h3n2

Ketotifen fumarate (HC 20511 fumarate) is a cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators.

Laninamivir octanoate (CS-8958) is a long acting influenza neuraminidase (NA) inhibitor which shows superior anti-influenza virus activity.

3M-011, a potent dual toll-like receptor TLR7/8 agonist and cytokine inducer, serves as a powerful adjuvant to radiotherapy, eliciting significant local and systemic immune responses. Additionally, it effectively inhibits H3N2 influenza viral replication in the nasal cavity and exhibits strong antitumor activity[1][2][3].

Anti-Flu A (H3N2) HA/Hemagglutinin Antibody (CR8043) is an antibody targeting Flu A HA/Hemagglutinin and can be used for infectious disease research.

Anti-Flu A (H3N2) HA/Hemagglutinin Antibody (C05) is an antibody targeting Flu A HA/Hemagglutinin and can be used for infectious disease research.

Oseltamivir phosphate (GS 4104) is a neuraminidase (NA) inhibitor with oral activity. Oseltamivir phosphate has antiviral activity and is effective against a wide range of influenza viruses, inhibiting mature influenza viruses from breaking away from host cells.

VNT-101 is an orally active influenza A virus (IAV) inhibitor with potent antiviral activity against multiple influenza A virus subtypes.

Influenza A virus-IN-1, a dihydropyrrolidones derivative, is a highly effective inhibitor of various subtypes of influenza A virus (IAV) with IC 50 values ranging from 3.11 μM to 7.13 μM. It effectively suppresses IAV replication and enhances the expression of key antiviral cytokines, such as IFN-β, and the antiviral protein MxA.

1. Dendrobine has a slight but demonstrable analgesic and antipyretic action. 2. Dendrobine produces moderate hyperglycemia, diminishes cardiac activity in large doses, lowers the blood pressure. 3. Dendrobine on the electrical activity and on amino acid-induced depolarizations of primary afferent terminals were tested on the frog isolated spinal cord.

3-Deoxysappanchalcone is an effective HO-1 inducer at the translational level.

DPQ is an antiviral compound. DPQ has also been shown to bind to a widened RNA major groove at the internal loop. DPQ acts against the H1N1 and H3N2 strains of influenza A as well as influenza B.

ATV03 is an antiviral agent exhibiting potent activity against both type A and type B influenza viruses. It inhibits the type A (H3N2) and type B influenza viruses with EC50 values of 0.78 nM and 2.02 nM, respectively. The mechanism of action of ATV03 involves the inhibition of the polymerase acidic protein (PA) and RNA-dependent RNA polymerase (RdRp), as well as the disruption of nucleoprotein, thereby exerting its antiviral effects against influenza.

Neuraminidase-IN-23 (33c) is a potent inhibitor of the neuraminidase enzyme (NA) targeted against influenza viruses. It exhibits inhibitory concentration (IC50) values of 0.049 μM for H1N1, 0.26 μM for H3N2, 0.17 μM for H5N1, 0.013 μM for H5N8, and 0.74 μM for H5N1-H274Y.

ATV2301 is an orally potent anti-influenza compound with an EC50 of 1.88 nM for H1N1 and 4.77 nM for H3N2. Its anti-influenza activity results from its impact on polymerase acidic protein (PA), nucleoprotein (NP), and RNA-dependent RNA polymerase (RdRp).

Anti-Influenza agent 10 (Compound 41) is an inhibitor of the RNA-dependent RNA polymerase (RdRp) of the influenza A virus. It shows potent antiviral activity against the A/PR/8/34(H1N1) strain, with an IC50 of 0.29 μM and a KD of 4.11 μM. The compound functions by disrupting the interaction between the PA and PB1 subunits, inhibiting the assembly of the viral RdRp complex, and thereby blocking transcription and replication of the viral genome. Anti-Influenza agent 10 also demonstrates significant broad-spectrum efficacy against various influenza strains, such as H3N2, H3N8, and H9N2, with IC50 values of 3.96, 1.91, and 1.45 μM, respectively. It is useful for research on influenza A virus infections.

