Search Result

Search Results for " fibrinolysis "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T11668	IQB-782		Others
	IQB-782 shows a potent mucolytic-expectorant activity. IQB-782 is a cysteine derivative. IQB-782 has inhibition for thrombin activatable fibrinolysis inhibitor (TAFI), with an Ki(app) of 0.14 μM.		Others
T0949	Tranexamic acid	Amstat,Tranexamsaeure	Others
	Tranexamic acid (Amstat) is an Antifibrinolytic Agent. The physiologic effect of tranexamic acid is by means of Decreased Fibrinolysis.		Others
T70118	PSI-112
	PSI-112 is a fibrinolysis inhibitor.
T28842	SQ-24,798	SQ 24,798,SQ24,798
	SQ-24,798 is an inhibitor of the thrombin-activatable fibrinolysis and carboxypeptidase N (CPN).
T70652	SAR-104772
	SAR-104772 is a novel inhibitor of TAFIa (activated thrombin-activatable fibrinolysis inhibitor).
T71129	AZD6564
	AZD6564 is a fibrinolysis inhibitor which acts via interference of a protein-protein interaction.
T39551	S62798	S62798
	S62798 is a highly potent and selective compound that inhibits activated thrombin activatable fibrinolysis inhibitor (TAFIa) with an IC50 value of 6 mM.
T11100	DS-1040 Tosylate		Others
	DS-1040 Tosylate is an oral active, selective thrombolytic inhibitor with IC50s of 5.92 nM and 8.01 nM for human and rat TAFIa, is an orally active, selective inhibitor of activated thrombin-activatable fibrinolysis inhi...		Others
T71851	5-trans-Prostaglandin E2
	5-trans-Prostaglandin E2 accelerates fibrinolysis by enhancing plasminogen activation mediated by tissue-type plasminogen activator. It also inhibits platelet aggregation in human PRP.
T82286	Glycylglycylcysteine
	Glycylglycylcysteine is an inhibitor of Thrombin Activatable Fibrinolysis Inhibitor (TAFI), exhibiting a K_i value of 0.99 µM and an IC_50 of 9.4 µM in TAFI substrate assays. TAFI, a basic carboxypeptidase, hinders fibri...
T82526	Drotrecogin alfa (activated)
	Drotrecogin alfa (activated) (DrotAA), a recombinant human activated protein C (APC), mitigates smoke-induced elevations in pulmonary microvascular permeability and proinflammatory cytokine IL-1β levels in rats. It also ...
T72113	6-Aminocaproic acid hydrochloride	EACA hydrochloride,EACA hydrochloride ; Epsilon-Amino-n-caproic Acid hydrochloride ; 6-Aminohexanoic acid hydrochloride,6-Aminohexanoic acid hydrochloride,Epsilon-Amino-n-caproic Acid hydrochloride
	6-Aminocaproic acid hydrochloride, a monoamino carboxylic acid derivative, serves as a potent, orally active antifibrinolytic agent by inhibiting plasmin and plasminogen. It functions through competitive binding to lysin...

Compounds

Synonym: Amstat,Tranexamsaeure

Synonym: SQ 24,798,SQ24,798

5-trans-Prostaglandin E2

Drotrecogin alfa (activated)

T82526

Synonym:

Target:

6-Aminocaproic acid hydrochloride

T72113

Synonym: EACA hydrochloride,EACA hydrochloride ; Epsilon-Amino-n-caproic Acid hydrochloride ; 6-Aminohexanoic acid hydrochloride,6-Aminohexanoic acid hydrochloride,Epsilon-Amino-n-caproic Acid hydrochloride

Target:

Cat No.	Product Name	Synonyms	Targets
T0881	6-Aminocaproic acid	EACA,6-Aminohexanoic acid,Epsilon-Amino-n-caproic Acid,(6-)ε-Aminocaproic acid	Others
	6-Aminocaproic acid (EACA) is an antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties.		Others

Natural Products

6-Aminocaproic acid

T0881

Synonym: EACA,6-Aminohexanoic acid,Epsilon-Amino-n-caproic Acid,(6-)ε-Aminocaproic acid

