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Results for "

ischemia

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    239
    TargetMol | Inhibitors_Agonists
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    5
    TargetMol | Compound_Libraries
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    TargetMol | Inhibitors_Agonists
Mexiletine hydrochloride
Mexiletine HCl, KOE-1173 (hydrochloride), KO1173
T10465370-01-4
Mexiletine hydrochloride (KOE-1173 hydrochloride) is a voltage-gated sodium channel blocker and a Class IB antiarrhythmic drug. Mexiletine hydrochloride exerts antiarrhythmic effects by inhibiting sodium current in myocardial cells, thereby reducing the rise rate of cardiac action potential (phase 0) and reducing the automaticity of Purkinje fibers.
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Luteolinidin chloride
TN18951154-78-5
Luteolinidin chloride is a natural product. It is a potent CD38 inhibitor which can protect the heart against I R injury with preservation of eNOS function and prevention of endothelial dysfunction in vivo.
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17-ODYA
Alkynyl Stearic Acid
T1418634450-18-5
Squalane is a lipid found in some fish oils (especially shark liver oil) and some vegetable oils. It has anticancer and antioxidant properties and is used as a skin moisturizer and emollient.
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D-GsMTx4 TFA
T37697L
D-GsMTx4 TFA, a selective spider venom peptide, is a TRPC1 6 and Piezo2 inhibitor that inhibits cation-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families, blocks cation-selective stretch-activated channels (SACs), and attenuates lysophosphatidylcholine (LPC)-induced astrocyte toxicity and microglia reactivity. toxicity and microglia reactivity.D-GsMTx4 TFA prevented myocardial infarction in a mouse model of ischemia reperfusion and can be used to characterize the role of excitatory MSCs in normal physiology and pathology.
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4-6 weeks
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TargetMol | Inhibitor Hot
CB2 modulator 1
T10696666261-80-9In house
CB2 modulator 1 is a potent CB2 modulator. It can be used for the research for immune disorders, osteoporosis, inflammation, renal ischemia.
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6-8 weeks
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MEG hemisulfate
Mercaptoethylguanidine hemisulfate
T219673979-00-8In house
MEG hemisulfate (Mercaptoethylguanidine hemisulfate) acts as a highly potent and selective suppressor of inducible NO synthase (iNOS), demonstrating EC50 values of 11.5 μM for iNOS, 110 μM for ecNOS, and 60 μM for bNOS in tissue homogenates. It is notably effective as a peroxynitrite scavenger and blocks peroxynitrite-triggered oxidative mechanisms. Furthermore, this compound offers protective benefits across various experimental inflammation prototypes, such as ischemia reperfusion injury, hemorrhagic shock, periodontitis, inflammatory bowel disease, and both endotoxic and septic shock.
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Cronidipine
LF 2.0254, LF-20254, LF20254, LF 20254
T27087113759-50-5In house
Cronidipine (LF 20254), a calcium channel antagonist, is used potentially for the treatment of hypertension and myocardia ischemia.
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6-8weeks
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TargetMol
(Rac)-Modipafant
UK 74505, UK74505, UK-74505, Modipafant racemate
T28081122956-68-7In house
(Rac)-Modipafantis an orally available and selective platelet-activating factor receptor (PAFR) antagonist that inhibits PAF-induced aggregation of washed platelets in rabbits, and can be used to study arthritis and ischemia reperfusion (I R) in the superior mesenteric artery (SMA) of the rat.
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8-10 weeks
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Tirilazad mesylate
U-74006 mesylate, U74006 mesylate, U 74006 mesylate, U 74006F mesylate, U-74006F mesylate, U74006F mesylate
T28978110101-67-2In house
Tirilazad mesylate (U 74006F) is a non-glucocorticoid, lipid peroxidation inhibitor with antiviral and neuroprotective activities. It confines intracellular intramembranous foci, attenuates spinal cord injuries induced by trauma, stroke, and ischemia reperfusion injuries, inhibits toxins in dogs, and is used in the study of neurological disorders.
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7-10 days
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FK-330
LS-192510, FR-260330, FK330, FK 330
T31795442198-67-6In house
FK-330 (FR-260330) is a novel orally active inducible nitric oxide synthase inhibitor with potential anticancer and antitumor activity that prevents ischemia and reperfusion injury in rat liver transplantation.
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6-8 weeks
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Orotirelin
Orotireline, CG 3509
T3382462305-86-6In house
Orotirelin(CG 3509), a thyrotropin-releasing hormone analog, reversed pentobarbital-induced sleep time.Orotirelin may be beneficial in animals with focal cerebral ischemia.
