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IRS

" in TargetMol Product Catalog
  • Inhibitors & Agonists
    35
    TargetMol | Inhibitors_Agonists
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    1
    TargetMol | Inhibitory_Antibodies
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Marein
TN1911535-96-6
Marein shows neuroprotective effect on PC12 cell damage induced by methylglyoxal, which is due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway, it may be a potent compound for preventing counteracting diabetic e
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TargetMol | Inhibitor Sale
Cirsiliol
T1082134334-69-5
Cirsiliol is a 5-lipoxygenase (5-LOX) inhibitor and low affinity benzodiazepine receptor ligand.Cirsiliol inhibits cell proliferation and promotes apoptosis of OS cells.Cirsiliol shows antitumor activity against OS cells in an in situ xenograft tumor model and can be used to study colon cancer.
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7-10 days
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Cirsimarin
Cirsitakaoside
T1082213020-19-4
Cirsimarin (Cirsitakaoside) is a flavonoid isolated from Microtea debilis. It shows a potent antilipogenic effect and decreases adipose tissue deposition in mice. Cirsimarin has antagonist activity on the adenosine A1 receptor and inhibitory effect on phosphodiesterase.
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Cirsilineol
SPM 927, Fastigenin, Eupatrin
T1988641365-32-6
Cirsilineol (Eupatrin) is isolated from the herb of Artemisia vestita Wall and shows immunosuppressive, anti-proliferative, and anti-tumor properties. Cirsilineol selectively induces apoptosis via the mitochondrial pathway.
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7-10 days
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Hirsutide
T38016865368-30-5
Hirsutide is a cyclotetrapeptide fungal metabolite produced by the entomopathogenic fungus Hirsutella. It has antibacterial activity against C. pyogenes, S. aureus, P. aeruginosa, and K. pneumonia (MICs = 25, 13, 6, and 21 μg/cm3, respectively). Hirsutide also has antifungal activity against C. albicans, M. audouinii, A. niger, and Ganoderma (MICs = 13, 6, 25, and 6 μg/cm3, respectively).
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Cirsiliol 4′-glucoside
T7553241087-98-3
Cirsiliol 4′-glucoside, a compound extracted from Ruellia tuberosa L., acts as a free radical scavenger and demonstrates potential anti-diabetic activity [1].
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Hirsutine
TN10657729-23-9
Hirsutine induces apoptosis and is a potent Dengue virus inhibitor exhibiting low cytotoxicity.Hirsutine has anticancer, cardioprotective, anti-hypertensive and anti-arrhythmic activities, it also has vasodilatation activity, the mechanism is related to blockade of Ca2+ influx through L-type Ca2+ channels and inhibition of intracellular Ca2+ release may have no relationship with K+ channels.
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Hirsuteine
TN108135467-43-7
Hirsuteine is a natural product. It non-competitively antagonizes nicotine-mediated dopamine release by blocking ion permeation through nicotinic receptor channel complexes.
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8alpha-(2-Methylacryloyloxy)-1-O-methylhirsutinolide 13-O-acetate
TN3293883872-71-7
8alpha-(2-Methylacryloyloxy)-1-O-methylhirsutinolide 13-O-acetate is a natural product for research related to life sciences. The catalog number is TN3293 and the CAS number is 883872-71-7.
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8alpha-(2-Methylacryloyloxy)hirsutinolide 13-O-acetate
TN329467667-71-4
8alpha-(2-Methylacryloyloxy)hirsutinolide 13-O-acetate shows inhibitory activity toward CYP2A6 and MAO-A and MAO-B enzymes.
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8alpha-(2-Methylacryloyloxy)hirsutinolide
TN3295188293-70-1
8alpha-(2-Methylacryloyloxy)hirsutinolide is a natural product for research related to life sciences. The catalog number is TN3295 and the CAS number is 188293-70-1.
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8alpha-Hydroxyhirsutinolide
TN32981394156-45-6
8alpha-Hydroxyhirsutinolide shows anti-inflammatory activity, it inhibits TNF-α-induced NF-κB activity with the IC(50) value of 1.9 uM.
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8alpha-Tigloyloxyhirsutinolide 13-O-acetate
TN330083182-58-5
8alpha-Tigloyloxyhirsutinolide 13-O-acetate shows inhibitory activity toward CYP2A6 and MAO-A and MAO-B enzymes. 8alpha-Tigloyloxyhirsutinolide 13-O-acetate has anti-cancer activity, it is active against both cancer cell lines (IC50 = 3.50 microM for HT29
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Hirsutanonol 5-O-glucoside
TN421193915-36-7
Hirsutanonol 5-O-glucoside (catalog number: TN4211; CAS number: 93915-36-7) is a natural product used in life sciences research.
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Hirsutanonol
TN421241137-86-4
Hirsutanonol is a secondary metabolite from the bark of Alnus glutinosa. Hirsutanonol has potent antioxidant and free radical scavenging activities and exhibits an inhibition effect on mitochondrial lipid peroxidation. Hirsutanonol can be used for studies
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Hirsutenone
TN421341137-87-5
Hirsutenone has potent antioxidant activity, it shows significant free radical scavenging activity and exhibits inhibition effect on the mitochondrial lipid peroxidation.Hirsutenone exhibits anti-cancer, and anti-filarial effects, it may exert a preventive effect against microbial endotoxin lipopolysaccharide-induced inflammatory skin diseases through inhibition of ERK pathway-mediated NF-kappaB activation. Hirsutenone attenuates adipogenesis by directly targeting PI3K and ERK during MCE in 3T3-L1 preadipocytes, underscoring the potential therapeutic application of Hirsutenone in preventing obesity.
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Cirsiumaldehyde
5,5'-oxydimethylenebis(2-furfural)
TN69757389-38-0
Cirsiumaldehyde is a compound isolated from the mature fruits of Lobelia chinensis, Cornus officinalis, and the fruits of Hippophae rhamnoides.Cirsiumaldehyde in the presence of collagen inhibited U46619-induced (1~5 uM) The inhibitory concentration of Cirsiumaldehyde on U46619-induced (1~5 uM) rat platelet aggregation in the presence of collagen was 0.8~1.0 ug mL.
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Cirsimaritin
TQ01196601-62-3
Cirsimaritin exhibits antibacterial, anti-inflammation, anti-tumor, antioxidant properties and renal protection. Cirsimaritin binds weakly to the benzodiazepine site on GABAA receptors.
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6-8 weeks
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Cholesterol
Cholesteryl alcohol, Cholesterin
T076057-88-5
Cholesterol (cholesteryl alcohol) is a natural product that is the major sterol in mammals and an agonist of estrogen-related receptor α (ERRα). Cholesterol is widely found in the cell membranes of animals and is also used in the synthesis of several important hormones and bile acids.
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Licarin B
(-)-Licarin B, Licarine B
T4S154551020-87-2
1.(-)-Licarin B (Licarine B) has anti-mycobacterial activity.
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Pinusolide
TL001431685-80-0
Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, and could be used to treat neurodegenerative diseases. Pinusolide attenuates blockade of insulin signaling by enhancing IRS-1 tyrosine phosphorylation by the activating the AMPK pathway, indicates the targeting of AMPK represents a new therapeutic strategy for hyperglycemia-induced insulin resistance and type 2 diabetes.
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Tectoruside
TN655138784-73-5
Tectoruside is a phenolic glycoside derived from Iris and Leopard lily with antimutagenic and antioxidant activity that attenuates palmitate-induced endothelial insulin resistance by targeting ROS-associated inflammation and the IRS-1 pathway Tectoruside can be used in cancer research.
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