cell-macrophage

Expression system: E. coli
Length: 29-151, Full Length of Mature Protein
Activity: Not Tested

Expression system: HEK293 Cells
Length: 17-294, Full Length of Mature Protein
Activity: Not Tested

Expression system: Baculovirus Insect Cells
Length: 1-325, Full Length
Activity: Not Tested

Expression system: E. coli
Length: 1-193, Full Length
Activity: Not Tested

Expression system: E. coli
Length: 23-354, Full Length of Mature Protein
Activity: Not Tested

Expression system: E. coli
Length: 1-226, Full Length
Activity: Not Tested

Expression system: Baculovirus Insect Cells
Length: 206-706, Partial
Activity: Not Tested

Expression system: E. coli
Length: 1-29, Partial
Activity: Not Tested

Expression system: E. coli
Length: 24-370, Full Length of Mature Protein
Activity: Not Tested

Expression system: E. coli
Length: 20-381, Full Length of Mature Protein
Activity: Not Tested

Expression system: E. coli
Length: 19-181, Extracellular Domain
Activity: Not Tested

Expression system: E. coli
Length: 21-89, Full Length of Mature Protein
Activity: Cell Activity

Expression system: E. coli
Length: 25-93, Full Length of Mature Protein
Activity: Cell Activity

Expression system: E. coli
Length: 24-92, Full Length of Mature Protein
Activity: Cell Activity

Expression system: E. coli
Length: 28-100, Full Length of Mature Protein
Activity: Not Tested

Expression system: HEK293 Cells
Length: 31-208, Full Length of Mature Protein
Activity: Not Tested

T cell immunoglobulin and mucin domain 3 is a member of the TIM family of immune regulating molecules. Mature cynomolgus TIM3 consists of a 182 amino acid (aa)extracellular domain (ECD), a 21 aa transmembrane segment, and a 78 aa cytoplasmic tail. TIM3 is up-regulated on several populations of activated myeloid cells (macrophage, monocyte, dendritic cell, microglia, mast cell) and T cells (Th1, CD8+, NK, Treg). Its binding to Galectin9 induces a range of immunosuppressive functions which enhance immune tolerance and inhibit anti-tumor immunity. TIM3 ligation attenuates CD8+ and Th1 cell responses and promotes the activity of Treg and myeloid derived suppressor cells. TIM3 interactions with Galectin-9 can trigger immune stimulatory effects, such as the coactivation of NK cell cytotoxicity.

Expression system: HEK293 Cells
Length: 33-255, Partial
Activity: Cell Activity

Surfactant Pulmonary-Associated Protein D (SP-D) is a 43 kDa member of the collectin family of innate immune modulators. Its principal components consist of a collagen-like region and a C-terminal carbohydrate recognition domain (CRD), a structure that places it in a subset of pattern recognition proteins termed defense collagens. SP-D is constitutively secreted by alveolar lining cells and epithelium associated with tubular structures and induced in cardiac smooth muscle and endothelial cells. It binds both secreted and transmembrane proteins that transduce its function. It binds human neutrophil defensins, modulating influenza anti-viral defense. It binds MD-2 LY96, a secreted protein that cooperates with Toll-like receptors (TLRs) in the response of macrophages to bacterial lipopolysaccharides (LPS) or cell wall components. It also binds macrophage CD14 and TLRs directly, blocking binding of LPS and down-regulating TNF-α secretion. SP-D binding of both SIRPα and the calreticulin CD91 complex on macrophages allows for a graded response to environmental challenge.

Hepatitis A virus cellular receptor 2(HAVCR2)is a single-pass type I membrane protein and it contains 1 Ig-like V-type (immunoglobulin-like) domain. The protein belongs to the immunoglobulin superfamily, and TIM family of proteins. The protein regulates macrophage activation. It inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. It may be also involved in T-cell homing and it is receptor for LGALS9. CD4 (MIM 186940)-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. TIM3 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice.

T cell immunoreceptor with Ig and ITIM domains (TIGIT), also called VSIG9 and Vstm3, is a member of the CD28 family within the Ig superfamily of proteins. TIGIT contains an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM), and is expressed on regulatory, memory, activated T cells and NK cells. TIGIT binds to CD155(PVR) that appear on dendritic cells (DC), macrophages and endothelium with high affinity, and CD112(PVRL2) with lower affinity, but not CD113 (PVRL3). TIGIT-Fc fusion protein could interact with PVR on DC and enhance the secretion of IL-10, but inhibit the macrophage activation. Mice lacking TIGIT show increased T cell responses and susceptibility to autoimmune challenges, while knockdown of TIGIT with siRNA in human memory T cells did not affect T cell responses.

Expression system: HEK293 Cells
Length: 19-148, Full Length of Mature Protein
Activity: Not Tested

Expression system: HEK293 Cells
Length: 72-332, Partial
Activity: Not Tested

Expression system: HEK293 Cells
Length: 33-254, Partial
Activity: Not Tested