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Search Results for " histone-demethylase "

Targets

57

Compounds

2

Natural Products

1

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T16435 PBIT Histone Demethylase , Histone Methyltransferase
PBIT inhibits JARID1B histone demethylase (IC50 of about 3 μM). PBIT also inhibits JARID1A and JARID1C (IC50s of 6 μM and 4.9 μM, respectively). PBIT is a specific inhibitor of the Jumonji AT-rich Interactive Domain 1 (J...
T9243 PFI-90 Histone Demethylase , Others
PFI-90 is a selective inhibitor of histone demethylase (KDM3B) that inhibits PAX3-FOXO1 action.PFI-90 has the potential for the antitumor activity. PFI-90 induces apoptosis and myogenic differentiation, resulting in the ...
T4214 KDM4D-IN-1 Histone Demethylase
KDM4D-IN-1 is a KDM4D inhibitor (IC50: 0.41±0.03 μM).
T15649 KDM5-IN-1 Histone Demethylase
KDM5-IN-1 is an effective and selective inhibitor of KDM5 with an IC50 of 15.1 nM.
T6847 GSK-J1 GSK J1 Histone Demethylase
GSK-J1 is a highly potent H3K27 histone demethylase inhibitor with IC50 of 28 nM and 53 nM in cell-free assays for JMJD3 (KDM6B) and UTX (KDM6A), respectively, >10-fold selectivity over other tested demethylases.
T6545 IOX1 Histone Demethylase
IOX1 is the most effective broad-spectrum 2OG oxygenases(including the JmjC demethylases) inhibitor. The IC50 of IOX1 for KDM4A, KDM3A, is 0.6 and 0.1 uM, respectively.
T3100 GSK-J4 GSK J4 HCl Apoptosis , Histone Demethylase
GSK-J4 (GSK J4 HCl) is a potent H3K27me3 demethylase inhibitor, with IC50s of 8.6 μM and 6.6 μM towards KDM6B and KDM6A respectively. It is the first selective inhibitor of the H3K27 histone demethylase JMJD3 and UTX wit...
T7057 Methylstat Histone Demethylase , Others
Methylstat is a methyl ester prodrug of a Jumonji C domain-containing histone demethylase (JMJD) inhibitor that has favorable cell permeability. The free acid of methylstat inhibits JMJD2A, JMJD2C, JMJD2E, PHF8, and JMJD...
T13055 T-3775440 hydrochloride Histone Demethylase
T-3775440 hydrochloride is an irreversible inhibitor of lysine-specific histone demethylase (LSD1)(IC50 : 2.1 nM).
T15648 KDM5-C70 Histone Demethylase
KDM5-C70 is an ethyl ester derivative of KDM5-C49. KDM5-C70 is an effective, cell-permeable, and pan-KDM5 histone demethylase inhibitor. KDM5-C70 has an antiproliferative effect in myeloma cells, inducing a genome-wide e...
T3552 CPI-455 CPI-455 HCl Histone Demethylase
CPI-455 is a specific KDM5 inhibitor.
T5484 GSK467 Histone Demethylase , Histone Methyltransferase
GSK467 is a potent and selective inhibitor of KDM5 (JARID1)(Ki : 10 nM).
TQ0050 NCGC00244536 KDM4B Inhibitor B3 Histone Demethylase
NCGC00244536 (KDM4B Inhibitor B3) is a potent KDM4B inhibitor (IC50: 10 nM).
T2304 SP2509 HCI-2509 Apoptosis , Histone Demethylase
SP2509 is a specific histone demethylase LSD1 inhibitor(IC50 =13 nM).
T4527 Seclidemstat SP-2577 Histone Demethylase
Seclidemstat (SP-2577) is an effective LSD1 inhibitor, with a mean IC50 of 127 nM.
T4100 AS8351 NSC51355,AS-8351,AS 8351 Histone Demethylase
AS8351 (NSC51355) is a histone demethylase inhibitor. It has been used in combination with CHIR99021, A 83-01, BIX01294, SC-1, Y-27632, OAC2, SU 16f, and JNJ-10198409 to induce reprogramming of human fetal lung fibroblas...
T6593 ML324 Histone Demethylase , Others , HSV
