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Chromatin/Epigenetic Epigenetic Reader Domain

Epigenetic Reader Domain

Epigenetic reader domains can be thought of as effector proteins that recognize and are recruited to specific epigenetic marks.
Cat No. Product Name
T14776 BRD4 Inhibitor-10 BRD4 Inhibitor-10 is an inhibitor of BRD4-BD1 (IC50: 8 nM).
T15014 CTPB CTPB is a p300 histone acetyltransferase (HAT) enzyme activator.
T1516 Curcumin Curcumin is a phytopolylphenol pigment isolated from the plant Curcuma longa, commonly known as turmeric, with a variety of pharmacologic properties. Curcumin b...
T15216 EML 425 EML425 is a potent and selective inhibitor of CREB binding protein (CBP)/p300 (IC50s: 2.9 and 1.1 μM, respectively).
T15397 GNE-049 GNE-049 is a highly potent and selective inhibitor of CBP (IC50: 1.1 nM in TR-FRET assay). GNE-049 also inhibits BRET and BRD4(1) (IC50s: 12 nM and 4200 nM, res...
T15399 GNE-207 GNE-207 is a selective and orally bioavailable inhibitor of the bromodomain of CBP (IC50: 1 nM). It has a selective index of >2500-fold against BRD4 (1). GNE-...
T15400 GNE-272 GNE-272 is a selective inhibitor of CBP/EP300 (IC50: 0.02, 0.03, and 13 μM for CBP, EP300, and BRD4, respectively) and a selective in vivo probe for CBP/EP300.
T15405 GNE-781 GNE-781 is a highly potent and selective inhibitor of CBP (IC50: 0.94 nM in TR-FRET assay). GNE-781 also inhibits BRET and BRD4(1) (IC50s: 6.2 nM and 5100 nM, r...
T15419 GS-626510 GS-626510 is an orally bioavailable inhibitor of BET family bromodomains (Kd: 0.59-3.2 nM for BRD2/3/4; IC50: 83 nM and 78 nM for BD1 and BD2).
T15441 GSK8573 GSK8573 is an inactive control compound for GSK2801. GSK8573 has binding activity to BRD9 (Kd of 1.04 μM).
T15443 GSK8814 GSK8814 displays 500-fold selectivity for ATAD2 over BRD4 BD1. GSK8814 binds to ATAD2 and BRD4 BD1 (pIC50s of 7.3 and 4.6, respectively). GSK8814 is a selective...
T15484 HJB97 HJB97 is used for the design of potential PROTAC BET degrader. It also has antitumor activity. HJB97 is a high-affinity inhibitor of BET (Kis: 0.9 nM (BRD2 BD1...
T15794 LUT014 LUT014 is a B-Raf inhibitor (IC50: 11.7 nM) and developed to decrease dose-limiting acneiform lesions associated with EGFR Inhibitors treatment.
T16139 MRS2698 MRS2698 is an effective and highly selective agonist of the P2Y2 receptor (EC50: 8 nM). MRS2698 also is >300-fold P2Y2-selective versus the P2Y4 and P2Y6 recept...
T16154 MS417 MS417 is an inhibitor of BET-specific BRD4(BRD4-BD1 and BRD4-BD2 with IC50s of 30, 46 nM and Kds of 36.1, 25.4 nM, respectively), with weak selectivity at CBP B...
T17147 TPOP146 TPOP146 is a selective CBP/P300 benzoxazepine bromodomain inhibitor (Kd: 134 nM and 5.02 μM for CBP and BRD4).
T17249 VZ185 VZ185 is an effective and selective dual BRD7/9 PROTAC degrader (DC50s: 4.5 and 1.8 nM, respectively).
T17294 ZL0454 ZL0454 is an effective and selective Bromodomain-containing protein 4 inhibitors (IC50: 49 and 32 nM for BD1 and BD2).
T17297 ZXH-3-26 ZXH-3-26 is a selective degrader of the PROTAC BRD4 (DC50/5h: ~ 5 nM).
