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Search Result

Search Results for " rok "

Targets

Neurokinin receptor ROCK

74

Compounds

14

Natural Products

8

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T2155 Thiazovivin ROCK
Thiazovivin, a ROCK inhibitor (IC50: 0.5 μM), increases the survival rate of hESC.
T12747 ROCK2-IN-2 ROCK
ROCK2-IN-2 is a selective inhibitor of ROCK2 (IC50 of <1 μM).
T1870 Y-27632 ROCK , Apoptosis
Y-27632 (Y-27632) is an orally potent, ATP-competitive inhibitor of ROCK-I and ROCK-II. Y-27632 also inhibits isolation-induced apoptosis in mouse prostate stem or progenitor cells.
TQ0187 SR-3677 ROCK , Autophagy
SR-3677 is an effective and specific inhibitor of ROCK2 (IC50: 3 nM).
T7301 BDP5290 ROCK
BDP5290 is a potent inhibitor of both ROCK and MRCK(IC50s of 5 nM, 50 nM, 10 nM and 100 nM for ROCK1, ROCK2, MRCKα and MRCKβ, respectively.)
T7391 SAR407899 ROCK , Rho
SAR407899 is Rho kinase inhibitor potently inhibits endothelin-1-induced constriction of renal resistance arteries.
T15798 LX7101 ROCK , LIM Kinase , PKA
LX7101 is an effective inhibitor of LIMK and ROCK2 (IC50: 24, 1.6, and 10 nM for LIMK1, LIMK2, and ROCK2, respectively). It also inhibits PKA (IC50 <1 nM).
T1898 RKI-1447 RKI1447 ROCK
RKI-1447 is a potent inhibitor of ROCK1 and ROCK2. It has anti-invasive and antitumor activities.
T3513 GSK180736A GSK180736 ROCK , GRK , PKA
GSK180736A is an effective and selective GRK2 inhibitor (IC50: 0.77 μM) and >100-fold selectivity over other GRKs. It is a weak inhibitor of PKA (IC50: 30 μM), but highly effective against ROCK1 (IC50: 100 nM).
T12746 ROCK inhibitor-2 ROCK
ROCK inhibitor-2 is a selective dual inhibitor of ROCK1 and ROCK2 (IC50s of 17 nM and 2 nM, respectively).
T2633 GSK429286A RHO-15 ROCK
GSK429286A (RHO-15) is a specific inhibitor of ROCK1/2 (IC50: 14/63 nM).
T14960 Chroman 1 ROCK
Chroman 1 is an inhibitor of ROCK2 (IC50: 1 nM).
T4095 ZINC00881524 ROCK inhibitor ROCK
ZINC00881524 (ROCK inhibitor) is an effective and specific ROCK inhibitor.
T2011 RKI1313 RKI 1313,RKI-1313 ROCK
RKI1313 (RKI-1313) was a selective inhibitor for ROCK-dependent signaling, cytoskeletal changes, anchorage-independent colony formation, migration, and invasion.
T14989 CMPD101 ROCK , GRK , PKC
CMPD101 is a membrane-permeable small-molecule inhibitor of GRK2/3 (IC50: 18 nM and 5.4 nM). Which can be used for the study of heart failure. CMPD101 exhibits less selectively against GRK1, GRK5, ROCK-2 and PKCα with I...
T4488 GSK-25 GSK25 ROCK , S6 Kinase , mTOR
GSK-25 maintains good selectivity against a panel of 31 kinases, as well as RSK1 and p70S6K (RSK1 IC50 of 398 nM, p70S6K IC50 of 1000nM), and a dramatically improved P450 profile (>2.2 uM at all isozymes tested).
T7885 Afuresertib hydrochloride ROCK , Akt , PKC
Afuresertib hydrochloride is an inhibitor of Akt kinase (Kis of 0.08/2/2.6 nM for Akt1/Akt2/Akt3 respectively)
