinone HCl Synonym 2,OPC-8212 HCl,Vesnarinone HCl(81840-15-5 Free base) Potassium Channel , Calcium Channel , PDE
Vesnarinone HCl (OPC-8212 HCl) is an orally active phosphodiesterase 3 (PDE3) inhibitor.Vesnarinone HCl modulates calcium and potassium ions, increasing calcium flux and decreasing potassium flux.Vesnarinone HCl is a new...
T21871 MMPSI Caspase-3/7 Inhibitor I Apoptosis , Caspase
MMPSI (Caspase-3/7 Inhibitor I) is a novel, non-peptide small molecule caspase 3 and caspase 7 inhibitor that reduces ischemic injury in isolated rabbit heart or cardiomyocytes and inhibits apoptosis of H16c2 cells in a ...
T14506 BAY 60-6583 Others , Adenosine Receptor
BAY 60-6583 is a potent, high-affinity adenosine A2B receptor agonist (EC50 = 3 nM) with affinity for A2B receptors that exceeds that for A1, A2A, and A3 receptors.BAY 60-6583 is cardioprotective in a model of myocardial...

Compounds

Resorcinolnaphthalein
T13865
Synonym:
Target: RAAS
Indacaterol
T2320
Synonym:
Target: Adrenergic Receptor
Gap19
TP1563
Synonym:
Target: Gap Junction Protein
DG-041
T15108
Synonym:
Target: Prostaglandin Receptor
Amrinone
T1265
Synonym: Inamrinone,Inocor,Wincoram
Target: TNF, PDE
SB 204741
T23312
Synonym:
Target: 5-HT Receptor
TJ-M2010-5
T9765
Synonym:
Target: MyD88
Regadenoson
T2671
Synonym: CVT-3146,Lexiscan
Target: Adenosine Receptor
VULM 1457
T23521
Synonym:
Target: Acyltransferase
GS-6201
T15418
Synonym: CVT-6883
Target: Adenosine Receptor
Indacaterol maleate
T1239
Synonym: QAB149
Target: Adrenergic Receptor
Isosorbide dinitrate
T1479
Synonym: Isordil,Nitrosorbide,Sorbide nitrate,Sorbidnitrate
Target: Others, NO Synthase
Trandolapril
T5329
Synonym:
Target: Angiotensin-converting Enzyme (ACE)
NLRP3-IN-9
T28178
Synonym: INF-4E,INF 4E,INF4E
Target: NOD
Temocapil
T7714
Synonym:
Target: Tyrosinase
Losartan Carboxylic Acid
T3461
Synonym: EXP-3174,E-3174
Target: RAAS
Mexiletine hydrochloride
T1046
Synonym: KOE-1173 (hydrochloride),Mexiletine HCl,KO1173
Target: AhR, Sodium Channel
Binodenoson
T9516
Synonym: WRC 0470,MRE-0470,2-(cyclohexylmethylidenehydrazino)adenos
Target: Adenosine Receptor
Minocycline hydrochloride
T1101
Synonym: Minocycline HCl
Target: HIF/HIF Prolyl-Hydroxylase, Antibacterial, Antibiotic
AG-1478
T2047
Synonym: AG1478,NSC 693255,Tyrphostin AG-1478
Target: EGFR, HCV Protease, Influenza Virus, HER, PDGFR
NLRP3-IN-2
T3230
Synonym: 5-Chloro-N-(p-sulfamoylphenethyl)-o-anisamide,NLRP3 Inflammasome Inhibitor I
Target: NOD-like Receptor (NLR), NOD
Temocapril hydrochloride
T6698
Synonym: CS-622 HCl,Acecol,Temocapril HCl,CS-622
Target: RAAS
Sinitrodil
T34648
Synonym: ITF296,ITF-296,ITF 296
Target: Guanylate cyclase
Libenzapril
T27827
Synonym: CGS 16617,Abutapril
Target: Angiotensin-converting Enzyme (ACE)
Didesethyl chloroquine
T11039
Synonym: Bisdesethylchloroquine
Target: Drug Metabolite
Pobilukast
T68130
Synonym: SKF 104353 Z2,SKF 104353
Target: Leukotriene Receptor
Ethacizine hydrochloride
T11239
Synonym: NIK-244,Ethacizin,NIK-244 hydrochloride
Target: Sodium Channel
Enrasentan
T31640
Synonym: SB-217242,SB 217242,SB217242
Target: Endothelin Receptor
Sulotroban potassium
T68022L
Synonym: BM 13177 potassium,Sulotroban potassium(72131-33-0 Free base)
Target: PPAR
Iodofiltic acid
T68088
Synonym:
Target:
Amp579 TFA
T67972L
Synonym: Amp579 TFA(213453-89-5 Free base)
