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GHSR

Growth hormone secretagogue receptor(GHS-R), also known as ghrelin receptor, is a G protein-coupled receptor that binds growth hormone secretagogues (GHSs), such as ghrelin, the "hunger hormone". The role of GHS-R is thought to be in regulating energy homeostasis and body weight. In the brain, they are most highly expressed in the hypothalamus, specifically the ventromedial nucleus and arcuate nucleus. GSH-Rs are also expressed in other areas of the brain, including the ventral tegmental area, hippocampus, and substantia nigra. Outside the central nervous system, too, GSH-Rs are also found in the liver, in skeletal muscle, and even in the heart.
Signaling Pathways | Target | TargetMol
Cat. No. Product name CAS No. Purity Chemical Structure
T80006 Emoghrelin 928262-58-2 98%
Emoghrelin
Emoghrelin, extracted from Heshouwu (Polygonum multiflorum), promotes the secretion of growth hormone by activating the ghrelin receptor [1].
T11798 L-692429 145455-23-8 99.90%
L-692429
L-692429 (MK-0751) is a potent nonpeptidyl growth hormone secretagogue (GHS) agonist, a benzolactam derivative, which reverses the inhibition of GH secretion by ...
T11560 HGPR91 antagonist 1 1314796-00-3 99.85%
hGPR91 antagonist 1
hGPR91 antagonist 1 is a potent and selective hGPR91 antagonist (IC50: 7 μM).
T34281 Relamorelin 661472-41-9 99.85%
Relamorelin
Relamorelin (RM-131), a selective and potent growth hormone-releasing peptide/growth hormone secretagogue receptor (GHSR) agonist, is a potent growth hormone-rel...
T16508 PF-5190457 1334782-79-4 99.34%
PF-5190457
PF-5190457 is an effective and selective ghrelin receptor inverse agonist (pKi: 8.36).
T23543 YIL 781 875258-85-8 99.3%
YIL 781
YIL 781 is a selective ghrelin receptor antagonist (GHS-R1a) (Ki = 17 nM), showing a weak affinity for kinesin receptors (K = 6 μM). YIL 781 improves glucose hom...
TP1155L Human growth hormone-releasing factor acetate 99.26%
Human growth hormone-releasing factor acetate
Human growth hormone-releasing factor acetate is a hypothalamic polypeptide and stimulates GH production and release by binding to the GHRH Receptor (GHRHR) on c...
T7225 AnaMorelin hydrochloride 861998-00-7 99.18%
AnaMorelin hydrochloride
AnaMorelin hydrochloride (RC-1291 hydrochloride) is a novel ghrelin receptor agonist(EC50 : 0.74 nM, in the FLIPR assay).
TP2279L Obestatin (rat) acetate 99.05%
Obestatin (rat) acetate
Obestatin (rat) acetate is an endogenous ligand of G-protein coupled receptor 39 (GPR39). Obestatin (rat) acetate has anti-inflammatory, anti-myocardial infarcti...
TP2236L Cortistatin-8 acetate TP2236L 99.01%
Cortistatin-8 acetate
Cortistatin-8 acetate is a corticosteroid analog, a GHS-R antagonist with inhibitory effects on the growth hormone pro-secretin receptor.Cortistatin-8 acetate is...
T4648 TC-G-1008 1621175-65-2 99%
TC-G-1008
TC-G-1008 (GPR39-C3) is a GPR39 (zinc receptor) agonist (EC50 values are 0.4 and 0.8 nM for rat and human receptors respectively).
TQ0022 Capromorelin Tartrate 193273-69-7 98.98%
Capromorelin Tartrate
Capromorelin Tartrate (CP 424391-18) is a potent, orally active growth hormone secretagogue receptor (GHSR) agonist (Ki: 7 nM for hGHS-R1a).
T11719 JMV 2959 hydrochloride (925238-89-7 free base) 2448414-54-6 98.09%
JMV 2959 hydrochloride (925238-89-7 free base)
JMV 2959 hydrochloride (925238-89-7 free base) is a growth hormone secretagogue receptor type 1a (GHS-R1a) antagonist with an IC50 of 32±3 nM in LLC-PK1 cells.
TP2328L CJC-1295 acetate(863288-34-0 free base) TP2328L 98%
CJC-1295 acetate(863288-34-0 free base)
CJC-1295 acetate(863288-34-0 free base) (DAC:GRF acetate) is a synthetic analogue of growth hormone-releasing hormone (GHRH) (also known as growth hormone-releas...
T7112 Ibutamoren Mesylate 159752-10-0 98%
Ibutamoren Mesylate
Ibutamoren Mesylate (MK-0677) is a potent, non-peptide Growth hormone secretagogue receptor (GHSR) agonist.