T13384L Y-33075 dihydrochloride CaMK , ROCK , PKC
Y-33075 dihydrochloride is a selective inhibitor of ROCK(IC50 of 3.6 nM).
T7648 HA-100 Myosin , PKA , PKC
HA-100 is an inhibitor of protein kinase
T2482 AT13148 ROCK , SGK , Akt , PKA , S6 Kinase
AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.
T1911 Afuresertib GSK2110183C,GSK2110183 ROCK , Akt , PKC
Afuresertib (GSK2110183) is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity.
T4276L Hydroxyfasudil Hydroxy-Fasudil,HA-1100 ROCK , PKA
Hydroxyfasudil (Hydroxy-Fasudil) is a ROCK inhibitor(IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively).
T7764 CCG-222740 ROCK , Rho , Ras
CCG-222740 is an inhibitor of Rho/MRTF pathway
TQ0110 ROCK-IN-2 TC-S 7001,Azaindole 1 ROCK
ROCK-IN-2 (Azaindole 1) is a selective and ATP-competitive ROCK inhibitor with IC50 of 0.6 and 1.1 nM for human ROCK-1 and ROCK-2.
TQ0319 Ripasudil K-115,Ripasudil hydrochloride dihydrate ROCK
Ripasudil (Ripasudil hydrochloride dihydrate) (K-115) hydrochloride dihydrate is a specific ROCK inhibitor (IC50s: 51/19 nM for ROCK1/ROCK2).
T3518 GSK269962A GSK269962B,GSK 269962,GSK269962A HCl ROCK , S6 Kinase
GSK269962A (GSK269962A HCl) is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.
T23308 SAR407899 hydrochloride ROCK
ATP-competitive ROCK inhibitor
T6867 Belumosudil KD025,Rezurock,ROCK inhibitor,SLx-2119 ROCK
Belumosudil (Rezurock) is an orally available, and specific ROCK2 inhibitor (IC50/Ki: 60/41 nM).
T4276 Hydroxyfasudil Hydrochloride Hydroxyfasudil (HA-1100) HCl,HA 1100 hydrochloride ROCK
Hydroxyfasudil Hydrochloride (HA 1100 hydrochloride) is a ROCK1/2 inhibitor (IC50s: 0.73/0.72 μM).
T7552 H-1152 ROCK
H-1152 is a potent, specific, ATP-competitive, and cell permeable ROCK inhibitor (Ki = 1.6 nM).
T1725 Y-27632 dihydrochloride Y-27632 2HCl ROCK , Apoptosis
Y-27632 dihydrochloride (Y-27632 2HCl) is an orally potent, ATP-competitive inhibitor of ROCK-I and ROCK-II. Y-27632 dihydrochloride also inhibits isolation-induced apoptosis in mouse prostate stem or progenitor cells.
T1606 Fasudil HA-1077,AT877 ROCK , Serine/threonin kinase , Calcium Channel , PKA , PKC , Autophagy
Fasudil (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.
T7492 Ripasudil free base K-115 (free base) ROCK , Antibacterial
Ripasudil free base (K-115 (free base)) is a selective and potent ROCK inhibitor, is a novel and potent antiglaucoma agent.
T3060 Fasudil hydrochloride Fasudil (HA-1077) HCl,HA-1077,Fasudil HCl,HA-1077 hydrochloride,AT-877 ROCK , Serine/threonin kinase , Calcium Channel , HIV Protease , PKA , PKC , Autophagy
Fasudil hydrochloride (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.
TP1008 Neurokinin A α-Neurokinin,Substance K,Neuromedin L Neurokinin receptor
Neurokinin A (NKA), formerly known as Substance K, is a neurologically active peptide translated from the pre-protachykinin gene.