ML324(IC50=920 nM) is a specific inhibitor of jumonji histone demethylase (JMJD2).
T7942 Tranylcypromine hemisulfate Tranylcypromine Sulfate,Tranylcypromine (hemisulfate) Histone Demethylase , MAO , Monoamine Oxidase
Tranylcypromine hemisulfate (Tranylcypromine Sulfate) is an inhibitor of monoamine oxidase (MAO) and lysine-specific demethylase 1 (LSD1) with a rapid onset of activity.
T5825 Iadademstat dihydrochloride ORY-1001(trans) Histone Demethylase
Iadademstat dihydrochloride (ORY-1001(trans)) , a Potent and Selective Covalent KDM1A/LSD1 Inhibitor, for the Treatment of Acute Leukemia.
T0802 Procaine hydrochloride Novocaine HCl,Procaine HCl Histone Demethylase , 5-HT Receptor , DNA/RNA Synthesis , Sodium Channel , NMDAR , AChR
Procaine hydrochloride (Novocaine HCl) is the hydrochloride salt form of procaine, a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds to and inhibits voltage-gated sodiumchannel...
T0029 Procaine Duracaine,Spinocaine,Novocaine,Vitamin H3 Histone Demethylase , DNA/RNA Synthesis , Sodium Channel
Procaine (Vitamin H3) is a local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block.
T21652 RN-1 dihydrochloride Histone Demethylase , MAO
RN-1 dihydrochloride is an effective and selective irreversible inhibitor of lysine-specific demethylase 1 (LSD1, IC50 = 70 nM).
T6073 OG-L002 Histone Demethylase , Monoamine Oxidase , HSV
OG-L002 is an effective and selective LSD1 inhibitor (IC50: 20 nM), showing 69- and 36-fold selectivity over MAO-A and MAO-B, respectively.
T2315 GSK-LSD1 dihydrochloride GSK-LSD1 (hydrochloride),GSK-LSD1 2HCl Histone Demethylase
GSK-LSD1 dihydrochloride (GSK-LSD1 2HCl) is a specificity irreversible LSD1 inhibitor (IC50: 16 nM). The selectivity of GSK-LSD1 for LSD1 is >1000 fold over other closely related FAD utilizing enzymes (i.e. MAO-A, LSD2, ...
T2167 Lutidinic acid 2,4-Pyridinedicarboxylic acid,2,4-Dicarboxypyridine,2, 4-PDCA,2,4-PDCA Histone Methyltransferase
lutidinic acid (2,4-Dicarboxypyridine) is an in vitro and in cell inhibitor, as well as a known inhibitor of the histone lysine demethylases.
T9094 JMJD7-IN-1 Benzoic acid, 2,4-dichloro-, 5-nitro-8-quinolinyl ester Histone Demethylase , Others
JMJD7-IN-1 (Benzoic acid, 2,4-dichloro-, 5-nitro-8-quinolinyl ester) is a potent JMJD7 inhibitor, with an IC50 of 6.62 μM. JMJD7-IN-1 shows good inhibitory activity against cells expressing a high level of JMJD7.
T4383 GSK-J4 Hydrochloride GSK J4 HCl,GSK J4 HCl (1373423-53-0 free base) Histone Demethylase
GSK-J4 Hydrochloride (GSK J4 HCl) is a cell permeable, potent and selective histone demethylase(JMJD3 )inhibitor. is an ethyl ester derivative of the GSK-J1 with an IC50 value greater than 50 μM in vitro.
T13748 L-2-Hydroxyglutaric acid disodium (S)-2-Hydroxyglutaric acid disodium Histone Demethylase , Mitochondrial Metabolism
L-2-Hydroxyglutaric acid disodium ((S)-2-Hydroxyglutaric acid disodium) is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activ...
T11882 Pulrodemstat benzenesulfonate LSD1-IN-7 benzenesulfonate,CC-90011 benzenesulfonate Histone Demethylase
Pulrodemstat benzenesulfonate (CC-90011 benzenesulfonate) is a potent and orally active inhibitor of lysine specific demethylase-1 (LSD1) with anticancer activity.
T1868 JIB-04 JIB 04,NSC 693627 Apoptosis , Histone Demethylase , Histone Methyltransferase
JIB-04 (NSC 693627) is a pan-selective Jumonji histone demethylase inhibitor.
