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Search Result

Search Results for " wee1 "

Targets

Wee1 Wee1

19

Compounds

1

Natural Products

2

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T8916 WEE1-IN-3 JUN76288 Wee1
WEE1-IN-3 (JUN76288) is a potent Wee1 kinase inhibitor with an IC50 of <10 nM. It treatment of cancer and other proliferative diseases.
T23881 Wee1 Inhibitor II Wee1-Inhibitor II,Wee1-Inhibitor-II,Wee1 Inhibitor-II
Wee1 Inhibitor II is an ATP-binding site-targeting Wee1 inhibitor.
T23869 WEE1-IN-4 Wee1-Inhibitor-I,Wee1 Inhibitor-I,Wee1 Inhibitor I,Wee1-Inhibitor I
Wee1 Inhibitor I is an ATP-binding site-targeting Wee1 inhibitor.
T9864 Debio-0123 WEE1-IN-5 Wee1
Debio-0123 (WEE1-IN-5) is a potent, orally available and highly specific WEE1 inhibitor with an IC 50 in the low nanomolar range. Debio-0123 inhibits phospho-CDC2 which translated into an increase in DNA damage and prema...
T6931 PD0166285 PD-166285 Apoptosis , Wee1 , Chk
PD0166285 is a potent Wee1 and Chk1 inhibitor with activity at nanomolar concentrations.PD0166285 is a novel G2 checkpoint abrogator.
T2077 Adavosertib AZD1775,MK-1775,Adavosertib (MK-1775) Wee1
Adavosertib (MK-1775) is a small molecule inhibitor of the checkpoint kinase WEE1 (IC50: 5.2 nM). It hinders the G2 DNA damage checkpoint.
T9643 ZN-c3 Wee1
ZN-c3 is a potent and selective Wee1 inhibitor with balanced potency, ADME, and pharmacokinetic properties.
T41163 ZNL 02-096 Pomalidomide-C3-adavosertib Apoptosis , Wee1
ZNL 02-096 (Pomalidomide-C3-adavosertib) is a rapid and selective degrader of Wee1 (IC50=3.58 nM).ZNL 02-096 selectively degrades Wee1 at submolar concentrations without damaging PLK1, a secondary target of AZD 1775.ZNL ...
T16446 PD 407824 PD-407824 Wee1 , Chk
PD 407824 is a chemical BMP sensitiser that promotes increased cellular sensitivity to subthreshold amounts of BMP4.PD 407824 is a potent inhibitor of the checkpoint kinases Chk1 and WEE1 (IC50s: 47 and 97 nM, respective...
T70126 CJM-061
CJM-061 is a Wee1 inhibitor.
T71067 MK-1775 hemihydrate
MK-1775 hemihydrate is a WEE1 inhibitor with potential antineoplastic sensitizing activity.
T74371 LEB-03-146
LEB-03-146, a WEE1 DUBTAC (deubiquitinase-targeting chimera), effectively links AZD1775 (Adavosertib) with the OTUB1 recruiter EN523 via a PEG2 linker. This compound demonstrates considerable WEE1 stabilization in HEP3B ...
T74275 LEB-03-144
LEB-03-144 is a WEE1 DUBTAC (deubiquitinase-targeting chimera) linking AZD1775 (Adavosertib) to the OTUB1 recruiter EN523 through a C3 alkyl linker. LEB-03-144 shows significant WEE1 stabilization in HEP3B hepatoma cance...
T74276 LEB-03-153
LEB-03-153 is a WEE1 DUBTAC (deubiquitinase-targeting chimera) linking AZD1775 (Adavosertib) to the OTUB1 recruiter EN523 through no linker [1] .
T74274 LEB-03-145
LEB-03-145 is a WEE1 DUBTAC (deubiquitinase-targeting chimera) linking AZD1775 (Adavosertib) to the OTUB1 recruiter EN523 through a C5 alkyl linker [1] .
T71462 GUN94110
GUN94110 is a WEE1 kinase inhibitors useful in treatment of cancer and other proliferative diseases. GUN94110 was reported in WO 2019028008. This product has no formal name at the moment. For the convenience of communica...
T82385 FMF-06-098-1 PROTACs
FMF-06-098-1 is a multitargeted depressant capable of promoting the degradation of a wide array of kinases, including AAK1, ABL2, AURKA, AURKB, BUB1B, CDC7, CDK1, CDK12, CDK13, CDK2, CDK4, CDK6, CDK7, CDK9, CHEK1, CSNK1D...
T74644 DB0614
DB0614 (Example 21) is a bifunctional compound designed for the targeted degradation of kinases, effectively breaking down a wide array of kinases including AAK1, AURKA, BMP2K, CAMKK1, CDK16, CML, CDK6, EIF2AK2, FER, GAK...
T6931L PD0166285 dihydrochloride PD-166285
PD-166285 is an effective and broadly active inhibitor of protein tyrosine kinase.
Cat No. Product Name Synonyms Targets
T3S0737 Flavokawain A Flavokavain A Apoptosis , p38 MAPK
NSC-37445 has anti-tumor activity, such as inhibits growth of bladder tumor cells in a nude mice model , prevents the recurrence and progression of non-muscle-invasive urothelial cell carcinoma. NSC-37445 can significant...

Natural Products

Flavokawain A
T3S0737
Synonym: Flavokavain A
Target: Apoptosis, p38 MAPK

Recombinant Proteins

Species：
Human (1)
Mouse (1)
Expression System：
Baculovirus-Insect Cells (1)
E. coli (1)
Tag：
His (1)
N-terminal 10xHis-tagged and C-terminal Myc-tagged (1)
Cat No. Product Name Species Expression System
TMPH-02884 CTDP1 Protein, Mouse, Recombinant (His & Myc) Mouse E. coli
Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit...
TMPY-04542 CDK2 Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
CDK2 is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinas...
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