Home Tools
Log in
Cart

Search Result

Search Results for " iκb-ikk "

Targets

31

Compounds

4

Natural Products

1

Recombinant Proteins

1

Libraries

Cat No. Product Name Synonyms Targets
T6176 IKK 16 IKK Inhibitor VII,IKK-16,IKK16 IκB/IKK , LRRK2
IKK 16 (IKK Inhibitor VII) is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively.
T10237 ACHP Hydrochloride IKK-2 Inhibitor VIII IκB/IKK
ACHP Hydrochloride (IKK-2 Inhibitor VIII) is a highly potent and selective IKK-β inhibitor with an IC50 of 8.5 nM.
TQ0306 MLN120B IκB/IKK
MLN120B is a selective and ATP competitive IKKβ inhibitor (IC50: 60 nM).
T3094 PS-1145 IKK Inhibitor X Apoptosis , IκB/IKK
PS-1145 (IKK Inhibitor X) is a specific IKK inhibitor with IC50 of 88 nM.
T6771 AZD3264 IκB/IKK
AZD3264 is a new type IKK2 inhibitor.
T5540 GSK8612 IκB/IKK
GSK8612 is a highly selective and potent inhibitor of Tank-binding Kinase-1 (TBK1, pIC50: 6.8) .
T6326 BMS-345541 BMS-345541 free base,IKK Inhibitor III,BMS345541 IκB/IKK
BMS-345541 (IKK Inhibitor III) is a highly selective inhibitor of the catalytic subunits of IKK-2 and IKK-1 with IC50 of 0.3 μM and 4 μM, respectively.
T15564 IMD-0560 IκB/IKK
IMD-0560 is a novel inhibitor of IκB kinase β.
T5209 INH14 IκB/IKK
INH14 is a novel inhibitor of the IKKα/β-dependent TLR inflammatory response (IC50s: 8.97/3.59 μM for IKKα/IKKβ).
T1830 BX795 IκB/IKK , Chk , CDK , c-Kit , PDK , Autophagy
BX795 is an effective and selective PDK1 inhibitor (IC50: 6 nM), and its selectivity is 140- and 1600-fold for PDK1 over PKA and PKC in cell-free assays, respectively. Meanwhile, the selectivity for PDK1 is 100-fold than...
T7951 TBK1/IKKε-IN-5 IκB/IKK
TBK1/IKKε-IN-5 is a dual TBK1 and IKKε inhibitor(IC50 of 1 nM and 5.6 nM, respectively).
T10477 BAY-985 IκB/IKK
BAY-985 is a potent, selective, and orally active ATP-competitive dual inhibitor of TBK1 and IKKε (IC50s: 2/30 and 2 nM for TBK1 (low/high ATP) and IKKε) with antitumor efficacy.
T8705 BOT-64 IκB/IKK
BOT-64 is an IKK-2 inhibitor which targets the Ser177 and/or Ser181 residues in the kinase's activation loop domain.BOT-64 is a cell-permeable benzoxathiole compound
T15559 TBK1/IKKε-IN-2 IκB/IKK
TBK1/IKKε-IN-2 is a dual inhibitor of TBK1 and IKKε.
T2081 LY2409881 trihydrochloride LY2409881 Apoptosis , IκB/IKK
LY2409881 trihydrochloride is a novel specific inhibitor of IKK2 (IC50: 30 nM); IC50 for IKK1 and other common kinases is at least one log higher.
T6141 IMD-0354 IKK2 Inhibitor V,IMD 0354 IκB/IKK
IMD-0354 (IKK2 Inhibitor V) is an IKKβ inhibitor and inhibits IκBα phosphorylation in NF-κB pathway.
T2279 Tizoxanide Desacetyl-nitazoxanide,TIZ Antiviral , HIV Protease , Antibacterial , Autophagy
Tizoxanide (Desacetyl-nitazoxanide) is a metabolite of lamivudine. Lamivudine (2', 3'-dideoxy-3'-thiacytidine, commonly called 3TC) is a potent nucleoside analog reverse transcriptase inhibitor (nRTI).
TD0099 Malachite green oxalate Apoptosis , Others , IκB/IKK , NF-κB
Malachite green oxalate is a triphenylmethane dye which can be used to detect the release of phosphate in enzymatic reactions.