Target: Adenosine Receptor
Linsidomine hydrochloride
T23356
Synonym: SIN-1 chloride
Target: Others
MMPP
T28077
Synonym:
Target: VEGFR, STAT
PDE5-IN-9
T67941
Synonym:
Target:
diaminohydroxypropanetetraacetic acid
T8687
Synonym:
Target: Others
Nifedipine
T1146
Synonym: BAY-a-1040,Procardia XL,Procardia,Adalat
Target: CaMK, Potassium Channel, Calcium Channel, Autophagy
GSK854
T24115
Synonym: GSK-854,GSK 854
Target: Apoptosis
Cutamesine dihydrochloride
T3597
Synonym: AGY94806 dihydrochloride,SA4503 (dihydrochloride),SA4503 dihydrochloride
Target: Sigma receptor
ML334
T12078
Synonym: LH601A
Target: Nrf2
Ranolazine
T6633
Synonym: CVT 303,Ranexa,RS 43285-003
Target: Calcium Channel, Sodium Channel
Trimetazidine dihydrochloride
T0988
Synonym: Yoshimilon,Kyurinett,Vastarel F
Target: Autophagy, Fatty Acid Synthase
LUF6096
T9180
Synonym: CF-602
Target: Adenosine Receptor
Obestatin (rat) acetate
TP2279L
Synonym:
Target: GHSR
PD-166793
T20563
Synonym: PD-166793-0000,PD 166793,PD166793
Target: MMP
Protectin D1
T37379
Synonym: Neuroprotectin D1,NPD1
Target: Akt, PI3K
Prasugrel
T0230
Synonym: LY640315,CS-747,PCR 4099
Target: P2Y Receptor
ABR-238901
T39115
Synonym:
Target: TLR
Vesnarinone HCl
T3465L
Synonym: Synonym 2,OPC-8212 HCl,Vesnarinone HCl(81840-15-5 Free base)
Target: Potassium Channel, Calcium Channel, PDE
MMPSI
T21871
Synonym: Caspase-3/7 Inhibitor I
Target: Apoptosis, Caspase
BAY 60-6583
T14506
Synonym:
Target: Others, Adenosine Receptor
1 2 3
Cat No. Product Name Synonyms Targets
T8158 Tilianin Others
Tilianin is a flavonoid glycoside of Dragocephalum moldavicum L.
TN6490 Regaloside C Others
Regaloside C is a glycerol glucoside isolated from Lilium genus with anti-inflammatory properties.
T2893 Muscone 3-Methylcyclopentadecanone,Methylexaltone MMP , TNF , NF-κB , NOD-like Receptor (NLR) , P-gp , Interleukin
Muscone (3-Methylcyclopentadecanone) is an organic compound that is the primary contributor to the odor of musk.
T5247 Trimethylamine N-oxide dihydrate TMANO Dihydrate Others , Endogenous Metabolite
Trimethylamine N-oxide dihydrate (TMANO Dihydrate), a product of the oxidation of trimethylamine, is considered as a protein stabilizer that may serve to counteract urea, the major osmolyte of sharks, skates and rays.
T3S0289 Araloside X Calcium Channel
Aralosides possess protective effect against experimental myocardial ischemia and infarction, the mechanism of myocardial protection may be attributed to the amelioration of FFA metabolic deterioration and membrane perox...
TN7089 Alashinol G (-)-Carinol Others
Alashinol G ((-)-Carinol) is isolated from the stem bark of Syringa pinnatifolia, a Mongolian folk medicine with anti-myocardial ischaemic effects.
T2844 Hyperoside Quercetin 3-galactoside,Hyperin Others , Influenza Virus , Antifungal
Hyperoside (Hyperin) is a naturally occuring flavonoid compound which shows multiple bioactivities, including myocardial protection, anti-redox, and anti-inflammatory activities.
T5S1632 Barlerin 8-O-Acetylshanzhiside methyl ester,ND01 VEGFR , TNF , NF-κB , Akt , Caspase
Barlerin (8-O-Acetylshanzhiside methyl ester) has potential against cerebral ischemic injury, and its protective effect on oxygen-glucose deprivation-induced injury might be due to the suppression of intracellular Ca2+ e...
