57
2
1
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T16435 | PBIT | Histone Demethylase , Histone Methyltransferase | |
PBIT inhibits JARID1B histone demethylase (IC50 of about 3 μM). PBIT also inhibits JARID1A and JARID1C (IC50s of 6 μM and 4.9 μM, respectively). PBIT is a specific inhibitor of the Jumonji AT-rich Interactive Domain 1 (J... | |||
T9243 | PFI-90 | Histone Demethylase , Others | |
PFI-90 is a selective inhibitor of histone demethylase (KDM3B) that inhibits PAX3-FOXO1 action.PFI-90 has the potential for the antitumor activity. PFI-90 induces apoptosis and myogenic differentiation, resulting in the ... | |||
T4214 | KDM4D-IN-1 | Histone Demethylase | |
KDM4D-IN-1 is a KDM4D inhibitor (IC50: 0.41±0.03 μM). | |||
T15649 | KDM5-IN-1 | Histone Demethylase | |
KDM5-IN-1 is an effective and selective inhibitor of KDM5 with an IC50 of 15.1 nM. | |||
T6847 | GSK-J1 | GSK J1 | Histone Demethylase |
GSK-J1 is a highly potent H3K27 histone demethylase inhibitor with IC50 of 28 nM and 53 nM in cell-free assays for JMJD3 (KDM6B) and UTX (KDM6A), respectively, >10-fold selectivity over other tested demethylases. | |||
T6545 | IOX1 | Histone Demethylase | |
IOX1 is the most effective broad-spectrum 2OG oxygenases(including the JmjC demethylases) inhibitor. The IC50 of IOX1 for KDM4A, KDM3A, is 0.6 and 0.1 uM, respectively. | |||
T3100 | GSK-J4 | GSK J4 HCl | Apoptosis , Histone Demethylase |
GSK-J4 (GSK J4 HCl) is a potent H3K27me3 demethylase inhibitor, with IC50s of 8.6 μM and 6.6 μM towards KDM6B and KDM6A respectively. It is the first selective inhibitor of the H3K27 histone demethylase JMJD3 and UTX wit... | |||
T7057 | Methylstat | Histone Demethylase , Others | |
Methylstat is a methyl ester prodrug of a Jumonji C domain-containing histone demethylase (JMJD) inhibitor that has favorable cell permeability. The free acid of methylstat inhibits JMJD2A, JMJD2C, JMJD2E, PHF8, and JMJD... | |||
T13055 | T-3775440 hydrochloride | Histone Demethylase | |
T-3775440 hydrochloride is an irreversible inhibitor of lysine-specific histone demethylase (LSD1)(IC50 : 2.1 nM). | |||
T15648 | KDM5-C70 | Histone Demethylase | |
KDM5-C70 is an ethyl ester derivative of KDM5-C49. KDM5-C70 is an effective, cell-permeable, and pan-KDM5 histone demethylase inhibitor. KDM5-C70 has an antiproliferative effect in myeloma cells, inducing a genome-wide e... | |||
T3552 | CPI-455 | CPI-455 HCl | Histone Demethylase |
CPI-455 is a specific KDM5 inhibitor. | |||
T5484 | GSK467 | Histone Demethylase , Histone Methyltransferase | |
GSK467 is a potent and selective inhibitor of KDM5 (JARID1)(Ki : 10 nM). | |||
TQ0050 | NCGC00244536 | KDM4B Inhibitor B3 | Histone Demethylase |
NCGC00244536 (KDM4B Inhibitor B3) is a potent KDM4B inhibitor (IC50: 10 nM). | |||
T2304 | SP2509 | HCI-2509 | Apoptosis , Histone Demethylase |
SP2509 is a specific histone demethylase LSD1 inhibitor(IC50 =13 nM). | |||
T4527 | Seclidemstat | SP-2577 | Histone Demethylase |
Seclidemstat (SP-2577) is an effective LSD1 inhibitor, with a mean IC50 of 127 nM. | |||
T4100 | AS8351 | NSC51355,AS-8351,AS 8351 | Histone Demethylase |
AS8351 (NSC51355) is a histone demethylase inhibitor. It has been used in combination with CHIR99021, A 83-01, BIX01294, SC-1, Y-27632, OAC2, SU 16f, and JNJ-10198409 to induce reprogramming of human fetal lung fibroblas... | |||
T6593 | ML324 | Histone Demethylase , Others , HSV | |
ML324(IC50=920 nM) is a specific inhibitor of jumonji histone demethylase (JMJD2). | |||
T7942 | Tranylcypromine hemisulfate | Tranylcypromine Sulfate,Tranylcypromine (hemisulfate) | Histone Demethylase , MAO , Monoamine Oxidase |
Tranylcypromine hemisulfate (Tranylcypromine Sulfate) is an inhibitor of monoamine oxidase (MAO) and lysine-specific demethylase 1 (LSD1) with a rapid onset of activity. | |||
