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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T1892 | Kobe2602 | Raf , Ras | |
Kobe 2602 is an inhibitor of Ras that exhibits anticancer chemotherapeutic activities. | |||
T2678 | LB42708 | Transferase | |
LB42708 is an orally active farnesyltransferase (FTase) inhibitor (IC50: 0.8/1.2/2.0 nM toward H/N/K-ras). | |||
T5368 | Eicosapentaenoic Acid | Histone Demethylase , Others , Endogenous Metabolite | |
Eicosapentaenoic Acid (EPA) is a ω-3 fatty acid abundantly available in marine organisms. | |||
T38050 | CP-609754 | Transferase | |
CP-609754 (LNK-754) is a potent and reversible farnesyltransferase inhibitor with potential anticancer activity.The IC50 for inhibiting farnesylation of recombinant human H-Ras is 0.57 ng/mL and recombinant K-Ras is 46 n... | |||
T6302 | Lonafarnib | Sarasar,Sch66336 | Raf , Transferase , Autophagy , Ras |
Lonafarnib (Sch66336) is an orally bioavailable FPTase inhibitor for H-ras, K-ras-4B, and N-ras (IC50: 1.9/5.2/2.8 nM). | |||
T5469 | K-Ras-IN-1 | Raf , Ras | |
K-Ras-IN-1 is a K-Ras inhibitor. | |||
T1876 | Kobe0065 | Apoptosis , Raf , Ras | |
Kobe0065 is a novel and effective small-molecule compound inhibiting Ras–Raf interaction by SBDD; shows potent activity to competitively inhibit the binding of H-Ras·GTP to c-Raf-1 RBD with a Ki value of 46 ± 13 μM. | |||
T22106 | MLS-573151 | CDK , Ras | |
MLS-573151 is a selective inhibitor of GTPase Cdc42(EC50 of 2 μM). It is inactive against other GTPases family members, such as Rab2, Rab7, H-Ras, Rac1, Rac 2 and RhoA wild-type. MLS-573151 acts by blocking the binding... | |||
T5S0620 | 3-Dehydrotrametenolic acid | Dehydrotrametenolic acid | Apoptosis , Others , Dehydrogenase |
1. 3-Dehydrotrametenolic acid can be a potential anticancer agent against H-ras transformed tumor. 2. Dehydrotrametenolic acid is a promising candidate for a new type of insulin-sensitizing drug. | |||
T2700 | FTI-277 hydrochloride | FTI 277 HCl | Apoptosis , Transferase , Ras |
FTI-277 hydrochloride (FTI 277 HCl) is an effective and specific farnesyltransferase (FTase) inhibitor (IC50: 500 pM); this selectivity is about 100-fold than the closely related GGTase I. | |||
T69710 | LB42908 | ||
LB42908 is a highly potent Ras farnesyltransferase inhibitor(IC(50)=0.9 nM against H-Ras and 2.4 nM against K-Ras) with potential anticancer activity. | |||
T62675 | FTI-277 | ||
FTI-277 is a farnesyltransferase FTase inhibitor and a potent Ras CAAX peptide mimetic.FTI-277 inhibits H-Ras and K-Ras signaling and inhibits hepatitis delta virus (HDV) infection. | |||
T41212 | FTI 277 | ||
FTI 277 is a prodrug form of FTI 276 that inhibits farnesyltransferase (FTase) (IC50 = 0.5 nM). Inhibits H-Ras and K-Ras processing in whole cells (IC50 values are 0.1 and 10μM respectively) and disrupts constitutive H-R... | |||
T27089 | CRT0066854 | CRT0066854 HCl,CRT-0066854 HCl,CRT 0066854,CRT-0066854 | |
CRT-0066854 is a PKCι and PKCζ inhibitor. CRT0066854 was able to restore polarized morphogenesis in the dysplastic H-Ras spheroids. | |||
T15353 | FTI-2153 | Others | |
FTI-2153 is a potent and highly selective farnesyltransferase (FTase) inhibitor (IC50: 1.4 nM). FTI-2153 is >3000-fold more potent at blocking H-Ras (IC50, 10 nM) than Rap1A processing. | |||
T26469 | A-176120 | ||
A-176120 is a potent farnesyl pyrophosphate (FPP) analogues, it selectively inhibits farnesyltransferase. It has anti-angiogenic potential and may reduce H-ras NIH3T3 tumour growth. | |||
T24188 | J-104871 | UNII-6137X5QNJF,J 104871 | |
J-104871 is an FTase inhibitor. J-104871 inhibits FTase in an FPP-competitive manner in whole cells as well as in the in vitro system. J-104871 suppressed tumor growth in nude mice transplanted with activated H-ras-trans... | |||
T68227 | BMS-214662 HCl | ||
BMS-214662 is a Farnesyltransferase inhibitor , is also a nonsedating benzodiazepine derivative with potential antineoplastic activity. BMS-214662 inhibits the enzyme farnesyltransferase and the post-translational farnes... | |||
T72707 | (Rac)-Lonafarnib | Sch66336 racemate | |
(Rac)-Lonafarnib (Sch66336 racemate) is the racemic form of the potent, orally active farnesyl transferase (FTase) inhibitor, Lonafarnib. It effectively inhibits H-ras, K-ras, and N-ras with IC50 values of 1.9 nM, 5.2 nM... | |||
T62379 | GGTI-286 | ||
GGTI-286 is a potent, cell permeable GGTase I inhibitor (IC50: 2 μM). GGTI-286 inhibits Rap1A geranylation in NIH3T3 cells (IC50: 2 μM) more potently than H-Ras farnesylation (IC50>30 μM). Ras4B stimulation (IC50: 1 μM). |