T17311 (+)-JQ1 PA (+)-JQ1 PA is a derivative of the Bromodomain and extra-terminal (BET) inhibitor JQ1(IC50 of 10.4 nM).
T1854 MS436 MS436 is a selective, small-molecule inhibitor for the BRD4 bromodomains.
T1906 Molibresib GSK 525762A (I-BET 762) is an inhibitor of BET proteins (IC50: about 35 nM).
T19608 Zinc sulfate heptahydrate Zinc sulfate heptahydrate is a dietary supplement used for zinc deficiency and to prevent the condition in those at high risk.
T19618 (R)-(-)-JQ1 Enantiomer (R)-(-)-JQ1 Enantiomer is the stereoisomer of (+)-JQ1. (+)-JQ1 is a BET bromodomain inhibitor, acting on BRD4(1/2)(IC50 of 77 nM/33 nM in a cell-free assay)
T1972 GSK 5959 GSK-5959 is an effective, specific and cell permeable BRPF1 bromodomain inhibitor (IC50: ~80 nM). The selectivity of GSK-5959 for BRPF1 is >100-fold over a pane...
T1973 PFI-4 PFI-4 is a potent and selective and cell-permeable BRPF1 bromodomain inhibitor.
T1993 J147 J147 is an experimental drug with reported effects against both Alzheimer's disease and ageing in mouse models of accelerated aging. It is a curcumin derivative...
T2072 BET bromodomain inhibitor BET bromodomain inhibitor is a potent BET inhibitor.
T2091 CPI-0610 CPI-0610 is an effective, specific, and cell-active BET bromodomain inhibitor CPI-0610 inhibits BRD4-BD1 (IC50: nM).
T2110 (+)-JQ-1HOT (+)-JQ1 is a BET bromodomain inhibitor (IC50: 77 nM/33 nM for BRD4 (1/2)).
T2120 I-BET151 I-BET151 (GSK1210151A) is a specific BET inhibitor for BRD2/3/4 (IC50: 0.5/0.25/0.79 μM, in cell-free assays).
T2127 OF-1 OF-1 is a potent inhibitor of BRPF1B and BRPF2 bromodomain.
T22345 INCB054329 INCB054329, a structurally distinct bromodomain and extraterminal domain (BET) inhibitor, inhibits BRD2-BD1, BRD2-BD2, BRD3-BD1, BRD3-BD2, BRD4-BD1, BRD4-BD2, B...
T2237 ICG001 ICG-001 antagonizes Wnt/β-catenin/TCF-mediated transcription and specifically binds to element-binding protein (CREB)-binding protein (CBP) with IC50 of 3 μM,...
T2252 UNC669 UNC669 is an effective and specific MBT (malignant brain tumor) inhibitor with IC50 of 4.2/3.1 uM for L3MBTL1/3.
T2379 UNC1215 UNC1215, an effective and specific MBT (malignant brain tumor) antagonist, binds L3MBTL3 (IC50/Kd: 40/120 nM). The selectivity of UNC1215 for L3MBTL3 is 50-fold...
T2436 GSK2801 GSK2801 is an effective, specific and cell active acetyl-lysine competitive inhibitor of BAZ2A(Kd: 136 nM) and BAZ2B(Kd: 257 nM) bromodomains.
T2442 CPI-203 CPI-203 is an effective BET bromodomain inhibitor (IC50: 37 nM for BRD4).
T2452 C646 C646, a histone acetyltransferase inhibitor, inhibits p300 (Ki: 400 nM, in a cell-free assay).
T2480 Apabetalone RVX-208, an effective BET bromodomain inhibitor,has been investigated for the treatment of diabetes, atherosclerosis, and coronary artery disease.
T3217 PF-CBP1 hydrochloride PF-CBP1 is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP).It inhibits CREBBP and p300 bromodomains with IC50 of 125 and 363 nM ...
T3311 GSK6853 GSK6853 is a potent, soluble, cell-active, and highly selective inhibitor of the BRPF1 bromodomain.