Target: Others

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPJ-00649	CPB2 Protein, Human, Recombinant (His)	Human	Human Cells
	Carboxypeptidase B2 (CPB2) is a secreted enzyme that belongs to the peptidase M14 family. CPB2 is synthesized by the liver and circulates in the plasma as a plasminogen-bound zymogen by the liver and circulates in the pl...
TMPY-02785	Tetranectin Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Tetranectin (TN), also known as C-type lectin domain family 3, member B (CLEC3B) is a member of the C-type lectin Family. It is plasminogen kringle 4 binding protein and regulates fibrinolysis and proteolytic processes v...
TMPY-00979	HRG/HPRG Protein, Human, Recombinant (His)	Human	HEK293
	Histidine-rich glycoprotein, also known as HRG and HPRG, is a glycoprotein located in plasma and platelets and contains an unusually large amount of histidine and proline. In humans, five distinct domains are recognized ...
TMPY-00904	Urokinase/uPA Protein, Human, Recombinant (His)	Human	HEK293
	Plasminogen activator, urokinase, also known as PLAU and uPA, is a serine protease which converts plasminogen to plasmin, a broad-spectrum protease active on extracellular matrix (ECM) components. It is involved in compl...
TMPY-01474	PAI-1 Protein, Human, Recombinant (His)	Human	HEK293
	Plasminogen activator inhibitor 1, also known as PAI-1, Endothelial plasminogen activator inhibitor, SerpinE1 and PLANH1, is a secreted glycoprotein that belongs to the serpin family. SerpinE1 is the primary physiologica...
TMPY-02505	Carboxypeptidase B2 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Carboxypeptidase B2, also known as Carboxypeptidase U, Thrombin-activable fibrinolysis inhibitor, Plasma carboxypeptidase B, CPB2, is a secreted protein which belongs to the peptidase M14 family. Carboxypeptidases are en...
TMPY-04490	Carboxypeptidase B2 Protein, Rat, Recombinant (His)	Rat	HEK293
	Carboxypeptidase B2, also known as Carboxypeptidase U, Thrombin-activable fibrinolysis inhibitor, Plasma carboxypeptidase B, CPB2, is a secreted protein which belongs to the peptidase M14 family. Carboxypeptidases are en...
TMPJ-00302	Serpin F2 Protein, Mouse, Recombinant (hFc)	Mouse	Human Cells
	Alpha-2-antiplasmin, also called Serpin F2, is a serine protease inhibitor (serpin) responsible for inactivating plasmin, and an important enzyme participates in fibrinolysis and degradation of other proteins. In liver c...
TMPH-02408	SPI Protein, Lentinula edodes, Recombinant (His)	Lentinula edodes	E. coli
	Serine protease inhibitor. Active against beta-trypsin and alpha-chymotrypsin with dissociation constants of 0.35 nM and 40 nM respectively. Inhibits factor XIa, but not other enzymes involved in coagulation and fibrinol...
TMPY-01631	Carboxypeptidase B2 Protein, Human, Recombinant (His)	Human	HEK293
	Carboxypeptidase B2, also known as Carboxypeptidase U, Thrombin-activable fibrinolysis inhibitor, Plasma carboxypeptidase B, CPB2, is a secreted protein which belongs to the peptidase M14 family. Carboxypeptidases are en...
TMPH-03106	Coagulation factor XII Protein, Pig, Recombinant (His)	Sus scrofa (Pig)	E. coli
	Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, whic...
TMPJ-00625	Serpin E1 Protein, Mouse, Recombinant (His)	Mouse	Human Cells
	Plasminogen activator inhibitor-1 (serpin E1) is a serine protease inhibitor which belongs to the serpin family. Serpin E1 acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. I...
TMPJ-00857	Thrombomodulin Protein, Mouse, Recombinant (His)	Mouse	Human Cells
	Thrombomodulin is also known as CD141 antigen and blood dendritic cell antigen 3 (BDCA3), which is encoded by the THBD gene. The deduced amino acid sequence of mouse THBD predicts a signal peptide (aa 1 to 16) and a matu...
TMPH-01508	HABP2 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fib...
TMPY-01398	Alpha 2 Antiplasmin/SerpinF2 Protein, Human, Recombinant (His)	Human	HEK293
	SerpinF2, also known as alpha-2 antiplasmin (alpha-2 AP), is a member of the Serpin superfamily. SerpinF2 is the principal physiological inhibitor of serine protease plasmin, and as well as, an efficient inhibitor of try...
TMPY-01026	Alpha 2 Antiplasmin/SerpinF2 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	SerpinF2, also known as alpha-2 antiplasmin (alpha-2 AP), is a member of the Serpin superfamily. SerpinF2 is the principal physiological inhibitor of serine protease plasmin, and as well as, an efficient inhibitor of try...
