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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T7128 | TH-257 | TH 257 | LIM Kinase |
TH-257 is a Potent and selective allosteric LIMK 1/2 inhibitor(LIMK1 and LIMK2, IC50 of 84 nM and 39 nM). | |||
T4600 | BMS-3 | LIM Kinase | |
BMS-3 is a potent LIMK inhibitor with IC50s of 5 nM and 6 nM for LIMK1 and LIMK2, respectively. | |||
T12609 | R-10015 | LIM Kinase , Reverse Transcriptase | |
R-10015 is a highly potent and selective LIMK inhibitor that blocks LIMK by binding to the ATP-binding pocket. It inhibits human LIMK1 with an IC50 value of 38 nM. It also exerts broad-spectrum antiviral effects and may ... | |||
T60783 | Aurora/LIM kinase-IN-1 | ||
Aurora/LIM kinase-IN-1 (Compound F114) is a potent aurora and lim kinase dual inhibitor. Aurora/LIM kinase-IN-1 inhibits the proliferation and invasion of GBM that may be used in drug development efforts for GBM, further... | |||
T4598 | BMS-5 | BMS5,LIMKi 3 | LIM Kinase |
BMS-5 (LIMKi 3) is a potent LIMK inhibitor with IC50s of 7 nM and 8 nM for LIMK1 and LIMK2, respectively. | |||
T3960 | T56-LIMKi | T5601640 | LIM Kinase |
T56-LIMKi (T5601640) is a selective inhibitor of LIMK2. | |||
T72399 | LIMK1 inhibitor BMS-4 | ||
LIMK1 inhibitor BMS-4 is a compound targeting LIM Kinase (LIMK) 1/2, specifically inhibiting the phosphorylation of its substrate, cofilin, but it remains noncytotoxic on A549 cells. | |||
T73545 | TH470 | ||
TH470, a potent and highly selective inhibitor of LIM kinase 1/2 (LIMK1/2), demonstrates specificity with IC50 values of 9.8 nM for LIMK1 and 13 nM for LIMK2, making it applicable in orphan disease research. | |||
T80253 | S3 Fragment | ||
S3 Fragment is a biologically active peptide featuring the amino-terminal phosphorylation site unique to Xenopus ADF/cofilin, which is the target of LIM kinase (LIMK) phosphorylation. LIMK1, a pivotal regulator of the ac... |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
TQ0183 | Narciclasine | Lycoricidinol | ROCK |
Narciclasine (Lycoricidinol), a natural product, modulates the Rho/Rho-kinase/LIM kinase/cofilin signaling pathway, greatly increasing GTPase RhoA activity. | |||
TN1533 | Cucurbitacin A | ROCK | |
Cucurbitacin I, cytotoxic triterpenoid sterols isolated from plants, elicits the formation of actin/phospho-myosin II co-aggregates by stimulation of the RhoA/ROCK pathway and inhibition of LIM-Kinase. |