T3504 AZD5153 6-Hydroxy-2-naphthoic acid AZD 5153 is an orally available, bivalent inhibitor of the bromodomain and extraterminal (BET) protein BRD4 (IC50 = 5 nM). It can simultaneously bind two brom...
T3697 3,6'-Disinapoyl sucrose 3,6'-Disinapoyl sucrose shows the neuroprotective effect and antidepressive activity in rats.
T3712 Mivebresib Mivebresib, also known as ABBV-075, is a potent BET inhibitor (bromodomain (BRD)-containing protein) with potential antineoplastic activity. Upon administration...
T3969 I-CBP112 I-CBP112 is a specific and potent acetyl-lysine competitive protein-protein interaction inhibitor targeting the CBP/p300 bromodomains.
T3973 PF-CBP1 PF-CBP1 HCl is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP). It inhibits CREBBP (IC50: 125 nM) and p300 bromodomains (IC50: 3...
T3986 SF2523 SF2523 is a highly selective and potent inhibitor.
T4012 UNC 926 hydrochloride UNC-926 inhibits L3MBTL1 (IC50: 3.9 μM). UNC-926 also exhibits a low micromolar affinity for L3MBTL3. UNC-926 inhibits binding of the 3xMBT domain to H4K20me1....
T4247 I-CBP112 hydrochloride I-CBP112 is a selective inhibitor of the bromodomain-containing transcription factors. I-CBP112 (1 mM) has little activity against other bromodomains. I-CBP112 ...
BRD4 Inhibitor-10
T14776CAS 1660117-38-3
BRD4 Inhibitor-10 is an inhibitor of BRD4-BD1 (IC50: 8 nM).
CTPB
T15014CAS 586976-24-1
CTPB is a p300 histone acetyltransferase (HAT) enzyme activator.
Curcumin
T1516CAS 458-37-7
Curcumin is a phytopolylphenol pigment isolated from the plant Curcuma longa, commonly known as turmeric, with a variety of pharmacologic properties. Curcumin b...
EML 425
T15216CAS 1675821-32-5
EML425 is a potent and selective inhibitor of CREB binding protein (CBP)/p300 (IC50s: 2.9 and 1.1 μM, respectively).
GNE-049
T15397CAS 1936421-41-8
GNE-049 is a highly potent and selective inhibitor of CBP (IC50: 1.1 nM in TR-FRET assay). GNE-049 also inhibits BRET and BRD4(1) (IC50s: 12 nM and 4200 nM, res...
GNE-207
T15399CAS 2158266-58-9
GNE-207 is a selective and orally bioavailable inhibitor of the bromodomain of CBP (IC50: 1 nM). It has a selective index of >2500-fold against BRD4 (1). GNE-...
GNE-272
T15400CAS 1936428-93-1
GNE-272 is a selective inhibitor of CBP/EP300 (IC50: 0.02, 0.03, and 13 μM for CBP, EP300, and BRD4, respectively) and a selective in vivo probe for CBP/EP300.
GNE-781
T15405CAS 1936422-33-1
GNE-781 is a highly potent and selective inhibitor of CBP (IC50: 0.94 nM in TR-FRET assay). GNE-781 also inhibits BRET and BRD4(1) (IC50s: 6.2 nM and 5100 nM, r...
GS-626510
T15419CAS 1637770-13-8
GS-626510 is an orally bioavailable inhibitor of BET family bromodomains (Kd: 0.59-3.2 nM for BRD2/3/4; IC50: 83 nM and 78 nM for BD1 and BD2).
GSK8573
T15441CAS 1693766-04-9
GSK8573 is an inactive control compound for GSK2801. GSK8573 has binding activity to BRD9 (Kd of 1.04 μM).
GSK8814
T15443CAS 1997369-78-4
GSK8814 displays 500-fold selectivity for ATAD2 over BRD4 BD1. GSK8814 binds to ATAD2 and BRD4 BD1 (pIC50s of 7.3 and 4.6, respectively). GSK8814 is a selective...