T5S2178 Fargesin (+/-)-Fargesin Adrenergic Receptor
1. Fargesin ((+/-)-Fargesin) as a potential β1AR antagonist through cAMP/PKA pathway could protect against myocardial ischemia/reperfusion injury in rats. 2. Fargesin improves dyslipidemia and hyperglycemia by activating...
T2S0500 Ilexsaponin A Ilexsaponin A1 Others
1. Ilexsaponin A (Ilexsaponin A1) shows protective effects on ischemia-reperfusion-induced myocardial injury through anti-apoptotic pathway.
T5S0053 Coptisine Coptisin Indoleamine 2,3-Dioxygenase (IDO)
1. Coptisine (Coptisin) treatment increases cell viability based on its reversal effect on the enhanced activity of Indoleamine 2, 3-dioxygenase . 2. Coptisine treats myocardial I/R likely through suppressing myocardial ...
T3920 Pseudoginsenoside F11 Ginsenoside A1 Others , Endogenous Metabolite
Pseudoginsenoside F11 (Ginsenoside A1) is a component of Panax quinquefolium (American ginseng) which main pharmacological activities are positive inotropic effect on isolated heart function, good therapeutic effect on m...
T4518 Licochalcone D ERK , NF-κB
Licochalcone D may be a potential drug for human melanoma treatment by inhibiting proliferation, inducing apoptosis via the mitochondrial pathway and blocking cell migration and invasion. Licochalcone D has cardioprotect...
T3427 Polydatin Piceid,Polydotin Peceid Apoptosis , Mitophagy , NF-κB , Autophagy
Polydatin (Piceid), the glycoside of Resveratrol, is originally isolated from the Chinese herb Polygonum cuspidatum. The compound can inhibit platelet aggregation and elevate the ratios of LDL-C/HDL-C and TC/HDL-C. In th...
T3921 Punicalagin SARS-CoV , HBV
Punicalagin is a major ellagitannin found in pomegranates that is reported to produce antioxidant, anti-inflammatory, and anticancer effects. It has been shown to prevent high-fat diet-induced obesity-associated accumula...
T3S1553 Trans-Cinnamaldehyde Cinnamaldehyde,Cinnamic aldehyde,Cinnamal,Phenylacrolein COX , Endogenous Metabolite
1. trans-Cinnamaldehyde (Phenylacrolein) exhibits excellent anti-inflammatory activities and antidepressant-like effects in stressed mid-aged rats as a COX-2 inhibitor. 2. Cinnamic aldehyde induces apoptosis of CML cells...
T3753 Sinapinic Acid Sinapic acid,Synapoic acid Apoptosis , RAAS , Reactive Oxygen Species , HDAC
Sinapinic Acid (Synapoic acid) protects the rat liver from CCl4-induced inflammation, most likely by acting as a free radical scavenger and modulator of NF-κB p65 activation and proinflammatory cytokine expression. Sinap...
T2973 Astragaloside IV AST-IV,AS-IV MMP , ERK , Estrogen/progestogen Receptor , JNK
Astragaloside IV (AS-IV), an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cel...
T4S2326 Cornuside 7-Galloylsecologanol,7-O-Galloylsecologanol,Comuside ERK , p38 MAPK , NF-κB , JNK
1. Cornuside (Comuside) has immunomodulatory activity . 2. Cornuside suppresses expression levels of cytokine-induced proinflammatory and adhesion molecules in the human endothelial cells. 3. Cornuside can treat myocardi...
T4S0280 Eleutheroside D
Eleutheroside has protective effect to myocardial ischemic-reperfusion injury(IRI) in isolated rats.
TN4882 Quinine HCl Adrenergic Receptor
Quinine HCl produces alpha-adrenergic blockade. Quinine modifies catecholamine- and calcium-induced myocardial contractile force responses.
TN1101 20(R)-Notoginsenoside R2 Others
20(R)-Notoginsenoside R2 is a natural product with Promote blood circulation and improve myocardial ischemia
TN1431 Baohuoside VII Others
Baohuoside aglycone possesses cardioprotective effect in prevention of ischemia/ reperfusion injury and reduce the myocardial infraction, the mechnism is due to the reduction of the injury of free radicals. Baohuoside VI...
T78489 Lotusine hydroxide
Lotusine (hydroxide), a pure alkaloid isolated from the green seed embryos of Nelumbo nucifera Gaertn, influences action potentials in myocardial tissue and the slow inward current in cardiac Purkinje fibers [1].
TN1875 Liriodenine BCL , Caspase , p53
Liriodenine is a potent inhibitor of topoisomerase II (EC 5.99.1.3) both in vivo and in vitro, it has antitumor, antibacterial and antifungal activities, it can suppress ventricular arrhythmias induced by myocardial isch...
