IAA

5-Ph-IAA is an IAA derivative and a highly efficient, low-toxicity, reversible protein degradation ligand specifically designed for the AID2 system. AID2 induces rapid and effective depletion of mAID fusion proteins, enabling the study of protein function in living cells; it also exhibits antitumor activity. 5-Ph-IAA can be used in antitumor research.

cvxIAA is an orthologous auxin-TIR1 receptor that hijacks downstream auxin signalling only in the presence of the complementary concave TIR1 (ccvTIR1) receptor, without interfering with endogenous auxin or TIR1/afb.

3-Indoleacetic acid (indolylacetic acid) (IAA) is the most common plant hormone of the auxin class and it regulates various aspects of plant growth and development.

3-Indoleacetic acid sodium (Heteroauxin sodium salt) is a naturally occurring plant hormone of the auxin class. It can stimulate cell elongation and division, promoting plant growth and development. However, at high concentrations, it exhibits growth inhibiting effects, including epinasty and prevention of shoot and root growth. This latter effect formed the basis for which synthetic auxins were developed as herbicides and bioregulators in agriculture.

trans-3-Indoleacrylic acid is one of the endogenous metabolites that inhibits RSL3-induced ferroptosis and can be used to study colorectal cancer.

Iodoacetyl-LC-Biotin (Iaa-Biotin) is a biotinylated and haloacetyl-activated sulfhydryl-responsive probe that forms irreversible thioether bonds at alkaline pH (7.5-8.5), is membrane-permeable, and can be used to label protein cysteines and other sulfhydryl-containing molecules.

4-Chloroindole-3-acetic acid is a chlorinated analog of the plant auxin indole-3-acetic acid (IAA). It exists in the seeds of Medicago truncatula, Indian crowfoot and clover, acting as a plant hormone.

3-Indoleacetic acid-BSA is a hapten-carrier protein conjugate formed by coupling 3-Indoleacetic acid (IAA) to bovine serum albumin (BSA). As a hapten, 3-Indoleacetic acid alone cannot induce an immune response and must be conjugated to a large molecular protein to become a complete antigen with immunogenicity. 3-Indoleacetic acid-BSA may be supplied as a lyophilized powder or as a solution. The solution is prepared in 0.01 M PBS (pH 7.4) buffer at a typical concentration of 1 mg/mL.

R(+)-IAA-94 (R(+)-Methylindazone) is a potent indanyloxyacetic acid blocker of epithelial chloride channels. R(+)-IAA-94 inhibits Nef-sdAb19 (single-domain antibody) interaction and binds to negative factor (Nef).

PEO-IAA (2-(1H-Indol-3-yl)-4-oxo-4-phenyl-butyric acid) is a novel potent auxin antagonist.

5-Ph-IAA-AM, an eggshell-permeable analog of 5-Ph-IAA, enhances protein degradation in laid embryos and can be used to reveal the roles of temporally controlled protein degradation in C. elegans embryogenesis and development [1].

BH-IAA, a potent auxin antagonist, inhibits auxin-induced cell elongation by binding to and blocking auxin receptors [Journal of Plant Growth Regulation, 2020].

IAA-94 is an inhibitor of chloride channels, it binds channels in bovine kidney cortex microsomes with a Ki value of 1 µM.

IAA65 is a potent and highly selective transient receptor potential ankyrin 1 (TRPA1) inhibitor (IC50 = 4.3 nM). It demonstrates significant analgesic activity in animal models of inflammatory and neuropathic pain by competitively blocking TRPA1-mediated calcium influx in sensory neurons.

DiaAlk is a novel clickable electrophilic diazene probe enabling capture of oxidative post-translational modifications (OxiPTMs) and site-centric proteomics analysis.

UIAA-II-232 (compound 19b) is a potent DNA gyrase catalytic inhibitor with an IC₅₀ of 3.5 μM.

Dethiaacetyl-CoA (Acetonyldethio-coenzyme A) is a derivative of coenzyme A.

Phenylethyl isothiocyanate (JC5411) is an HDAC inhibitor. It potentially for the treatment of benign prostatic hypertrophy.

Thianthrene (Dibenzodithiodioxane) is a sulfur-containing heterocyclic chemical compound that is a derivative of the parent heterocycle called dithiin and is easy to oxidize.

Daminozide (Succinic Acid) is a plant growth regulator, selectively inhibits the KDM2/7 JmjC subfamily.

5-Hydroxyindole-3-acetic acid (5-HIAA) is a breakdown product of serotonin that is excreted in the urine. Serotonin and 5HIAA are produced in excess amounts by carcinoid tumors, and levels of these substances may be measured in the urine to test for carcinoid tumors (NCI).

Niaprazine is a histamine H1-receptor antagonist exhibiting significant sedative properties.

p-Ethynylphenylalanine hydrochloride (4-Ethynyl-L-phenylalanine HCL) is a novel, potent, and specific inhibitor of TPH[1]. Its potential to selectively and reversibly inhibit serotonin biosynthesis may contribute to characterizing the role of serotonin in behavioral and physiological activities[1].

(-)-Hydroxycitric acid (Garcinia acid) is the principal acid found in the fruit rinds of Garcinia cambogia. It acts as a potent and competitive inhibitor of ATP citrate lyase, suppressing fatty acid synthesis, food intake, lipogenesis, and inducing weight loss.