HJB97
T15484CAS 2093391-24-1
HJB97 is used for the design of potential PROTAC BET degrader. It also has antitumor activity. HJB97 is a high-affinity inhibitor of BET (Kis: 0.9 nM (BRD2 BD1...
LUT014
T15794CAS 2274819-46-2
LUT014 is a B-Raf inhibitor (IC50: 11.7 nM) and developed to decrease dose-limiting acneiform lesions associated with EGFR Inhibitors treatment.
MRS2698
T16139CAS 934014-05-8
MRS2698 is an effective and highly selective agonist of the P2Y2 receptor (EC50: 8 nM). MRS2698 also is >300-fold P2Y2-selective versus the P2Y4 and P2Y6 recept...
MS417
T16154CAS 916489-36-6
MS417 is an inhibitor of BET-specific BRD4(BRD4-BD1 and BRD4-BD2 with IC50s of 30, 46 nM and Kds of 36.1, 25.4 nM, respectively), with weak selectivity at CBP B...
TPOP146
T17147CAS 2018300-62-2
TPOP146 is a selective CBP/P300 benzoxazepine bromodomain inhibitor (Kd: 134 nM and 5.02 μM for CBP and BRD4).
VZ185
T17249CAS 2306193-61-1
VZ185 is an effective and selective dual BRD7/9 PROTAC degrader (DC50s: 4.5 and 1.8 nM, respectively).
ZL0454
T17294CAS 2229042-77-5
ZL0454 is an effective and selective Bromodomain-containing protein 4 inhibitors (IC50: 49 and 32 nM for BD1 and BD2).
ZXH-3-26
T17297CAS 2243076-67-5
ZXH-3-26 is a selective degrader of the PROTAC BRD4 (DC50/5h: ~ 5 nM).
(+)-JQ1 PA
T17311CAS 2115701-93-2
(+)-JQ1 PA is a derivative of the Bromodomain and extra-terminal (BET) inhibitor JQ1(IC50 of 10.4 nM).
MS436
T1854CAS 1395084-25-9
MS436 is a selective, small-molecule inhibitor for the BRD4 bromodomains.
Molibresib
T1906CAS 1260907-17-2
GSK 525762A (I-BET 762) is an inhibitor of BET proteins (IC50: about 35 nM).
Zinc sulfate heptahydrate
T19608CAS 7446-20-0
Zinc sulfate heptahydrate is a dietary supplement used for zinc deficiency and to prevent the condition in those at high risk.
(R)-(-)-JQ1 Enantiomer
T19618CAS 1268524-71-5
(R)-(-)-JQ1 Enantiomer is the stereoisomer of (+)-JQ1. (+)-JQ1 is a BET bromodomain inhibitor, acting on BRD4(1/2)(IC50 of 77 nM/33 nM in a cell-free assay)
GSK 5959
T1972CAS 901245-65-6
GSK-5959 is an effective, specific and cell permeable BRPF1 bromodomain inhibitor (IC50: ~80 nM). The selectivity of GSK-5959 for BRPF1 is >100-fold over a pane...
PFI-4
T1973CAS 900305-37-5
PFI-4 is a potent and selective and cell-permeable BRPF1 bromodomain inhibitor.
J147
T1993CAS 1146963-51-0
J147 is an experimental drug with reported effects against both Alzheimer's disease and ageing in mouse models of accelerated aging. It is a curcumin derivative...
BET bromodomain inhibitor
T2072CAS 1505453-59-7
BET bromodomain inhibitor is a potent BET inhibitor.
CPI-0610
T2091CAS 1380087-89-7
CPI-0610 is an effective, specific, and cell-active BET bromodomain inhibitor CPI-0610 inhibits BRD4-BD1 (IC50: nM).
(+)-JQ-1 HOT
T2110CAS 1268524-70-4
(+)-JQ1 is a BET bromodomain inhibitor (IC50: 77 nM/33 nM for BRD4 (1/2)).
I-BET151
T2120CAS 1300031-49-5
I-BET151 (GSK1210151A) is a specific BET inhibitor for BRD2/3/4 (IC50: 0.5/0.25/0.79 μM, in cell-free assays).
