immunological

CL097 is an effective agonist of TLR7 and TLR8. CL097 induces pro-inflammatory cytokines in macrophages and NADPH oxidase priming, thereby increasing the fMLF-stimulated ROS production.

Lipid A-11 is a lipid component of endotoxin that is primarily responsible for the toxic properties of gram-negative bacteria. Lipid A-11 constitutes the innermost region of the lipopolysaccharide (LPS) molecule, also known as endotoxin, and its hydrophobic nature facilitates anchoring of the LPS structure into the bacterial outer membrane. Lipid A-11 plays a critical role in host-pathogen interactions, contributing to septic shock and immunological activation during bacterial infections.

4-Hydroxy-3-Nitrophenyl Acetate-KLH is a hapten-protein conjugate serving as a carrier protein for immunological studies. 4-Hydroxy-3-Nitrophenyl Acetate-KLH facilitates the generation of hapten-specific immune responses and is frequently employed to investigate antibody production, antigen presentation, and immune system activation mechanisms.

Sodium Hydrogen Sulfide (hydrate) is, like nitric oxide, an important gaseous mediator that has significant effects on the immunological, neurological, cardiovascular and pulmonary systems of mammals. Sodium Hydrogen Sulfide (hydrate) is an H2S donor commonly used in cellular and whole animal experimental systems. For example, it has been used to suggest that H2S promotes neutrophil migration, reduces airway inflammation, and protects neurites, heart, and intestine from chemical or ischemic-reperfusion damage.

Tyramine hydrochloride is a biogenic trace amine that is generated via the decarboxylation of the amino acid tyrosine, exhibiting neuromodulatory properties as well as cardiovascular and immunological effects.

Tacalcitol (1,24(R)-Dihydroxyvitamin D3; 1.alpha.,24R-Dihydroxyvitamin D3) promotes normal bone development by regulating calcium and modulates immunological and inflammatory processes.

SM360320 (CL-087) is an effective and selective agonist of TLR7. SM360320 inhibits HCV replication in hepatocytes via a type I IFN-independent mechanism in addition to its IFN-mediated activity. SM360320 can be used for research on acting as an immunological adjuv

RC529-MDP is an immunological adjuvant that couples Toll-like receptors (TLR4a) and NOD-like receptors (NOD2a) to enhance the innate immune response through the TLR4 and NOD2 signaling pathways. In mouse models, RC529-MDP induces high levels of the cytokine interleukin-related factor (IL-6), highlighting its immunostimulatory activity. Additionally, when injected into mice models with ovalbumin (OVA), RC529-MDP elevates OVA-specific antibody responses, T cell responses, and the proportion of memory T cells.

AYK004-C1 is a TLR agonist used in the formulation of immunological adjuvants.

Monophosphoryl lipid A (free acid) acts as an agonist for toll-like receptor 4. It is employed in immunological and vaccine research.

AYK004-B1, a TLR7 agonist (EC50=0.2265 nM), can be utilized in the formulation of immunological adjuvants.

Dihydrotestosterone-KLH is a hapten-carrier protein conjugate formed by coupling Dihydrotestosterone (DHT) to keyhole limpet hemocyanin (KLH). As a hapten, Diethylstilbestrol alone cannot induce an immune response and must be conjugated to a large molecular protein to become a complete antigen with immunogenicity. Dihydrotestosterone-KLH may be supplied as a lyophilized powder or as a solution. The solution is prepared in 0.01 M TBS (pH 7.4) buffer at a typical concentration of 1 mg/mL.

Human Immunoglobulin G (Human IgG) is an immunoglobulin that provides protective and antigen-neutralising functions in humoral immunity, suitable for immunological and inflammatory studies.

11β-HSD2-IN-1 (compound CDSN) serves as a potent inhibitor of 11β-HSD2, effectively hindering this enzyme from metabolizing Cholestane-3β,5α,6β-triol (CT) into carcinogenic androstenedione within cells. By inhibiting testosterone biosynthesis, 11β-HSD2-IN-1 suppresses the proliferation of MCF-7 cells. Additionally, this compound exhibits immunological activity and offers protection against viral infections.

FAZ-3532 is a potent G3BP inhibitor that binds to G3BP1 with a dissociation constant (Kd) of 0.54 μM, inhibiting the co-condensation of G3BP1, Caprin1, and RNA, and preventing the formation of intracellular stress granules. It selectively targets the protein-protein interactions within the G3BP1 NTF2L domain without affecting its dimerization or RNA binding, making it an effective tool for studying the immunological role of stress granules during viral infections.

Enpp-1-IN-29 (Compound 1) is a highly selective inhibitor of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) with an IC50 of 0.05 nM. This compound shows potential for research into cancers with overexpressed ENPP1, such as breast cancer, head and neck cancer, and metastatic chromosomal instability tumors, as well as immunological disorders like autoimmune diseases and tumor immune evasion.

Allotrap 2702 is a peptide that can extend the survival time of grafts and is applicable for use in immunological research.

LAG-3-IN-2 (Compound LG-17) is an inhibitor of LAG-3, suitable for use in immunological research.

Butixocort propionate (JO 1222) is a potent glucocorticoid receptor agonist, categorized as a corticosteroid. It possesses anti-inflammatory properties and is applicable for research in inflammatory, immunological, and metabolic disorders such as asthma and arthritis.

PROTACHPK1 Degrader-7 (compound D02) is a potent and selective PROTACHPK1 degrader with a DC50 of 3.07 nM, showing selectivity for GLK. It induces HPK1 degradation in a CRBN and proteasome-dependent manner. Additionally, PROTACHPK1 Degrader-7 inhibits the phosphorylation of SLP-76 and stimulates the secretion of IL-2 and IFN-γ by human primary T cells, making it useful for immunological research.

Ginkgolide A (BN-52020) is a highly active PAF antagonist cage molecule isolated from Ginkgo biloba leaves, showing potential in various inflammatory and immunological disorders.

N-Retinoylleucine has less toxicity and has similar immunological effects as retinoic acid.

Dehydro warfarin, a metabolite of (±)-warfarin, is formed by rat liver microsomes from (±)-warfarin.

1,3,4,6-Tetra-O-acetyl-2-azido-2-deoxy-α-D-mannopyranose is an analog of N-acetylmannosamine (ManNAc) and a building block. It has been used as a precursor in the synthesis of differently substituted trimers of the group A [N. meningitidis] capsular polysaccharide repeating unit for immunological experiments. It has also been used in the synthesis of fluorescent probes for lysosomal labeling.