Influenza A virus-IN-17 (Compound 6a) is a potent inhibitor of the influenza A virus, exhibiting EC90 values of 3.5 μM and 2.6 μM against H3N2 and H1N1 strains, respectively. It also inhibits U2-PB2 chimeric mRNA with an EC90 for cap-snatching polymerase of 2.1 μM.

PB2-IN-2 is an orally active PB2 inhibitor with RNP inhibitory activity (IC50) of 0.2 nM, cellular level replication inhibition activity (LRAEC50) of 0.8 nM, and cytopathic effect inhibition activity (CPEEC50) of 0.1 nM. It demonstrates nanomolar range broad-spectrum antiviral efficacy against various influenza A strains, including H1N1pdm09, Lyon/1337/2007/H1N1, Tex12-Like/H3N2, PR/8/34/H1N1, WSN/1933/H1N1, and rPR8(H1N1)/H7N9, with EC50 values of 1.5, 3.6, 3.7, 13.8, 2.9, and 9.8 nM, respectively, and CC50 values all greater than 2 μM. PB2-IN-2 also shows excellent metabolic stability and pharmacokinetic properties, making it suitable for influenza research.

Methyl brevifolincarboxylate (Brevifolincarboxylic acid methyl ester) is a potent influenza virus PB2 cap-binding inhibitor, exhibiting inhibitory activity against influenza virus A/Puerto Rico/8/34 (H1N1) and A/Aichi/2/68 (H3N2) with IC50s of 27.16 μM and 33.41 μM, respectively, and possessing anti-oxidant activity[1][2].

Pyrindolol is a bacterial metabolite that has been found inS. alboverticillatus.1It inhibits neutral β-galactosidase by 50% under acidic, but not neutral, conditions when used at a concentration of 2 μg/ml. It is selective for β-galactosidase isolated from bovine liver over β-galactosidases isolated from human, bovine, pig, and rat tissues and sialidases isolated fromC. perfringens,Streptomyces, and the H3N2 strain of influenza virus (IC50s = >250 μg/ml for all).1,2 1.Aoyagi, T., Kumagai, M., Hazato, T., et al.Pyridindolol, a new β-galactosidase inhibitor produced by actinomycetesJ. Antibiot. (Tokyo)28(7)555-557(1975) 2.Kumagai, M., Aoyagi, T., and Umezawa, H.Inhibitory activity of pyridindolol on β-galactosidaseJ. Antibiot. (Tokyo)29(7)696-703(1976)

Aureonitol is a fungal metabolite that has been found inChaetomiumand has antiviral activity.1It inhibits replication of the influenza A subtype H3N2 with an EC50value of 30 nM at a multiplicity of infection (MOI) of 0.01. It also inhibits replication of laboratory-adapted and clinical isolates of H3N2 (EC50s = 100 and 312 nM, respectively), as well as clinical isolates of the influenza A subtype H1N1 (EC50= 417 nM). Aureonitol inhibits hemagglutination activity of H3N2 and H1N1. 1.Sacramento, C.Q., Marttorelli, A., Fintelman-Rodrigues, N., et al.Aureonitol, a fungi-derived tetrahydrofuran, inhibits influenza replication by targeting its surface glycoprotein hemagglutininPLoS One10(10)e0139236(2015)

Oseltamivir (GS 4104) is an orally active and highly potent viral neuraminidase (NA) with antiviral activity, inhibits A/H3N2, A/H1N2, A/H1N1 and influenza B viruses, and can be used in studies of influenza and pneumonia.

Anti-Influenza agent 3 (compound 11h) is a potent anti-influenza agent with low cytotoxicity for MDCK epithelial cells, inhibiting the M2 WT and S31N ion channel conductivity. It has an EC50 value of 3.29 μM for A/HK/68 (H3N2, M2-WT) and 2.45 μM for A/WSN/33 (H1N1, M2-S31N) strain [1].

HSP90-IN-14 (compound 4) is an effective Hsp90 inhibitor (Kd=0.26 μM). In MDCK cells, HSP90-IN-14 demonstrated anti-influenza virus activity with EC50 values of 2.6 μM against influenza A/H3N2, 3.9 μM against A/H1N1, and 17 μM against the B virus.

Influenza virus-IN-5 (Compound 5f) is an inhibitor of influenza virus hemagglutinin (HA) with an EC50 of 1 nM against the A/H3N2 virus.