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Cat No. | Product Name | Synonyms | Targets |
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T10791 | CHK1-IN-3 | Chk | |
CHK1-IN-3 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 0.4 nM). | |||
T10792L | CHK1-IN-4 hydrochloride | CHK1-IN-4 hydrochloride(2120398-41-4 Free base) | Chk |
CHK1-IN-4 hydrochloride is a potent inhibitor of checkpoint kinase 1 (chk1). CHK1-IN-4 hydrochloride potently inhibits chk1 phosphorylation in the tumor cells. CHK1-IN-4 hydrochloride has anti-tumor activity. | |||
T40091 | Chk1-IN-6 | Chk1-IN-6 | |
Chk1-IN-6 is a potent, selective, and orally bioavailable CHK1 inhibitor candidate. | |||
T37098 | Chk1-IN-5 | Chk1-IN-5 | |
Chk1-IN-5 is a highly effective inhibitor of checkpoint kinase 1 (Chk1), which hinders the phosphorylation of Chk1 and effectively suppresses tumor growth in a colon cancer xenograft model[1]. | |||
T10790 | CHK1-IN-2 | Chk | |
CHK1-IN-2 is an inhibitor of checkpoint kinase 1 (CHK1; IC50: 6 nM). | |||
T10793 | CHK1 inhibitor | GDC-0575 analog | Chk |
CHK1 inhibitor (GDC-0575 analog) is a CHK1 inhibitor. | |||
T10792 | CHK1-IN-4 | Chk | |
CHK1-IN-4 is a potent inhibitor of checkpoint kinase 1 (chk1) and potently inhibits chk1 phosphorylation in the tumor cells with anti-tumor activity. | |||
T82393 | FLT3/CHK1-IN-1 | ||
Compound 18, also known as FLT3/CHK-IN-1, is a dual inhibitor targeting FLT3 and CHK1, exhibiting over 1700-fold selectivity towards c-KIT and significantly diminishing hERG affinity, with an IC50 of 58.4 μM. It demonstr... | |||
T6028 | PF 477736 | PF 00477736,PF-477736,PF-736,PF-00477736,PF477736 | c-Fms , VEGFR , FGFR , FLT , c-RET , Chk , CDK , Src , Aurora Kinase |
PF 477736 (PF-736,PF-00477736) is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (CSF1R), Ret and Yes. | |||
T7300 | GDC-0575 | ARRY-575,RG7741 | Chk |
GDC-0575 (ARRY-575) is a highly-selective oral small-molecule Chk1 inhibitor(IC50 of 1.2 nM). | |||
T27407 | GDC0575 monohydrochloride | ARRY-575,GDC-0575,GDC 0575,ARRY575,GDC0575 | Chk |
GDC0575 monohydrochloride (ARRY575) is a potent and selective inhibitor of cell cycle checkpoint kinase 1 (Chk1) with an IC50 of 1.2 nM. GDC-0575 specifically binds to and inhibits Chk1; this may result in tumor cells by... | |||
T7080 | CCT245737 | SRA737 | Chk |
CCT245737 (SRA737) is an orally active and selective Chk1 inhibitor (IC50: 1.3 nM); CCT245737 shows much less activity against Chk2 (IC50: 2440 nM). | |||
T6931 | PD0166285 | PD-166285 | Apoptosis , Wee1 , Chk |
PD0166285 is a potent Wee1 and Chk1 inhibitor with activity at nanomolar concentrations.PD0166285 is a novel G2 checkpoint abrogator. | |||
T6350 | CHIR-124 | CHIR124,CHIR 124 | Apoptosis , GSK-3 , FLT , Chk , PDGFR , Src |
CHIR-124 is an effective Chk1 inhibitor (IC50: 0.3 nM). It has 2, 000-fold selectivity against Chk2, 500- to 5, 000-fold less activity against Cdc2 and CDK2/4. | |||
T6093 | AZD-7762 | AZD7762 | Chk |
AZD-7762, an effective and specific inhibitor of Chk1(IC50=5 nM), is equally potent against Chk2 and less potent against CAM, Yes, Fyn, Lyn, Hck and Lck. | |||