TMPY-01718	Serpin B12 Protein, Mouse, Recombinant (His)	Mouse	Baculovirus-Insect Cells
	Serpins are the largest and most diverse family of serine protease inhibitors which are involved in some fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesis, infl...
TMPY-04860	Alpha 2 Antiplasmin/SerpinF2 Protein, Rat, Recombinant (His)	Rat	HEK293
	SerpinF2, also known as alpha-2 antiplasmin (alpha-2 AP), is a member of the Serpin superfamily. SerpinF2 is the principal physiological inhibitor of serine protease plasmin, and as well as, an efficient inhibitor of try...
TMPY-01363	Serpin A11 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Serpins are the largest and most diverse family of serine protease inhibitors which are involved in a number of fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesi...
TMPJ-01282	Serpin B12 Protein, Human, Recombinant (His)	Human	Human Cells
	Serpin B12 is a member of the serpin family. Serpins are the largest and most diverse family of serine protease inhibitors. Most serpins are secreted and attain physiologic concentrations in the blood and extracellular f...
TMPJ-00472	Vitronectin Protein, Human, Recombinant (Truncated, His)	Human	Human Cells
	Vitronectin, also known as VTN, is a large glycoprotein found in blood and the extracellular matrix (ECM). Vitronectin is a plasma glycoprotein implicated as a regulator of diverse physiological process, including blood ...
TMPH-02833	PAI-1 Protein, Mouse, Recombinant (His)	Mouse	Yeast
	Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-reg...
TMPH-02834	PAI-1 Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-reg...
TMPJ-01116	HABP2 Protein, Human, Recombinant (His)	Human	Human Cells
	Hyaluronan-binding protein 2（HABP2） is an extracellular serine protease which binds hyaluronic acid. It secreted as an inactive single-chain precursor and is then activated to a heterodimeric form, which consists of a 50...
TMPY-01841	Serpin I2 Protein, Human, Recombinant (His)	Human	HEK293
	Serpins are the largest and most diverse family of serine protease inhibitors which are involved in some fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesis, infl...
TMPJ-01064	Serpin G1 Protein, Mouse, Recombinant (His)	Mouse	Human Cells
	SERPIN G1 is a member of the serpin family, The C-terminal serpin domain is similar to other serpins, and this part of C1-INH provides the inhibitory activity. SERPIN G1 is involved in the inhibition of the complement sy...
TMPY-02140	Tetranectin Protein, Human, Recombinant (His)	Human	HEK293
	Tetranectin (TN), also known as C-type lectin domain family 3, member B (CLEC3B) is a member of the C-type lectin Family. It is plasminogen kringle 4 binding protein and regulates fibrinolysis and proteolytic processes v...
TMPY-01551	Serpin B8 Protein, Mouse, Recombinant (His)	Mouse	Baculovirus-Insect Cells
	Serpins are the largest and most diverse family of serine protease inhibitors which are involved in a number of fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesi...
TMPY-00121	Vitronectin Protein, Human, Recombinant (His)	Human	HEK293
	Vitronectin, also known as VTN, is a member of the pexin family. It is an abundant glycoprotein found in serum the extracellular matrix and promotes cell adhesion and spreading. Vitronectin is a secreted protein and exis...
TMPY-02504	Carboxypeptidase M Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Carboxypeptidase M, also known as CPM, is a membrane-bound arginine/lysine carboxypeptidase which is a member of the carboxypeptidases family. These enzymes remove C-terminal amino acids from peptides and proteins and ex...
TMPY-01313	Carboxypeptidase M Protein, Human, Recombinant (His)	Human	HEK293
	Carboxypeptidase M, also known as CPM, is a membrane-bound arginine/lysine carboxypeptidase which is a member of the carboxypeptidases family. These enzymes remove C-terminal amino acids from peptides and proteins and ex...
TMPJ-00332	TPA Protein, Human, Recombinant (His)	Human	Human Cells
	Tissue-type plasminogen activator (PLAT) is a protein that secreted into extracellular space. PLAT contains five domains: EGF-like domain, fibronectin type-I domain, 2 kringle domains and peptidase S1 domain. It belongs...
