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Search Result

Search Results for " hif-hif-prolyl-hydroxylase "

Targets

HIF/HIF Prolyl-Hydroxylase

48

Compounds

15

Natural Products

1

Recombinant Proteins

1

Libraries

Cat No. Product Name Synonyms Targets
T64336 Izilendustat HIF/HIF Prolyl-Hydroxylase
Tert-butyl 4-[[1-[(4-chlorophenyl)methyl]-3-hydroxy-2-oxopyridin-4-yl]methyl]piperazine-1-carboxylate inhibit of human recombinant EGLN-1 as substrate after 20 mins by mass spectrophotometric analysis.
T22022 Adaptaquin HIF
Adaptaquin is an inhibitor of the hypoxia-inducing factor prolyl hydroxylase (HIF-PH) [1] [2].
T3169 KC7F2 HIF/HIF Prolyl-Hydroxylase , HIF
KC7F2 is a potent HIF-1 pathway inhibitor with potential anti-cancer activity.
T11561 HIF-2α-IN-2 HIF/HIF Prolyl-Hydroxylase , HIF
HIF-2α-IN-2 is a hypoxia-inducible factor (HIF-2α) inhibitor (IC50: 16 nM in scintillation proximity assay).
T0244 Tilorone dihydrochloride Influenza Virus , HIF/HIF Prolyl-Hydroxylase , IFNAR
Tilorone dihydrochloride is an orally active interferon inducer, and has antineoplastic and anti-inflammatory actions.
T50099 HIF-2α-IN-4 Others , HIF/HIF Prolyl-Hydroxylase
HIF-2a translation inhibitor is a compound used as a molecular building block.
T21653 1,4-DPCA HIF/HIF Prolyl-Hydroxylase
1,4-DPCA is an inhibitor of prolyl-hydroxylase with an IC50 of 2.4 µM for collagen hydroxylation in human foreskin fibroblasts and 60 μM for factor inhibiting HIF (FIH).
T5392 TP0463518 HIF/HIF Prolyl-Hydroxylase
TP-0463518 is a highly potent HIF prolyl hydroxylase (PHD) inhibitor (IC50s: 13 nM and 18 nM for human and rat PHD2, respectively).
T13050 SYP-5 HIF/HIF Prolyl-Hydroxylase , HIF
SYP-5 is a novel inhibitor of HIF-1, suppresses tumor cells invasion and angiogenesis.
T12675L PT2399 HIF/HIF Prolyl-Hydroxylase , HIF
PT2399 shows effective antitumor activity in vivo. PT2399 is an effective and selective HIF-2α antagonist, which directly binds to the HIF-2α PAS B domain (IC50: 6 nM).
T5537 IDF-11774 HIF/HIF Prolyl-Hydroxylase , HIF
IDF-11774 is a HIF-1 inhibitor.It reduces hif-1α HRE luciferase activity (IC50 = 3.65 μM).
T7880 IOX4 HIF/HIF Prolyl-Hydroxylase
IOX4 is a potent PHD2 inhibitor (IC50 = 1.6 nM)
T13398 ZINC13466751 HIF
ZINC13466751 is a potent HIF-1α/von Hippel-Lindau interaction inhibitor(IC50 of 2.0 µM).
T7848 PT-2385 HIF/HIF Prolyl-Hydroxylase , HIF
PT-2385 is a selective HIF-2α inhibitor (Kd<50 nM).
T3180 JNJ-42041935 HIF-PHD Inhibitor II HIF/HIF Prolyl-Hydroxylase
JNJ-42041935 (HIF-PHD Inhibitor II) is a potent (pKi = 7.3-7.9), 2-oxoglutarate competitive, reversible, and selective inhibitor of PHD enzymes.
T4106 MK-8617 MK8617 HIF/HIF Prolyl-Hydroxylase
MK-8617 is an orally available HIF PHD1 3 pan-inhibitor, inhibiting PHD1/2/3 (IC50: 1.0/1.0/14 nM).
T2488 BAY 87-2243 Ferroptosis , HIF/HIF Prolyl-Hydroxylase , HIF
BAY 87-2243 is a potent and selective inhibitor of hypoxia-inducible factor-1 (HIF-1).
T29797 AKB-6899 AKB6899 VEGFR , HIF/HIF Prolyl-Hydroxylase , HIF
AKB-6899 is an inhibitor of prolyl hydroxylase domain 3 (PHD3) and increases the soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treated macrophages. AKB-6899 leads to stabilization of HIF-2α which in...
