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Histone Demethylase

T1868 JIB-04 JIB-04 is a pan-selective Jumonji histone demethylase inhibitor.
T2304 SP2509 SP2509 is a specific histone demethylase LSD1 inhibitor(IC50 =13 nM).
T2315 GSK-LSD1 dihydrochloride GSK-LSD1 2HCl is a specificity irreversible LSD1 inhibitor (IC50: 16 nM). The selectivity of GSK-LSD1 for LSD1 is >1000 fold over other closely related FAD util...
T3100 GSK J4 GSK-J4 is a potent H3K27me3 demethylase inhibitor, with IC50s of 8.6 µM and 6.6 µM towards KDM6B and KDM6A respectively. It is the first selective inhibitor ...
T3552 CPI-455 CPI-455 is a specific KDM5 inhibitor.
T3576 KDM5-inhibitor KDM5 inhibitor
T3719 Daminozide Daminozide is a plant growth regulator, selectively inhibits the KDM2/7 JmjC subfamily.
T4214 KDM4D-IN-1 KDM4D-IN-1 is a KDM4D inhibitor (IC50: 0.41±0.03 μM).
T4383 GSK-J4 Hydrochloride GSK J4 HCl is a cell permeable prodrug of GSK J1, which is the first selective inhibitor of the H3K27 histone demethylase JMJD3 and UTX with IC50 of 60 nM in a ...
T4418 GSK2879552 2HCl (1401966-69-5(free base)) GSK2879552 is an orally available, irreversible inhibitor of lysine specific demethylase 1 (LSD1), with potential antineoplastic activity.
T4527 Seclidemstat Seclidemstat is an effective LSD1 inhibitor, with a mean IC50 of 127 nM.
T5825 ORY-1001(trans) ORY-1001, a Potent and Selective Covalent KDM1A/LSD1 Inhibitor, for the Treatment of Acute Leukemia.
T6073 OG-L002 OG-L002 is an effective and selective LSD1 inhibitor (IC50: 20 nM), showing 69- and 36-fold selectivity over MAO-A and MAO-B, respectively.
T6545 IOX1 IOX1 is the most effective broad-spectrum 2OG oxygenases(including the JmjC demethylases) inhibitor. The IC50 of IOX1 for KDM4A, KDM3A, is 0.6 and 0.1 uM, res...
T6593 ML324 ML324(IC50=920 nM) is a specific inhibitor of jumonji histone demethylase (JMJD2).
T6847 GSK J1 GSK-J1 is a highly potent H3K27 histone demethylase inhibitor with IC50 of 28 nM and 53 nM in cell-free assays for JMJD3 (KDM6B) and UTX (KDM6A), respectively, ...
T6922 ORY-1001 ORY-1001 (RG-6016) is an orally active and selective lysine-specific demethylase LSD1/KDM1A inhibitor,with high selectivity against related FAD dependent amin...
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