TMPJ-00502	Serpin G1 Protein, Human, Recombinant (His)	Human	Human Cells
	As protease inhibitors, serpins have an array of functions including regulating blood clotting, the complement pathway, extracellular matrix remodeling, and cell motility. Serpin G1 is a serine protease inhibitor protein...
TMPY-01589	Serpin B10 Protein, Mouse, Recombinant (His)	Mouse	Baculovirus-Insect Cells
	Serpins are the largest and most diverse family of serine protease inhibitors which are involved in a number of fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesi...
TMPY-01861	Vitronectin Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Vitronectin, also known as VTN, is a member of the pexin family. It is an abundant glycoprotein found in serum the extracellular matrix and promotes cell adhesion and spreading. Vitronectin is a secreted protein and exis...
TMPY-01711	Serpin B2 Protein, Human, Recombinant (GST)	Human	Baculovirus-Insect Cells
	Serpins are the largest and most diverse family of serine protease inhibitors which are involved in some fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesis, infl...
TMPH-00324	SVTLE Protein, Calloselasma rhodostoma, Recombinant (His)	Calloselasma rhodostoma	Yeast
	Thrombin-like snake venom serine protease that acts as an anticoagulant. It cleaves fibrinogen (FGA) to split off the A-fibrinopeptides (A, AY and AP), but not the B-fibrinopeptide. The resulting fibrin polymers are impe...
TMPY-01606	Kininogen 1 Protein, Mouse, Recombinant (His)	Mouse	HEK293
	Kininogen-1, also known as high molecular weight kininogen, Williams-Fitzgerald-Flaujeac factor, Alpha-2-thiol proteinase inhibitor, Fitzgerald factor, KNG1, and BDK, is a secreted protein that contains three cystatin do...
TMPY-01632	Serpin B4 Protein, Mouse, Recombinant (His)	Mouse	Baculovirus-Insect Cells
	Serpins are the largest and most diverse family of serine protease inhibitors which are involved in a number of fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesi...
TMPY-01598	Kininogen 1 Protein, Human, Recombinant (His)	Human	HEK293
	Kininogen-1, also known as high molecular weight kininogen, Williams-Fitzgerald-Flaujeac factor, Alpha-2-thiol proteinase inhibitor, Fitzgerald factor, KNG1, and BDK, is a secreted protein that contains three cystatin do...
TMPY-00938	TPA Protein, Human, Recombinant	Human	HEK293
	Tissue plasminogen activator (abbreviated tPA or PLAT), is traditionally viewed as a simple serine protease whose main function is to convert plasminogen into biologically active plasmin. As a protease, tPA plays a cruci...
TMPY-04788	HRG/HPRG Protein, Rat, Recombinant (His)	Rat	HEK293
	Histidine-rich glycoprotein, also known as HRG and HPRG, is a glycoprotein located in plasma and platelets and contains an unusually large amount of histidine and proline. In humans, five distinct domains are recognized ...
TMPY-00937	TPA Protein, Human, Recombinant (hFc)	Human	HEK293
	Tissue plasminogen activator (abbreviated tPA or PLAT), is traditionally viewed as a simple serine protease whose main function is to convert plasminogen into biologically active plasmin. As a protease, tPA plays a cruci...
TMPY-02898	TPA Protein, Mouse, Recombinant (hFc)	Mouse	HEK293
	Tissue plasminogen activator (abbreviated tPA or PLAT), is traditionally viewed as a simple serine protease whose main function is to convert plasminogen into biologically active plasmin. As a protease, tPA plays a cruci...
TMPY-02559	PAI-1 Protein, Rat, Recombinant (His)	Rat	HEK293
	Plasminogen activator inhibitor 1, also known as PAI-1, Endothelial plasminogen activator inhibitor, SerpinE1 and PLANH1, is a secreted glycoprotein that belongs to the serpin family. SerpinE1 is the primary physiologica...
TMPY-00629	PAI-1 Protein, Rat, Recombinant (hFc)	Rat	HEK293
	Plasminogen activator inhibitor 1, also known as PAI-1, Endothelial plasminogen activator inhibitor, SerpinE1 and PLANH1, is a secreted glycoprotein that belongs to the serpin family. SerpinE1 is the primary physiologica...
TMPY-04504	Urokinase/uPA Protein, Rat, Recombinant (His)	Rat	HEK293
	Plasminogen activator, urokinase, also known as PLAU and uPA, is a serine protease which converts plasminogen to plasmin, a broad-spectrum protease active on extracellular matrix (ECM) components. It is involved in compl...