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Search Result

Search Results for " cardiomyocyte "

Targets

Apoptosis

17

Compounds

2

Natural Products

15

Recombinant Proteins

1

Libraries

Cat No. Product Name Synonyms Targets
T7845 BTZO-1 Apoptosis
BTZO-1 is an antioxidant response element (ARE) activator with cardioprotective activity.
T16104 ML-9 Myosin , Akt
ML-9 suppresses MLCK, PKA, and PKC activity with Ki values of 4, 32, and 54 μM, respectively. ML-9 is a selective and effective inhibitor of Akt kinase, inhibits myosin light-chain kinase (MLCK), and stromal interaction ...
T8786 VUT-MK142 Others
VUT-MK142 is a new cardiomyogenic small molecule promoting the differentiation of pre-cardiac mesoderm into cardiomyocytes,which may be useful to differentiate stem cells into cardiomyocytes for cardiac repair.
T2052 KY02111 Wnt/beta-catenin
KY02111 facilitates differentiation of hPSCs to cardiomyocytes by inhibiting Wnt signaling, maybe affect downstream of GSK3β and APC.
TP1035 Cyclic somatostatin SRIF-14,Somatostatin-14 Others
Cyclic somatostatin (SRIF-14) is a cyclic tetradecapeptide regulating many endocrine and nervous system functions.
T3597 Cutamesine dihydrochloride AGY94806 dihydrochloride,SA4503 (dihydrochloride),SA4503 dihydrochloride Sigma receptor
Cutamesine dihydrochloride (SA4503 dihydrochloride) is a selective σ1 receptor agonist (IC50: 17.4 nM). It shows selectivity for σ1 over σ2 receptors, and inhibits angiotensin II-induced cardiomyocyte hypertrophy in vitr...
T5483 DMX-5804 DMX-5084 MAPK
DMX-5804 is a potent, selective MAP4K4 inhibitor, with an IC50 of 3 nM.DMX-5804 enhances cardiomyocyte survival, and reduces ischemia-reperfusion injury in mice.
TP2158 TRV-120027 TFA TRV-120027 TFA (1234510-46-3 free base) RAAS , Arrestin
TRV120027 TFA is a β-arrestin-1-biased agonist of the angiotensin II receptor type 1 (AT1R) and engages ß-arrestins while blocking G-protein signaling.
T35832 Brain Natriuretic Peptide (1-32), rat acetate
Brain Natriuretic Peptide (1-32), rat acetate (BNP (1-32), rat acetate) is a 32 amino acid polypeptide hormone synthesized by ventricular cardiomyocytes as a result of myocardial cell stretching (cardiomyocyte distension...
TP2158L TRV-120027 Others
TRV120027 is a β-arrestin-1-biased agonist of the angiotensin II receptor type 1. TRV120027 inhibits angiotensin II-mediated vasoconstriction and increases cardiomyocyte contractility.
T62986 CCG-271423
CCG-271423 is a potent and selective inhibitor of GRK5, acting on both GRK5 (IC50: 0.0021 μM) and GRK2 (IC50: 44 μM). CCG-271423 reduces Ca2+ transients and inhibits cardiomyocyte contractility.
T35875 CCG258208 hydrochloride
GRKs-IN-1 hydrochloride, Compound 14as, has remarkable potency against and selectivity for G protein-coupled receptor kinase 2 GRK2 (IC50=130 nM) and GRK5 (IC50=7.1 μM).GRKs-IN-1 hydrochloride is a derivative 14as of pa...
T60825 FC9402
FC9402 is a potent and selective inhibitor of sulfide quinone oxidoreductase(SQOR). FC9402 can be used in the regulation of cardiovascular that reduces cardiomyocyte hypertrophy and left ventricle (LV) fibrosis induced b...
T76252L WLSEAGPVVTVRALRGTGSW TFA
WLSEAGPVVTVRALRGTGSW TFA, a cardiomyocyte-specific peptide, exhibits enhanced performance through its expression in exosomes, which notably improves uptake by cardiomyocytes, reduces apoptosis within these cells, and inc...
T35541 Lipoxygenin
Lipoxygenin is an inhibitor of 5-lipoxygenase (5-LO) with an IC50value of 5 μM for inhibition of 5-LO product synthesis in isolated human granulocytes stimulated with the cation ionophore A23187 .1It inhibits hedgehog-de...
T80130 SDF-1α (human) CXCR
SDF-1α (human) serves as a chemotactic agent for mononuclear cells through its interaction with the CXCR4 receptor, facilitating critical biological processes such as stem cell homing, retention, survival, and proliferat...
T36215 17R(18S)-EpETE
17R(18S)-EpETE is an oxylipin and a cytochrome P450 metabolite of eicosapentaenoic acid .1,217R(18S)-EpETE is an activator of large-conductance calcium-activated potassium (BKCa) channels, increasing the potassium curren...
Cat No. Product Name Synonyms Targets
TN4892 Randialic acid B Others
Randialic acid B shows significant cell-protective effects against H2O2-induced H9c2 cardiomyocyte injury.
T36667 2'-Deoxyadenosine-5'-triphosphate dATP,Deoxyadenosine 5-triphosphate DNA/RNA Synthesis , Endogenous Metabolite
2'-Deoxyadenosine-5'-triphosphate (Deoxyadenosine 5-triphosphate) (dATP) is a naturally occurring small molecule nucleotide used in cells for DNA synthesis or replication. 2'-Deoxyadenosine-5'-triphosphate (dATP) is a su...

