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Search Results for " lfa-1 "

12

Compounds

Cat No. Product Name Synonyms Targets
T21781 A-286982 Integrin
A 286982 is an inhibitor that blocks the integrin-ligand interaction between leukocyte function-associated antigen-1 (LFA-1) and intercellular adhesion molecule-1.
T3977 Lifitegrast SHP-606,SAR 1118 Integrin
Lifitegrast (SAR 1118) is a lymphocyte, function-associated antigen-1 antagonist.
T14676 BMS-688521 Integrin
BMS-688521 BMS-688521 is an orally active and potent inhibitor of LFA-1/ICAM interaction, a small molecule antagonist of leukocyte function-associated antigen-1 (LFA-1), with potential anti-inflammatory activity.
T12783 RWJ 50271 Integrin
RWJ 50271 is a selective lymphocyte function-associated antigen-1/intercellular adhesion molecule-1(LFA-1/ICAM-1) interaction inhibitor( IC50 of 5.0 μM in HL60 cells).
T23796 BIRT-377 BIRT377,BIRT 377 IL Receptor , Integrin
BIRT-377 is a negative allosteric and orally bioavailable inhibitor of ICAM-1 and LFA-1(Ki = 25.8 nM). BIRT-377 inhibits the production of IL-2 and can be used in studies about inflammatory and immune disorders.
T76924 Efalizumab Hu1124,HU 1124 Integrin
Efalizumab, a novel potent regulator of T cells, is a humanized LFA-1 α subunit (CD11a) monoclonal antibody. Efalizumab has inhibitory effects on T cell activation, skin T cell transport, and T cell adhesion to keratinoc...
T24155 ICAM-1988 ICAM 1988
ICAM-1988 is a LFA-1 antagonist.
T14558 BI-1950 Integrin
BI-1950 is a highly potent lymphocyte function associated antigen-1 (LFA-1) inhibitor and the LFA-1 is an essential component in normal immune system function and a target for drug discovery[1].
T30533 BMS-587101 UNII-5V7E4UQL93
BMS-587101 is a small molecule antagonist of LFA-1, which can reduce inflammation and joint destruction in the mouse model of arthritis.
T3977L Lifitegrast sodium SAR-1118-023,SAR1118-023,SAR 1118-023,Xiidra
Lifitegrast sodium (SAR-1118) is an LFA-1 antagonist for the therapy of vascular complications of the eye. It inhibits T cell-mediated inflammation by blocking the binding of two cell surface proteins (lymphocyte functio...
T40274 XVA143 XVA143
XVA143, an α/β I-like allosteric antagonist, effectively blocks LFA-1 dependent firm adhesion but simultaneously increases adhesion under shear flow and rolling conditions, both in vitro and in vivo.
T77106 Odulimomab
Odulimomab (anti-LFA1), an anti-LFA-1 monoclonal antibody, inhibits T lymphocyte proliferation and provides protection against ischemia and reperfusion injury. It is utilized in researching transplant rejection and immun...
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