malignancy — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T13176	TNO155	Batoprotafib	Phosphatase
	TNO155 is a protein tyrosine phosphatase (PTP) non-receptor type 11 (SHP2; src homology region 2 domain phosphatase; PTPN11) inhibitor(IC50 : 0.011 µM),with potential antineoplastic activity.		Phosphatase
T8958	PU-H54		GPR
	PU-H54 is a purine-based inhibitor of Grp94. It is a Grp94-selective resorcinol-based inhibitor isolated through probing of the exclusive binding region of S2 subpocket in Grp94.		GPR
T9756	AZD-9574		PARP
	AZD-9574 is a selective inhibitor of PARP1 at the sites of SSBs. AZD-9574 exhibits anti-cancer activities and can be used in studies about HRD+ breast cancer and advanced solid malignancies.		PARP
T21505	Suberoyl bis-hydroxamic acid	SBHA,Suberohydroxamic acid	Apoptosis , HDAC
	Suberoyl bis-hydroxamic acid (SBHA) is a Histone deacetylase (HDAC) inhibitor. HDAC is required for transcriptional modulation, cell cycle regulation and development. It is an enzyme that deacetylates lysine residues on ...		Apoptosis , HDAC
TN2064	Physcion 8-O-β-D-glucopyranoside	Physcion 8-O-beta-D-monoglucoside	TNF
	Physcion 8-O-β-D-glucopyranoside (Physcion 8-O-beta-D-monoglucoside) has anti-inflammatory and anti-cancer activities. Physcion 8-O-β-D-glucopyranoside can be used in studies about common malignancy cancer.		TNF
T60152	AZ5576		CDK
	AZ5576 is a potent and highly selective CDK9 inhibitor. AZ5576 can be used for the research of Hematological Malignancy [1].		CDK
T19461	N1,N8-Diacetylspermidine		Endogenous Metabolite
	N1,N8-Diacetylspermidine is a polyamine found in human urine.N1,N8-Diacetylspermidine can be used as a marker for cancer and malignancy.		Endogenous Metabolite
T6739	Zoledronic Acid	CGP-4244,CGP42446A,Zoledronate,CGP 42446,ZOL 446,Zometa	Apoptosis , Rho , Autophagy
	Zoledronic Acid (ZOL 446) is a bisphosphonate. Zoledronic Acid (ZOL 446) is used to prevent skeletal fractures in patients with cancers such as multiple myeloma and prostate cancer. It can also be used to treat hypercalc...		Apoptosis , Rho , Autophagy
T6960L	PU-H71 HCl	PU-H71 HCl(873436-91-0 Free base),Zelavespib HCl	HSP , DNA/RNA Synthesis
	PU-H71 HCl (Zelavespib HCl) is a novel Hsp90 inhibitor, a novel purine-based analog, and a radiosensitizer that may be a promising agent for CIRT. PU-H71 HCL shows antitumor activity in many preclinical models of maligna...		HSP , DNA/RNA Synthesis
T28143	ND-2110	ND2110
	ND-2110, a selective interleukin-1 receptor-associated kinase 4 inhibitors, is used for the treatment of autoimmune disorders and lymphoid malignancy.
T64310	KUSC-5001
	KUSC-5001 is a potent inhibitor (IC50: 18 μM) of HIF-1, which has a key role in tumour survival and malignancy.
T70677	PLS-123
	PLS-123 is a novel covalent irreversible Btk inhibitor with potential anti-proliferative activity. PLS-123 exhibited more potent anti-proliferative effects than ibrutinib in multiple cellular and in vivo preclinical mode...
T63221	PI3Kδ/γ-IN-2
	PI3Kδ/γ-IN-2 is a potent, orally bioavailable dual inhibitor of PI3Kδ (IC50: 1 nM) and PI3Kγ (IC50: 4.3 nM) with potential for use in anti-B-cell malignancy studies.
T9922	Matuzumab		EGFR
	Matuzumab is a humanized monoclonal antibody used in cancer treatment. It has a high affinity for EGFR frequently associated with the growth of blood vessels in malignancy facilitating tumor growth and survival.		EGFR
T81351	PTH-Related Protein (1-34) amide (human, mouse, rat)	Human PTHrP-(1-34)NH2
	Human PTHrP-(1-34)NH2, also known as PTH-Related Protein (1-34) amide for human, mouse, and rat, is the N-terminal fragment of PTHrP. This peptide induces hypercalcemia and is utilized in the study of humoral hypercalcem...
T83219	ABBV-467
	ABBV-467, a selective MCL-1 inhibitor (K i : <0.01 nM), induces apoptosis and effectively promotes cancer cell death while inhibiting tumor growth in hematological malignancy models, including multiple myeloma [1].
T77990	Human PTHrP-(1-36)
	Human PTHrP-(1-36) is a secreted form of parathyroid hormone-related protein that exhibits anticalciuric effects and promotes beta cell function and proliferation. It is utilized in research pertaining to humoral hyperca...
T62408	PI3Kδ-IN-11
	PI3Kδ-IN-11 is a potent and selective PI3Kδ inhibitor (IC50: 27.5 nM) that dose-dependently blocks PI3K/Akt pathway activity. PI3Kδ-IN-11 can be used in B- or T-cell-associated malignancy studies.
T73132	DS69910557
	DS69910557, a potent, selective, and orally active antagonist of the human parathyroid hormone receptor 1 (hPTHR1), exhibits antagonistic activity with an IC50 value of 0.08 μM. It is useful in researching hyperparathyro...
T75670	Lacto-N-fucopentaose II
	Lacto-N-fucopentaose II (LNFP II), a sialyl-Lewis hapten of the human Lewis blood group determinant, serves as a monosialo-ganglioside/glycolipid and sialyl derivative, CA 19-9. It is recognized as a molecular tumor mark...