T2517 | SCH900776 | MK 8776,MK-8776 | Chk , CDK |
SCH900776 (MK-8776) is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities. | |||
T6084 | Rabusertib | LY2603618,IC-83 | Chk , PDK , Autophagy |
Rabusertib (IC-83) is an inhibitor of the cell cycle checkpoint kinase 1 (chk1) with potential chemopotentiating activity. Rabusertib has been used in trials studying the treatment of Cancer, Solid Tumors, Advanced Cance... | |||
T21331 | SAR-020106 | Chk | |
SAR-020106 is a potent, ATP-competitive, and selective CHK1 inhibitor with an IC50 of 13.3 nmol/L on the isolated human enzyme. | |||
T71259 | GNE-900 | GNE900,GNE 900 | Apoptosis , Chk |
GNE-900 is an ATP-competitive ChK1 inhibitor with selective and oral activity.GNE-900 inhibits ChKl and ChK2 with IC50 values of 0.0011 and 1.5 µM, respectively.GNE-900 enhances DNA damage and induces apoptosis. GNE-900 ... | |||
T4310 | Prexasertib | LY2606368 | Apoptosis , Chk |
Prexasertib (LY2606368) is an inhibitor of checkpoint kinase 1 (chk1) with potential antineoplastic activity. | |||
T3700 | SCH900776 (S-isomer) | MK-8776 S-isomer,SCH900776 S-isomer | Chk , CDK |
SCH900776 S-isomer (MK-8776 S-isomer) is an effective, specific and orally bioavailable inhibitor of checkpoint kinase Chk1 (IC50: 3 nM). It also inhibitors Chk2 (IC50: 1500 nM) and cyclin-dependent kinase CDK2 (IC50: 16... | |||
T13148 | CHK-IN-1 | Chk | |
CHK-IN-1 is a dual inhibitor of CHK1 and CHK2 with antiproliferative activity. | |||
T9252 | LY2880070 | Chk | |
LY2880070 is a new checkpoint kinase 1 (CHK1) inhibitor for cancer therapy. | |||
T4327 | Prexasertib dihydrochloride | LY2606368 (dihydrochloride),Prexasertib HCl,LY2606368 | Apoptosis , Chk , S6 Kinase |
Prexasertib dihydrochloride (LY2606368) is an ATP-competitive CHK1 inhibitor (Ki: 0.9 nmol/L). in the cell-free assay, its IC50 values are 8 nM and 9 nM for CHK2 and RSK, respectively. | |||
T10406 | Tuvusertib | M1774,ATR inhibitor 1 | Apoptosis , ATM/ATR , Others , Chk |
Tuvusertib (M1774) is an orally available ataxia telangiectasia and Rad3-related (ATR) kinase inhibitor (Ki< 1 µΜ) with selective and potentially antitumor activity.Tuvusertib selectively inhibits ATR activity and blocks... | |||
T6532 | Hesperadin | Influenza Virus , Parasite , Aurora Kinase , Autophagy | |
Hesperadin(IC50=250 nM) effectively inhibits Aurora B. It potently reduces the activity of AMPK, MAPKAP-K1, MKK1, Lck, CHK1 and PHK, but it could not inhibit MKK1 activity in vivo. | |||
T6077 | ZM-447439 | Apoptosis , MEK , Src , Aurora Kinase | |
ZM 447439 is a selective and ATP-competitive inhibitor for Aurora A and Aurora B with IC50 of 110 nM and 130 nM, respectively. It is more than 8-fold selective for Aurora A/B than MEK1, Src, Lck and has little effect aga... | |||
T5425 | ML367 | Epigenetic Reader Domain | |
ML367 is a potent inhibitor of ATPase family AAA domain-containing protein 5 (ATAD5) stabilization and acts as a probe molecule that has low micromolar inhibitory activity | |||
T14904 | CCT244747 | Chk | |
CCT244747 is a CHK1 inhibitor (IC50: 7.7 nM) and also abrogates G2 checkpoint (IC50: 29 nM). | |||
T4310L2 | Prexasertib mesylate | LY-2606368,LY2606368,LY 2606368 | |