T15219 Enarodustat JTZ-951 Others , HIF/HIF Prolyl-Hydroxylase
Enarodustat (JTZ-951) is an orally active factor inhibitor of prolyl hydroxylase (EC50: 0.22 μM) and has the potential for renal anemia treatment.
T2445 FG-2216 YM-311,FG2216,FG 2216 HIF/HIF Prolyl-Hydroxylase
FG-2216 (YM-311) is a potent HIF-prolyl hydroxylase inhibitor for the PDH2 enzyme (IC50: 3.9 uM); orally bioavailable and induced reversible and significant Epo induction in vivo.
T7802 M1001 HIF/HIF Prolyl-Hydroxylase , HIF
M1001 is a HIF-2α agonist.
T21806 HNHA HDAC
HNHA is an inhibitor of HDAC.
T3494 LW6 HIF-1α inhibitor,CAY10585,LW8 Apoptosis , Dehydrogenase , HIF/HIF Prolyl-Hydroxylase , HIF
LW6 (HIF-1α inhibitor) is a novel HIF-1 inhibitor.
T1823 IOX2 IOX 2,JICL38 HIF/HIF Prolyl-Hydroxylase
IOX2 (IOX 2) is a selective inhibitor of the Hypoxia Inducible Factor (HIF) Prolyl-Hydroxylases (PHD); active in cells with the IC50 value of 21 nM for PHD2/ELGN-1 and no inhibition at FIH (20uM).
T6961 PX-478 PX-478 2HCl HIF/HIF Prolyl-Hydroxylase , HIF , Autophagy
PX-478 is a HIF-1α inhibitor with selectivity, oral activity, and blood-brain barrier permeability. PX-478 has antitumor activity and also protects pancreatic β-cell function in diabetes mellitus and is used in type 2 di...
T9627 PHD-1-IN-1 HIF/HIF Prolyl-Hydroxylase
PHD-1-IN-1 is a potent inhibitor of hypoxia-inducible factor prolylhydroxylase domain-1 (PHD-1) enzyme(IC50 = 0.034 μM).
T1613 Hydralazine hydrochloride Hydralazine HCl,Apresoline MAO , HIF/HIF Prolyl-Hydroxylase
Hydralazine hydrochloride (Apresoline) is the hydrochloride salt of hydralazine, a phthalazine derivative with antihypertensive and potential antineoplastic activities. Hydralazine alters intracellular calcium release an...
T16679 Belzutifan PT2977,MK-6482 HIF
Belzutifan (MK-6482) is a potential treatment for clear cell renal cell carcinoma (ccRCC). Belzutifan is an orally active and selective HIF-2α inhibitor (IC50: 9 nM). Belzutifan , as a second-generation HIF-2α inhibitor,...
T13289 EHP-101 VCE-​004.8 Cannabinoid Receptor , HIF/HIF Prolyl-Hydroxylase , PPAR
EHP-101 (VCE-004.8) is a specific dual agonist of PPARγ and CB2 receptor with potent anti-inflammatory activity. EHP-101 attenuates adipogenesis and prevents diet-induced obesity.
T9890 HIF1-IN-3  Benzenepropanamide, N-[(8-hydroxy-7-quinolinyl)(4-methoxyphenyl)methyl]- HIF
HIF1-IN-3 (Benzenepropanamide, N-[(8-hydroxy-7-quinolinyl)(4-methoxyphenyl)methyl]-) is an effective inhibitor of HIF-1 (EC50 = 0.9 μM) and can be used in anticancer studies.
T1939 DMOG Dimethyloxalylglycine,Dimethyloxallyl Glycine,Dimethyloxaloylglycine HIF/HIF Prolyl-Hydroxylase , HIF , Autophagy
DMOG (Dimethyloxalylglycine), an antagonist of the α-ketoglutarate cofactor, is an inhibitor for HIF prolyl hydroxylase.
T3289 Amifostine Ethyol,WR2721,Gammaphos Others , HIF/HIF Prolyl-Hydroxylase
Amifostine (Ethyol) anhydrous is a cytoprotective agent, acts as a free radical scavenging activity.
T6381 Amifostine trihydrate Ethyol trihydrate,WR2721,Amifostine Others , HIF/HIF Prolyl-Hydroxylase
Amifostine trihydrate (WR2721) is the first approved radioprotective drug, used to decrease the risk of kidney problems caused by treatment with cisplatin.
T0153 Oltipraz NSC 347901,RP 35972 HIF/HIF Prolyl-Hydroxylase , HIV Protease , Reverse Transcriptase , Nrf2 , HIF