TN3914 Echinatine ATPase , IL Receptor , TNF
Echinatin exerts a protective effect against ischemia/reperfusion (I/R)-induced myocardial injury on hearts, this effect may be attributed to the antioxidant and anti-inflammatory activities of this compound. Echinatin c...

Natural Products

Tilianin
T8158
Synonym:
Target: Others
Regaloside C
TN6490
Synonym:
Target: Others
Muscone
T2893
Synonym: 3-Methylcyclopentadecanone,Methylexaltone
Target: MMP, TNF, NF-κB, NOD-like Receptor (NLR), P-gp, Interleukin
Trimethylamine N-oxide dihydrate
T5247
Synonym: TMANO Dihydrate
Target: Others, Endogenous Metabolite
Araloside X
T3S0289
Synonym:
Target: Calcium Channel
Alashinol G
TN7089
Synonym: (-)-Carinol
Target: Others
Hyperoside
T2844
Synonym: Quercetin 3-galactoside,Hyperin
Target: Others, Influenza Virus, Antifungal
Barlerin
T5S1632
Synonym: 8-O-Acetylshanzhiside methyl ester,ND01
Target: VEGFR, TNF, NF-κB, Akt, Caspase
Fargesin
T5S2178
Synonym: (+/-)-Fargesin
Target: Adrenergic Receptor
Ilexsaponin A
T2S0500
Synonym: Ilexsaponin A1
Target: Others
Coptisine
T5S0053
Synonym: Coptisin
Target: Indoleamine 2,3-Dioxygenase (IDO)
Pseudoginsenoside F11
T3920
Synonym: Ginsenoside A1
Target: Others, Endogenous Metabolite
Licochalcone D
T4518
Synonym:
Target: ERK, NF-κB
Polydatin
T3427
Synonym: Piceid,Polydotin Peceid
Target: Apoptosis, Mitophagy, NF-κB, Autophagy
Punicalagin
T3921
Synonym:
Target: SARS-CoV, HBV
trans-Cinnamaldehyde
T3S1553
Synonym: Cinnamaldehyde,Cinnamic aldehyde,Cinnamal,Phenylacrolein
Target: COX, Endogenous Metabolite
Sinapinic Acid
T3753
Synonym: Sinapic acid,Synapoic acid
Target: Apoptosis, RAAS, Reactive Oxygen Species, HDAC
Astragaloside IV
T2973
Synonym: AST-IV,AS-IV
Target: MMP, ERK, Estrogen/progestogen Receptor, JNK
Cornuside
T4S2326
Synonym: 7-Galloylsecologanol,7-O-Galloylsecologanol,Comuside
Target: ERK, p38 MAPK, NF-κB, JNK
Eleutheroside D
T4S0280
Synonym:
Target:
Quinine HCl
TN4882
Synonym:
Target: Adrenergic Receptor
20(R)-Notoginsenoside R2
TN1101
Synonym:
Target: Others
Baohuoside VII
TN1431
Synonym:
Target: Others
Lotusine hydroxide
T78489
Synonym:
Target:
Liriodenine
TN1875
Synonym:
Target: BCL, Caspase, p53
Echinatine
TN3914
Synonym:
Target: ATPase, IL Receptor, TNF

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-05004 FGF-4 Protein, Human, Recombinant Human E. coli
FGF (fibroblast growth factor) signalling is known to be required for many aspects of mesoderm formation and patterning during Xenopus development and has been implicated in regulating genes required for the specificati...
TMPY-05636 G-CSF Protein, Mouse, Recombinant Mouse HEK293
Granulocyte-colony stimulating factor (G-CSF) is a growth factor and an essential cytokine belonging to the CSF family of hormone-like glycoproteins. It is produced by numerous cell types including immune and endothelial...
TMPY-04829 G-CSF Protein, Human, Recombinant Human HEK293
Granulocyte-colony stimulating factor (G-CSF) is a growth factor and an essential cytokine belonging to the CSF family of hormone-like glycoproteins. It is produced by numerous cell types including immune and endothelial...
TMPY-00545 Dermcidin Protein, Human, Recombinant (hFc) Human HEK293
Hepatocellular carcinoma (HCC) is a major contributor to cancer-related deaths due to its often late stage diagnosis, and dermcidin (DCD) may have the potential to be used as a serum biomarker for HCC for more timely dia...
