Search Result

Search Results for " cardioprotection "

Targets

Apoptosis Others Protease-activated Receptor

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T12870	SCH79797 dihydrochloride		Apoptosis , Others , Protease-activated Receptor
	SCH79797 dihydrochloride is an effective and selective antagonist of protease activated receptor 1 (PAR1) with an IC50 of 70 nM and a Ki of 35 nM. SCH79797 dihydrochloride has antiproliferative and pro-apoptotic effects.		Apoptosis , Others , Protease-activated Receptor
T37890L	GLP-1(28-36)amide acetate	GLP-1(28-36)amide acetate(1225021-13-5 Free base)	Antioxidant , Glucagon Receptor
	GLP-1(28-36)amide acetate inhibits mitochondrial permeability transition with antioxidant, anti-diabetic and cardioprotection activities.		Antioxidant , Glucagon Receptor
T22305	Dexrazoxane	ICRF-187	Others
	Dexrazoxane (ICRF-187) is an anticancer drug used to block mitosis and arrest dividing cells. It is an iron chelator and provides cardioprotection against anthracycline toxicity.		Others
T21871	MMPSI	Caspase-3/7 Inhibitor I	Apoptosis , Caspase
	MMPSI (Caspase-3/7 Inhibitor I) is a novel, non-peptide small molecule caspase 3 and caspase 7 inhibitor that reduces ischemic injury in isolated rabbit heart or cardiomyocytes and inhibits apoptosis of H16c2 cells in a ...		Apoptosis , Caspase
T16420	P-1075		Potassium Channel
	P-1075 opens mitochondrial K(ATP) channels and generates reactive oxygen species causing cardioprotection of rabbit hearts. P-1075 is an effective activator of sulfonylurea receptor 2-associated ATP-sensitive potassium c...		Potassium Channel
T25102	Aprikalim	RP52891,RP-52891,RP 52891
	Aprikalim is a specific and selective ATP-sensitive K+ (KATP) channel opener. Aprikalim affords cardioprotection and at higher doses also cause peripheral or coronary vasodilatation.
T37890	GLP-1(28-36)amide
	GLP-1(28-36)amide, a C-terminal nonapeptide derived from the cleavage of GLP-1 by neutral endopeptidase (NEP), is a significant product. It functions as an antioxidant and primarily targets the mitochondrion, where it ef...
T70421	VCP746
	VCP-746 is a potent adenosine A2B receptor agonist that stimulates anti-fibrotic signalling. VCP746 reduces hypertrophy in a rat neonatal cardiac myocyte model. VCP746 is a hybrid molecule consisting of an adenosine moie...
T61540	F15845
	F 15845 is a potent and persistent blocker of the sodium current. It possesses cardioprotective properties and exhibits both anti-ischemic activity and short- and long-term cardioprotection following myocardial infarctio...
T78007	Vasonatrin Peptide (VNP) TFA
	Vasonatrin Peptide (VNP) TFA, a chimeric compound derived from atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP), exhibits venodilating properties reminiscent of CNP, natriuretic effects akin to ANP, ...
T35463	(±)14(15)-EET	(±)14,15-EET,(±)14,15-EpETrE,(±)14(15)-EET
	(±)14(15)-EET is a metabolite of arachidonic acid that is formed via epoxidation of arachidonic acid by cytochrome P450.[1],[2] It prevents increases in leukotriene B4, ICAM-1, and chemokine (C-C motif) ligand 1 (CCL2) i...

Compounds

SCH79797 dihydrochloride

T12870

Synonym:

Target: Apoptosis, Others, Protease-activated Receptor

GLP-1(28-36)amide acetate

T37890L

Synonym: GLP-1(28-36)amide acetate(1225021-13-5 Free base)

Target: Antioxidant, Glucagon Receptor

Synonym: Caspase-3/7 Inhibitor I

Target: Apoptosis, Caspase

P-1075

T16420

Synonym:

Target: Potassium Channel

Aprikalim

T25102

Synonym: RP52891,RP-52891,RP 52891

Vasonatrin Peptide (VNP) TFA

Synonym: (±)14,15-EET,(±)14,15-EpETrE,(±)14(15)-EET

Target:

Cat No.	Product Name	Synonyms	Targets
T4721	β-Nicotinamide mononucleotide	β-NM	Others , Endogenous Metabolite
	β-Nicotinamide mononucleotide (β-NM) is an important intermediate metabolite in the nicotinate and nicotinamide metabolism pathway. Mammals predominantly use nicotinamide rather than nicotinic acid as a precursor for NAD...		Others , Endogenous Metabolite
T2961	Notoginsenoside R1	Sanqi glucoside R1,Sanchinoside R1	Apoptosis , ERK , Beta Amyloid
	Notoginsenoside R1 (Sanchinoside R1) has been shown to exhibit antioxidant, antiapoptotic, anti-inflammatory, and immune-stimulatory properties.		Apoptosis , ERK , Beta Amyloid
T3388	Calycosin-7-O-β-D-glucoside	calycosin-7-O-beta-D-glucopyranoside,Calycosin-7-O-beta-D-glucoside	MMP , Reactive Oxygen Species
	Calycosin-7-O-β-D-glucoside (calycosin-7-O-beta-D-glucopyranoside) possesses a protective effect on rat hepatocytes, an inhibitory effect on COX-2 activity. Calycosin 7-O-β-D-glucoside has antimicrobial activity. Calycos...		MMP , Reactive Oxygen Species
T7028	Licochalcone C	LICOCHALCONEC	Phosphatase , Antioxidant , Glucosidase
	Licochalcone C (LICOCHALCONEC) has potent antioxidant properties and inhibition of bacterial growth and cellular respiration. It has cardioprotection effect, via antioxidant, anti-inflammatory, and anti-apoptotic activit...		Phosphatase , Antioxidant , Glucosidase
T2S1008	Oxysophoridine	Sophoridine N-oxide	Apoptosis , Antioxidant
	Oxysophoridine (Sophoridine N-oxide) has a protective effect on focal cerebral ischemic injury through antioxidant and anti-apoptotic mechanisms; it may be a potential neuroprotective agent for cerebral ischemia injury, ...		Apoptosis , Antioxidant

Natural Products

β-Nicotinamide mononucleotide

T4721

Synonym: β-NM

Target: Others, Endogenous Metabolite

Notoginsenoside R1

T2961

Synonym: Sanqi glucoside R1,Sanchinoside R1

Target: Apoptosis, ERK, Beta Amyloid

Calycosin-7-O-β-D-glucoside

T3388

Synonym: calycosin-7-O-beta-D-glucopyranoside,Calycosin-7-O-beta-D-glucoside

Target: MMP, Reactive Oxygen Species

Licochalcone C

T7028

Synonym: LICOCHALCONEC

Target: Phosphatase, Antioxidant, Glucosidase

Oxysophoridine

T2S1008

Synonym: Sophoridine N-oxide

Target: Apoptosis, Antioxidant

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPJ-01074	PKCE Protein, Human, Recombinant (His)	Human	E. coli
	Protein Kinase C Epsilon type is a member of the serine- and threonine-specific protein kinase family that can be activated by calcium and the second messenger diacylglycerol. Protein Kinase C Epsilon contains these doma...

PKCE Protein, Human, Recombinant (His)

TMPJ-01074

Species: Human

Expression System: E. coli