T10056 Neurokinin antagonist 1 Neuropeptide Y Receptor
Neurokinin antagonist 1 is a potent is a neuropeptide antagonist that can be used to study neurological disorders.
TP1385 Neurokinin A(4-10) TFA(97559-35-8 free base) Neurokinin A(4-10) TFA Neurokinin receptor
Neurokinin A(4-10) TFA(97559-35-8 free base) is a tachykinin NK2 receptor agonist[1].
TP1363L Neurokinin B acetate(86933-75-7 free base) Neurokinin K Neurokinin receptor
Neurokinin B acetate(86933-75-7 free base) is the acetate form of Neurokinin B, which belongs to the tachykinin family. Neurokinin binds to neurokinin receptor 1 (NK1R), nk2r and NK3R, and mediates its biological effects...
T22517 5,7-Dichlorokynurenic acid 5,7-dichlorokynurenic acid sodium,5,7-DCKA NMDAR
5,7-Dichlorokynurenic acid (5,7-dichlorokynurenic acid sodium) is an NMDA receptor antagonist.
T26116 Rokitamycin
Rokitamycin is a macrolide antibiotic produced from strains of Streptomyces kitasatoensis.
TP1279 Neurokinin B (TFA) Neurokinin B TFA
Neurokinin B TFA belongs to the tachykinin family.Neurokinin B binds to a series of GPCR, including neurokinin receptors 1 (NK1R), NK2R, and nk3r, to modulate their biological effects
T76426 [Lys5,MeLeu9,Nle10]Neurokinin A(4-10)
[Lys5,MeLeu9,Nle10]Neurokinin A(4-10) (LMN-NKA), a Neurokinin A analogue, serves as a selective and potent agonist for the NK2 receptor (NK2R). This compound exhibits prokinetic activity, making it a valuable tool for re...
T7559 Neurokinin A(4-10) Neurokinin A(4-10)(TFA) Neurokinin receptor
Neurokinin A(4-10)(TFA) is an agonist of tachykinin NK2 receptor .
TP2472 Leucopyrokinin Pglu-thr-ser-phe-thr-pro-arg-leu-NH2
Leucopyrokinin is a myotropic neuropeptide.
T80915 Tyr0-Neurokinin A
Tyr0-Neurokinin A, a member of the tachykinin peptide family, acts as an agonist for the Tacr2 receptor. It is utilized in research focused on insulin resistance, obesity, and diabetes [1] [2].
T76655 Prokineticin 2 Isoform 2 (human)
Prokineticin 2 Isoform 2 (human), a hypothalamic neuropeptide, regulates thermoregulation and energy metabolism while decreasing food intake in rodents. This isoform is implicated in the study of metabolic syndrome (MetS...
T70654 Ciprokiren
Ciprokiren is a renin inhibitor discovered by Roche. Ciprokinen inhibited human renin in a buffer and human plasma with an IC50 of 0.07 and 0.65 nmol/L, respectively. In animal models, acute and chronic administration of...
T82511 Ebdarokimab
Ebdarokimab (AK101), a humanized IgG1-κ antibody, is typically produced in Chinese Hamster Ovary (CHO) cells [1].
T80577 Varokibart
Varokibart (TEV-53275) is a human IgG4λ antibody that targets interleukin-5 (IL-5) [1].
T124721 7,8-Dihydrokawain-5-ol
7,8-Dihydrokawain-5-ol is a useful organic compound for research related to life sciences. The catalog number is T124721 and the CAS number is 52247-81-1.