TMPY-00369 LY6D Protein, Human, Recombinant (mFc) Human HEK293
LY6D (Lymphocyte Antigen 6 Family Member D) is a Protein Coding gene. It may act as a specification marker at the earliest stage specification of lymphocytes between B- and T-cell development. Marks the earliest stage of...
TMPY-01613 Periostin/OSF-2 Protein, Mouse, Recombinant (His) Mouse HEK293
Periostin ( POSTN ), also known as OSF2 (osteoblast specific factor 2), is a heterofunctional secreted extracellular matrix (ECM) protein comprised of four fasciclin domains that promotes cellular adhesion and movement, ...
TMPY-01020 Periostin/OSF-2 Protein, Human, Recombinant (His) Human HEK293
Periostin ( POSTN ), also known as OSF2 (osteoblast specific factor 2), is a heterofunctional secreted extracellular matrix (ECM) protein comprised of four fasciclin domains that promotes cellular adhesion and movement, ...
TMPY-01727 GLA/alpha-Galactosidase A Protein, Human, Recombinant (His) Human HEK293
Alpha-galactosidase A, also known as Alpha-D-galactoside galactohydrolase, Alpha-D-galactosidase A, Melibiase and GLA, is a member of the glycosyl hydrolase 27 family. GLA is used as a long-term enzyme replacement therap...
TMPY-01694 Clusterin Protein, Mouse, Recombinant (His) Mouse HEK293
Clusterin, also known as complement-associated protein SP-40, Complement cytolysis inhibitor, Apolipoprotein J, Testosterone-repressed prostate message 2, Aging-associated gene 4 protein, CLU and APOJ, is a secreted prot...
TMPY-01691 Clusterin Protein, Human, Recombinant (CLU34, His) Human HEK293
Clusterin, also known as complement-associated protein SP-40, Complement cytolysis inhibitor, Apolipoprotein J, Testosterone-repressed prostate message 2, Aging-associated gene 4 protein, CLU and APOJ, is a secreted prot...
TMPY-00803 Fibronectin Protein, Human, Recombinant (aa 607-1265, His) Human HEK293
Fibronectin (FN) is a glycoprotein component of the extracellular matrix of the extracellular matrix (ECM) with roles in embryogenesis, development, and wound healing. More recently, FN has emerged as player in platelet ...
TMPY-00904 Urokinase/uPA Protein, Human, Recombinant (His) Human HEK293
Plasminogen activator, urokinase, also known as PLAU and uPA, is a serine protease which converts plasminogen to plasmin, a broad-spectrum protease active on extracellular matrix (ECM) components. It is involved in compl...
TMPK-01229 IL-19 Protein, Human, Recombinant (hFc) Human HEK293
Interleukin-19 (IL-19) has been shown to be involved in coronary artery diseases and atherosclerosis, while its expression in myocardial infarction is poorly understood. In this study, the dynamic increase in circulating...
TMPH-01595 KMO Protein, Human, Recombinant (His) Human E. coli
Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA r...
TMPY-00813 G-CSF Protein, Human, Recombinant (hFc) Human HEK293
Granulocyte-colony stimulating factor (G-CSF) is a growth factor and an essential cytokine belonging to the CSF family of hormone-like glycoproteins. It is produced by numerous cell types including immune and endothelial...
TMPJ-00278 Clusterin Protein, Human, Recombinant (hFc & His) Human Human Cells
Clusterin is a secreted protein which belongs to the Clusterin family. Clusterin is expressed in adult testis, heart, ovary, adrenal gland, brain and liver. Clusterin has been suggested to be involved in several basic bi...
TMPJ-00279 Clusterin Protein, Human, Recombinant (His) Human Human Cells
Clusterin is a secreted protein which belongs to the Clusterin family. Clusterin is expressed in adult testis, heart, ovary, adrenal gland, brain and liver. Clusterin has been suggested to be involved in several basic bi...
TMPY-01481 FLAP Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
Arachidonate 5-Lipoxygenase-Activating Protein (ALOX5AP), also known as FLAP, belongs to the MAPEG family. ALOX5AP/FLAP is an essential partner of 5-LO for this process. The FLAP (ALOX5AP) gene has been linked to risk fo...
TMPJ-00402 CD117 Protein, Human, Recombinant (hFc) Human Human Cells
C-Kit/SCF R is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). c-Kit contains 5 Ig-like C2-type (immunoglobulin-like) domains and 1 protein kinase domain. It belongs to ...
TMPY-04115 LAMP2 Protein, Human, Recombinant (His) Human HEK293
LAMP2 (Lysosomal Associated Membrane Protein 2) is a Protein Coding gene. LAMP2, also known as CD107b (Cluster of Differentiation 107b), is a member of a family of membrane glycoproteins. This glycoprotein provides selec...