Oltipraz (RP 35972) is a synthetic dithiolethione with potential chemopreventive and anti-angiogenic properties. Oltipraz induces phase II detoxification enzymes, such as glutathione S transferase (GST) and NAD(P)H: quin...
T15396 GN44028 N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine HIF
GN44028 (N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine) is a hypoxia-inducible factor inhibitor of (HIF)-1 (IC50: 14 nM). GN44028 inhibits hypoxia-induced HIF-1α transcriptional activity. H...
T1637 Deferoxamine Mesylate desferrioxamine B,Desferrioxamine B mesylate,DFO,DFOM Mitophagy , Beta Amyloid , Others , Ferroptosis , HIF/HIF Prolyl-Hydroxylase , Autophagy
Deferoxamine Mesylate (DFOM) is an iron chelator and iron death inhibitor. Deferoxamine Mesylate binds free iron into a stable complex and reduces iron accumulation. Deferoxamine Mesylate up-regulates HIF-1α levels and i...
T1101 Minocycline hydrochloride Minocycline HCl HIF/HIF Prolyl-Hydroxylase , Antibacterial , Antibiotic
Minocycline hydrochloride (Minocycline HCl) is a tetracycline antibiotic with excellent absorption and tissue penetration that is used for several bacterial infections as well as treatment of acne. Minocycline hydrochlor...
T6823 E3330 HIF/HIF Prolyl-Hydroxylase , DNA/RNA Synthesis
E3330 is a potent and selective APE1(Ref-1) inhibitor, which suppressed NF-kappa B DNA-binding activity.
T7692 2,4-DPD HIF
2,4-DPD is competitive inhibitor of the oxygen-sensing enzyme HIF-α prolyl hydroxylase (HIF-PH)
T61822 M1002 HIF
M1002 is a hypoxia-inducible factor-2 (HIF-2) agonist that enhances the affinity of HIF-2alpha and ARNT for transcriptional activation.M1002 alters the Tyr2 conformation of the HIF-281alpha PAS-B structural domain and ac...
T17105 TM6089 HIF/HIF Prolyl-Hydroxylase
TM6089 is an inhibitor of Prolyl Hydroxylase that stimulates HIF activity without iron chelation, induces angiogenesis, and protects organ against ischemia.
T24148 HPCG
HPCG is an inhibitor of HIF-1α prolyl hydroxylase.
T23988 DHPCG
DHPCG is an inhibitor of HIF-1α prolyl hydroxylase.
T12547 Prolyl Hydroxylase inhibitor 1 Others
Prolyl Hydroxylase inhibitor 1 is an orally active inhibitor of hypoxia inducible factor (HIF)-prolyl hydroxylase (PHD) (IC50 of 62.23 nM).
T39040 HIF-PHD-IN-1
HIF-PHD-IN-1 is a pharmacological compound that acts as an orally active inhibitor of the hypoxia-inducible factor prolyl hydroxylase domain (HIF-PHD), displaying an IC50 of 54 nM for hHIF-PHD2. Its potential as a therap...
T63035 Izilendustat hydrochloride
Izilendustat (hydrochloride) is a potent inhibitor of prolyl hydroxylase that stabilizes hypoxia-inducible factor-1 alpha (HIF-1α) and hypoxia-inducible factor-2 (HIF-2). Potential for HIF-1α-related diseases (including ...
T79241 PHD2-IN-1 HIF/HIF Prolyl-Hydroxylase
PHD2-IN-1, a potent and orally active HIF prolyl hydroxylase 2 (PHD2) inhibitor, exhibits an IC50 of 22.53 nM and is applicable in anemia research [1].
T69966 Roxadustat-d5
Roxadustat-d5 is intended for use as an internal standard for the quantification of roxadustat by GC- or LC-MS. Roxadustat is an inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH; IC50s = 1.4, 1.26, and 1....