Compounds

Thiazovivin
T2155
Synonym:
Target: ROCK
ROCK2-IN-2
T12747
Synonym:
Target: ROCK
Y-27632
T1870
Synonym:
Target: ROCK, Apoptosis
SR-3677
TQ0187
Synonym:
Target: ROCK, Autophagy
BDP5290
T7301
Synonym:
Target: ROCK
SAR407899
T7391
Synonym:
Target: ROCK, Rho
LX7101
T15798
Synonym:
Target: ROCK, LIM Kinase, PKA
RKI-1447
T1898
Synonym: RKI1447
Target: ROCK
GSK180736A
T3513
Synonym: GSK180736
Target: ROCK, GRK, PKA
ROCK inhibitor-2
T12746
Synonym:
Target: ROCK
GSK429286A
T2633
Synonym: RHO-15
Target: ROCK
Chroman 1
T14960
Synonym:
Target: ROCK
ZINC00881524
T4095
Synonym: ROCK inhibitor
Target: ROCK
RKI1313
T2011
Synonym: RKI 1313,RKI-1313
Target: ROCK
CMPD101
T14989
Synonym:
Target: ROCK, GRK, PKC
GSK-25
T4488
Synonym: GSK25
Target: ROCK, S6 Kinase, mTOR
Afuresertib hydrochloride
T7885
Synonym:
Target: ROCK, Akt, PKC
Y-33075 dihydrochloride
T13384L
Synonym:
Target: CaMK, ROCK, PKC
HA-100
T7648
Synonym:
Target: Myosin, PKA, PKC
AT13148
T2482
Synonym:
Target: ROCK, SGK, Akt, PKA, S6 Kinase
Afuresertib
T1911
Synonym: GSK2110183C,GSK2110183
Target: ROCK, Akt, PKC
Hydroxyfasudil
T4276L
Synonym: Hydroxy-Fasudil,HA-1100
Target: ROCK, PKA
CCG-222740
T7764
Synonym:
Target: ROCK, Rho, Ras
ROCK-IN-2
TQ0110
Synonym: TC-S 7001,Azaindole 1
Target: ROCK
Ripasudil
TQ0319
Synonym: K-115,Ripasudil hydrochloride dihydrate
Target: ROCK
GSK269962A
T3518
Synonym: GSK269962B,GSK 269962,GSK269962A HCl
Target: ROCK, S6 Kinase
SAR407899 hydrochloride
T23308
Synonym:
Target: ROCK
Belumosudil
T6867
Synonym: KD025,Rezurock,ROCK inhibitor,SLx-2119
Target: ROCK
Hydroxyfasudil Hydrochloride
T4276
Synonym: Hydroxyfasudil (HA-1100) HCl,HA 1100 hydrochloride
Target: ROCK
H-1152
T7552
Synonym:
Target: ROCK
Y-27632 dihydrochloride
T1725
Synonym: Y-27632 2HCl
Target: ROCK, Apoptosis
Fasudil
T1606
Synonym: HA-1077,AT877
Target: ROCK, Serine/threonin kinase, Calcium Channel, PKA, PKC, Autophagy
Ripasudil free base
T7492
Synonym: K-115 (free base)
Target: ROCK, Antibacterial
Fasudil hydrochloride
T3060
Synonym: Fasudil (HA-1077) HCl,HA-1077,Fasudil HCl,HA-1077 hydrochloride,AT-877
Target: ROCK, Serine/threonin kinase, Calcium Channel, HIV Protease, PKA, PKC, Autophagy
Neurokinin A
TP1008
Synonym: α-Neurokinin,Substance K,Neuromedin L
Target: Neurokinin receptor
Neurokinin antagonist 1
T10056
Synonym:
Target: Neuropeptide Y Receptor
Neurokinin A(4-10) TFA(97559-35-8 free base)
TP1385
Synonym: Neurokinin A(4-10) TFA
Target: Neurokinin receptor
Neurokinin B acetate(86933-75-7 free base)
TP1363L
Synonym: Neurokinin K
Target: Neurokinin receptor
5,7-Dichlorokynurenic acid
T22517
Synonym: 5,7-dichlorokynurenic acid sodium,5,7-DCKA
Target: NMDAR
Rokitamycin
T26116
Synonym:
Target:
Neurokinin B (TFA)
TP1279
Synonym: Neurokinin B TFA
Target:
[Lys5,MeLeu9,Nle10]Neurokinin A(4-10)
T76426
Synonym:
Target:
Neurokinin A(4-10)
T7559
Synonym: Neurokinin A(4-10)(TFA)
Target: Neurokinin receptor
Leucopyrokinin
TP2472
Synonym: Pglu-thr-ser-phe-thr-pro-arg-leu-NH2
Target:
Tyr0-Neurokinin A
T80915
Synonym:
Target:
Prokineticin 2 Isoform 2 (human)