T3677 GSK2879552 GSK2879552 2HCl Histone Demethylase
GSK2879552 is a selective, orally bioavailable, irreversible, mechanism-based inactivator of lysine-specific demethylase 1 (LSD1)/corepressor, with potential antineoplastic activity.
T39389 KDM2B-IN-2 KDM2B-IN-2 Histone Demethylase
KDM2B-IN-2 is a potent histone demethylase (kdm2b) inhibitor.
T67781 SD49-7 HNASH Histone Demethylase
SD49-7 is an inhibitor of histone lysine demethylase 4 (KDM4) with an IC50 of 0.19 µM.
T17211 Vafidemstat ORY-2001 Histone Demethylase , MAO
Vafidemstat (ORY-2001) is a selective, orally active lysyl-histone demethylase (LSD1)/MAO-B inhibitor that crosses the blood-brain barrier for the study of neurological diseases.
T10983L DDP-38003 dihydrochloride Histone Demethylase
DDP-38003 dihydrochloride is an orally available histone lysine-specific demethylase 1A (KDM1A/LSD1) inhibitor (IC50: 84 nM).
T12193 NCGC00247743 Others
NCGC00247743 is an inhibitor of histone lysine demethylase KDM4.
T23429 KDM2/7-IN-1 TC-E 5002 Others
Selective histone demethylase KDM2/7 subfamily inhibitor
T10698 CBB1003 Others
CBB1003 is a new inhibitor of histone demethylase LSD1 (IC50: 10.54 μM).
T29014 Tripartin
Tripartin specifically inhibits the histone H3 lysine 9 demethylase KDM4 in HeLa cells.
T61559 KDM2B-IN-4
KDM2B-IN-4 is a potent inhibitor of histone demethylase KDM2B. It is primarily employed in cancer research [1].
T61771 KDM2B-IN-3
KDM2B-IN-3 is a potent inhibitor of the histone demethylase KDM2B. It holds promise for cancer research applications [1].
T70321 CBB3001
CBB3001 is a selective lysine-specific histone demethylase LSD1 inhibitor.
T38774 E67-2 E67-2
E67-2, a derivative of E67, is a low-toxicity, selective inhibitor of the KIAA1718 Jumonji domain. It has an IC 50 value of 3.4 μM. E67-2 specifically inhibits the Jumonji demethylase for histone H3 lysine 9 (H3K9) and h...
T10698L CBB1003 hydrochloride (1379573-88-2 free base) CBB1003 hydrochloride Others
CBB1003 hydrochloride is a new inhibitor of histone demethylase LSD1 (IC50: 10.54 μM).
T11880 LSD1-IN-5 Histone Demethylase
LSD1-IN-5 increases dimethylated Lys4 of histone H3, shows no effect on expression of LSD1. LSD1-IN-5 is a potent and reversible inhibitor of lysine-specific demethylase 1 (LSD1), with an IC50 of 121 nM.
T70121 Zavondemstat QC8222,TACH 101,TACH101
Zavondemstat is an inhibitor of histone lysine demethylase 4D ( KDM4D ) with antineoplastic activity .
T39390 KDM2B-IN-1 KDM2B-IN-1
KDM2B-IN-1 is a potent inhibitor designed specifically to target and inhibit the activity of histone demethylase KDM2B. This compound is ideal for conducting research related to hyperproliferative diseases.
T11881 LSD1-IN-6 Histone Demethylase
LSD1-IN-6 increases dimethylated Lys4 of histone H3, shows no effect on expression of LSD1. LSD1-IN-6 is a potent and reversible inhibitor of lysine-specific demethylase 1 (LSD1), with an IC50 of 123 nM.
T10983 DDP-38003 trihydrochloride Others
DDP-38003 trihydrochloride is a novel, orally available histone lysine-specific demethylase 1A (KDM1A/LSD1) inhibitor with an IC50 of 84 nM.
T61565 KDM5B-IN-3
KDM5B-IN-3 (Compound 5) is an inhibitor of histone lysine-specific demethylase 5B (KDM5B) or JARID1B. It effectively inhibits the activity of KDM5B with an IC50 value of 9.32 μM. Consequently, KDM5B-IN-3 serves as a valu...