Compounds

Izilendustat
T64336
Synonym:
Target: HIF/HIF Prolyl-Hydroxylase
Adaptaquin
T22022
Synonym:
Target: HIF
KC7F2
T3169
Synonym:
Target: HIF/HIF Prolyl-Hydroxylase, HIF
HIF-2α-IN-2
T11561
Synonym:
Target: HIF/HIF Prolyl-Hydroxylase, HIF
Tilorone dihydrochloride
T0244
Synonym:
Target: Influenza Virus, HIF/HIF Prolyl-Hydroxylase, IFNAR
HIF-2α-IN-4
T50099
Synonym:
Target: Others, HIF/HIF Prolyl-Hydroxylase
1,4-DPCA
T21653
Synonym:
Target: HIF/HIF Prolyl-Hydroxylase
TP0463518
T5392
Synonym:
Target: HIF/HIF Prolyl-Hydroxylase
SYP-5
T13050
Synonym:
Target: HIF/HIF Prolyl-Hydroxylase, HIF
PT2399
T12675L
Synonym:
Target: HIF/HIF Prolyl-Hydroxylase, HIF
IDF-11774
T5537
Synonym:
Target: HIF/HIF Prolyl-Hydroxylase, HIF
IOX4
T7880
Synonym:
Target: HIF/HIF Prolyl-Hydroxylase
ZINC13466751
T13398
Synonym:
Target: HIF
PT-2385
T7848
Synonym:
Target: HIF/HIF Prolyl-Hydroxylase, HIF
JNJ-42041935
T3180
Synonym: HIF-PHD Inhibitor II
Target: HIF/HIF Prolyl-Hydroxylase
MK-8617
T4106
Synonym: MK8617
Target: HIF/HIF Prolyl-Hydroxylase
BAY 87-2243
T2488
Synonym:
Target: Ferroptosis, HIF/HIF Prolyl-Hydroxylase, HIF
AKB-6899
T29797
Synonym: AKB6899
Target: VEGFR, HIF/HIF Prolyl-Hydroxylase, HIF
Enarodustat
T15219
Synonym: JTZ-951
Target: Others, HIF/HIF Prolyl-Hydroxylase
FG-2216
T2445
Synonym: YM-311,FG2216,FG 2216
Target: HIF/HIF Prolyl-Hydroxylase
M1001
T7802
Synonym:
Target: HIF/HIF Prolyl-Hydroxylase, HIF
HNHA
T21806
Synonym:
Target: HDAC
LW6
T3494
Synonym: HIF-1α inhibitor,CAY10585,LW8
Target: Apoptosis, Dehydrogenase, HIF/HIF Prolyl-Hydroxylase, HIF
IOX2
T1823
Synonym: IOX 2,JICL38
Target: HIF/HIF Prolyl-Hydroxylase
PX-478
T6961
Synonym: PX-478 2HCl
Target: HIF/HIF Prolyl-Hydroxylase, HIF, Autophagy
PHD-1-IN-1
T9627
Synonym:
Target: HIF/HIF Prolyl-Hydroxylase
Hydralazine hydrochloride
T1613
Synonym: Hydralazine HCl,Apresoline
Target: MAO, HIF/HIF Prolyl-Hydroxylase
Belzutifan
T16679
Synonym: PT2977,MK-6482
Target: HIF
EHP-101
T13289
Synonym: VCE-​004.8
Target: Cannabinoid Receptor, HIF/HIF Prolyl-Hydroxylase, PPAR
HIF1-IN-3 
T9890
Synonym: Benzenepropanamide, N-[(8-hydroxy-7-quinolinyl)(4-methoxyphenyl)methyl]-
Target: HIF
DMOG
T1939
Synonym: Dimethyloxalylglycine,Dimethyloxallyl Glycine,Dimethyloxaloylglycine
Target: HIF/HIF Prolyl-Hydroxylase, HIF, Autophagy
Amifostine
T3289
Synonym: Ethyol,WR2721,Gammaphos
Target: Others, HIF/HIF Prolyl-Hydroxylase
Amifostine trihydrate
T6381
Synonym: Ethyol trihydrate,WR2721,Amifostine
Target: Others, HIF/HIF Prolyl-Hydroxylase
Oltipraz
T0153
Synonym: NSC 347901,RP 35972
Target: HIF/HIF Prolyl-Hydroxylase, HIV Protease, Reverse Transcriptase, Nrf2, HIF
GN44028
T15396
Synonym: N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine
Target: HIF
