T5996 |
CB1-IN-1
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DBPR211,1-(2,4-二氯苯基)-N-1-哌啶基-4-[[(1-吡咯烷基磺酰基)氨基]甲基]-5-[5-[2-[4-(三氟甲基)苯基]乙炔基]-2-噻吩基]-1H-吡唑-3-甲酰胺 |
Cannabinoid Receptor
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CB1-IN-1 是新型的外周大麻素-1受体 (CB1R) 拮抗剂,作用于CB1R (EC50 = 3 nM) 和 CB2R 的Ki 分别为0.3 nM 和 21 nM。 |
T14881 |
CB1 antagonist 2
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AM4113 |
Cannabinoid Receptor
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CB1 antagonist 2 是一种 caimabinoid 1 拮抗剂,在体内抑制 CB1 的IC50值为 25.5 nM。摘自 WO2016184310A1 中获得,化合物 3。 |
T28468 |
PSNCBAM-1
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PSNCBAM 1 |
Cannabinoid Receptor
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PSNCBAM-1 是一种 CB1 受体负变构调节剂 (EC50 = 0.1 μM),在体内具有吞噬作用。 PSNCBAM-1 可用于肥胖研究。 |
TN5131 |
Tetrahydrocannabivarin
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delta9-Tetrahydrocannabivarin,THCV,Tetrahydrocannavarin,CRM |
Cannabinoid Receptor
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Tetrahydrocannabivarin 是 cannabinoid type 1 receptor 的中性拮抗剂,对 2 型糖尿病有潜在治疗价值。 |
T36520 |
COR659
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Cannabinoid Receptor
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GABA Receptor
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COR659 是一种有效的 GABAB 的阳性变构调节剂。COR659具有缓解大鼠对酒精和巧克力成瘾的作用。 |
T9466 |
RTICBM-189
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Others
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RTICBM-189 是可透过血脑屏障的大麻素 1 型受体变构调节剂,在 Ca2+动员试验中pIC50为 7.54,对 hCB1和 mCB1的 pIC50分别为 5.29 和 6.25。 |
T8425 |
Linoleoyl Ethanolamide
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TRP/TRPV Channel
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Linoleoyl ethanolamide 是脂肪酸乙醇酰胺。它可弱结合 CB1 和 CB2 受体,并分别抑制[3H]CP-55,940的结合,Ki 分别为 10 和 25μM。它在引起小鼠过氧化氢酶方面的效力是 anandamide 的... |
T10510 |
CB1 antagonist 1
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Cannabinoid Receptor
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CB1 antagonist 1 is a CB1 receptor antagonist, used in the research of obesity and metabolic syndrome, neuroinflammatory... |
T61849 |
AM8936
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AM8936 is a well-balanced and highly potent agonist for the cannabinoid receptor type-1 (CB1) in functional assays, with... |
T62180 |
CB1/2 agonist 2
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CB1/2 agonist 2 (compound 23) 是一种有效的非选择性大麻素 (cannabinoid) 配体,其Ki 分别为 3.5 nM 和 1.2 nM。CB1/2 agonist 2 是一种 CB1 的完全激动剂,也是 C... |
T61609 |
CB1-IN-2
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CB1-IN-2 (Compound 4g) is a potent and selective inhibitor of the CB1 receptor, exhibiting an IC50 value of 0.644 μM. Th... |
T38204 |
GAT229
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GAT229 is a positive allosteric modulator of cannabinoid receptor 1 (CB1) and the S-(-) enantiomer of the CB1 modulator ... |
T72395 |
CB1 inverse agonist 2
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CB1inverse agonist 2 是一种口服有效的大麻素受体 CB1反向激动剂。CB1inverse agonist 2 在小鼠模型中,能有效抑制 CP55940 导致的体温失温和厌食情况。 |
T69740 |
AMG-315
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AMG-315 is a Potent Endocannabinoid Ligand with Stability to Metabolizing Enzymes. AMG-315 is a chiral arachidonoyl eth... |
T38138 |
Arachidonoyl 2'-Chloroethylamide
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Arachidonoyl 2'-Chloroethylamide,2'-chloro-AEA,ACEA |
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Arachidonoyl 2-chloroethylamide (ACEA) is a potent and selective cannabinoid (CB) receptor 1 agonist with Ki values of 1... |
T38049 |
Glycerophospho-N-Palmitoyl Ethanolamine
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N-Acylated ethanolamines (NAE) are naturally-occurring lipids that have diverse bioactivities. For example, arachidonoyl... |
T21811 |
LH 21
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LH-21 是一种有效的体内中性大麻素 CB1受体拮抗剂。LH-21 会导致剂量依赖性进食抑制,减少肥胖 Zucker 大鼠的食物摄入和体重增加。 |
T22146 |
S-1 Methanandamide
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S-1 Methanandamide ((S)-Methanandamide) 是 Anandamide 的类似物,是一种 CB1受体配体,Ki 值为 173 nM。S-1 Methanandamide 抑制小鼠输精管中电诱发的抽搐反应,I... |
T75798 |
Hemopressin(rat) TFA
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Hemopressin(rat) TFA 是一种源自血红蛋白 α1 链的九肽,最初是从大鼠脑匀浆中分离出来的。Hemopressin(rat) TFA 是口服有效的,选择性的CB1大麻素受体的反向激动剂。Hemopressin(rat) T... |
T11834 |
Leelamine hydrochloride
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Others
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Leelamine hydrochloride suppresses transcriptional activity of androgen receptor, which is known to regulate fatty acid ... |