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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T15411 | GPNA hydrochloride | Apoptosis , Others | |
GPNA hydrochloride is specific glutamine (Gln) transporter ASCT2(SLC1A5) inhibitor. GPNA reversibly induces apoptosis in A549 cells. GPNA hydrochloride is a well-known substrate of the enzyme γ-glutamyltransferase (GGT).... | |||
T25450L | GGTI 2147 FA | GGTI2147 FA,GGTI-2147 FA,GGTI 2147 FA(191102-87-1 Free base) | Others |
GGTI 2147 FA, a selective GGT inhibitor, abolishes bicuculline-induced increase in dendritic spine density in hippocampal experiments and may reduce learning and memory abilities in mice. | |||
T6844 | GGTI298 Trifluoroacetate | GGTI 298,GGTI 298 TFA salt | Apoptosis , Transferase , Ras |
GGTI298 Trifluoroacetate (GGTI 298 TFA salt) is a geranylgeranyltransferase I inhibitor with ability to arrest human tumor cells in the G1 phase of the cell cycle and induce apoptosis. | |||
T24088 | GGTI-2133 | GGTI2133,GGTI 2133 | Transferase |
GGTI-2133 is a potent mimetic peptidyl geranylgeranyltransferase type I inhibitor (GGTase I) with an IC50 value of 38 nM.GGTI-2133 inhibits the invasion of inflammatory cells into the airways in experimental asthma in mi... | |||
T25450 | GGTI 2147 | GGTI2147,Geranylgeranyl transferase inhibitor-2147,GGTI-2147 | NF-κB , Rho |
GGTI 2147 decreased Rac1 activity, down-regulated p65 expression, and ameliorated OGD/R-induced neuronal apoptosis. | |||
T27412 | GGTI2417 | GGTI-2417 | |
GGTI2417 is a potent and selective inhibitor of Geranylgeranyltransferase I. GGTI2417 targets RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growth. | |||
T11397 | GGTI298 | Others | |
GGTI298, a CAAZ peptidomimetic and potent geranylgeranyltransferase I (GGTase I) inhibitor, efficiently blocks the processing of geranylgeranylated Rap1A while exerting minimal impact on the processing of farnesylated Ha... | |||
T70157 | GGTI-297 | ||
GGTI-297 is a potent, cell-permeable, and selective peptidomimetic inhibitor of GGTase I compared to Farnesyl Transferase (FTase). | |||
T37446 | GGTI-2154 | ||
GGTI-2154 is a potent, selective geranylgeranyltransferase I (GGTase I) inhibitor, boasting an IC50 of 21 nM and demonstrating over 200-fold selectivity against FTase (IC50=5600 nM). Its efficacy and specificity make it ... | |||
T62379 | GGTI-286 | ||
GGTI-286 is a potent, cell permeable GGTase I inhibitor (IC50: 2 μM). GGTI-286 inhibits Rap1A geranylation in NIH3T3 cells (IC50: 2 μM) more potently than H-Ras farnesylation (IC50>30 μM). Ras4B stimulation (IC50: 1 μM). | |||
T62844 | GGTI-2154 hydrochloride | ||
GGTI-2154 hydrochloride is a potent and selective inhibitor of geranylgeranyltransferase I (GGTase I) (IC50: 21 nM). GGTI-2154 hydrochloride can be used in cancer research. | |||
T11396 | GGTI-2418 | Transferase | |
GGTI-2418 is a highly potent, competitive, and selective inhibitor of geranylgeranyltransferase I (GGTase I), showing inhibitory activities with IC50 values of 9.5 nM for GGTase I and 53 μM for FTase, respectively. Addit... | |||
T62980 | GGTI-286 hydrochloride | ||
GGTI-286 hydrochloride is a potent inhibitor of GGTase I (IC50: 2 μM) and is also effective in inhibiting K-Ras4B (IC50: 1 μM). farnesylation (IC50=2 and >30 μM). | |||
T73822 | GGTI-286 TFA | ||
GGTI-286 TFA is a potent, cell-permeable inhibitor of GGTase I, exhibiting 25 times greater effectiveness (IC 50 = 2 μM) compared to the corresponding methyl ester of FTI-276. It specifically targets the geranylgeranylat... | |||
T69205 | GGTI-2166 | ||
GGTI-2166 is a geranylgeranyl transferase I inhibitor. GGTI-2166 inhibit the pOC formation induced by RANKL or TNF-alpha in cultures of both mouse marrow-derived macrophage-colony-stimulating factor (M-CSF) dependent mo... | |||
T5415 | γ-GT | H-GLA(PNA)-OH | Others |
γ-GT (H-GLA(PNA)-OH) is used as a synthetic substrate for gamma-glutamyltransferase (GGT) to determine GGT activity. | |||
T22128 | OU749 | Transferase | |
OU749 is a γ-glutamyl transferase (GGT) inhibitor with an intrinsic Ki of 17.6 μM. | |||
T11282 | FGTI-2734 | Transferase | |
FGTI-2734 is a dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT-1) inhibitor, exhibiting IC50 values of 250 nM and 520 nM for FT and GGT-1, respectively. It effectively prevents the membrane localizat... | |||
T11282L | FGTI-2734 mesylate (1247018-19-4 free base) | FGTI-2734 mesylate | Others |
FGTI-2734 mesylate, a RAS C-terminal mimetic compound with dual farnesyl transferase (FT) and geranylgeranyl transferase-1 (GGT) inhibitory activities (IC50s of 250 nM and 520 nM for FT and GGT, respectively), mitigates ... | |||
T15379 | GGsTop | Nahlsgen | Others |
GGsTop is a non-toxic and irreversible inhibitor of γ glutamyl transpeptidase (GGT) (Ki: 170 μM for Human GGT). GGsTop protects hepatic ischemia-reperfusion injury in the rat model. GGsTop shows Kons of 150±10 and 51±3 /... |