delivery

SM-102 is the only ionizable amino cationic lipid currently clinically approved for RNA therapeutics and can be used to synthesize lipid nanoparticles (LNPs). It shows potential in the development of LNPs for the delivery of mRNA-based vaccines.

C12-200 is a benchmark ionizable cationic lipidoid along with helper lipids and can be used in the delivery of mRNA.

D-Lin-MC3-DMA, an ionizable cationic lipid, serves as a potent siRNA delivery vehicle.

5A2-SC8 is an ionizable cationic lipid that is an ideal vehicle for the delivery of small RNAs, interacts with negatively charged cell membranes, and can be used for gene delivery and drug delivery.

ATX-002 is a property-tunable lipid for RNA drug delivery.

PLGA (poly(lactic-co-glycolic acid)) is be used to fabricate devices for drug delivery and tissue engineering applications.

DODAP is an ionic cationic lipid with low cytotoxicity and high transfection efficiency that can be used to synthesize liposomes and encapsulate biologically active molecules such as mRNA, siRNA and plasmid DNA.

4-Vinylcyclohexene Dioxide is a reactive epoxide monomer for thermosetting/thermoplastic polymer production via ring-opening polymerization, used in industrial coatings, automotive/aerospace adhesives, and fiber-reinforced composites, with biomedical applications in drug delivery and tissue engineering due to its biocompatibility.

7-Oxotridecanedioic Acid is a biodegradable cationic lipid intermediate for formulating active-agent-loaded lipid nanoparticles.

Witepsol can be utilized as a selective lipid carrier in drug delivery systems.

Human Serum Albumin (HSA) is the most abundant protein in human plasma, is produced in the liver and is water soluble, with a molecular weight of 66.5 kDa. HSA inhibits Alzheimer's disease by selectively binding to cross-structured A oligomers. HSA is a key endogenous inhibitor of amyloid-β (Αβ) aggregation. HSA is used as a carrier protein in cell culture for the transport of fatty acids, steroids, and thyroid hormones and to regulate osmolality of the blood, and is also used in drug delivery studies, immunoassays, and cell freezing. cell freezing.

Hexanoic anhydride is a reactive chemical compound utilized as a key reactant in the synthetic pathway for acremomannolipin A. Applied in the green synthesis of acyclovir ester prodrugs to enhance bioavailability, and employed in the preparation of hexanoyl-modified chitosan nanoparticles through N-acylation reactions to create chitosan-based polymeric surfactants and drug delivery systems.

DOTAP chloride (1, 2-dioleoyl-3-trimethylammonium-propane chloride) is an efficient cationic lipid, and its target is mainly the negatively charged components on the cell membrane. DOTAP chloride binds to negatively charged nucleic acids (such as DNA and RNA) by electrostatic interaction to form complexes, thereby achieving the delivery of nucleic acids.

DLin-KC2-DMA is a cation that can be used for siRNA delivery and is also an ionizable lipid. DLinKC2-DMA can bind to LNP and enable siRNA-mediated GAPDH gene silencing.

DOPE (DOPE) is a neutral helper lipid for cationic liposomes.It is used in combination with cationic phospholipids to increase efficiency during DNA transfection studies as a non-viral method of gene delivery.

PEG(2000)-C-DMG is a polyethylene glycolated derivative of 1,2-Dimyristoyl-sn-glycerol and can be combined with other lipids to form lipid nanoparticles (LNP) for siRNA delivery.

DSPE-PEG-OH (MW 6000) is a phospholipid with a hydroxyl-terminated PEG chain. Its hydrophobic tail facilitates the encapsulation and aggregation of other hydrophobic drugs, while the hydroxyl end allows for further chemical reactions. DSPE-PEG-OH (MW 6000) can be utilized to prepare liposomes or lipid nanoparticles, offering potential applications in drug delivery studies and enhancing drug absorption research.

DSPE-PEG-OH (MW 10000) is a hydroxyl-terminated PEGylated phospholipid, with its hydrophobic tail enabling the encapsulation and aggregation of other hydrophobic drugs, while the hydroxyl end allows for further reaction. This compound can be used to prepare liposomes or lipid nanoparticles, which are valuable for research in drug delivery and enhancing drug absorption.

DSPE-PEG-OH (MW 8000) is a hydroxyl-terminated PEGylated phospholipid. Its hydrophobic tail facilitates the encapsulation and aggregation of other hydrophobic drugs, while the hydroxyl terminus allows for further reactions. DSPE-PEG-OH (MW 8000) can be used in the formulation of liposomes or lipid nanoparticles for research in drug delivery and enhancement of drug absorption.

DSPE-PEG-OH (MW 4000) is a hydroxy-terminated PEGylated phospholipid with a hydrophobic tail that enables the encapsulation and aggregation of other hydrophobic drugs. The hydroxyl end allows for further reactions. DSPE-PEG-OH (MW 4000) is suitable for the preparation of liposomes or lipid nanoparticles and can be used in studies related to drug delivery and absorption enhancement.

Lipid A-11 is a lipid component of endotoxin that is primarily responsible for the toxic properties of gram-negative bacteria. Lipid A-11 constitutes the innermost region of the lipopolysaccharide (LPS) molecule, also known as endotoxin, and its hydrophobic nature facilitates anchoring of the LPS structure into the bacterial outer membrane. Lipid A-11 plays a critical role in host-pathogen interactions, contributing to septic shock and immunological activation during bacterial infections.

18:1 PE (DOPE) pSar25 is a derivative of polyethylene glycol, suitable for use in liposome and lipid nanoparticle delivery systems.

NT1-O12B, an endogenous neurotransmitter-derived lipidoid (NT-lipidoid), serves as a highly efficient carrier for enhancing the transportation of various blood-brain barrier (BBB)-impermeable cargos to the brain. Incorporating NT1-O12B into BBB-impermeable lipid nanoparticles (LNPs) enables these LNPs to effectively traverse the BBB. In addition to enabling cargo passage through the BBB, NT-lipidoid formulations facilitate efficient delivery of the cargo into neuronal cells for purposes such as functional gene silencing or gene recombination[1].

93-O17S is a chalcogen-containing cationic lipidoid. It has been used in the synthesis of lipid nanoparticles (LPNs) for the delivery of Cre recombinase and ribonucleoproteins for genome editing in mice. LPNs containing 93-O17S have been utilized for the intratumoral delivery of cGAMP to enhance cross-presentation of tumor antigens and stimulation of interferon genes [STING] activation in a B16 F10 murine melanoma model.