chelates

Magnesium glycinate (magnesium 2-aminoacetate) is a supplement that boost magnesium levels in people with a deficiency of the mineral. Magnesium is a vital nutrient for regulating many body processes, including muscle and nerve function, blood sugar levels, and blood pressure. This mineral also supports the making of protein, bone, and DNA.

Penicillamine (Artamine), possessing antineoplastic properties, induces apoptosis by a p53-mediated mechanism and inhibits angiogenesis by chelating with copper, a cofactor for angiogenesis. Artamine is a beta dimethyl analog of the amino acid cysteine. As a degradation product of penicillin antibiotics, Artamine chelates with heavy metals and increases their urinary excretion.

Diclofenac (Diclofenacum) is a nonsteroidal benzeneacetic acid derivative with anti-inflammatory activity. Diclofenac binds and chelates both isoforms of cyclooxygenase (COX-1 and-2), thereby blocking the conversion of arachidonic acid to pro-inflammatory-proprostaglandins.

Trisodium HEDTA (HEDTA-Na3) is a chelating agent that chelates sodium ions and acts as a chelating agent in cosmetic formulations.

Nocardamine is a ferrioxamine siderophore that has been found inStreptomycesand has diverse biological activities.1,2,3,4It chelates iron in a chrome azurol S assay (IC50= 9.9 μM).1Nocardamine inhibitsM. smegmatisandM. bovisbiofilm formation (MIC = 10 μM for both), an effect that can be reversed by iron.2It is cytotoxic to T47D, SK-MEL-5, SK-MEL-28, and RPMI-7951 cancer cells (IC50s = 6, 18, 12, and 14 μM, respectively).3Nocardamine also induces morphological changes in BM-N4 insect cells.4 1.Lopez, J.A.V., Nogawa, T., Futamura, Y., et al.Nocardamin glucuronide, a new member of the ferrioxamine siderophores isolated from the ascamycin-producing strain Streptomyces sp. 80H647J. Antibiot. (Tokyo)72(12)991-995(2019) 2.Ishida, S., Arai, M., Niikawa, H., et al.Inhibitory effect of cyclic trihydroxamate siderophore, desferrioxamine E, on the biofilm formation of Mycobacterium speciesBiol. Pharm. Bull.34(6)917-920(2011) 3.Kalinovskaya, N.I., Romaneko, L.A., Irisawa, T., et al.Marine isolate Citricoccus sp. KMM 3890 as a source of a cyclic siderophore nocardamine with antitumor activityMicrobiol. Res.166(8)654-661(2011) 4.Matsubara, K., Sakuda, S., Tanaka, M., et al.Morphological changes in insect BM-N4 cells induced by nocardamineBiosci. Biotechnol. Biochem.62(10)2049-2051(1998)

p-SCN-Bn-DOTA is a chelator that simultaneously binds radionuclides and links monoclonal antibodies. It is utilized as a tracer for radio-guided surgery and serves in radio-immunoassay studies of tumors.

AChE/BChE-IN-9 (Compound 7a) is a potent, orally active inhibitor of AChE and BChE, with IC50 values of 5.74 μM and 14.05 μM against hAChE and eqBChE, respectively. It also demonstrates effective antioxidant activity (IC50 = 57.35 μM), chelates iron, and modulates amyloid β 1-42 aggregation. Notably, AChE-IN-16 can cross the blood-brain barrier [1].

Pulcherriminic acid, a cyclic dipeptide antimicrobial compound predominantly found in Bacillus and yeast, exhibits a strong affinity for Fe3+. It chelates iron ions via a non-enzymatic reaction, forming the extracellular red pigment pulcherrimin. This pigment competes for iron nutrition, thereby exerting an antibacterial effect. Pulcherriminic acid holds significant potential for applications in the food, agriculture, and medical industries [1] [2].

Fmoc-D-Dap(Boc)-OH, an amino acid derivative featuring an Fmoc protecting group, is utilized in the synthesis of bioactive peptide mimetics, including DOTA-modified peptides and their metal chelates, which are noted for their cancer diagnostic capabilities.

Diclofenac-d4 is a deuterated compound of Diclofenac. Diclofenac has a CAS number of 15307-86-5. Diclofenac is a nonsteroidal benzeneacetic acid derivative with anti-inflammatory activity. Diclofenac binds and chelates both isoforms of cyclooxygenase (COX-1 and-2), thereby blocking the conversion of arachidonic acid to pro-inflammatory-proprostaglandins.

Diclofenac (Standard) is the standard substance of Diclofenac, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Diclofenac (Diclofenacum) is a nonsteroidal benzeneacetic acid derivative with anti-inflammatory activity. Diclofenac binds and chelates both isoforms of cyclooxygenase (COX-1 and-2), thereby blocking the conversion of arachidonic acid to pro-inflammatory-proprostaglandins.

Nicotianamine, an amino acid that chelates iron, facilitates the absorption of iron from the soil.

Ethylenediaminetetraacetic acid diammonium is an organic compound containing both ammonium and carboxylic acid functional groups. It is commonly employed as a chelating agent in a variety of industrial and medical applications, particularly within the food and pharmaceutical sectors. With strong metal ion binding properties, it chelates trace metals that might affect product quality or stability. Additionally, it serves as an anticoagulant in blood collection tubes and functions as a clarifying agent in cosmetics and personal care products.