OF-1
T2127CAS 919973-83-4
OF-1 is a potent inhibitor of BRPF1B and BRPF2 bromodomain.
INCB054329
T22345CAS 1628607-64-6
INCB054329, a structurally distinct bromodomain and extraterminal domain (BET) inhibitor, inhibits BRD2-BD1, BRD2-BD2, BRD3-BD1, BRD3-BD2, BRD4-BD1, BRD4-BD2, B...
ICG001
T2237CAS 847591-62-2
ICG-001 antagonizes Wnt/β-catenin/TCF-mediated transcription and specifically binds to element-binding protein (CREB)-binding protein (CBP) with IC50 of 3 μM,...
UNC669
T2252CAS 1314241-44-5
UNC669 is an effective and specific MBT (malignant brain tumor) inhibitor with IC50 of 4.2/3.1 uM for L3MBTL1/3.
UNC1215
T2379CAS 1415800-43-9
UNC1215, an effective and specific MBT (malignant brain tumor) antagonist, binds L3MBTL3 (IC50/Kd: 40/120 nM). The selectivity of UNC1215 for L3MBTL3 is 50-fold...
GSK2801
T2436CAS 1619994-68-1
GSK2801 is an effective, specific and cell active acetyl-lysine competitive inhibitor of BAZ2A(Kd: 136 nM) and BAZ2B(Kd: 257 nM) bromodomains.
CPI-203
T2442CAS 202591-23-9
CPI-203 is an effective BET bromodomain inhibitor (IC50: 37 nM for BRD4).
C646
T2452CAS 328968-36-1
C646, a histone acetyltransferase inhibitor, inhibits p300 (Ki: 400 nM, in a cell-free assay).
Apabetalone
T2480CAS 1044870-39-4
RVX-208, an effective BET bromodomain inhibitor,has been investigated for the treatment of diabetes, atherosclerosis, and coronary artery disease.
PF-CBP1 hydrochloride
T3217CAS 2070014-93-4
PF-CBP1 is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP).It inhibits CREBBP and p300 bromodomains with IC50 of 125 and 363 nM ...
GSK6853
T3311CAS 1910124-24-1
GSK6853 is a potent, soluble, cell-active, and highly selective inhibitor of the BRPF1 bromodomain.
AZD5153 6-Hydroxy-2-naphthoic acid
T3504CAS 1869912-40-2
AZD 5153 is an orally available, bivalent inhibitor of the bromodomain and extraterminal (BET) protein BRD4 (IC50 = 5 nM). It can simultaneously bind two brom...
3,6'-Disinapoyl sucrose
T3697CAS 139891-98-8
3,6'-Disinapoyl sucrose shows the neuroprotective effect and antidepressive activity in rats.
Mivebresib
T3712CAS 1445993-26-9
Mivebresib, also known as ABBV-075, is a potent BET inhibitor (bromodomain (BRD)-containing protein) with potential antineoplastic activity. Upon administration...
I-CBP112
T3969CAS 1640282-31-0
I-CBP112 is a specific and potent acetyl-lysine competitive protein-protein interaction inhibitor targeting the CBP/p300 bromodomains.
PF-CBP1
T3973CAS 1962928-21-7
PF-CBP1 HCl is a highly selective inhibitor of the bromodomain of CREB-binding protein(CREBBP). It inhibits CREBBP (IC50: 125 nM) and p300 bromodomains (IC50: 3...
SF2523
T3986CAS 1174428-47-7
SF2523 is a highly selective and potent inhibitor.
UNC 926 hydrochloride
T4012CAS 1184136-10-4
UNC-926 inhibits L3MBTL1 (IC50: 3.9 μM). UNC-926 also exhibits a low micromolar affinity for L3MBTL3. UNC-926 inhibits binding of the 3xMBT domain to H4K20me1....
I-CBP112 hydrochloride
T4247CAS 2147701-33-3
I-CBP112 is a selective inhibitor of the bromodomain-containing transcription factors. I-CBP112 (1 mM) has little activity against other bromodomains. I-CBP112 ...