d5 dopamine receptor

dopamine D1 receptor antagonist

SKF83959, a benzazepine analog, is a selective and potent partial agonist of the dopamine D1 receptor with Ki values of 1.18, 7.56, 920, and 399 nM for rat D1, D5, D2, and D3 receptors, respectively.SKF83959 is a potent variant modulator of the sigma (σ)-1 receptor, which ameliorates cognitive dysfunction for the study depression and Alzheimer's disease.

Nuciferine ((-)-Nuciferine) is an alkaloid found within the plants Nymphaea caerulea and Nelumbo nucifera. It has a profile of action associated with dopamine receptor blockade.

Ecopipam (UNII-0X748O646K) is a potent, selective, and orally active antagonist of dopamine D1 D5 receptors, with Kis of 1.2 nM and 2.0 nM, respectively. Ecopipam demonstrates more than 40-fold selectivity over D2, D4, 5-HT, and α2a receptors (Ki=0.98, 5.52, 0.08, and 0.73 μM, respectively). It is used in research on schizophrenia and obesity.

SCH-23390 hydrochloride (R-(+)-SCH23390 hydrochloride) is an effective dopamine receptor antagonist, with high affinity for the D1 (Ki=0.2 nM) and D5 (Ki=0.3 nM) receptors.

SKF 38393 hydrochloride (SKF38393 HCl) is a selective dopamine D1 D5 receptor agonist.

carfenazine targets the Dopamine receptor and is used for schizophrenia research.

Blonanserin D5 is a deuterium-labeled Blonanserin. Blonanserin (AD-5423) is a dopamine D2/5-HT2 receptor antagonist with an atypical antipsychotic effect.

SCH-23390 maleate (R-(+)-SCH-23390 maleate) is a potent and selective dopamine D1-like receptor antagonist, specifically targeting D1 and D5 receptors with Ki values of 0.2 nM and 0.3 nM, respectively.

Dihydrexidine is a full efficacy D1-like dopamine receptor (D1 D5) agonist (IC50: 10 nM for D1 receptor). It also shows potent antiparkinsonian activity.

Tavapadon (CVL-751) is an orally active and highly selective dopamine D1 D5 receptor partial agonist.

SCH-23390 is a dopamine D1-like receptor antagonist (with Ki values of 0.2 nM for the D1 receptor subtype and 0.3 nM for the D5 receptor subtype). It reduces the latency of lever pressing behavior induced by cocaine in rats. Additionally, SCH-23390 can eliminate generalized seizures triggered by the chemical convulsants pilocarpine and soman, making it useful for studies on neurodegenerative diseases related to the dopamine system.

Rotigotine Hydrochloride (N-0924), a dopamine receptor agonist prefering for D3 receptors over D1 and D2, has effective activity of anti-Parkinsonian. Racemic rotigotine hydrochloride is about 50 times as potent as quinpirole, the gold standard D2 agonist.

7-Hydroxy-DPAT hydrobromide is a selective D3 dopamine receptor agonist that blocks dopamine reuptake and inhibits sympathetic activation of BAT induced by cold exposure or direct activation of NMDA receptors, used in neurodegenerative disease research.

SKF 81297 hydrobromide is a selective agonist of the dopamine D1-like receptor, with a high affinity for both D1 and D5 subtypes (Ki = 1.9 nM). SKF 81297 hydrochloride exhibits central activity in vivo and is widely used to study the neuromodulatory effects of the dopamine system, particularly in studies related to cognitive function and motor activity, such as Parkinson's disease.

NGB 2904 is a potent and selective antagonist of dopamine D3 receptor (Ki values are 1.4, 217, 223, 642, > 5000, > 10000 and > 10000 nM for D3, D2, 5-HT2, α1, D4, D1 and D5 receptors respectively). NGB2904 potently antagonizes mitogenesis stimulated by quinpirole (IC50 = 6.8 nM).

A-381393 is a selective and brain penetrate dopamine D4 receptor antagonist (Kis: 1.9 1.5 1.6 nM for human dopamine D4.2 D4.4 D4.7 receptor).

Ecopipam (SCH 39166) hydrobromide is a highly potent, specific, and orally active dopamine D1 D5 receptor antagonist with K i values of 1.2 nM for D1 and 2.0 nM for D5 receptors. It shows over 40-fold greater selectivity for D1 D5 over D2, D4, 5-HT, and α2a receptors, with K i values of 0.98, 5.52, 0.08, and 0.73 μM, respectively, and is relevant for schizophrenia and obesity research.

DETQ, a selective, allosteric, and orally active potentiator of the dopamine D1 receptor (Dopamine Receptor), enhances cAMP production in HEK293 cells expressing the human D1 receptor, achieving an EC50 of 5.8 nM and a K b of 26 nM. It demonstrates approximately 30-fold reduced potency at rat and mouse D1 receptors and shows no activity at the human D5 receptor [1].

ABT-724 is an agonist of dopamine D4 receptor(EC50: 12.4 nM)

(-)-Apomorphine hydrochloride hydrate is a broad-spectrum dopamine agonist and ferroptosis inhibitor with affinity for all subtypes of dopamine D1 receptors of the D5 receptor. (-)-Apomorphine hydrochloride hydrate can be used to study mitochondrial diseases.

SKF-83566 is a blood-brain permeable and orally active antagonist of D1-like dopamine receptor and a weaker competitive 5-HT2 receptor antagonist with Ki of 11 nM

Sulpiride-d5 is a deuterated compound of Sulpiride. Sulpiride has a CAS number of 15676-16-1. Sulpiride is a dopamine D2-receptor antagonist, used therapeutically as an antidepressant, antipsychotic, and as a digestive aid.