Deferoxamine Mesylate
T1637
Synonym: desferrioxamine B,Desferrioxamine B mesylate,DFO,DFOM
Target: Mitophagy, Beta Amyloid, Others, Ferroptosis, HIF/HIF Prolyl-Hydroxylase, Autophagy
Minocycline hydrochloride
T1101
Synonym: Minocycline HCl
Target: HIF/HIF Prolyl-Hydroxylase, Antibacterial, Antibiotic
E3330
T6823
Synonym:
Target: HIF/HIF Prolyl-Hydroxylase, DNA/RNA Synthesis
2,4-DPD
T7692
Synonym:
Target: HIF
M1002
T61822
Synonym:
Target: HIF
TM6089
T17105
Synonym:
Target: HIF/HIF Prolyl-Hydroxylase
HPCG
T24148
Synonym:
Target:
DHPCG
T23988
Synonym:
Target:
Prolyl Hydroxylase inhibitor 1
T12547
Synonym:
Target: Others
HIF-PHD-IN-1
T39040
Synonym:
Target:
Izilendustat hydrochloride
T63035
Synonym:
Target:
PHD2-IN-1
T79241
Synonym:
Target: HIF/HIF Prolyl-Hydroxylase
Roxadustat-d5
T69966
Synonym:
Target:
Cat No. Product Name Synonyms Targets
T6S0071 Fraxinellone HIF/HIF Prolyl-Hydroxylase , STAT , PD-1/PD-L1
1. Fraxinellone significantly reduced weight loss and diarrhea in mice and alleviated the macroscopic and microscopic signs of the disease. 2. Fraxinellone exhibited a variety of insecticidal activities including feeding...
T5S2347 Deoxyshikonin Arnebin 7 Others , HIF/HIF Prolyl-Hydroxylase , Antibacterial
1. Deoxyshikonin (Arnebin 7) may be a new drug candidate for wound healing and treatment of lymphatic diseases. 2. Deoxyshikonin enhances the ability of human dermal lymphatic microvascular endothelial cells (HMVEC-dLy) ...
T5684 Ethyl 3,4-dihydroxybenzoate Apoptosis , Others , Reactive Oxygen Species , HIF/HIF Prolyl-Hydroxylase , NO Synthase , Autophagy
Ethyl 3,4-dihydroxybenzoate (EDHB): a prolyl hydroxylase inhibitor attenuates acute hypobaric hypoxia mediated vascular leakage in brain.
TL0001 Dencichine L-Dencichin,ODAP,Dencichin Others , HIF/HIF Prolyl-Hydroxylase
Dencichine (ODAP) is a neurotoxic agent. Dencichine is a haemostatic agent, the hemostatic effect relates to modulation of the coagulation system, platelet aggregation and fibrinolytic system. It has renoprotective effec...
T0429 Glucosamine Chitosamine,D-Glucosamine MMP , Others , TNF , NF-κB , Reactive Oxygen Species , HIF/HIF Prolyl-Hydroxylase , Endogenous Metabolite , CFTR , Autophagy
Glucosamine (Chitosamine) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Supplemental glucosamine may help to rebuild cartilage and treat arthritis.
T2763 Panaxadiol 20(R)-Panaxadiol Others , HIF/HIF Prolyl-Hydroxylase
Panaxadiol (20(R)-Panaxadiol) is a novel antitumor agent extracted from the Chinese medical herb Panax ginseng.
T6S1315 Oroxylin A 6-Methoxybaicalein,Baicalein 6-methyl ether Virus Protease , HIF/HIF Prolyl-Hydroxylase , Autophagy
