light-sensitive

Nimodipine (BAY-e 9736), a 1, 4-dihydropyridine calcium channel blocker, acts primarily on vascular smooth muscle cells.

N-Nitrosomorpholine is a light-sensitive nitrosamine with strong carcinogenicity in animals and is commonly used to induce liver cancer models.

L-750667 is a selective dopamine D4 receptor antagonist ligand. The compound labeled with I specifically binds to dopamine D4 receptors in the rat retina, exhibiting a Kd value of 0.06 nM. L-750667 is involved in the regulation of light-sensitive cAMP pools.

18:0-PhoDAG is a photoswitchable diacylglycerol (DAG) that enables the rapid light activation of TRP channels sensitive to these DAGs.

QAQ dichloride is a photoswitchable compound that blocks voltage-gated Na v and K v channels. Its channel-blocking activity is observed in the trans form of the azobenzene photoswitch, while the cis form does not exhibit this effect. This compound is membrane-impermeant and selectively enters pain-sensing neurons expressing endogenous import channels. QAQ dichloride functions as a light-sensitive analgesic and provides a valuable tool for investigating signaling mechanisms involved in acute and chronic pain [1] [2].

Bicuculline is an alkaloid extracted from Corydalis decumbens, acting as a competitive antagonist of the neurotransmitter GABAA receptor (IC50 = 2 μM). It also blocks Ca2+-activated potassium (SK) channels and inhibits slow afterhyperpolarization (slow AHP). Bicuculline has anticonvulsant effects and is commonly used to establish mouse seizure models.

OptoBI-1 is a light-sensitive molecule that is photochromic TRPC3 agonist. OptoBI-1 asts as a photopharmacological tool to control of neuronal firing [1].

DMNB-caged-Serine is a photocaged amino acid, with DMNB as a blue light-sensitive caging group. It can be incorporated into proteins in Saccharomyces cerevisiae in response to the amber nonsense codon (TAG), facilitating control over the chemical composition of mammalian proteins.

Mal-PEG-SCM (MW 40000) is a linear heterobifunctional PEG compound featuring maleimide and N-hydroxysuccinimide ester (NHS) functional groups. It serves as a significant PEGylated crosslinker. The maleimide group reacts with thiol, SH, mercapto, or sulfhydryl groups, while SCM stands for succinimidyl carboxymethyl, which can interact with primary amines. The maleimide includes a reactive C=C double bond that is sensitive to light and oxygen.

Mal-PEG-SCM (MW 3400) is a linear heterobifunctional PEG compound with maleimide and NHS ester groups. It is an essential PEG chain-containing crosslinker. Maleimide reacts with thiols (SH groups), while SCM (succinimidyl carboxymethyl ester) can react with primary amines. The maleimide group contains a reactive C=C double bond and is sensitive to light and oxygen.

Mal-PEG-SCM (MW 1000) is a linear heterobifunctional PEG compound featuring maleimide and NHS ester succinimidyl groups. As a crucial PEG-linked crosslinker, maleimide reacts with thiols, SH groups, and sulfhydryls, while SCM, representing succinimidyl carboxymethyl, interacts with primary amines. The maleimide moiety contains a reactive C=C double bond that is sensitive to light and oxygen.

Mal-PEG-SCM (MW 20000) is a linear heterobifunctional PEG compound featuring maleimide and N-hydroxysuccinimide (NHS) ester groups. It serves as an essential PEGylated crosslinker. The maleimide group reacts with thiols, such as SH or sulfhydryl groups, while SCM stands for succinimidyl carboxymethyl, which can react with primary amines. The maleimide possesses a reactive C=C double bond, which is sensitive to light and oxygen.

Mal-PEG-SCM (MW 5000) is a linear heterobifunctional PEG compound featuring maleimide and N-hydroxysuccinimide (NHS) ester groups. As a significant PEG-based crosslinker, it facilitates reactions with thiol, SH, mercapto, or sulfhydryl groups via the maleimide moiety. SCM stands for succinimidyl carboxymethyl ester, which can react with primary amines. The maleimide contains a reactive C=C double bond and is sensitive to light and oxygen.

Mal-PEG-SCM (MW 2000) is a linear heterobifunctional PEG compound that features maleimide and NHS ester (succinimidyl) groups. It serves as a significant PEGylated crosslinker. The maleimide moiety reacts with thiols, SH groups, mercaptans, or sulfhydryls, while SCM stands for succinimidyl carboxymethyl ester, which can interact with primary amines. Maleimide contains a reactive C=C double bond, sensitive to light or oxygen.

Mal-PEG-SCM (MW 10000) is a linear heterobifunctional PEG compound featuring maleimide and succinimidyl (NHS) ester groups. It acts as a significant PEG-containing crosslinker. The maleimide group reacts with thiols, SH groups, sulfhydryls, or mercaptans, while SCM denotes succinimidyl carboxymethyl ester, which can react with primary amines. Maleimide includes a reactive C=C double bond that is sensitive to light and oxygen.

N-Nitrosomorpholine (Standard) is the standard substance of N-Nitrosomorpholine, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. N-Nitrosomorpholine is a light-sensitive nitrosamine with strong carcinogenicity in animals and is commonly used to induce liver cancer models.

Ageladine A dihydrochloride, derived from the marine sponge Agelas nakamurai, serves as a matrix metalloproteinase (MMP) inhibitor with anti-angiogenic properties. It inhibits MMP-2, MMP-1, MMP-8, MMP-9, MMP-12, and MMP-13, with IC50 values of 4.65 μM, 2.79 μM, 907.12 nM, 1.83 μM, 767.57 nM, and 1.09 μM, respectively. As a pH-sensitive membrane-permeable dye, it emits fluorescence in the blue-green range when excited by ultraviolet light, with a maximum absorption peak at 370 nm. Additionally, Ageladine A dihydrochloride is used as a reliable and stable fluorescent pH sensor to detect intracellular pH changes.

Rhodopsin peptide is a peptide with the sequence H2N-Val-Ser-Lys-Thr-Glu-Thr-Ser-Gln-Val-Ala-Pro-Ala-OH, MW= 1217.33. Rhodopsin is a biological pigment in photoreceptor cells of the retina that is responsible for the first events in the perception of ligh

Bathocuproine disulfonate disodium (BCS) is an organic compound utilized as a highly sensitive colorimetric reagent for copper ions in biochemical and analytical applications. Its bright yellow color and specific light absorption make it effective for detecting and quantifying trace amounts of copper. In biochemistry, BCS is commonly employed to study the role of copper ions in various biological processes. Copper, being an essential nutrient for many organisms, can be toxic at high concentrations, thus precise measurement is crucial to understanding its impact on living systems. Analytically, BCS is often used for environmental monitoring and assessing copper pollution in water quality testing. It can detect copper even at very low concentrations, making it a valuable tool for identifying potential contamination sources and evaluating the impact of industrial activities on aquatic ecosystems.