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Hippo pathway

The Hippo signaling pathway, also known as the Salvador-Warts-Hippo (SWH) pathway, controls organ size in animals through the regulation of cell proliferation and apoptosis. The pathway takes its name from one of its key signaling components—the protein kinase Hippo (Hpo). Mutations in this gene lead to tissue overgrowth, or a "hippopotamus"-like phenotype.The Hippo signaling pathway appears to be highly conserved. While most of the Hippo pathway components were identified in the fruit fly (Drosophila melanogaster) using mosaic genetic screens, orthologs to these components (genes that function analogously in different species) have subsequently been found in mammals. Thus, the delineation of the pathway in Drosophila has helped to identify many genes that function as oncogenes or tumor suppressors in mammals.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T8851 I3MT-3 459420-09-8 99.86%
I3MT-3
I3MT-3 (HMPSNE) (HMPSNE) is a potent, selective and cell membrane permeability inhibitor of 3-mercaptopyruvate sulfur transferase (3MST), which targets the persu...
T4212 XMU-MP-1 2061980-01-4 99.68%
XMU-MP-1
XMU-MP-1 is an inhibitor of the pro-apoptotic, sterile 20-like kinases MST1 and 2.
T6104 Cerdulatinib hydrochloride 1369761-01-2 99.23%
Cerdulatinib hydrochloride
Cerdulatinib hydrochloride (PRT2070 hydrochloride) is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 nM and 32 nM for ...
T62512 IHMT-MST1-58 2414484-25-4 98.31%
IHMT-MST1-58
IHMT-MST1-58 is a STE20-like protein 1 kinase (MST1) inhibitor (IC50:23 nM) with high efficiency, selectivity and oral activity. IHMT-MST1-58 can be used to stud...
T5093 Pim1/AKK1-IN-1 1093222-27-5 97.67%
Pim1/AKK1-IN-1
Pim1/AKK1-IN-1 (LKB1/AAK1 dual inhibitor) is a potent multi-kinase inhibitor with Kd values of 35 nM/53 nM/75 nM/380 nM for Pim1/AKK1/MST2/LKB1 respectively, and...
I3MT-3
T8851
I3MT-3 (HMPSNE) (HMPSNE) is a potent, selective and cell membrane permeability inhibitor of 3-mercaptopyruvate sulfur transferase (3MST), which targets the persu...
XMU-MP-1
T4212
XMU-MP-1 is an inhibitor of the pro-apoptotic, sterile 20-like kinases MST1 and 2.
Cerdulatinib hydrochloride
T6104
Cerdulatinib hydrochloride (PRT2070 hydrochloride) is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 nM and 32 nM for ...
IHMT-MST1-58
T62512
IHMT-MST1-58 is a STE20-like protein 1 kinase (MST1) inhibitor (IC50:23 nM) with high efficiency, selectivity and oral activity. IHMT-MST1-58 can be used to stud...
Pim1/AKK1-IN-1
T5093
Pim1/AKK1-IN-1 (LKB1/AAK1 dual inhibitor) is a potent multi-kinase inhibitor with Kd values of 35 nM/53 nM/75 nM/380 nM for Pim1/AKK1/MST2/LKB1 respectively, and...
TargetMol