T12216L NF-56-EJ40 hydrochloride 2728500-80-7 97.02%
NF-56-EJ40 hydrochloride
NF-56-EJ40 hydrochloride is a potent, high-affinity, and highly selective human SUCNR1 (GPR91) antagonist with an IC50 of 25 nM and a Ki of 33 nM, and shows almo...
T17103 TM-N1324 1144477-35-9 90.39%
TM-N1324
TM-N1324 is a GPR39 agonist. TM-N1324 activates human GPR39 with high efficacy and potencies of 280 nM and 9 nM in the absence and presence of Zn2+, respectively...
T10319 Anamorelin 249921-19-5 98%
Anamorelin
Anamorelin (ONO-7643) is a novel ghrelin receptor agonist (EC50: 0.74 nM in the FLIPR assay).
Emoghrelin
T80006
Emoghrelin, extracted from Heshouwu (Polygonum multiflorum), promotes the secretion of growth hormone by activating the ghrelin receptor [1].
L-692429
T11798
L-692429 (MK-0751) is a potent nonpeptidyl growth hormone secretagogue (GHS) agonist, a benzolactam derivative, which reverses the inhibition of GH secretion by ...
hGPR91 antagonist 1
T11560
hGPR91 antagonist 1 is a potent and selective hGPR91 antagonist (IC50: 7 μM).
Relamorelin
T34281
Relamorelin (RM-131), a selective and potent growth hormone-releasing peptide/growth hormone secretagogue receptor (GHSR) agonist, is a potent growth hormone-rel...
PF-5190457
T16508
PF-5190457 is an effective and selective ghrelin receptor inverse agonist (pKi: 8.36).
YIL 781
T23543
YIL 781 is a selective ghrelin receptor antagonist (GHS-R1a) (Ki = 17 nM), showing a weak affinity for kinesin receptors (K = 6 μM). YIL 781 improves glucose hom...
Human growth hormone-releasing factor acetate
TP1155L
Human growth hormone-releasing factor acetate is a hypothalamic polypeptide and stimulates GH production and release by binding to the GHRH Receptor (GHRHR) on c...
AnaMorelin hydrochloride
T7225
AnaMorelin hydrochloride (RC-1291 hydrochloride) is a novel ghrelin receptor agonist(EC50 : 0.74 nM, in the FLIPR assay).
Obestatin (rat) acetate
TP2279L
Obestatin (rat) acetate is an endogenous ligand of G-protein coupled receptor 39 (GPR39). Obestatin (rat) acetate has anti-inflammatory, anti-myocardial infarcti...
Cortistatin-8 acetate
TP2236L
Cortistatin-8 acetate is a corticosteroid analog, a GHS-R antagonist with inhibitory effects on the growth hormone pro-secretin receptor.Cortistatin-8 acetate is...
TC-G-1008
T4648
TC-G-1008 (GPR39-C3) is a GPR39 (zinc receptor) agonist (EC50 values are 0.4 and 0.8 nM for rat and human receptors respectively).
Capromorelin Tartrate
TQ0022
Capromorelin Tartrate (CP 424391-18) is a potent, orally active growth hormone secretagogue receptor (GHSR) agonist (Ki: 7 nM for hGHS-R1a).
JMV 2959 hydrochloride (925238-89-7 free base)
T11719
JMV 2959 hydrochloride (925238-89-7 free base) is a growth hormone secretagogue receptor type 1a (GHS-R1a) antagonist with an IC50 of 32±3 nM in LLC-PK1 cells.
CJC-1295 acetate(863288-34-0 free base)
TP2328L
CJC-1295 acetate(863288-34-0 free base) (DAC:GRF acetate) is a synthetic analogue of growth hormone-releasing hormone (GHRH) (also known as growth hormone-releas...
Ibutamoren Mesylate
T7112
Ibutamoren Mesylate (MK-0677) is a potent, non-peptide Growth hormone secretagogue receptor (GHSR) agonist.
NF-56-EJ40 hydrochloride
T12216L
NF-56-EJ40 hydrochloride is a potent, high-affinity, and highly selective human SUCNR1 (GPR91) antagonist with an IC50 of 25 nM and a Ki of 33 nM, and shows almo...
TM-N1324
T17103
TM-N1324 is a GPR39 agonist. TM-N1324 activates human GPR39 with high efficacy and potencies of 280 nM and 9 nM in the absence and presence of Zn2+, respectively...
Anamorelin
T10319
Anamorelin (ONO-7643) is a novel ghrelin receptor agonist (EC50: 0.74 nM in the FLIPR assay).
TargetMol