1. Oroxylin A (Baicalein 6-methyl ether) has various anti-tumor effects including apoptosis, cell cycle arrest, drug-resistant reversion. 2. Oroxylin A possesses abilities of inhibiting the ATRA-induced IL-6 production v...
T1152 Albendazole SKF-62979 HIF/HIF Prolyl-Hydroxylase , Microtubule Associated , Antibiotic , Parasite
Albendazole (SKF-62979) is used as a drug indicated for the treatment of a variety of worm infestations.
T2792 Glucosamine sulfate D-Glucosamine sulphate,D-Glucosaminesulfate MMP , Reactive Oxygen Species , HIF/HIF Prolyl-Hydroxylase , Endogenous Metabolite , Autophagy
Glucosamine sulfate (D-Glucosaminesulfate) was extracted from synthetic product;Store the product in sealed, cool and dry condition.
T2805 Chlorogenic Acid NSC-407296,3-O-Caffeoylquinic acid,Heriguard Others , Influenza Virus , Reactive Oxygen Species , HIF/HIF Prolyl-Hydroxylase , Endogenous Metabolite , Antibacterial
Chlorogenic Acid (NSC-407296) is a naturally occurring phenolic acid which is a carcinogenic inhibitor. It has also been shown to prevent paraquat-induced oxidative stress in rats.
T1205 Chloramphenicol Chlornitromycin,Levomycetin,Chloromycetin ribosome , HIF/HIF Prolyl-Hydroxylase , Antibacterial , Antibiotic
Chloramphenicol (Chloromycetin), a broad-spectrum antibiotic, blocks bacterial protein synthesis.
T11589 Hydroxycitric acid tripotassium hydrate Potassium citrate monohydrate ATP Citrate Lyase , HIF/HIF Prolyl-Hydroxylase , HIF
Hydroxycitric acid tripotassium hydrate (Potassium citrate monohydrate) effectively inhibits stones formation and also inhibits HIF, and has antioxidation, anti-inflammation, and anti-tumor effects. Hydroxycitric acid tr...
T0256 Citric acid trilithium salt tetrahydrate Lithium citrate tribasic tetrahydrate,Trilithium citrate tetrahydrate Dehydrogenase , GSK-3 , HIF/HIF Prolyl-Hydroxylase , Antibacterial , GluR
Citric acid trilithium salt tetrahydrate (Lithium citrate tribasic tetrahydrate) , the active component of Lithium, is a medicine used in the therapy of psychiatric disease. It has shown the effects of signaling pathways...
T2941 Glucosamine hydrochloride Chitosamine hydrochloride,2-Amino-2-deoxy-glucose HCl,Chitosamine HCl,D-(+)-Glucosamine hydrochloride Reactive Oxygen Species , HIF/HIF Prolyl-Hydroxylase , Endogenous Metabolite , Autophagy
Glucosamine hydrochloride (Chitosamine hydrochloride) is commonly used as a treatment for osteoarthritis, although its acceptance as a medical therapy varies.
T5S1569 AKBA 3-O-Acetyl-11-keto-β-boswellic acid,3-O-Acetyl-11-keto-beta-boswellic acid,Acetyl-11-keto-β-boswellic acid Others , Reactive Oxygen Species , HIF/HIF Prolyl-Hydroxylase , Endogenous Metabolite
AKBA (3-O-Acetyl-11-keto-beta-boswellic acid), a natural component from frankincense, is a novel activator of Nrf2.