Natural Products

Randialic acid B
TN4892
Synonym:
Target: Others
2'-Deoxyadenosine-5'-triphosphate
T36667
Synonym: dATP,Deoxyadenosine 5-triphosphate
Target: DNA/RNA Synthesis, Endogenous Metabolite

Recombinant Proteins

Species：
Human (6)
Mouse (4)
Human,Rhesus (2)
Rat (2)
Bovine (1)
Expression System：
HEK293 (11)
E. coli (3)
Yeast (1)
Tag：
hFc (6)
His (4)
Tag Free (2)
GST (1)
N-terminal 10xHis-tagged (1)
N-terminal 6xHis-KSI-tagged (1)
Cat No. Product Name Species Expression System
TMPY-02813 ErbB4 Protein, Human, Rhesus, Recombinant (His) Human,Rhesus HEK293
ERBB4 is a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. ERBB4 is ...
TMPY-04829 G-CSF Protein, Human, Recombinant Human HEK293
Granulocyte-colony stimulating factor (G-CSF) is a growth factor and an essential cytokine belonging to the CSF family of hormone-like glycoproteins. It is produced by numerous cell types including immune and endothelial...
TMPY-05636 G-CSF Protein, Mouse, Recombinant Mouse HEK293
Granulocyte-colony stimulating factor (G-CSF) is a growth factor and an essential cytokine belonging to the CSF family of hormone-like glycoproteins. It is produced by numerous cell types including immune and endothelial...
TMPH-00286 Myotrophin Protein, Bovine, Recombinant (His) Bovine Yeast
Promotes dimerization of NF-kappa-B subunits and regulates NF-kappa-B transcription factor activity. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy. Plays a ro...
TMPY-04327 VEGFB Protein, Human, Recombinant (hFc) Human HEK293
Vascular endothelial growth factor-B (VEGF-B) is closely related to VEGF-A, an effector of blood vessel growth during development and disease and a strong candidate for angiogenic therapies. In detail, VEGFB can positive...
TMPH-02910 Somatostatin Protein, Mouse, Recombinant (His & KSI) Mouse E. coli
Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH-stimulated secretion of GH1 and LH; the inhib...
TMPY-03021 ErbB4 Protein, Mouse, Recombinant (His) Mouse HEK293
ERBB4 is a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. ERBB4 is ...
TMPY-03158 ErbB4 Protein, Rat, Recombinant (hFc) Rat HEK293
ERBB4 is a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. ERBB4 is ...
TMPY-02814 ErbB4 Protein, Human, Rhesus, Recombinant (hFc) Human,Rhesus HEK293
ERBB4 is a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. ERBB4 is ...
TMPY-03822 ErbB4 Protein, Rat, Recombinant (His) Rat HEK293
ERBB4 is a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. ERBB4 is ...
TMPY-01000 BVES Protein, Human, Recombinant (GST) Human E. coli
Blood vessel epicardial substance (BVES), or POPDC1, is a tight junction-associated transmembrane protein that modulates epithelial-to-mesenchymal transition (EMT) via junctional signaling pathways. BVES plays a protecti...
TMPY-02531 S100B Protein, Human, Recombinant (His) Human E. coli
S100B is a member of the S100 family of proteins containing two EF-hand-type calcium-binding motifs. S100B exerts both intracellular and extracellular functions. Intracellular S100B acts as a stimulator of cell prolifera...
TMPY-03020 S100B Protein, Mouse, Recombinant (hFc) Mouse HEK293
S100B is a member of the S100 family of proteins containing two EF-hand-type calcium-binding motifs. S100B exerts both intracellular and extracellular functions. Intracellular S100B acts as a stimulator of cell prolifera...
TMPY-00813 G-CSF Protein, Human, Recombinant (hFc) Human HEK293
Granulocyte-colony stimulating factor (G-CSF) is a growth factor and an essential cytokine belonging to the CSF family of hormone-like glycoproteins. It is produced by numerous cell types including immune and endothelial...
TMPY-00913 S100B Protein, Human, Recombinant (hFc) Human HEK293
S100B is a member of the S100 family of proteins containing two EF-hand-type calcium-binding motifs. S100B exerts both intracellular and extracellular functions. Intracellular S100B acts as a stimulator of cell prolifera...
Cat No. Product Name
L4000 Bioactive Compound Library

14590 compounds
A collection of 14590 small molecule compounds with validated activity for high throughput screening (HTS), high content screening (HCS), cell induction, and target identification;

Libraries

Bioactive Compound Library
L4000
Compounds: 14590
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