TMPY-02382 LAMP2 Protein, Mouse, Recombinant (His) Mouse HEK293
LAMP2 (Lysosomal Associated Membrane Protein 2) is a Protein Coding gene. LAMP2, also known as CD107b (Cluster of Differentiation 107b), is a member of a family of membrane glycoproteins. This glycoprotein provides selec...
TMPY-03685 LAMP2 Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293
LAMP2 (Lysosomal Associated Membrane Protein 2) is a Protein Coding gene. LAMP2, also known as CD107b (Cluster of Differentiation 107b), is a member of a family of membrane glycoproteins. This glycoprotein provides selec...
TMPH-01027 CAMK2D Protein, Human, Recombinant (His) Human E. coli
Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in C...
TMPJ-00091 G-CSF Protein, Mouse, Recombinant (His) Mouse Human Cells
Granulocyte colony-stimulating factor (G-CSF) is a growth factor and an essential cytokine which belongs to the IL-6 superfamily. Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis ...
TMPY-03191 PTH Protein, Human, Recombinant (hFc) Human HEK293
Parathyroid hormone (PTH), parathormone or parathyrin, is secreted by the chief cells of the parathyroid glands as a polypeptide. PTH elevates calcium level by dissolving the salts in bone and preventing their renal excr...
TMPY-05241 SIRT5 Protein, Human, Recombinant (Flag) Human E. coli
The sirtuin SIRT5 resides primarily in the mitochondrial matrix and catalyzes the removal of negatively charged lysine acyl modifications; succinyl, malonyl, and glutaryl groups SIRT5 as a significant regulator of cellul...
TMPY-06954 SIRT5 Protein, Human, Recombinant (His) Human E. coli
The sirtuin SIRT5 resides primarily in the mitochondrial matrix and catalyzes the removal of negatively charged lysine acyl modifications; succinyl, malonyl, and glutaryl groups SIRT5 as a significant regulator of cellul...
TMPJ-00785 FABP3 Protein, Human, Recombinant (His) Human E. coli
Fatty Acid Binding Protein 3 (FABP3) is a small cytoplasmic protein (15 kDa) that is released from cardiac myocytes following an ischemic episode. Like the nine other distinct FABPs that have been identified, FABP3 is in...
TMPY-02764 PTH Protein, Human, Recombinant (aa 32-65, GST) Human E. coli
Parathyroid hormone (PTH), parathormone or parathyrin, is secreted by the chief cells of the parathyroid glands as a polypeptide. PTH elevates calcium level by dissolving the salts in bone and preventing their renal excr...
TMPJ-00362 MMP-2 Protein, Human, Recombinant (His) Human Human Cells
72 kDa type IV collagenase also known as matrix metalloproteinase-2 (MMP-2) and gelatinase A is an enzyme that in humans is encoded by the MMP2 gene.It belongs to the matrix metalloproteinase (MMP) family. Matrix metallo...
TMPY-06908 Clusterin Protein, Human, Recombinant (sCLU, His) Human HEK293
Clusterin, also known as complement-associated protein SP-40, Complement cytolysis inhibitor, Apolipoprotein J, Testosterone-repressed prostate message 2, Aging-associated gene 4 protein, CLU and APOJ, is a secreted prot...
TMPY-02857 GLA/alpha-Galactosidase A Protein, Mouse, Recombinant (His) Mouse HEK293
Alpha-galactosidase A, also known as Alpha-D-galactoside galactohydrolase, Alpha-D-galactosidase A, Melibiase and GLA, is a member of the glycosyl hydrolase 27 family. GLA is used as a long-term enzyme replacement therap...
TMPY-06211 Clusterin Protein, Chinese hamster, Recombinant (His) Chinese hamster CHO
Clusterin, also known as complement-associated protein SP-40, Complement cytolysis inhibitor, Apolipoprotein J, Testosterone-repressed prostate message 2, Aging-associated gene 4 protein, CLU and APOJ, is a secreted prot...
TMPY-04387 AKT2 Protein, Human, Recombinant (His & GST) Human Baculovirus-Insect Cells
AKT (AK mouse plus Transforming or Thymoma) is a frequent oncogene expressed in most tissues which includes three isoforms AKT1, AKT2, and AKT3. Hyperactivation of AKT signaling is a central key in many human cancer prog...