T5825 | Iadademstat dihydrochloride | ORY-1001(trans) | Histone Demethylase |
Iadademstat dihydrochloride (ORY-1001(trans)) , a Potent and Selective Covalent KDM1A/LSD1 Inhibitor, for the Treatment of Acute Leukemia. | |||
T0802 | Procaine hydrochloride | Novocaine HCl,Procaine HCl | Histone Demethylase , 5-HT Receptor , DNA/RNA Synthesis , Sodium Channel , NMDAR , AChR |
Procaine hydrochloride (Novocaine HCl) is the hydrochloride salt form of procaine, a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds to and inhibits voltage-gated sodiumchannel... | |||
T0029 | Procaine | Duracaine,Spinocaine,Novocaine,Vitamin H3 | Histone Demethylase , DNA/RNA Synthesis , Sodium Channel |
Procaine (Vitamin H3) is a local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. | |||
T21652 | RN-1 dihydrochloride | Histone Demethylase , MAO | |
RN-1 dihydrochloride is an effective and selective irreversible inhibitor of lysine-specific demethylase 1 (LSD1, IC50 = 70 nM). | |||
T6073 | OG-L002 | Histone Demethylase , Monoamine Oxidase , HSV | |
OG-L002 is an effective and selective LSD1 inhibitor (IC50: 20 nM), showing 69- and 36-fold selectivity over MAO-A and MAO-B, respectively. | |||
T2315 | GSK-LSD1 dihydrochloride | GSK-LSD1 (hydrochloride),GSK-LSD1 2HCl | Histone Demethylase |
GSK-LSD1 dihydrochloride (GSK-LSD1 2HCl) is a specificity irreversible LSD1 inhibitor (IC50: 16 nM). The selectivity of GSK-LSD1 for LSD1 is >1000 fold over other closely related FAD utilizing enzymes (i.e. MAO-A, LSD2, ... | |||
T2167 | Lutidinic acid | 2,4-Pyridinedicarboxylic acid,2,4-Dicarboxypyridine,2, 4-PDCA,2,4-PDCA | Histone Methyltransferase |
lutidinic acid (2,4-Dicarboxypyridine) is an in vitro and in cell inhibitor, as well as a known inhibitor of the histone lysine demethylases. | |||
T9094 | JMJD7-IN-1 | Benzoic acid, 2,4-dichloro-, 5-nitro-8-quinolinyl ester | Histone Demethylase , Others |
JMJD7-IN-1 (Benzoic acid, 2,4-dichloro-, 5-nitro-8-quinolinyl ester) is a potent JMJD7 inhibitor, with an IC50 of 6.62 μM. JMJD7-IN-1 shows good inhibitory activity against cells expressing a high level of JMJD7. | |||
T4383 | GSK-J4 Hydrochloride | GSK J4 HCl,GSK J4 HCl (1373423-53-0 free base) | Histone Demethylase |
GSK-J4 Hydrochloride (GSK J4 HCl) is a cell permeable, potent and selective histone demethylase(JMJD3 )inhibitor. is an ethyl ester derivative of the GSK-J1 with an IC50 value greater than 50 μM in vitro. | |||
T13748 | L-2-Hydroxyglutaric acid disodium | (S)-2-Hydroxyglutaric acid disodium | Histone Demethylase , Mitochondrial Metabolism |
L-2-Hydroxyglutaric acid disodium ((S)-2-Hydroxyglutaric acid disodium) is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activ... | |||
T11882 | Pulrodemstat benzenesulfonate | LSD1-IN-7 benzenesulfonate,CC-90011 benzenesulfonate | Histone Demethylase |
Pulrodemstat benzenesulfonate (CC-90011 benzenesulfonate) is a potent and orally active inhibitor of lysine specific demethylase-1 (LSD1) with anticancer activity. | |||
T1868 | JIB-04 | JIB 04,NSC 693627 | Apoptosis , Histone Demethylase , Histone Methyltransferase |
JIB-04 (NSC 693627) is a pan-selective Jumonji histone demethylase inhibitor. | |||
T3677 | GSK2879552 | GSK2879552 2HCl | Histone Demethylase |
GSK2879552 is a selective, orally bioavailable, irreversible, mechanism-based inactivator of lysine-specific demethylase 1 (LSD1)/corepressor, with potential antineoplastic activity. | |||
T39389 | KDM2B-IN-2 | KDM2B-IN-2 | Histone Demethylase |
KDM2B-IN-2 is a potent histone demethylase (kdm2b) inhibitor. | |||
T67781 | SD49-7 | HNASH | Histone Demethylase |
SD49-7 is an inhibitor of histone lysine demethylase 4 (KDM4) with an IC50 of 0.19 µM. | |||
