delivery

SM-102 is the only ionizable amino cationic lipid currently clinically approved for RNA therapeutics and can be used to synthesize lipid nanoparticles (LNPs). It shows potential in the development of LNPs for the delivery of mRNA-based vaccines.

C12-200 is a benchmark ionizable cationic lipidoid along with helper lipids and can be used in the delivery of mRNA.

D-Lin-MC3-DMA, an ionizable cationic lipid, serves as a potent siRNA delivery vehicle.

5A2-SC8 is an ionizable cationic lipid that is an ideal vehicle for the delivery of small RNAs, interacts with negatively charged cell membranes, and can be used for gene delivery and drug delivery.

ATX-002 is a property-tunable lipid for RNA drug delivery.

PLGA (poly(lactic-co-glycolic acid)) is be used to fabricate devices for drug delivery and tissue engineering applications.

DODAP is an ionic cationic lipid with low cytotoxicity and high transfection efficiency that can be used to synthesize liposomes and encapsulate biologically active molecules such as mRNA, siRNA and plasmid DNA.

DLin-KC2-DMA is a cation that can be used for siRNA delivery and is also an ionizable lipid. DLinKC2-DMA can bind to LNP and enable siRNA-mediated GAPDH gene silencing.

DOPE (DOPE) is a neutral helper lipid for cationic liposomes.It is used in combination with cationic phospholipids to increase efficiency during DNA transfection studies as a non-viral method of gene delivery.

PEG(2000)-C-DMG is a polyethylene glycolated derivative of 1,2-Dimyristoyl-sn-glycerol and can be combined with other lipids to form lipid nanoparticles (LNP) for siRNA delivery.

NT1-O12B, an endogenous neurotransmitter-derived lipidoid (NT-lipidoid), serves as a highly efficient carrier for enhancing the transportation of various blood-brain barrier (BBB)-impermeable cargos to the brain. Incorporating NT1-O12B into BBB-impermeable lipid nanoparticles (LNPs) enables these LNPs to effectively traverse the BBB. In addition to enabling cargo passage through the BBB, NT-lipidoid formulations facilitate efficient delivery of the cargo into neuronal cells for purposes such as functional gene silencing or gene recombination[1].

93-O17S is a chalcogen-containing cationic lipidoid. It has been used in the synthesis of lipid nanoparticles (LPNs) for the delivery of Cre recombinase and ribonucleoproteins for genome editing in mice. LPNs containing 93-O17S have been utilized for the intratumoral delivery of cGAMP to enhance cross-presentation of tumor antigens and stimulation of interferon genes [STING] activation in a B16 F10 murine melanoma model.

5-PA-dUTP (5-Propargylamino-dUTP) is a modified nucleotide with a C5 modification, designed for incorporation into DNA nanoparticles (DNPs) to facilitate efficient delivery of photosensitizers.

Lipid 5, an amino lipid compound, demonstrates proficient mRNA delivery in rodent and primate models, with favorable pharmacokinetics and minimal toxicity.

BAMEAO16B is a lipid nanoparticle that incorporates disulfide bonds for efficient delivery of Cas9 mRNA and sgRNA into cells. In the intracellular environment, BAMEAO16B responds to reduction by releasing RNA, facilitating genome editing. This compound is valuable for gene editing research purposes.

24:0 Lyso PC, a lysophospholipid (LyP), has potential applications in mRNA drug delivery.

1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol sodium, catalog number T67435 and CAS number 200880-42-8, is a valuable organic compound for life sciences research.

(Rac)-DSPG sodium ((Rac)-1,2-Distearoyl-sn-Glycero-3-Phosphatidylglycerol sodium) is a derivative of phosphatidylglycerol, which, as an amphiphilic molecule, is commonly used in the study of drug delivery and biofilm research.

CLinDMA, a cationic lipid, is known to induce an inflammatory response and serves as a precursor in the synthesis of LNP201, a liposome assembly designed for the systemic delivery of siRNA [1].

98N12-5, a novel multi-tail ionizable lipid, demonstrates efficient in vivo siRNA delivery to the liver.

7-Oxotridecanedioic acid, a biodegradable cationic lipid intermediate, facilitates the formation of lipid nanoparticles. This compound enables the incorporation into lipid particles for the efficient delivery of active agents [1].

DSPE-PEG Carboxylic Acid Sodium (MW 2000), a PEG-lipid, facilitates the formation of micelle nanoparticles for drug delivery and extends the blood circulation time of liposomes [1].

6-Oxohexyl 2-hexyldecanoate is a lipid product utilized for drug delivery [1].

DSPE-mPEG-2000, a PEG-based phospholipid, facilitates the synthesis of liposomes for cancer agent delivery [1] [2].