TMPJ-00952 CXCL12 Protein, Mouse, Recombinant Mouse E. coli
Mouse Cxcl12 is a secreted and highly conserved protein which belongs to the intercrine alpha (chemokine CxC) family.CXCL12 is widely expressed in various organs including brain, kidney, skeletal muscle, heart, liver, an...
TMPH-02640 ZC3H12A Protein, Mouse, Recombinant (His & Myc) Mouse E. coli
Endoribonuclease involved in various biological functions such as cellular inflammatory response and immune homeostasis, glial differentiation of neuroprogenitor cells, cell death of cardiomyocytes, adipogenesis and angi...
TMPY-05562 Fibronectin Protein, Human, Recombinant (aa 1722-1811, His) Human HEK293
Fibronectin (FN) is a glycoprotein component of the extracellular matrix of the extracellular matrix (ECM) with roles in embryogenesis, development, and wound healing. More recently, FN has emerged as player in platelet ...
TMPY-01358 ALK-5 Protein, Human, Recombinant (His & hFc) Human HEK293
Transforming growth factor, beta receptor I, also known as Transforming growth factor-beta receptor type I , Serine / threonine-protein kinase receptor R4, Activin receptor-like kinase 5, SKR4, ALK-5, and TGFBR1, is a si...
TMPY-05771 ALK-5 Protein, Human, Recombinant (hFc) Human HEK293
Transforming growth factor, beta receptor I, also known as Transforming growth factor-beta receptor type I , Serine / threonine-protein kinase receptor R4, Activin receptor-like kinase 5, SKR4, ALK-5, and TGFBR1, is a si...
TMPY-04366 ALK-5 Protein, Human, Recombinant (aa 200-503, His & GST) Human Baculovirus-Insect Cells
Transforming growth factor, beta receptor I, also known as Transforming growth factor-beta receptor type I , Serine / threonine-protein kinase receptor R4, Activin receptor-like kinase 5, SKR4, ALK-5, and TGFBR1, is a si...
TMPY-00681 BMP-5 Protein, Human, Recombinant (hFc) Human HEK293
Bone Morphogenetic Protein 5 (BMP-5) is a member of the structurally and functionally related bone morphogenetic proteins (BMPs) which constitute a novel subfamily of the transforming growth factor β (TGF-β) superfamily....
TMPY-04504 Urokinase/uPA Protein, Rat, Recombinant (His) Rat HEK293
Plasminogen activator, urokinase, also known as PLAU and uPA, is a serine protease which converts plasminogen to plasmin, a broad-spectrum protease active on extracellular matrix (ECM) components. It is involved in compl...
TMPY-01732 LRPAP1 Protein, Mouse, Recombinant (His) Mouse HEK293
Receptor-associated protein (RAP) is a molecular chaperone for low-density lipoprotein receptor-related protein (LRP), which plays a key role in cholesterol metabolism. The lipoprotein receptor-related protein (LRP) is a...
TMPY-01233 LRPAP1 Protein, Human, Recombinant (His) Human HEK293
Receptor-associated protein (RAP) is a molecular chaperone for low-density lipoprotein receptor-related protein (LRP), which plays a key role in cholesterol metabolism. The lipoprotein receptor-related protein (LRP) is a...
FGF-4 Protein, Human, Recombinant
TMPY-05004
Species: Human
Expression System: E. coli
G-CSF Protein, Mouse, Recombinant
TMPY-05636
Species: Mouse
Expression System: HEK293
G-CSF Protein, Human, Recombinant
TMPY-04829
Species: Human
Expression System: HEK293
Dermcidin Protein, Human, Recombinant (hFc)
TMPY-00545
Species: Human
Expression System: HEK293
LY6D Protein, Human, Recombinant (mFc)
TMPY-00369
Species: Human
Expression System: HEK293
Periostin/OSF-2 Protein, Mouse, Recombinant (His)
TMPY-01613
Species: Mouse
Expression System: HEK293
Periostin/OSF-2 Protein, Human, Recombinant (His)
TMPY-01020
Species: Human
Expression System: HEK293
GLA/alpha-Galactosidase A Protein, Human, Recombinant (His)
TMPY-01727
Species: Human
Expression System: HEK293
Clusterin Protein, Mouse, Recombinant (His)
TMPY-01694
Species: Mouse
Expression System: HEK293
Clusterin Protein, Human, Recombinant (CLU34, His)
TMPY-01691
Species: Human