T17211 | Vafidemstat | ORY-2001 | Histone Demethylase , MAO |
Vafidemstat (ORY-2001) is a selective, orally active lysyl-histone demethylase (LSD1)/MAO-B inhibitor that crosses the blood-brain barrier for the study of neurological diseases. | |||
T10983L | DDP-38003 dihydrochloride | Histone Demethylase | |
DDP-38003 dihydrochloride is an orally available histone lysine-specific demethylase 1A (KDM1A/LSD1) inhibitor (IC50: 84 nM). | |||
T12193 | NCGC00247743 | Others | |
NCGC00247743 is an inhibitor of histone lysine demethylase KDM4. | |||
T23429 | KDM2/7-IN-1 | TC-E 5002 | Others |
Selective histone demethylase KDM2/7 subfamily inhibitor | |||
T10698 | CBB1003 | Others | |
CBB1003 is a new inhibitor of histone demethylase LSD1 (IC50: 10.54 μM). | |||
T29014 | Tripartin | ||
Tripartin specifically inhibits the histone H3 lysine 9 demethylase KDM4 in HeLa cells. | |||
T61559 | KDM2B-IN-4 | ||
KDM2B-IN-4 is a potent inhibitor of histone demethylase KDM2B. It is primarily employed in cancer research [1]. | |||
T61771 | KDM2B-IN-3 | ||
KDM2B-IN-3 is a potent inhibitor of the histone demethylase KDM2B. It holds promise for cancer research applications [1]. | |||
T70321 | CBB3001 | ||
CBB3001 is a selective lysine-specific histone demethylase LSD1 inhibitor. | |||
T38774 | E67-2 | E67-2 | |
E67-2, a derivative of E67, is a low-toxicity, selective inhibitor of the KIAA1718 Jumonji domain. It has an IC 50 value of 3.4 μM. E67-2 specifically inhibits the Jumonji demethylase for histone H3 lysine 9 (H3K9) and h... | |||
T10698L | CBB1003 hydrochloride (1379573-88-2 free base) | CBB1003 hydrochloride | Others |
CBB1003 hydrochloride is a new inhibitor of histone demethylase LSD1 (IC50: 10.54 μM). | |||
T11880 | LSD1-IN-5 | Histone Demethylase | |
LSD1-IN-5 increases dimethylated Lys4 of histone H3, shows no effect on expression of LSD1. LSD1-IN-5 is a potent and reversible inhibitor of lysine-specific demethylase 1 (LSD1), with an IC50 of 121 nM. | |||
T70121 | Zavondemstat | QC8222,TACH 101,TACH101 | |
Zavondemstat is an inhibitor of histone lysine demethylase 4D ( KDM4D ) with antineoplastic activity . | |||
T39390 | KDM2B-IN-1 | KDM2B-IN-1 | |
KDM2B-IN-1 is a potent inhibitor designed specifically to target and inhibit the activity of histone demethylase KDM2B. This compound is ideal for conducting research related to hyperproliferative diseases. | |||
T11881 | LSD1-IN-6 | Histone Demethylase | |
LSD1-IN-6 increases dimethylated Lys4 of histone H3, shows no effect on expression of LSD1. LSD1-IN-6 is a potent and reversible inhibitor of lysine-specific demethylase 1 (LSD1), with an IC50 of 123 nM. | |||
T10983 | DDP-38003 trihydrochloride | Others | |
DDP-38003 trihydrochloride is a novel, orally available histone lysine-specific demethylase 1A (KDM1A/LSD1) inhibitor with an IC50 of 84 nM. | |||
T61565 | KDM5B-IN-3 | ||
KDM5B-IN-3 (Compound 5) is an inhibitor of histone lysine-specific demethylase 5B (KDM5B) or JARID1B. It effectively inhibits the activity of KDM5B with an IC50 value of 9.32 μM. Consequently, KDM5B-IN-3 serves as a valu... |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T3719 | Daminozide | Succinic Acid,DMASA,Aminozide | Histone Demethylase |
Daminozide (Succinic Acid) is a plant growth regulator, selectively inhibits the KDM2/7 JmjC subfamily. | |||
T5368 | Eicosapentaenoic Acid | Histone Demethylase , Others , Endogenous Metabolite | |
Eicosapentaenoic Acid (EPA) is a ω-3 fatty acid abundantly available in marine organisms. |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-01459 | Human herpesvirus 7 (HHV-7) (strain JI) Probable ganciclovir kinase (His & Myc) | HHV-7 | E. coli |
Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activ... |