Prexasertib is a potent and selective Chk1/Chk2 inhibitor. Prexasertib increases the effectiveness of conventional therapy in B-/T- cell progenitor acute lymphoblastic leukemia. LY2606368 causes replication catastrophe a... | |||
T16141 | MRT00033659 | Others | |
MRT00033659 is an effective broad-spectrum kinase inhibitor of CK1 (IC50=0.9 µM for CK1δ) and CHK1 (IC50=0.23 µM). MRT00033659 is a pyrazolo-pyridine analogue. It also induces p53 pathway activation and E2F-1 destabiliza... | |||
T16848 | SB-218078 | Chk , PKC | |
SB-218078 is less potently inhibits Cdc2 (IC50: 250 nM) and PKC (IC50: 1000 nM). SB-218078 is a potent, ATP-competitive, and cell-permeable checkpoint kinase 1 inhibitor that inhibits Chk1 phosphorylation of cdc25C (IC50... | |||
T16446 | PD 407824 | PD-407824 | Wee1 , Chk |
PD 407824 is a chemical BMP sensitiser that promotes increased cellular sensitivity to subthreshold amounts of BMP4.PD 407824 is a potent inhibitor of the checkpoint kinases Chk1 and WEE1 (IC50s: 47 and 97 nM, respective... | |||
T4310L | Prexasertib lactate hydrate | Prexasertib monolactate monohydrate,LY-2606368,LY 2606368,LY2606368,Prexasertib monolactate monohydrate salt | |
Prexasertib is an effective and selective Chk1/Chk2 inhibitor. Prexasertib causes Replication Catastrophe and Antitumor Effects through CHK1-Dependent Mechanisms. | |||
T70553 | CCT245737(S) | ||
CCT245737(S) is a highly selective oral checkpoint kinase 1 (CHK1) inhibitor. | |||
T23447 | TCS 2312 | Others | |
checkpoint kinase 1 (chk1) inhibitor | |||
T24506 | MU-380 | MU 380,MU380 | |
MU-380 is an effective and selective inhibitor of CHK1. | |||
T27424 | GNE-783 | ||
GNE-783 is a selective inhibitor of CHK1. | |||
T68981 | PD-321852 | ||
PD-321852 is a small-molecule Chk1 inhibitor, which potentiates gemcitabine-induced clonogenic death in a panel of pancreatic cancer cell lines and evaluated the relationship between endpoints associated with Chk1 inhibi... | |||
T38620 | Prexasertib dimesylate | LY2606368 dimesylate | |
Prexasertib dimesylate (LY2606368 dimesylate) is a highly selective ATP-competitive second-generation inhibitor of checkpoint kinase 1 (CHK1). With a K i of 0.9 nM and an IC 50 of <1 nM, Prexasertib dimesylate effectivel... | |||
T36704 | CCT241533 dihydrochloride | CCT 241533 dihydrochloride | |
Potent Chk2 inhibitor (IC50 = 3 nM). Shows >63-fold selectivity for Chk1 over Chk2 and a panel of 84 other kinases. Inhibits Chk2 activation in response to etoposide-induced DNA damage in HT29 cells. Blocks ionizing radi... | |||
T62735 | GDC-0575 dihydrochloride | ||
GDC-0575 dihydrochloride (ARRY-575 dihydrochloride) is a selective, orally active CHK1 inhibitor (IC50: 1.2 nM) that exhibits antitumour effects. | |||
T10407 | Gartisertib | ATR inhibitor 2 | ATM/ATR |
ATR inhibitor 2 is an orally active, ATP-competitive, and selective ATR inhibitor (Ki <150 pM) with antitumor activity. ATR inhibitor 2 potently inhibits ATR-driven phosphorylated checkpoint kinase-1 (Chk1) phosphorylati... | |||
T9666 | GDC-0425 | ||
GDC-0425 (RG-7602) is an orally administered, selective small molecule inhibitor targeting checkpoint kinase 1 (ChK1), utilized in research focused on various malignancies [1] [2]. | |||
