cullin — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T23371	SMER3	SMER 3	Others , Ligand for E3 Ligase
	SMER3 is an inhibitor of the Skp1-Cullin-F-box (SCF)(Met30) ubiquitin ligase, a member of the SCF E3-ligase family, which regulates diverse cellular processes including transcription, cell-cycle control and immune respon...		Others , Ligand for E3 Ligase
T2850	Bicuculline	(+)-Bicuculline,d-Bicuculline	GABA Receptor
	Bicuculline ((+)-Bicuculline) is a light-sensitive competitive antagonist of GABAA receptors. It was originally identified in 1932 in plant alkaloid extracts and has been isolated from Dicentra cucullaria, Adlumia fungos...		GABA Receptor
T22604	(-)-Bicuculline methiodide		Others
	(-)-Bicuculline methiodide is a GABAA receptor antagonist.		Others
T12043	(-)-Bicuculline methobromide	l-Bicuculline methobromide	GABA Receptor
	(-)-Bicuculline methobromide is a potent antagonist of GABAA receptor .		GABA Receptor
T72246	Bicuculline methobromide	(+)-Bicuculline methobromide,d-Bicuculline methobromide,(+)-Bicuculline methobromide ; d-Bicuculline methobromide
	Bicuculline methobromide, a selective GABAA Receptor antagonist with an IC50 value of 3 μM, induces tonic-clonic convulsions in mammals and blocks Ca2+ activated potassium channels. It is applicable in researching epilep...
T74112	Bicuculline methochloride
	Bicuculline methochloride ((+)-Bicuculline; d-Bicuculline), a selective GABAA receptor antagonist, exhibits an IC50 of 3 μM. It induces tonic-clonic convulsions in mammals and blocks Ca2+ activated potassium channels, ma...
T12044	(-)-Bicuculline methochloride	l-Bicuculline methochloride	GABA Receptor
	(-)-Bicuculline methochloride is a potent antagonist of GABAA receptor.		GABA Receptor
T77525	EN450		NF-κB
	EN450 is a cysteine-responsive covalent molecular gel degrader of targeted NF-κB with antiproliferative and potentially anticancer activity, which acts through a dependence on Cullin E3 ligase and protease, and can be us...		NF-κB
T9140	NAcM-OPT HCl(2089293-61-6 free base)		NEDD8
	NAcM-OPT HCL is an orally bioavailable cullin neddylation 1 (DCN1) inhibitor that targets N-Acetyl-UBE2M (E2 conjugating enzyme, UBC12) interaction with DCN1 with IC50 of 79 nM.		NEDD8
T5374	NAcM-OPT		E1/E2/E3 Enzyme , NEDD8
	NAcM-OPT is a specific, reversible inhibitor targeting N-Acetyl-UBE2M interaction with DCN1 （IC50: 79 nM).		E1/E2/E3 Enzyme , NEDD8
T0213	Thalidomide	Thalomid,Sedoval	Apoptosis , TNF , Autophagy , Ligand for E3 Ligase , Molecular Glues
	Thalidomide (Thalomid) is a synthetic derivative of glutamic acid (alpha-phthalimido-glutarimide) with teratogenic, immunomodulatory, anti-inflammatory and anti-angiogenic properties.
T23989	DI-404
	DI-404 is a high-Affinity Peptidomimetic the DCN1-UBC12 Protein-Protein Interaction inhibitor (Kd= 6.9 nM). DI-404 effectively and selectively inhibits the neddylation of cullin 3 over other cullin members.
T71830	DT204
	DT204 is a SCFSkp2 inhibitor which blocks Skp2 binding to Cullin-1 and Commd1, thereby synergistically enhancing BTZ-induced apoptosis and stabilization. DT204 also increases p27 levels.
T63930	DI-1859
	DI-1859 is a selective, potent and covalent inhibitor of DCN1. At low nanomolar concentrations, DI-1859 inhibits the neddylation of cullin 3 in cells. DI-1859 induces a significant increase in NRF2 protein, a CRL3 substr...
T78194	Skp2 inhibitor 2		E1/E2/E3 Enzyme
	Skp2 inhibitor 2 (14f) impedes the F-box protein S-phase kinase-associated protein 2 (Skp2), demonstrating an IC50 of 10.2 μM against Skp2-Cks1. This compound targets Skp2, a component of cullin-RING ligases that recruit...		E1/E2/E3 Enzyme
T18598	PROTAC BRD2/BRD4 degrader-1		Others
	PROTAC BRD2/BRD4 degrader-1 (compound 15) serves as a potent, selective degrader of BET proteins BRD4 and BRD2, achieving rapid, reversible, and unexpectedly selective elimination of BRD4 and BRD2 compared to BRD3. Its e...		Others