T76655
Synonym:
Target:
Ciprokiren
T70654
Synonym:
Target:
Ebdarokimab
T82511
Synonym:
Target:
Varokibart
T80577
Synonym:
Target:
7,8-Dihydrokawain-5-ol
T124721
Synonym:
Target:
1 2
Cat No. Product Name Synonyms Targets
TQ0183 Narciclasine Lycoricidinol ROCK
Narciclasine (Lycoricidinol), a natural product, modulates the Rho/Rho-kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity.
TN1204 2,3-Dehydrokievitone Antifungal
2,3-Dehydrokievitone, an isoflavone extracted from Erythrina sacleuxii, has antimicrobial activity against methicillin-resistant Staphylococcus aureus infections by decreasing the expression of α-hemolysin.
TN2029 P-Hydroxy-5,6-dehydrokawain 4'-Hydroxydehydrokawain Others
p-Hydroxy-5,6-dehydrokawain (4'-Hydroxydehydrokawain) is isolated from Kawain.
TN1406 Dihydrokaempferol Aromadendrin Apoptosis , BCL
Dihydrokaempferol (Aromadendrin) is a natural product. It induces apoptosis and inhibits Bcl-2 and Bcl-xL expression, possesses anti-inflammatory, antioxidant, and anti-diabetic properties, it exhibits anti-inflammatory ...
T10191L 7-Chlorokynurenic acid 7-chloro-4-hydroxy-2-carboxyquinoline,7-CKA GluR , NMDAR
7-Chlorokynurenic acid (7-chloro-4-hydroxy-2-carboxyquinoline) is an effecitve and selective antagonist of NMDA receptor with IC50 of 0.56 μM for the glycine B coagonist site. 7-Chlorokynurenic acid inhibits the reuptake...
T4591 Dihydrokavain Marindinin,7,8-Dihydrokavain,7,8-Dihydrokawain Others
Dihydrokavain (Marindinin), a prominent kavalactone in the kava plant, significantly contributes to the plant's anxiolytic effects, as evidenced by a study conducted on chicks.
TN2987 3Alaph-Tigloyloxypterokaurene L3 Others
3Alaph-Tigloyloxypterokaurene L3 is a natural product from Wedelia trilobata.
TN6178 Dihydrokaempferol 3-O-glucoside Aromadendrin 3-O-glucoside
Dihydrokaempferol 3-O-glucoside is a natural product for research related to life sciences. The catalog number is TN6178 and the CAS number is 31049-08-8.
TN4853 Pterokaurane R Others
Pterokaurane R is a natural product for research related to life sciences. The catalog number is TN4853 and the CAS number is 67349-43-3.
TN2920 3alpha-Angeloyloxypterokaurene L3 Others
3alpha-Angeloyloxypterokaurene L3 is a natural product from Wedelia trilobata.
TN6375 Dihydrokaempferide Aromadendrin 4'-methyl ether
Dihydrokaempferide is a natural product for research related to life sciences. The catalog number is TN6375 and the CAS number is 137225-59-3.
TN5039 Sorokinianin Antifection
Sorokinianin is a phytotoxin, it has antifungal activity, it is highly effective in suppressing spore germination of F. solani (75%) at 100 ug/ml concentration.
TN2921 3alpha-Cinnamoyloxypterokaurene L3 Others
3alpha-Cinnamoyloxypterokaurene L3 is a natural product for research related to life sciences. The catalog number is TN2921 and the CAS number is 79406-13-6.
TN4854 Pterokaurene L3 Others
Pterokaurene L3 is a natural product for research related to life sciences. The catalog number is TN4854 and the CAS number is 77658-38-9.

