d14:1

C2 Ceramide (d14:1/2:0) is a bioactive sphingolipid that, when administered dietarily at 100 μM, induces lipotoxic cardiomyopathy by increasing diastolic and systolic diameter, reducing fractional shortening, and decreasing the number of normal cardiac contractile events in Drosophila.

Sphingosine (d14:1) is a bioactive sphingolipid that has been found in B. mori (silkworm), P. clarkii (crayfish), and A. aurita (jellyfish) extracts. It increases the germination rate of N. rileyi, an entomopathogenic fungus, with an EC50 value of 10.2 nM. Sphingosine (d14:1) inhibits protein kinase C (PKC) in vitro (IC50 = 7.3 mol%) as well as superoxide generation induced by phorbol 12-myristate 13-acetate in neutrophils and reduces growth of CHO cells (IC50s = 19 and 8 μM, respectively).

Azido sphingosine (d14:1) is a clickable sphingolipid, suitable for use in click chemistry reactions.

NBD-14189 is a potent HIV-1 entry antagonist that acts against the HIV-1HXB2 pseudovirus (IC50: 89 nM). NBD-14189 binds to HIV-1 gp120 and exhibits a strong antiviral effect (EC50 < 200 nM).

LYP-IN-4 (compound D14), a reversible and selective lymphotyrosine phosphatase (LYP) inhibitor (Ki=1.34 μM, IC50=3.52μM), regulates TCR signaling, increases PD-1/PD-L1 expression, and strengthens anti-tumor immunity. It also stimulates T cell activation, impedes M2 macrophage polarization, and suppresses tumor progression in MC38 isogenic mouse models.

Probenecid-d14 is a deuterated form of Probenecid. Probenecid serves as a potent and selective agonist of the transient receptor potential vanilloid 2 (TRPV2) channel. Additionally, it acts as an inhibitor of pannexin 1 channels.