T26981 | Ceralasertib formate | Ceralasertib,AZD-6738,AZD 6738,AZD6738 | |
Ceralasertib is an orally available inhibitor of ataxia telangiectasia and rad3 related (ATR) kinase. Ceralasertib selectively inhibits ATR activity by blocking the downstream phosphorylation of the serine/threonine prot... | |||
T83740 | Ziptide TFA | ||
Ziptide, a peptide substrate, is recognized by several serine/threonine protein kinases, such as MAPK activated protein kinase 2 (MAPKAPK2), MAPKAPK3, MAPKAPK5, checkpoint kinase 1 (Chk1), AMP-activated protein kinase (A... | |||
T10704 | CCB02 | Microtubule Associated | |
CCB02 is a selective CPAP-tubulin interaction inhibitor (IC50: 689 nM) with anti-tumor activity. CCB02 shows no inhibition on the cell cycle- and centrosome-related kinases, or the phosphorylation status of Aurora-A, CDK... | |||
T33737 | NSC 109555 | NSC-109555,DDUG dimethanesulfonate,NSC109555,DDUG diMS | |
NSC 109555 is a selective, reversible, ATP-competitive Chk2 inhibitor (IC50 = 0.2 μM) that displays no effect on a range of other kinases including Chk1 (IC50 > 10 μM). Inhibits histone H1 phosphorylation (IC50 = 0.24 μM... | |||
T63152 | Prexasertib Mesylate Hydrate | ||
Prexasertib Mesylate Hydrate (LY2606368 Mesylate Hydrate) is an ATP-competitive, selective, second generation cell cycle detection site kinase 1 (CHK1) inhibitor (IC50<1 nM, Ki: 0.9 nM). Prexasertib Mesylate Hydrate inhi... | |||
T69091 | CBP501 | ||
CBP501 is a peptide with G2 checkpoint-abrogating activity. G2 checkpoint inhibitor CBP501 inhibits multiple serine/threonine kinases, including MAPKAP-K2, C-Tak1, and CHK1, that phosphorylate serine 216 of the dual-spec... |
Cat No. | Product Name | Synonyms | Targets |
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T3824 | Jaceosidin | Apoptosis , BCL , COX , UGT | |
Jaceosidin has anti-oxidative activity. Jaceosidin has anti-inflammatory activity, also a microglial inhibitor with anti-neuroinflammation activity. aceosidin has anticancer activity, modulates the ERK/ATM/Chk1/2 pathway... |
Cat No. | Product Name | Species | Expression System |
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TMPY-04368 | Chk1 Protein, Human, Recombinant (GST) | Human | Baculovirus-Insect Cells |
CHK1 / CHEK1 contains 1 protein kinase domain and belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, NIM1 subfamily. It is a member of checkpoint kinases (Chks). Chks Checkpoint kinases (Chks)... | |||
TMPY-04433 | Chk1 Protein, Mouse, Recombinant (His & GST) | Mouse | Baculovirus-Insect Cells |
CHK1 / CHEK1 contains 1 protein kinase domain and belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family, NIM1 subfamily. It is a member of checkpoint kinases (Chks). Chks Checkpoint kinases (Chks)... | |||
TMPY-02228 | P53 Protein, Cynomolgus, Recombinant | Cynomolgus | E. coli |
p53, also known as Tp53, is a DNA-binding protein which belongs to the p53 family. It contains transcription activation, DNA-binding, and oligomerization domains. p53 protein is expressed at low level in normal cells and... |