T3049 TPCA-1 GW683965,IKK2 Inhibitor IV,TPCA1 Apoptosis , IκB/IKK , STAT
TPCA-1 (TPCA1) is an effective and specific IKK-2 inhibitor (IC50: 17.9 nM); shows >22-fold selectivity over IKK-1 and >550-fold selectivity over others kinases and enzymes.
T0097 MRT67307 MRT67307 HCl IκB/IKK , Autophagy
Through its effects on ULK1 and ULK2, MRT67307 blocks autophagy. MRT67307 prevents the phosphorylation of IRF3 and the production of IFN-β and increases toll-like receptor-induced IL-10 and IL-1ra secretion in macrophage...
T1902 BAY 11-7082 BAY 11-7821 Apoptosis , Others , IκB/IKK , DUB , Autophagy
BAY 11-7082, a NF-κB inhibitor, inhibits TNFα-induced IκBα phosphorylation. BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21.
T1639 Amlexanox CHX3673,Amoxanox,AA673 IL Receptor , FGFR , Others , IκB/IKK
Amlexanox (AA673) is an anti-aphthous ulcer drug. Amlexanox inhibits the synthesis and release of inflammatory mediators, including leukotrienes and histamine, from mast cells, neutrophils, and mononuclear cells. Amlexan...
T8542 BMS-345541 hydrochloride IκB/IKK
BMS-345541 hydrochloride is a selective IKK inhibitor (IKK2 and IKK1 with IC50 of 0.3 μM and 4 μM,respectively).
T0708 Oxaprozin Oxaprozinum,Wy21743 NF-κB , COX
Oxaprozin (Oxaprozinum) is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of oxaprozin is as a Cyclooxygenase Inhibitor. The chemical classification of oxaprozin is Nonsteroidal Anti-inflammatory Compound...
T25465 GS143 GS-143,GS 143 IκB/IKK , E1/E2/E3 Enzyme , NF-κB
GS143 is a selec­tive IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. GS143 sup­presses NF-κB acti­va­tion and tran­scrip­tion of tar­get genes and does not inhibit protea...
T9105 NF-κB-IN-1 1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)- IκB/IKK , NF-κB
NF-κB-IN-1 (1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-) is a potent NF-κB signaling pathway inhibitor. It is a 4-arylidene crucumin analogue. NF-κB-IN-1 dir...
T2118 SC-514 GK 01140 IκB/IKK , p38 MAPK , Serine Protease , CDK , Aurora Kinase
SC-514 (GK 01140) is a selective, orally active, ATP-competitive IKK-2 inhibitor (IC50=11.2±4.7 μM), obstructs NF-κB-dependent gene expression.
T23191 PS 1145 dihydrochloride Others
IκB kinase (IKK) inhibitor
T15557 IKK 16 hydrochloride Others
IKK 16 hydrochloride is a selective IKK2, IKK complex, and IKK1 IκB kinase (IKK) inhibitor (IC50s: 40 nM, 70 nM and 200 nM, respectively). IKK16 inhibits leucine-rich repeat kinase-2 (LRRK2; IC50: 50 nM).
T36198 Avenanthramide-C methyl ester
Avenanthramide-C methyl ester is an inhibitor of NF-κB activation that acts by blocking the phosphorylation of IKK and IκB (IC50 ~ 40 μM). Through this mechanism, avenanthramide-C methyl ester dose dependently inhibits t...
T37449 SR 12460
SR 12460 is a mimetic of the IκB kinase β (IKKβ) NEMO/IKKγ-binding domain (NBD) that inhibits the protein-protein interaction between the IKK complex subunits NF-κB essential modulator (NEMO/IKKγ) and IKKβ.1It inhibits T...