Compounds

PBIT
T16435
Synonym:
Target: Histone Demethylase, Histone Methyltransferase
PFI-90
T9243
Synonym:
Target: Histone Demethylase, Others
KDM4D-IN-1
T4214
Synonym:
Target: Histone Demethylase
KDM5-IN-1
T15649
Synonym:
Target: Histone Demethylase
GSK-J1
T6847
Synonym: GSK J1
Target: Histone Demethylase
IOX1
T6545
Synonym:
Target: Histone Demethylase
GSK-J4
T3100
Synonym: GSK J4 HCl
Target: Apoptosis, Histone Demethylase
Methylstat
T7057
Synonym:
Target: Histone Demethylase, Others
T-3775440 hydrochloride
T13055
Synonym:
Target: Histone Demethylase
KDM5-C70
T15648
Synonym:
Target: Histone Demethylase
CPI-455
T3552
Synonym: CPI-455 HCl
Target: Histone Demethylase
GSK467
T5484
Synonym:
Target: Histone Demethylase, Histone Methyltransferase
NCGC00244536
TQ0050
Synonym: KDM4B Inhibitor B3
Target: Histone Demethylase
SP2509
T2304
Synonym: HCI-2509
Target: Apoptosis, Histone Demethylase
Seclidemstat
T4527
Synonym: SP-2577
Target: Histone Demethylase
AS8351
T4100
Synonym: NSC51355,AS-8351,AS 8351
Target: Histone Demethylase
ML324
T6593
Synonym:
Target: Histone Demethylase, Others, HSV
Tranylcypromine hemisulfate
T7942
Synonym: Tranylcypromine Sulfate,Tranylcypromine (hemisulfate)
Target: Histone Demethylase, MAO, Monoamine Oxidase
Iadademstat dihydrochloride
T5825
Synonym: ORY-1001(trans)
Target: Histone Demethylase
Procaine hydrochloride
T0802
Synonym: Novocaine HCl,Procaine HCl
Target: Histone Demethylase, 5-HT Receptor, DNA/RNA Synthesis, Sodium Channel, NMDAR, AChR
Procaine
T0029
Synonym: Duracaine,Spinocaine,Novocaine,Vitamin H3
Target: Histone Demethylase, DNA/RNA Synthesis, Sodium Channel
RN-1 dihydrochloride
T21652
Synonym:
Target: Histone Demethylase, MAO
OG-L002
T6073
Synonym:
Target: Histone Demethylase, Monoamine Oxidase, HSV
GSK-LSD1 dihydrochloride
T2315
Synonym: GSK-LSD1 (hydrochloride),GSK-LSD1 2HCl
Target: Histone Demethylase
lutidinic acid
T2167
Synonym: 2,4-Pyridinedicarboxylic acid,2,4-Dicarboxypyridine,2, 4-PDCA,2,4-PDCA
Target: Histone Methyltransferase
JMJD7-IN-1
T9094
Synonym: Benzoic acid, 2,4-dichloro-, 5-nitro-8-quinolinyl ester
Target: Histone Demethylase, Others
GSK-J4 Hydrochloride
T4383
Synonym: GSK J4 HCl,GSK J4 HCl (1373423-53-0 free base)
Target: Histone Demethylase
L-2-Hydroxyglutaric acid disodium
T13748
Synonym: (S)-2-Hydroxyglutaric acid disodium
Target: Histone Demethylase, Mitochondrial Metabolism
Pulrodemstat benzenesulfonate
T11882
Synonym: LSD1-IN-7 benzenesulfonate,CC-90011 benzenesulfonate
Target: Histone Demethylase
JIB-04
T1868
Synonym: JIB 04,NSC 693627
Target: Apoptosis, Histone Demethylase, Histone Methyltransferase
GSK2879552
T3677
Synonym: GSK2879552 2HCl
Target: Histone Demethylase
KDM2B-IN-2
T39389
Synonym: KDM2B-IN-2
Target: Histone Demethylase
SD49-7
T67781
Synonym: HNASH
Target: Histone Demethylase
Vafidemstat
T17211
Synonym: ORY-2001
Target: Histone Demethylase, MAO
DDP-38003 dihydrochloride
T10983L
Synonym:
Target: Histone Demethylase
NCGC00247743
T12193
Synonym:
Target: Others
KDM2/7-IN-1
T23429
Synonym: TC-E 5002
Target: Others
CBB1003
T10698
Synonym:
Target: Others
Tripartin
T29014
Synonym:
Target:
KDM2B-IN-4
T61559
Synonym:
Target:
KDM2B-IN-3
T61771
Synonym:
Target:
CBB3001
T70321
Synonym:
Target:
E67-2
T38774
Synonym: E67-2
Target:
CBB1003 hydrochloride (1379573-88-2 free base)
T10698L
Synonym: CBB1003 hydrochloride
Target: Others
LSD1-IN-5
T11880
Synonym:
Target: Histone Demethylase
Zavondemstat
T70121
Synonym: QC8222,TACH 101,TACH101
Target:
KDM2B-IN-1
T39390
Synonym: KDM2B-IN-1
Target:
LSD1-IN-6
T11881
Synonym:
Target: Histone Demethylase
DDP-38003 trihydrochloride
T10983
Synonym:
Target: Others
KDM5B-IN-3
T61565
Synonym:
Target:
1 2
Cat No. Product Name Synonyms Targets
T3719 Daminozide Succinic Acid,DMASA,Aminozide Histone Demethylase
Daminozide (Succinic Acid) is a plant growth regulator, selectively inhibits the KDM2/7 JmjC subfamily.
T5368 Eicosapentaenoic Acid Histone Demethylase , Others , Endogenous Metabolite
Eicosapentaenoic Acid (EPA) is a ω-3 fatty acid abundantly available in marine organisms.

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPH-01459 Human herpesvirus 7 (HHV-7) (strain JI) Probable ganciclovir kinase (His & Myc) HHV-7 E. coli
Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activ...
TargetMol