autophagosome — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T8081	LC3-mHTT-IN-AN1		Others , Autophagy , ATTECs
	LC3-mHTT-IN-AN1 is a mHTT-LC3 linker compound that interacts with both mutant huntingtin protein (mHTT) and LC3B. LC3-mHTT-IN-AN1 targeted mHTT to autophagosomes reduces the levels of mHTT in an allele-selective manner...		Others , Autophagy , ATTECs
T8946	Indophagolin		P2X Receptor , 5-HT Receptor , Autophagy
	Indophagolin is a potent, indoline-containing autophagy inhibitor with IC50 of 140 nM. Indophagolin antagonizes the purinergic receptor P2X4 as well as P2X1 and P2X3 with IC50s of 2.71, 2.40 and 3.49 μM, respectively.		P2X Receptor , 5-HT Receptor , Autophagy
T5070	LC3-mHTT-IN-AN2	5,7-Dihydroxy-4-phenylcoumarin	Antibacterial , Autophagy , ATTECs
	LC3-mHTT-IN-AN2 (5,7-Dihydroxy-4-phenylcoumarin) is found in the plant Passiflora serratodigitata with the antibacterial activity.		Antibacterial , Autophagy , ATTECs
T11142	EACC		Autophagy
	EACC, a reversible autophagy inhibitor, selectively impedes Stx17, an autophagosome-specific SNARE, from translocating, hence obstructing the fusion between autophagosomes and lysosomes. This compound effectively halts a...		Autophagy
T4079	LY-294002 hydrochloride	SF 1101,LY 294002,NSC 697286	PI3K
	LY-294002 hydrochloride (NSC 697286) is a synthetic molecule inhibitor of PI3Kα/δ/β (IC50: 0.5/0.57/0.97 μM, in cell-free assays); more stable than Wortmannin in solution, and also is a blocker of autophagosome formation...		PI3K
T27084	Crisdesalazine	AAD2004,AAD 2004,AAD-2004	Prostaglandin Receptor
	Crisdesalazine (AAD 2004) is an inhibitor of microsomal prostaglandin E2 synthase-1 (mPGES-1). Crisdesalazine reduces autophagosome formation, axonopathy, and motor neuron degeneration, improving motor function and incre...		Prostaglandin Receptor
T5181	CA-5f		Apoptosis , Autophagy
	CA-5f is a potent late-stage macroautophagy/autophagy inhibitor via inhibiting autophagosome-lysosome fusion.		Apoptosis , Autophagy
T16104	ML-9		Myosin , Akt
	ML-9 suppresses MLCK, PKA, and PKC activity with Ki values of 4, 32, and 54 μM, respectively. ML-9 is a selective and effective inhibitor of Akt kinase, inhibits myosin light-chain kinase (MLCK), and stromal interaction ...		Myosin , Akt
T4S1102	Liensinine diperchlorate	Liensinine-Perchlorate	Mitophagy , Others , Autophagy
	Liensinine Diperchlorate is an isoquinoline alkaloid extracted from the embryonic seeds of the sacred lotus. It inhibits late autophagy by blocking autophagosome-lysosome fusion and exhibits biological activities such as...		Mitophagy , Others , Autophagy
T73550	CUR5g
	CUR5g, a potent autophagy inhibitor, selectively prevents autophagosome degradation in cancer cells by hindering the fusion of autophagosomes with lysosomes. It disrupts the recruitment of STX17 to autophagosomes through...
T22034	ARP 101
	ARP101, a potent and selective matrix metalloproteinase-2 (MMP-2) inhibitor, effectively promotes autophagy-associated cell death in cancer cells by inducing autophagosome formation and converting LC3I into LC3II [1].
T16103	ML-9 Free Base		Others
	ML-9 (free base) suppresses MLCK, PKA, and PKC activity (Ki: 4, 32, and 54 μM, respectively). ML-9 (free base) is a selective and effective inhibitor of Akt kinase, inhibits myosin light-chain kinase (MLCK), and stromal ...		Others
T83945	XIE62-1004
	XIE62-1004 is a chemical compound that induces the interaction between p62 and LC3 by binding to the ZZ domain of p62. This interaction promotes p62 self-aggregation and its subsequent interaction with LC3 on autophagoso...
T76506	Coibamide A
	Coibamide A, an N-methyl-stabilized cytotoxic depsipeptide, exhibits potent antiproliferative activity alongside inducing autophagosome accumulation through an mTOR-independent mechanism and triggering apoptosis. Additio...
T35807	C18 dihydro Ceramide (d18:0/18:0)	C18 dihydro Ceramide (d18:0/18:0),Cer(d18:0/18:0)
	C18 dihydro Ceramide is a bioactive sphingolipid and precursor in the de novo synthesis of C18 ceramide that lacks the 4,5-trans double bond. [1] Increased C18 dihydroceramide lipid levels lead to increased triacylglycer...