Compounds

IKK 16
T6176
Synonym: IKK Inhibitor VII,IKK-16,IKK16
Target: IκB/IKK, LRRK2
ACHP Hydrochloride
T10237
Synonym: IKK-2 Inhibitor VIII
Target: IκB/IKK
MLN120B
TQ0306
Synonym:
Target: IκB/IKK
PS-1145
T3094
Synonym: IKK Inhibitor X
Target: Apoptosis, IκB/IKK
AZD3264
T6771
Synonym:
Target: IκB/IKK
GSK8612
T5540
Synonym:
Target: IκB/IKK
BMS-345541
T6326
Synonym: BMS-345541 free base,IKK Inhibitor III,BMS345541
Target: IκB/IKK
IMD-0560
T15564
Synonym:
Target: IκB/IKK
INH14
T5209
Synonym:
Target: IκB/IKK
BX795
T1830
Synonym:
Target: IκB/IKK, Chk, CDK, c-Kit, PDK, Autophagy
TBK1/IKKε-IN-5
T7951
Synonym:
Target: IκB/IKK
BAY-985
T10477
Synonym:
Target: IκB/IKK
BOT-64
T8705
Synonym:
Target: IκB/IKK
TBK1/IKKε-IN-2
T15559
Synonym:
Target: IκB/IKK
LY2409881 trihydrochloride
T2081
Synonym: LY2409881
Target: Apoptosis, IκB/IKK
IMD-0354
T6141
Synonym: IKK2 Inhibitor V,IMD 0354
Target: IκB/IKK
Tizoxanide
T2279
Synonym: Desacetyl-nitazoxanide,TIZ
Target: Antiviral, HIV Protease, Antibacterial, Autophagy
Malachite green oxalate
TD0099
Synonym:
Target: Apoptosis, Others, IκB/IKK, NF-κB
TPCA-1
T3049
Synonym: GW683965,IKK2 Inhibitor IV,TPCA1
Target: Apoptosis, IκB/IKK, STAT
MRT67307
T0097
Synonym: MRT67307 HCl
Target: IκB/IKK, Autophagy
BAY 11-7082
T1902
Synonym: BAY 11-7821
Target: Apoptosis, Others, IκB/IKK, DUB, Autophagy
Amlexanox
T1639
Synonym: CHX3673,Amoxanox,AA673
Target: IL Receptor, FGFR, Others, IκB/IKK
BMS-345541 hydrochloride
T8542
Synonym:
Target: IκB/IKK
Oxaprozin
T0708
Synonym: Oxaprozinum,Wy21743
Target: NF-κB, COX
GS143
T25465
Synonym: GS-143,GS 143
Target: IκB/IKK, E1/E2/E3 Enzyme, NF-κB
NF-κB-IN-1
T9105
Synonym: 1,6-Heptadiene-3,5-dione, 1,7-bis(3,4-dimethoxyphenyl)-4-[(4-hydroxy-3-methoxyphenyl)methylene]-, (1E,6E)-
Target: IκB/IKK, NF-κB
SC-514
T2118
Synonym: GK 01140
Target: IκB/IKK, p38 MAPK, Serine Protease, CDK, Aurora Kinase
PS 1145 dihydrochloride
T23191
Synonym:
Target: Others
IKK 16 hydrochloride
T15557
Synonym:
Target: Others
Avenanthramide-C methyl ester
T36198
Synonym:
Target:
SR 12460
T37449
Synonym:
Target:
Cat No. Product Name Synonyms Targets
T5796 Plantainoside D Isoplantamajoside RAAS , PKC
Plantainoside D (Isoplantamajoside) shows potent antioxidative effects as those of ascorbic acid, it shows angiotensin-converting enzyme (ACE) inhibitory inhibitory activity in vitro with the IC(50) value of 2.17 mM, it ...
T0167 Vinpocetine RGH-4405,Ethyl apovincaminate IκB/IKK , NF-κB , Sodium Channel , PDE
Vinpocetine (RGH-4405) is a selective inhibitor of cyclic GMP phosphodiesterase (PDE).
T1558 Resveratrol trans-Resveratrol,SRT 501 Apoptosis , Mitophagy , IκB/IKK , Lipoxygenase , Sirtuin , COX , NADPH , DNA/RNA Synthesis , Nrf2 , Antibacterial , Antibiotic , Autophagy , Antifungal
Resveratrol (SRT 501) is a polyphenolic natural product, a plant antitoxin with antioxidant and chemopreventive activities. Resveratrol has a wide range of targets including COX, SIRT, LOC, etc. Resveratrol induces autop...
TN1504 Citreorosein cAMP , NF-κB , PI3K
Citreorosein is a cAMP phosphodiesterase inhibitor, it has anti-inflammatory effect, inhibits proinflammatory cytokines production through the inhibition of both MAPKs and AKT-mediated IκB kinase (IKK) phosphorylation an...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-02544 FANCA Protein, Human, Recombinant (His) Human Baculovirus-Insect Cells
FANCA is one of the six known Fanconi anemia gene products (FANCA, FANCC, FANCD2, FANCE, FANCF, and FANCG proteins). Fanconi anemia (FA) is a genetic disorder predisposing to aplastic anemia and cancer characterized by h...
Cat No. Product Name
L3800 NF-κB Signaling Compound Library

740 compounds
A unique collection of 740 compounds targeting NF-κB signaling for high throughput screening and high content screening;
TargetMol