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6-8weeks
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Raxofelast
IRFI016, IRFI-016, IRFI 016
T34268128232-14-4In house
Raxofelast (IRFI-016) is a hydrophilic, non-systemic, vitamin-like antioxidant that reduces ischemia-reperfusion injury in testis. Raxofelast is a good candidate compound for stopping oxidative stress after acute testicular torsion. Raxofelast has the potential to treat diabetic complications and atherosclerosis.
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6-8weeks
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Sinitrodil
ITF296, ITF-296, ITF 296
T34648143248-63-9In house
Sinitrodil (ITF-296) is a guanylate cyclase stimulant that may be used in the treatment of myocardial ischemia and angina pectoris.
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6-8weeks
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Protectin D1
NPD1, Neuroprotectin D1
T37379660430-03-5In house
Protectin D1 (Neuroprotectin D1) is a neuroprotectin produced by neuronal cells and is a potential cardioprotective agent.Protectin D1 attenuates myocardial ischemia reperfusion injury and inhibits imiquimod-induced psoriasis-like skin inflammation by modulating the PI3K AKT signaling pathway.
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10-14 weeks
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Iodofiltic acid
T68088116754-87-1In house
Iodofiltic acid can be used in the adjuvant treatment of acute coronary syndromes (Zeus ACS) and can be imaged to detect myocardial ischemia.
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Tienoxolol FA
Tienoxolol FA (90055-97-3 Free base)
T68161L In house
Tienoxolol FA is a small molecule beta-adrenergic receptor antagonist used in the treatment of cardiovascular disease and in the study of hypertension and cardiac machine ischemia.
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FK-330 dihydrate
FR-260330 dihydrate
T68879682813-92-9In house
FK-330 dihydrate (FR-260330 dihydrate) is a novel and effective nitric oxide synthase inhibitor. It can prevent ischemia and reperfusion injury in rat liver transplantation.
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6-8 weeks
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BIIB 722 Mesylate
T83977261505-81-1In house
BIIB 722 Mesylate is a selective sodium-hydrogen exchange inhibitor with cardioprotective properties and can be used to study myocardial ischemia and myocardial infarction.
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LUF6096
CF-602
T91801116652-18-6In house
LUF6096 (CF-602) is a potent allosteric enhancer of the adenosine A3 receptor, exhibiting the capability to enhance agonist binding allosterically while demonstrating low orthosteric affinity across adenosine receptors. It displays protective effects in myocardial ischemia reperfusion injury.
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Azilsartan
TAK-536
T1057147403-03-0
Azilsartan (TAK-536) is an Angiotensin 2 Receptor Blocker that acts as an Angiotensin 2 Type 1 Receptor Antagonist, leading to a physiologic effect of decreased blood pressure.
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Minocycline hydrochloride
Minocycline HCl
T110113614-98-7
Minocycline hydrochloride (Minocycline HCl) is a tetracycline antibiotic with excellent absorption and tissue penetration that is used for several bacterial infections as well as treatment of acne. Minocycline hydrochloride can cause both an acute hepatitis-like syndrome occurring within 1 to 3 months of starting therapy or a more insidious chronic hepatitis with autoimmune features typically after long-term treatment.
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Citicoline sodium
Citicoline sodium salt, CDP-choline
T120833818-15-4
Citicoline sodium (CDP-choline) is an endogenous intermediate in the synthesis of phosphatidylcholine. It also serves as a choline donor in the biosynthesis of the neurotransmitter acetylcholine. Citicoline sodium demonstrates protective effects in cerebral ischemia, traumatic brain injury, and memory disorders. Exogenous administration of citicoline to rodents (500 mg kg i.p. immediately after ischemia and at 3-h reperfusion) has been shown to stimulate the synthesis of phosphatidylcholine, sphingomyelin, and cardiolipin and to attenuate the release of arachidonic acid and the accumulation of ceramide.
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Montelukast sodium
MK0476
T1677L151767-02-1
Montelukast sodium (MK0476) is an orally available leukotriene receptor antagonist which is widely used for the prophylaxis and chronic treatment of asthma and has been linked to rare cases of clinically apparent liver injury.
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Sesamin
Fsesamin
T2919607-80-7
Sesamin is a selective delta 5 desaturase inhibitor in the biosynthesis of polyunsaturated fatty acids and is a lignan abundantly present in sesame oil. It has potent neuroprotective effects against cerebral ischemia.
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