Natural Products

Fraxinellone
T6S0071
Synonym:
Target: HIF/HIF Prolyl-Hydroxylase, STAT, PD-1/PD-L1
Deoxyshikonin
T5S2347
Synonym: Arnebin 7
Target: Others, HIF/HIF Prolyl-Hydroxylase, Antibacterial
Ethyl 3,4-dihydroxybenzoate
T5684
Synonym:
Target: Apoptosis, Others, Reactive Oxygen Species, HIF/HIF Prolyl-Hydroxylase, NO Synthase, Autophagy
dencichine
TL0001
Synonym: L-Dencichin,ODAP,Dencichin
Target: Others, HIF/HIF Prolyl-Hydroxylase
Glucosamine
T0429
Synonym: Chitosamine,D-Glucosamine
Target: MMP, Others, TNF, NF-κB, Reactive Oxygen Species, HIF/HIF Prolyl-Hydroxylase, Endogenous Metabolite, CFTR, Autophagy
Panaxadiol
T2763
Synonym: 20(R)-Panaxadiol
Target: Others, HIF/HIF Prolyl-Hydroxylase
Oroxylin A
T6S1315
Synonym: 6-Methoxybaicalein,Baicalein 6-methyl ether
Target: Virus Protease, HIF/HIF Prolyl-Hydroxylase, Autophagy
Albendazole
T1152
Synonym: SKF-62979
Target: HIF/HIF Prolyl-Hydroxylase, Microtubule Associated, Antibiotic, Parasite
Glucosamine sulfate
T2792
Synonym: D-Glucosamine sulphate,D-Glucosaminesulfate
Target: MMP, Reactive Oxygen Species, HIF/HIF Prolyl-Hydroxylase, Endogenous Metabolite, Autophagy
Chlorogenic Acid
T2805
Synonym: NSC-407296,3-O-Caffeoylquinic acid,Heriguard
Target: Others, Influenza Virus, Reactive Oxygen Species, HIF/HIF Prolyl-Hydroxylase, Endogenous Metabolite, Antibacterial
Chloramphenicol
T1205
Synonym: Chlornitromycin,Levomycetin,Chloromycetin
Target: ribosome, HIF/HIF Prolyl-Hydroxylase, Antibacterial, Antibiotic
Hydroxycitric acid tripotassium hydrate
T11589
Synonym: Potassium citrate monohydrate
Target: ATP Citrate Lyase, HIF/HIF Prolyl-Hydroxylase, HIF
Citric acid trilithium salt tetrahydrate
T0256
Synonym: Lithium citrate tribasic tetrahydrate,Trilithium citrate tetrahydrate
Target: Dehydrogenase, GSK-3, HIF/HIF Prolyl-Hydroxylase, Antibacterial, GluR
Glucosamine hydrochloride
T2941
Synonym: Chitosamine hydrochloride,2-Amino-2-deoxy-glucose HCl,Chitosamine HCl,D-(+)-Glucosamine hydrochloride
Target: Reactive Oxygen Species, HIF/HIF Prolyl-Hydroxylase, Endogenous Metabolite, Autophagy
AKBA
T5S1569
Synonym: 3-O-Acetyl-11-keto-β-boswellic acid,3-O-Acetyl-11-keto-beta-boswellic acid,Acetyl-11-keto-β-boswellic acid
Target: Others, Reactive Oxygen Species, HIF/HIF Prolyl-Hydroxylase, Endogenous Metabolite

Recombinant Proteins

Species：
Human (1)
Expression System：
E. coli (1)
Tag：
N-terminal 10xHis-tagged and C-terminal Myc-tagged (1)
Cat No. Product Name Species Expression System
TMPH-01280 EGLN1 Protein, Human, Recombinant (His & Myc) Human E. coli
Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of th...
Cat No. Product Name
L8500 HIF-1 Signaling Pathway Compound Library

1352 compounds
A unique collection of 1352 HIF-1 related small chemicals can be used for drug discovery in ischemic disease and cancer and related mechanism studies；

Libraries

HIF-1 Signaling Pathway Compound Library
L8500
Compounds: 1352
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