15
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T5773 | Moslosooflavone | 5-hydroxy-7,8-dimethoxyflavone | NF-κB , Reactive Oxygen Species |
Moslosooflavone (5-hydroxy-7,8-dimethoxyflavone) has anti-hypoxia activity, it can significantly prolong the survival time of hypoxic mice. 5-hydroxy-7,8-dimethoxyflavone significantly inhibits the transcriptional activi... | |||
T21806 | HNHA | HDAC | |
HNHA is an inhibitor of HDAC. | |||
T2763 | Panaxadiol | 20(R)-Panaxadiol | Others , HIF/HIF Prolyl-Hydroxylase |
Panaxadiol (20(R)-Panaxadiol) is a novel antitumor agent extracted from the Chinese medical herb Panax ginseng. | |||
T11589 | Hydroxycitric acid tripotassium hydrate | Potassium citrate monohydrate | ATP Citrate Lyase , HIF/HIF Prolyl-Hydroxylase , HIF |
Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) effectively inhibits stones formation and also inhibits HIF, and has antioxidation, anti-inflammation, and anti-tumor effects. Hydroxycitric acid tr... | |||
T0256 | Citric acid trilithium salt tetrahydrate | Lithium citrate tribasic tetrahydrate,Trilithium citrate tetrahydrate | Dehydrogenase , GSK-3 , HIF/HIF Prolyl-Hydroxylase , Antibacterial , GluR |
Citric acid trilithium salt tetrahydrate (Lithium citrate tribasic tetrahydrate) , the active component of Lithium, is a medicine used in the therapy of psychiatric disease. It has shown the effects of signaling pathways... | |||
T30549 | BMY-21502 | Bms-181168,Bms 181168,Bmy 21502,Bmy21502,Bms181168 | Antioxidant |
BMY-21502 is a potential cognitive enhancer that shows anti-hypoxia effects in the KCN-hypoxia model, delays the decay of hippocampal synaptic enhancement in vitro, and can be used to study Alzheimer's disease. | |||
TN1916 | Matairesinol | ATPase , p38 MAPK , ROS | |
Matairesinol has radical and superoxide scavenging activities,; it also has anti-angiogenic activity by suppressing mROS signaling , can decrease hypoxia-inducible factor-1α± in hypoxic HeLa cells. | |||
T2515 | Roxadustat | ASP1517,FG-4592 | Ferroptosis , HIF/HIF Prolyl-Hydroxylase , HIF |
Roxadustat (FG-4592) is an orally bioavailable, hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI), with potential anti-anemic activity. | |||
TWS1977 | Kamebakaurin | Kamebakaurine | NF-κB |
1. Kamebakaurin (Kamebakaurine) has the ability to protect the liver from APAP-induced hepatotoxicity, presumably by both inhibiting the inflammatory response and oxidative stress. 2. Kamebakaurin inhibits the expression... | |||
T3822 | Bellidifolin | Bellidifoline,Bellidifolium | Others , HIV Protease |
Bellidifolin (Bellidifoline) has anti-oxidation, hepatoprotective, anti-inflammatory and antitumor actions, it may contribute to the protective effects associated with nerve injury initiated by hypoxia by mechanisms rela... | |||
T2S0843 | Negletein | 7-O-Methylbaicalein,Baicalein-7-methylether | IL Receptor , TNF , NOS , Interleukin |
1. Negletein (7-O-Methylbaicalein) has anti-inflammatory and immunomodulatory activities via inhibition of TNF-α, iNOS and IL-1β. 2. Negletein as a neuroprotectant enhances the action of nerve growth factor and induces n... | |||
TN6417 | N-Methylcorydalmine | ||
N-Methylcorydalmine may exhibit significant anti-hypoxia activity. | |||
T61635 | HCAI/II-IN-4 | ||
hCAI/II-IN-4 (compound 6d) is a powerful inhibitor of both hCA I and hCA II enzymes, with Ki values of 16.95 nM and 15.22 nM, respectively. It demonstrates inhibitory activity against hCA IX with a Ki value of 27.04 nM. ... | |||
T68324 | KCN1 | ||
KCN1, a novel synthetic sulfonamide, is a HIF pathway inhibitor with potential anticancer activity in vitro and in vivo anti-pancreatic cancer activities and preclinical pharmacology. KCN1 specifically inhibited HIF repo... | |||
T75074 | 6-Methoxypurine-9-β-D-5’(R)-C-methylriboside | ||
6-Methoxypurine-9-β-D-5’(R)-C-methylriboside, an analog of hypoxanthine—a purine base predominantly found in muscle tissue and a metabolite generated when purine oxidase acts on xanthine—displays anti-inflammatory proper... |