Natural Products

Narciclasine
TQ0183
Synonym: Lycoricidinol
Target: ROCK
2,3-Dehydrokievitone
TN1204
Synonym:
Target: Antifungal
p-Hydroxy-5,6-dehydrokawain
TN2029
Synonym: 4'-Hydroxydehydrokawain
Target: Others
Dihydrokaempferol
TN1406
Synonym: Aromadendrin
Target: Apoptosis, BCL
7-Chlorokynurenic acid
T10191L
Synonym: 7-chloro-4-hydroxy-2-carboxyquinoline,7-CKA
Target: GluR, NMDAR
Dihydrokavain
T4591
Synonym: Marindinin,7,8-Dihydrokavain,7,8-Dihydrokawain
Target: Others
3Alaph-Tigloyloxypterokaurene L3
TN2987
Synonym:
Target: Others
Dihydrokaempferol 3-O-glucoside
TN6178
Synonym: Aromadendrin 3-O-glucoside
Target:
Pterokaurane R
TN4853
Synonym:
Target: Others
3alpha-Angeloyloxypterokaurene L3
TN2920
Synonym:
Target: Others
Dihydrokaempferide
TN6375
Synonym: Aromadendrin 4'-methyl ether
Target:
Sorokinianin
TN5039
Synonym:
Target: Antifection
3alpha-Cinnamoyloxypterokaurene L3
TN2921
Synonym:
Target: Others
Pterokaurene L3
TN4854
Synonym:
Target: Others

Recombinant Proteins

Species：
Human (4)
Bovine (2)
Mouse (1)
Rat (1)
Expression System：
Baculovirus Insect Cells (3)
HEK293 Cells (3)
P. pastoris (Yeast) (2)
Tag：
C-His (3)
His (2)
C-hFc (1)
His, GST (1)
Tag Free (1)
Cat No. Product Name Species Expression System
TMPY-00904 Urokinase/uPA Protein, Human, Recombinant (His) Human HEK293 Cells
Urokinase/uPA Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 46 kDa and the accession number is A0A024QZM9.
TMPY-02945 Prokineticin 1/EG-VEGF Protein, Human, Recombinant (His) Human Baculovirus Insect Cells
EG-VEGF, also known as prokineticin-1, is a member of the AVIT (prokineticin) family. Prokineticins are secreted proteins that can promote angiogenesis and induce strong gastrointestinal smooth muscle contraction. EG-VEG...
TMPY-00274 Enterokinase Protein, Bovine, Recombinant (His) Bovine P. pastoris (Yeast)
Enterokinase Protein, Bovine, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 27.1 kDa and the accession number is P98072-1.
TMPY-00519 Gastrokine 1 Protein, Human, Recombinant (His) Human Baculovirus Insect Cells
Gastrokine 1 (GKN1) belongs to the BRICHOS domain family and plays a major role in maintaining gastric mucosa integrity. GKN1 is highly expressed in gastric tissue and is secreted into the stomach but is not expressed in...
TMPK-00972 PK-1/PROK1 Protein, Mouse, Recombinant (hFc) Mouse HEK293 Cells
PK-1 (Ac10) is a baculovirus-encoded serine/threonine kinase,a pk-1 knockout AcMNPV failed to produce infectious progeny, while the pk-1 repair virus could rescue this defect.the kinase activity of PK-1 is essential in r...
TMPY-04626 Enterokinase/EK Protein, Bovine, Recombinant Bovine P. pastoris (Yeast)
Enterokinase is a member of the trypsin family of serine proteases. The precursor protein is cleaved into two chains which then forms a heterodimer linked by a disulfide bond. The heavy chain anchors enterokinase in the ...
TMPY-04504 Urokinase/uPA Protein, Rat, Recombinant (His) Rat HEK293 Cells
Urokinase/uPA Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 47.3 kDa and the accession number is A6KKR2.
TMPY-04559 CDC42BPB Protein, Human, Recombinant (His & GST) Human Baculovirus Insect Cells
CDC42BPB is a member of the serine / threonine protein kinase family that contains a Cdc42 / Rsc-binding p21 binding domain similar to that of PAK kinase. The kinase domain of this protein is related to the myotonic dyst...
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