Expression System: HEK293
Fibronectin Protein, Human, Recombinant (aa 607-1265, His)
TMPY-00803
Species: Human
Expression System: HEK293
Urokinase/uPA Protein, Human, Recombinant (His)
TMPY-00904
Species: Human
Expression System: HEK293
IL-19 Protein, Human, Recombinant (hFc)
TMPK-01229
Species: Human
Expression System: HEK293
KMO Protein, Human, Recombinant (His)
TMPH-01595
Species: Human
Expression System: E. coli
G-CSF Protein, Human, Recombinant (hFc)
TMPY-00813
Species: Human
Expression System: HEK293
Clusterin Protein, Human, Recombinant (hFc & His)
TMPJ-00278
Species: Human
Expression System: Human Cells
Clusterin Protein, Human, Recombinant (His)
TMPJ-00279
Species: Human
Expression System: Human Cells
FLAP Protein, Human, Recombinant (His)
TMPY-01481
Species: Human
Expression System: Baculovirus-Insect Cells
CD117 Protein, Human, Recombinant (hFc)
TMPJ-00402
Species: Human
Expression System: Human Cells
LAMP2 Protein, Human, Recombinant (His)
TMPY-04115
Species: Human
Expression System: HEK293
LAMP2 Protein, Mouse, Recombinant (His)
TMPY-02382
Species: Mouse
Expression System: HEK293
LAMP2 Protein, Cynomolgus, Recombinant (His)
TMPY-03685
Species: Cynomolgus
Expression System: HEK293
CAMK2D Protein, Human, Recombinant (His)
TMPH-01027
Species: Human
Expression System: E. coli
G-CSF Protein, Mouse, Recombinant (His)
TMPJ-00091
Species: Mouse
Expression System: Human Cells
PTH Protein, Human, Recombinant (hFc)
TMPY-03191
Species: Human
Expression System: HEK293
SIRT5 Protein, Human, Recombinant (Flag)
TMPY-05241
Species: Human
Expression System: E. coli
SIRT5 Protein, Human, Recombinant (His)
TMPY-06954
Species: Human
Expression System: E. coli
FABP3 Protein, Human, Recombinant (His)
TMPJ-00785
Species: Human
Expression System: E. coli
PTH Protein, Human, Recombinant (aa 32-65, GST)
TMPY-02764
Species: Human
Expression System: E. coli
MMP-2 Protein, Human, Recombinant (His)
TMPJ-00362
Species: Human
Expression System: Human Cells
Clusterin Protein, Human, Recombinant (sCLU, His)
TMPY-06908
Species: Human
Expression System: HEK293
GLA/alpha-Galactosidase A Protein, Mouse, Recombinant (His)
TMPY-02857
Species: Mouse
Expression System: HEK293
Clusterin Protein, Chinese hamster, Recombinant (His)
TMPY-06211
Species: Chinese hamster
Expression System: CHO
AKT2 Protein, Human, Recombinant (His & GST)
TMPY-04387
Species: Human
Expression System: Baculovirus-Insect Cells
CXCL12 Protein, Mouse, Recombinant
TMPJ-00952
Species: Mouse
Expression System: E. coli
ZC3H12A Protein, Mouse, Recombinant (His & Myc)
TMPH-02640
Species: Mouse
Expression System: E. coli
Fibronectin Protein, Human, Recombinant (aa 1722-1811, His)
TMPY-05562
Species: Human
Expression System: HEK293
ALK-5 Protein, Human, Recombinant (His & hFc)
TMPY-01358
Species: Human
Expression System: HEK293
ALK-5 Protein, Human, Recombinant (hFc)
TMPY-05771
Species: Human
Expression System: HEK293
ALK-5 Protein, Human, Recombinant (aa 200-503, His & GST)
TMPY-04366
Species: Human
Expression System: Baculovirus-Insect Cells
BMP-5 Protein, Human, Recombinant (hFc)
TMPY-00681
Species: Human
Expression System: HEK293
Urokinase/uPA Protein, Rat, Recombinant (His)
TMPY-04504
Species: Rat
Expression System: HEK293
LRPAP1 Protein, Mouse, Recombinant (His)
TMPY-01732
Species: Mouse
Expression System: HEK293
LRPAP1 Protein, Human, Recombinant (His)
TMPY-01233
Species: Human
Expression System: HEK293
Cat No. Product Name
L2910 Antioxidant Compound Library

1330 compounds
Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species (ROS) and a biological system's ability to readily detoxify the reactive intermediates or repair the resulting damage. ...
L6750 PBCRBS Traditional Chinese Medicine Compound Library

588 compounds
A unique collection of 588 compounds derived from traditional Chinese medicines (TCMs) for promoting blood circulation and removing blood stasis.
TargetMol