astragalus

2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside (Astragalus polyphenols) is a compound isolated from the roots of Polygonum species, which inhibits the formation of 5-HETE, HHT, and thromboxane B2.

Astragalus polysaccharide, a natural product derived from Astragalus propinquus, exhibits anticancer activity and has been shown to be effective in hepatocellular carcinoma (HCC) by inhibiting the M2 polarization of tumor-associated macrophages (TAM).

polysachoride of Astragalus mongholicus is a natural product that can be used in related research in the field of life sciences. Its product number is TN8875.

Astragaloside IV (AS-IV), an active component isolated from Astragalus membranaceus, suppresses the activation of ERK1 2 and JNK, and downregulates matrix metalloproteases (MMP)-2, (MMP)-9 in MDA-MB-231 breast cancer cells. Astragaloside IV is a bioactive saponin first isolated from the dried plant roots of the genus Astragalus, which is used in traditional Chinese medicine.1 It dose-dependently inhibits human adenovirus type 3 (HAdV-3) in A549 cells (IC50 = 23 μM; LC50 = 865 μM).It inhibits replication of HAdV-3 and decreases HAdV-3-induced apoptosis. It has diverse protective effects for the cardiovascular, immune, digestive, and nervous systems. In particular, it reduces myocardial infarct size in dogs when administered prior to coronary ligation and reduces reperfusion arrhythmias in isolated rat hearts.

Formononetin (Flavosil) is an O-methylated isoflavone and a phytoestrogen from the root of Astragalus membranaceus.

Cyclogalegenin (Astramembrangenin) is able to elongate telomeres, resulting in increased lifespan of the animals.

Astramembrangenin (Cycloastragenol (Astramembrangenin)) is a triterpenoid saponin compound and a hydrolysis product of the main active ingredient in Astragalus membranaceus. Cycloastragenol (CAG) may have a novel therapeutic role in depression

Astragaloside A (Astramembrannin I) is the primary pure saponin isolated from Astragalus membranaceus.

Calycosin-7-O-β-D-glucoside (calycosin-7-O-beta-D-glucopyranoside) exhibits a protective effect on rat hepatocytes, inhibits COX-2 activity, has antimicrobial properties, and is a promising anti-HIV agent. Additionally, it demonstrates scavenging activity against DPPH radicals and superoxide anions, alleviates osteoarthritis, and increases brain cell membrane fluidity in ischemia-reperfusion rats.

Calycosin (Cyclosin) acts as a selective estrogen receptor modulator. Calycosin induces apoptosis in human ovarian cancer SKOV3 cells by activating caspases and Bcl-2 family proteins. Calycosin suppresses breast cancer cell growth via ERβ-dependent regulation of IGF-1R, p38 MAPK and PI3K Akt pathways. Calycosin has antineoplastic effects against osteosarcoma through inducing apoptosis showing in vitro and in vivo investigations. Calycosin was shown to induce angiogenesis in human umbilical vein endothelial cell cultures (HUVEC) in vitro. Calycosin may be an effective skin-lightening agent that regulates the expression of melanogenic enzymes. Calycosin exhibited tyrosinase inhibitory activity with an IC(50) value of 38.4 microM.

Astragaloside, one of the main active ingredients in Astragalus membranaceus.

Taurohyodeoxycholic acid (THDCA) is a bile acid that plays a key role in regulating the hepatic inflammatory microenvironment.THDCA reduces the expression of TNF-α and IL-6 and inhibits the development of hepatocellular carcinoma (HCC). It is able to inhibit non-alcoholic fatty liver disease and regulate bile acid metabolism in combination with astragalus polysaccharides: it reduces CD36 expression in the liver and decreases hepatic lipid accumulation by up-regulating CYP7B1 and down-regulating CYP7A1.

7,2′-Dihydroxy-3′,4′-dimethoxyisoflavan 7-O-β-D-glucoside (Isomucronulatol 7-O-glucoside) is a biologically active isoflavone isolated from Astragalus membranaceus.

Glycerol Tridecanoate is an orally active precursor (DA precursor) of caprylic acid that can be hydrolyzed to caprylic acid. It is a major component of medium chain triglycerides (MCT) and has antiandrogenic and antihyperglycemic properties. It can be used as an additive in food, pharmaceuticals and cosmetics.

Complanatoside A (a flavonol glycoside) is isolated from Astragalus complanatus.

Astragaloside II (Astrasieversianin VIII) is an effective MDR reversal agent and may be a potential adjunctive agent for hepatic cancer chemotherapy. Astragaloside II also induces osteogenic activities, differentiation, proliferation, and mineralization, through the bone morphogenetic protein-2 MAPK and Smad1 5 8 pathways.

Astragaloside I (Cyclosieversioside B) is a natural product isolated from Astragalus membranaceus. It can stimulate osteoblast differentiation through the Wnt β-catenin signaling pathway and can be used to study osteogenic activity.

Complanatuside (Complanatoside) is a flavonoid isolated from the traditional Chinese medicine Semen Astragali Complanati.

Methylnissolin-3-O-glucoside ((6aR, 11 aR)-3-hydroxy-9,l0-diMethoxy pt) has anti-inflammatory effects,antioxidant activity.

Astragaloside III has cardioprotective effects as well as causing improvement in cognitive function. It can be used in the prevention of cardio-cerebral vascular diseases. It also is antioxidant.

Isoastragaloside II (Astrasieversianin VII) is a derivative Astragaloside I, an ingredient in Astragalus membranaceus which is reported to have osteogenic properties.

Cyclocephaloside II is a natural product extracted from the roots of Astragalus brachypterus and Astragalus microcephalus, belonging to the class of cycloalkane triterpenoid saponins with potential biological activities. Astragalus saponin has the effect of improving myocardial function.

Complanatin I, a natural product, is isolated from Astragalus complanatus [1].

Complanatin, an acylated flavonol glycoside, is derived from Astragalus complanatus R. Br. [1].