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GHSR

Growth hormone secretagogue receptor(GHS-R), also known as ghrelin receptor, is a G protein-coupled receptor that binds growth hormone secretagogues (GHSs), such as ghrelin, the "hunger hormone". The role of GHS-R is thought to be in regulating energy homeostasis and body weight. In the brain, they are most highly expressed in the hypothalamus, specifically the ventromedial nucleus and arcuate nucleus. GSH-Rs are also expressed in other areas of the brain, including the ventral tegmental area, hippocampus, and substantia nigra. Outside the central nervous system, too, GSH-Rs are also found in the liver, in skeletal muscle, and even in the heart.

Human growth hormone-releasing factor acetate
TP1155L
Human growth hormone-releasing factor acetate is a hypothalamic polypeptide and stimulates GH production and release by binding to the GHRH Receptor (GHRHR) on cells in the anterior pituitary[1].
  • $119
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Anamorelin
T10319249921-19-5
Anamorelin (ONO-7643) is a novel ghrelin receptor agonist (EC50: 0.74 nM in the FLIPR assay).
  • $55
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CJC-1295 acetate(863288-34-0 free base)
TP2328L
CJC-1295 acetate(863288-34-0 free base) (DAC:GRF acetate) is a synthetic analogue of growth hormone-releasing hormone (GHRH) (also known as growth hormone-releasing factor (GRF)) and a growth hormone secretagogue (GHS)
  • $80
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Ibutamoren Mesylate
T7112159752-10-0
Ibutamoren Mesylate (MK-0677) is a potent, non-peptide Growth hormone secretagogue receptor (GHSR) agonist.
  • $57
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TC-G-1008
T46481621175-65-2
TC-G-1008 (GPR39-C3) is a zinc receptor agonist with EC50 values of 0.4 nM for rat GPR39 and 0.8 nM for human GPR39.
  • $32
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TargetMol | Inhibitor Sale
Capromorelin Tartrate
TQ0022193273-69-7
Capromorelin Tartrate (CP 424391-18) is a potent, orally active growth hormone secretagogue receptor (GHSR) agonist (Ki: 7 nM for hGHS-R1a).
  • $33
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Relamorelin
T34281661472-41-9In house
Relamorelin(BIM28131, RM131) is a selective and potent ghrelin/growth hormone secretagogue receptor (GHSR) agonist with high affinity for GHS-1a receptor (Ki value is 0.42 ± 0.063 nM). Relamorelin(BIM28131, RM131) is also a centrally permeable pentapeptide analog that can increase growth hormone levels and accelerate gastric emptying, and has the potential to study cachexia.
  • $497
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L-692429
T11798145455-23-8In house
L-692429 (MK-0751) is a potent nonpeptidyl growth hormone secretagogue (GHS) agonist and benzolactam derivative, known for reversing glucocorticoid-induced inhibition of GH secretion. L-692429 exhibits high affinity for the G protein-coupled receptor and is useful in studying acromegaly and obesity.
  • $158
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AnaMorelin hydrochloride
T7225861998-00-7
AnaMorelin hydrochloride (RC-1291 hydrochloride) is a novel ghrelin receptor agonist(EC50 : 0.74 nM, in the FLIPR assay).
  • $30
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TM-N1324
T171031144477-35-9
TM-N1324 is a GPR39 agonist. TM-N1324 activates human GPR39 with high efficacy and potencies of 280 nM and 9 nM in the absence and presence of Zn2+, respectively. TM-N1324 has similar potencies to murine GPR39 with EC50s of 180 nM and 5 nM, respectively.
  • $44
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JMV 2959 hydrochloride (925238-89-7 free base)
T117192448414-54-6
JMV 2959 hydrochloride (925238-89-7 free base) is a growth hormone secretagogue receptor type 1a (GHS-R1a) antagonist with an IC50 of 32±3 nM in LLC-PK1 cells.
  • $35
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PF-5190457
T165081334782-79-4
PF-5190457 is an effective and selective ghrelin receptor inverse agonist (pKi: 8.36).
  • $31
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YIL 781
T23543875258-85-8
YIL 781 is a selective ghrelin receptor antagonist (GHS-R1a) (Ki = 17 nM), showing a weak affinity for kinesin receptors (K = 6 μM). YIL 781 improves glucose homeostasis in vivo and in vitro by blocking ghrelin secretion.
  • $44
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Obestatin (rat) acetate
TP2279L
Obestatin (rat) acetate is an endogenous ligand of G-protein coupled receptor 39 (GPR39). Obestatin (rat) acetate has anti-inflammatory, anti-myocardial infarction and antioxidant properties. Obestatin (rat) acetate suppresses food intake, inhibits jejunal contraction, and decreases body-weight gain.
  • $117
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Ibutamoren
T20095159634-47-6
Ibutamoren (MK-677) is a drug which acts as a potent, orally active growth hormone secretagogue, mimicking the GH stimulating action of the endogenous hormone ghrelin. It also alters the metabolism of body fat and so may have an application in the treatment of obesity.
  • $59
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Cortistatin-8 acetate
TP2236L
Cortistatin-8 acetate is a corticosteroid analog, a GHS-R antagonist with inhibitory effects on the growth hormone pro-secretin receptor.Cortistatin-8 acetate is a synthetic corticosteroid-derived ligand for the growth hormone-releasing peptide receptor and does not alter the endocrine response to acylated growth hormone-releasing peptide or hesperidin in humans.Cortistatin-8 acetate is a synthetic corticosteroid-derived ligand for the growth hormone-releasing peptide receptor.
  • $240
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Emoghrelin
T80006928262-58-2
Emoghrelin, extracted from Heshouwu (Polygonum multiflorum), promotes the secretion of growth hormone by activating the ghrelin receptor [1].
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Tezusomant
T2071712802416-72-2
Tezusomant is an antagonist of the growth hormone receptor (growth hormone receptor). It is being investigated for potential use in conditions like acromegaly, which are caused by excessive secretion of growth hormone.
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pf-04628935
T283661383719-97-8
PF-04628935 is a potent antagonist inverse agonist of the ghrelin receptor, growth hormone secretagogue receptor 1a (GHS-R1a) with an IC50 of 4.6 nM. PF-04628935 is orally bioavailable and brain penetrant.
  • $1,250
35 days
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SM-130686
T28812259667-25-9
SM-130,686 is a potent, orally-active agonist of the ghrelin/growth hormone secretagogue receptor (GHSR) and growth hormone secretagogue. It has around half the potency of the endogenous agonist ghrelin as a stimulator of growth hormone release.
  • $1,670
6-8 weeks
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L 163255
T32435159634-54-5
L 163255 is a type of growth hormone secretagogue (GHS).
  • $2,120
8-10 weeks
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[His1,Nle27] GHRF (1-32), amide, human
T7631794034-78-3
[His1,Nle27] GHRF (1-32), amide, human is a synthetic analog of the growth hormone-releasing hormone (GHRH) with enhanced affinity for the growth hormone-releasing hormone receptor (GHRHR) [1].
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L-692585
T22898145455-35-2
ghrelin receptor (GHS-R1a) agonist
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6-8 weeks
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GSK 894281
T27443874958-63-1
GSK 894281 is a ghrelin receptor agonist. It may produces myocardial degeneration/necrosis in rats.
  • $1,520
6-8 weeks
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