Search Result

Search Results for " anti-cholinesterase "

Targets

Compounds

Natural Products

Cat No.	Product Name	Synonyms	Targets
T1552	Itopride hydrochloride	HSR803,Ganaton	Dopamine Receptor , AChE
	Itopride hydrochloride (Ganaton) is an AChE and D2DR inhibitor.		Dopamine Receptor , AChE
T7002	Trihexyphenidyl hydrochloride	Triesifenidile,Benzhexol hydrochloride,Tremin,Artane hydrochloride	AChR
	Trihexyphenidyl hydrochloride (Benzhexol hydrochloride) is an antiparkinsonian agent of the antimuscarinic class.		AChR
T14194	β-NETA	α-NETA	AChE
	β-NETA (α-NETA) is a stable, noncompetitive, slowly reversible choline acetyltransferase (ChAT) inhibitor with an IC50 of 9 μM and is a potent chemokine-like receptor-1 (CMKLR1) antagonist. β-NETA has anti-cancer activit...		AChE
T32535	Ladostigil	TV-3326,Ladostigil,TV 3326,TV3326,Ladostigil free base	Antioxidant , MAO , AChE
	Ladostigil (Ladostigil free base) is an orally active dual inhibitor of cholinesterase and brain-selective monoamine oxidase (MAO) with inhibitory effects on MAO-B and AChE, with IC50 values of 37.1 and 31.8 μM, respecti...		Antioxidant , MAO , AChE
T69507	Silatrane
	Silatrane is a reversible cholinesterase inhibitor and anti-tumor agent.
T39513	Ladostigil hemitartrate	TV-3326 hemitartrate,Ladostigil hemitartrate
	Ladostigil hemitartrate (TV-3326) is a compound that acts as a dual inhibitor of cholinesterase and brain-selective monoamine oxidase (MAO). It has IC50 values of 37.1 μM for MAO-B and 31.8 μM for AChE. In addition, Lado...
T80100	Ovotransferrin (328-332)		Angiotensin-converting Enzyme (ACE)
	Ovotransferrin (328-332), with an IC50 of 20 μM, exhibits protective activity against hypertension by inhibiting the Angiotensin-Converting Enzyme (ACE) and also displays anti-Cholinesterase (ChE) activity, suggesting a ...		Angiotensin-converting Enzyme (ACE)
T72247	Ladostigil hydrochloride	TV-3326 hydrochloride
	Ladostigil hydrochloride (TV-3326), an orally active compound, acts as a dual inhibitor targeting both cholinesterase and brain-selective monoamine oxidase (MAO), demonstrating inhibition constants (IC50s) of 31.8 μM for...
T61454	α-NETA
	α-NETA is a potent and noncompetitive choline acetyltransferase (ChA) inhibitor with an IC 50 of 9 μM. α-NETA is a potent ALDH1A1 ( IC 50 =0.04 μM) and chemokine-like receptor-1 (CMKLR1) antagonist. α-NETA weakly inhibit...

Compounds

Itopride hydrochloride

T1552

Synonym: HSR803,Ganaton

Target: Dopamine Receptor, AChE

Trihexyphenidyl hydrochloride

T7002

Synonym: Triesifenidile,Benzhexol hydrochloride,Tremin,Artane hydrochloride

Synonym: TV-3326,Ladostigil,TV 3326,TV3326,Ladostigil free base

Target: Antioxidant, MAO, AChE

Ladostigil hemitartrate

T39513

Synonym: TV-3326 hemitartrate,Ladostigil hemitartrate

Target:

Ovotransferrin (328-332)

T80100

Synonym:

Target: Angiotensin-converting Enzyme (ACE)

Ladostigil hydrochloride

T72247

Synonym: TV-3326 hydrochloride

Cat No.	Product Name	Synonyms	Targets
T11366	Garcinol		Apoptosis , Endogenous Metabolite , Histone Acetyltransferase , AChR , AChE
	Garcinol also inhibits histone acetyltransferases (HATs, IC50= 7 μM) and p300/CPB-associated factor (PCAF, IC50 = 5 μM). Garcinol has anti-inflammatory and anti-cancer activity. Garcinol, a polyisoprenylated benzophenone...
T2S1200	Sinapine		Antioxidant , P-gp , AChE
	1. Sinapine, an alkaloid from seeds of the cruciferous species, can be used as an effective natural compound for chemo-resistance. 2. Sinapine has antioxidant and radio-protective activities.		Antioxidant , P-gp , AChE
T3392	Sinapine thiocyanate		P-gp , AChE
	Sinapine Thiocyanate, is a derivative of Sinapine (S486605), an alkaloidal amine found in black mustard seeds. It is the choline ester of Sinapic Acid (S486800). It is also a phenolic-chloine conjugates, acting as anti-o...		P-gp , AChE
T9862	Pseudocoptisine chloride	Isocoptisine chloride	AChE
	Pseudocoptisine chloride (Isocoptisine chloride) is isolated from Corydalis Tuber with anti-inflammatory and anti-amnestic properties. Pseudocoptisine chloride inhibits acetylcholinesterase (AChE) activity (IC50 = 12.8 μ...		AChE
T3026	(-)-Huperzine A	HupA,Huperzine A	Apoptosis , AChR , AChE , iGluR
	(-)-Huperzine A (HupA) , an active Lycopodium alkaloid extracted from the traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the tr...		Apoptosis , AChR , AChE , iGluR
TN6786	O-Desmethyl Galanthamine	Sanguinine	AChE
	O-Desmethyl Galanthamine (Sanguinine) is galanthamine-type alkaloid and it is an acetylcholinesterase (AChE) inhibitor, with an IC50 1.83 μM.		AChE
TN2130	Manghaslin	Quercetin 3-O-rutinoside-(1->2)-O-rhamnoside	AChE , Glucosidase
	Manghaslin (Quercetin 3-O-rutinoside-(1->2)-O-rhamnoside) has considerable α-glucosidase inhibitory activity, illustrating the anti-diabetic potential of phenolic-rich litchi pulp extracts. Manghaslin also shows inhibito...		AChE , Glucosidase
TN2298	Vincosamide		AChE
	Vincosamide is an alkaloid from Psychotria leiocarpa extract, inhibits the acetylcholinesterase (AChE) activity with anti-inflammatory activity. Vincosamide can effect relaxation of the supercoiled pBR322 plasmid DNA in ...		AChE
TN3466	Atherosperminine		cAMP , Calcium Channel , AChR , Parasite
	Atherosperminine shows cholinesterase inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Atherosperminine shows strong anti-plasmodial activity against Plasmodium falciparum, with t...		cAMP , Calcium Channel , AChR , Parasite
TN2714	2',4'-Dihydroxy-3',6'-dimethoxychalcone		Others
	2',4'-Dihydroxy-3',6'-dimethoxychalcone has cytotoxic, anti-inflammatory activity and anti-cholinesterase activities, it has significant NO inhibitory activity.		Others
TN1428	(+)-Balanophonin		Antioxidant , AChE
	(+)-Balanophonin is a natural phenolic compound isolated from Passiflora edulis with antioxidant, anti-inflammatory, anticancer and anti-neurodegenerative activities, cholinesterase inhibition, and marginal inhibition of...		Antioxidant , AChE